CN102151266A - Oral liquid for treating white scour of chicken and preparation method thereof - Google Patents
Oral liquid for treating white scour of chicken and preparation method thereof Download PDFInfo
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- CN102151266A CN102151266A CN2011100417726A CN201110041772A CN102151266A CN 102151266 A CN102151266 A CN 102151266A CN 2011100417726 A CN2011100417726 A CN 2011100417726A CN 201110041772 A CN201110041772 A CN 201110041772A CN 102151266 A CN102151266 A CN 102151266A
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Abstract
The invention discloses an oral liquid for treating white scour of chicken and a preparation method thereof, aiming at providing an oral liquid which can be used for treating white scour infection of chicken with treatment of both principal and secondary aspects of disease and is convenient for medicate and a preparation method thereof which has a simple process and is easy to realize. The composition of each 100L of oral liquid is as follow: 1-7kg of enrofloxacin, 5-15kg of sulfamonomethoxine, 1-3kg of TMP (Trimethoprim), 0.1-0.5kg of atropine sulfate, 30L of dimethylformamide, 20L of 95% ethanol, 1-2kg of sodium hydroxide and the balance of water. In the oral liquid disclosed by the invention, all ingredients are combined and reasonably proportioned to play a multiaspect role on the white scour of chicken with treatment of both principal and secondary aspects of disease; in addition, the oral liquid is a compound preparation and can reach the effect of a plurality of medicines through once administration; and the oral liquid is convenient to use and can ease clinical symptoms when chicken are sicken. The oral liquid disclosed by the invention can intersoluble with water according to any proportion and can be medicated in mass group.
Description
Technical field
The present invention relates to a kind of oral liquid that is used for the treatment of the white scour of chicken and preparation method thereof.
Background technology
The white scour of chicken is a kind of commonly encountered diseases of chickling, and cause of disease is a Salmonella, and main clinical manifestation is the chickling inappetence, the fine hair pine disorderly, be afraid of cold, health is rolled up, and wing is sagging, depressed or the lethargy of spirit, arrange white thickness or yellowish, light green loose stool, the excrement piece sealing that anus is hardened sometimes, dyspnea etc., the course of disease is short, the mortality rate height.
Because this type of disease generally takes place recently, medication is general, cause drug resistance commonplace, and bacterial infections such as normal secondary infection escherichia coli infect, and take the simple treatment of general conventional medicine now, and therapeutic effect is not good, in therapeutic process, because drug regimen, collocation problem bring inconvenience for numerous culturists, disease can not better controlled, and treatment time is untimely and be easy to cause very big loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provides a kind of white scour of chicken of can treating to infect, and reduces bacterial drug resistance, can alleviate the clinical symptoms of ill chickling when ill, oral liquid easy to use.
It is simple that another object of the present invention provides a kind of technology, easily the above-mentioned preparation method that is used for the treatment of the oral liquid of the white scour of chicken that realizes.
The present invention is achieved through the following technical solutions:
The oral liquid of the one treatment white scour of chicken, it is characterized in that, consisting of of every 100L oral liquid: enrofloxacin 1～7kg, sulfamonomethoxine sodium 5～15kg, TMP 1～3kg, atropine sulfate 0.1～0.5kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1～2kg, surplus is a water.
A kind of preparation method for the treatment of the oral liquid of the white scour