CN101966198A - Compound sulfamethoxydiazine sodium injection and preparation method thereof - Google Patents
Compound sulfamethoxydiazine sodium injection and preparation method thereof Download PDFInfo
- Publication number
- CN101966198A CN101966198A CN2010102363980A CN201010236398A CN101966198A CN 101966198 A CN101966198 A CN 101966198A CN 2010102363980 A CN2010102363980 A CN 2010102363980A CN 201010236398 A CN201010236398 A CN 201010236398A CN 101966198 A CN101966198 A CN 101966198A
- Authority
- CN
- China
- Prior art keywords
- injection
- sodium
- water
- treatment
- edta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses compound sulfamethoxydiazine sodium injection and a preparation method thereof, aiming to provide the compound sulfamethoxydiazine sodium injection which is used for treating infection with pig toxoplasmosis and reducing bacterial drug resistance and is convenient to administrate and the preparation method thereof which is simple in process and easy to implement. The injection per 100L comprises 5-15kg of sulfamethoxydiazine sodium, 4-10kg of lincomycin hydrochloride, 1-3kg of TMP, 5-10kg of amidopyrine, 0.05kg of bethanechol chloride, 20L of dimethyl formamide, 15L of 95% of ethanol, 15L of propylene glycol, 0.2kg of anhydrous sodium sulfite, 0.01kg of EDTA-2Na and 100L of water for injection. Through reasonable proportioning of several drugs, the injection has multidirectional effects on infection with toxoplasmosis, reduces the bacterial drug resistance, achieves the effects of several drugs through one-time administration, is convenient to use and can relieve the clinical symptoms of the pigs attacked by toxoplasmosis and accelerate recovery of the pigs.
Description
Technical field
The present invention relates to a kind of compound sulfonamide of pig arch insect infection that is used for the treatment of to Sulfamonomethoxine sodium injection and preparation method thereof.
Background technology
The pig arch insect infection is the more common a kind of disease of pig, mainly cause by toxoplasma, clinically mainly show as the pig hyperpyrexia and be continued fever, lassitude, loss of appetite or useless exhausted, many constipation, respiratory symptom, lymphadenectasis are arranged, there are congestion speckle or large tracts of land cyanosis in lower body part or ear, get the visible toxoplasma of disease sample microscopy, toxoplasma tachyzoite and polypide colony (false capsule).
Because this type of disease generally takes place recently, medication is general, cause drug resistance commonplace, and the simple treatment of general conventional medicine is taked in gram positive bacteria, negative bacterium mixed infections such as normal and streptococcus, Salmonella now, and therapeutic effect is not good, in therapeutic process, because drug regimen, collocation problem bring inconvenience for numerous culturists, disease can not better controlled, and treatment time is untimely and be easy to cause very big loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of treatment pig arch insect infection to be provided, and reduces bacterial drug resistance, can alleviate the clinical symptoms of trouble pig when ill, and compound sulfonamide easy to use is to the Sulfamonomethoxine sodium injection.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned porcine compound sulfameter sodium injection of realizing.
The present invention is achieved through the following technical solutions:
A kind of porcine compound sulfameter sodium injection, it is characterized in that the consisting of of every 100L injection: sulfameter sodium 5～15kg, lincomycin hydrochloride 4～10kg, TMP (dimethoxy benzyl Aminometradine) 1～3kg, aminophenazone 5～10kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, the water for injection of surplus.
A kind of preparation method that is used for the treatment of the compound sulfonamide of pig arch insect infection to the Sulfamonomethoxine sodium injection is characterized in that, comprises the steps:
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 5～15kg successively, lincomycin hydrochloride 4～10kg;
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP1～3kg, aminophenazone 5～10kg successively, and the dissolving back adds propylene glycol 15L, 95% ethanol 15L, stirs;
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
The preferable content of each component is in wherein every 100L injection: sulfameter sodium 8～12kg, lincomycin hydrochloride 6～8kg, TMP 1.6～2.4kg, aminophenazone 7～9kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, the water for injection of surplus.
The optimum content of each component is in every 100L injection: sulfameter sodium 10kg, lincomycin hydrochloride 7kg, TMP 2kg, aminophenazone 8kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, the water for injection of surplus.
The present invention has following technique effect:
The present invention is a compound preparation, adopt sulfameter sodium and the dual toxoplasma of killing of lincomycin hydrochloride, reduce the drug resistance probability of pathogen, and prevent the resistance decline that causes because of toxoplasma gondii infection with treatment, other antibacterial secondary infection that cause to a certain extent; TMP has potentiation to sulfameter sodium and lincomycin hydrochloride, strengthens the effect to pathogen; Aminophenazone acts on hypothalamus, have powerful bring down a fever, antiinflammatory action; Carbamylcholine chloride stimulating gastrointestinal road wriggling, stimulating appetite promotes ill pig to search for food, and strengthening resistance against diseases, and light moderate constipation is had the good curing effect.All medicines share and the proportioning by science, and arch insect infection is had multi-faceted effect, treating both the principal and secondary aspects of a disease.And this product is a compound preparation, and a drug reaches the effect of multiple medications, and is easy to use, can alleviate to suffer from the clinical symptoms of pig when ill, makes pig recover to accelerate, and under normal conditions, can reduce the chemical sproof generation of pathogen.The preparation method technology of porcine compound sulfameter sodium injection of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 5kg, lincomycin hydrochloride 10kg successively.
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP1kg, aminophenazone 10kg successively, and the dissolving back adds propylene glycol 15L, 95% ethanol 15L, stirs.
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
Embodiment 2
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 15kg, lincomycin hydrochloride 40kg successively.
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP3kg, aminophenazone 5kg successively, and the dissolving back adds propylene glycol 15L, 95% ethanol 15L, stirs.
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
Embodiment 3
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 8kg, lincomycin hydrochloride 8kg successively.
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP1.6kg, aminophenazone 7kg successively, and the dissolving back adds propylene glycol 15L, 95% ethanol 15L, stirs.
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
Embodiment 4
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 12kg, lincomycin hydrochloride 6kg successively.
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP2.4kg, aminophenazone 9kg successively, and the dissolving back adds propylene glycol 15L, 95% ethanol 15L, stirs.
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
Embodiment 5
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 9kg successively, lincomycin hydrochloride 7.5kg.
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP1.8kg, aminophenazone 7.5kg successively, and the dissolving back adds propylene glycol 15L, 95% ethanol 15L, stirs.
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
Embodiment 6
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 10kg, lincomycin hydrochloride 7kg successively.
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP2kg, aminophenazone 8kg successively, and the dissolving back adds propylene glycol 15L, 95% ethanol 15L, stirs.
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
Clinical trial:
1. laboratory animal:
100 of the ill pigs of picked at random.
2. experiment medicine
The compound sulfonamide that is used for the treatment of the pig arch insect infection of the embodiment of the invention 6 preparations is developed Sulfamonomethoxine sodium injection our unit;
The compound injection our unit prepared in laboratory of 10% sulfameter sodium and 2%TMP;
7% carbonic acid lincomycin inj our unit prepared in laboratory.
3. experimental technique:
The A group does not give Drug therapy for the blank group.
The B group is treated usage with the compound injection of 10% sulfameter sodium and 2%TMP: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
The C group is treated usage with 7% lincomycin hydrochloride injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
The D group is treated usage with the compound sulfonamide that is used for the treatment of the pig arch insect infection of the embodiment of the invention 6 preparations to the Sulfamonomethoxine sodium injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, the distribution of pig health situation of change suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the pig symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the pig symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from pig and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from pig and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from pig and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the compound sulfonamide that is used for the treatment of the pig arch insect infection of the embodiment of the invention 6 preparation is to the compound injection treatment group of Sulfamonomethoxine sodium injection treatment group, 10% sulfameter sodium and 2%TMP and 7% lincomycin hydrochloride injection group and matched group difference extremely remarkable (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end | A dead number |
| A | Matched group | 25 | 0 | 0 | 18 | 7 |
| B | The compound injection treatment of 10% sulfameter sodium and 2%TMP | 11 | 14 | 6 | 13 | 6 |
| C | The treatment of 7% lincomycin hydrochloride injection | 12 | 13 | 7 | 12 | 6 |
| D | Embodiment 6 preparation compound sulfonamides are treated the Sulfamonomethoxine sodium injection | 3 | 22 | 18 | 5 | 2 |
Claims (6)
1. a compound sulfonamide that is used for the treatment of the pig arch insect infection is to the Sulfamonomethoxine sodium injection, it is characterized in that the consisting of of every 100L injection: sulfameter sodium 5～15kg, lincomycin hydrochloride 4～10kg, TMP 1～3kg, aminophenazone 5～10kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, the water for injection of surplus.
2. the compound sulfonamide of pig arch insect infection that is used for the treatment of according to claim 1 is to the Sulfamonomethoxine sodium injection, it is characterized in that the consisting of of every 100L injection: sulfameter sodium 8～12kg, lincomycin hydrochloride 6～8kg, TMP 1.6～2.4kg, aminophenazone 7～9kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, the water for injection of surplus.
3. the compound sulfonamide of pig arch insect infection that is used for the treatment of according to claim 1 is to the Sulfamonomethoxine sodium injection, it is characterized in that the consisting of of every 100L injection: sulfameter sodium 10kg, lincomycin hydrochloride 7kg, TMP 2kg, aminophenazone 8kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na0.01kg, the water for injection of surplus.
4. the described preparation method that is used for the treatment of the compound sulfonamide of pig arch insect infection to the Sulfamonomethoxine sodium injection of claim 1 is characterized in that, comprises the steps:
(1) gets 70～80 ℃ water for injection 30L, dissolve anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, carbamylcholine chloride 0.05kg, sulfameter sodium 5～15kg, lincomycin hydrochloride 4～10kg successively;
(2) get dimethyl formamide 20L, heating in water bath dissolves TMP 1～3kg, aminophenazone 5～10kg successively, adds propylene glycol 15L, 95% ethanol 15L after the dissolving again, stirs;
(3) combining step (1) and the prepared solution of step (2), after stirring, add the injection water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 9.5～11.00, treat medicinal liquid promptly make after clear and bright be used for the treatment of the pig arch insect infection compound sulfonamide to the Sulfamonomethoxine sodium injection.
5. the preparation method that is used for the treatment of the compound sulfonamide of pig arch insect infection to the Sulfamonomethoxine sodium injection according to claim 4, it is characterized in that, consisting of in every 100L injection: sulfameter sodium 8～12kg, lincomycin hydrochloride 6～8kg, TMP 1.6～2.4kg, aminophenazone 7～9kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, water for injection adds to 100L.
6. the preparation method that is used for the treatment of the compound sulfonamide of pig arch insect infection to the Sulfamonomethoxine sodium injection according to claim 4 is characterized in that, the consisting of of effective ingredient in every 100L injection: sulfameter sodium 10kg, lincomycin hydrochloride 7kg, TMP 2kg, aminophenazone 8kg, carbamylcholine chloride 0.05kg, dimethyl formamide 20L, 95% ethanol 15L, propylene glycol 15L, anhydrous sodium sulfite 0.2kg, EDTA-2Na 0.01kg, water for injection adds to 100L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102363980A CN101966198A (en) | 2010-07-26 | 2010-07-26 | Compound sulfamethoxydiazine sodium injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102363980A CN101966198A (en) | 2010-07-26 | 2010-07-26 | Compound sulfamethoxydiazine sodium injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101966198A true CN101966198A (en) | 2011-02-09 |
Family
ID=43545460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102363980A Pending CN101966198A (en) | 2010-07-26 | 2010-07-26 | Compound sulfamethoxydiazine sodium injection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101966198A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494834A (en) * | 2013-10-12 | 2014-01-08 | 成都乾坤动物药业有限公司 | Anti-infectious veterinary pharmaceutical composition and preparation method and application thereof |
-
2010
- 2010-07-26 CN CN2010102363980A patent/CN101966198A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494834A (en) * | 2013-10-12 | 2014-01-08 | 成都乾坤动物药业有限公司 | Anti-infectious veterinary pharmaceutical composition and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101301291B (en) | Compound enrofloxacin injection for animals and preparation thereof | |
| CN101606945A (en) | Compound sodium sulfadimidine injection liquid for pig and preparation method thereof | |
| CN100548301C (en) | Be used for the treatment of injection of swine dysentery and preparation method thereof | |
| CN101297813B (en) | Compound niacin norfloxacin injection for animals and preparation thereof | |
| CN101628109A (en) | Compound neomycin sulphate solution and preparation method thereof | |
| CN101966198A (en) | Compound sulfamethoxydiazine sodium injection and preparation method thereof | |
| CN101642460A (en) | Compound solution of diclazuril for curing avian coccidium infection and preparation method thereof | |
| CN101966184A (en) | Vitamin B complex injection for treating porcine indigestion and preparation method | |
| CN101612118A (en) | Porcine compound astragalus polysaccharide injection and preparation method thereof | |
| CN101670094A (en) | Compound gentamycin sulfate soluble powder and preparation method thereof | |
| CN103417571A (en) | Composition for treating chicken mycoplasma respiratory infection and preparing method thereof | |
| CN103432154A (en) | Injection for treating hyperthermia caused by porcine bacterial infection and preparation method thereof | |
| CN101879179A (en) | Compound Ofloxacin solution and preparation method thereof | |
| CN101297808B (en) | Compound ofloxacin injection for fowl and preparation method thereof | |
| CN101297794B (en) | Compound kanamycin sulphate injection for dogs and preparation thereof | |
| CN101653486A (en) | Compound Bailongsan for treating diarrhoea of nursery pig and preparation method thereof | |
| CN101601676A (en) | Compound hydrochloric acid oxytetracycline soluble powder and preparation method that the treatment spirochaeta gallinarum infects | |
| CN101606946A (en) | Compound kanamycin sulfate injection liquid for pig and preparation method thereof | |
| CN101653596A (en) | Soluble powder for treating canine colibacillosis and preparation method thereof | |
| CN101972262A (en) | Oral liquid for treating poultry coccidium and bacterium mixed infection and preparation method thereof | |
| CN101297858B (en) | Oral liquid for treating infection by avian viruses mixed with salmonella and preparation | |
| CN101653597A (en) | Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof | |
| CN101422464A (en) | Compound fubennikao injection | |
| CN101966323A (en) | Compound common andrographis herb injection for treating high fever of pigs and preparation method thereof | |
| CN102151266A (en) | Oral liquid for treating white scour of chicken and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110209 |
|
| WD01 | Invention patent application deemed withdrawn after publication |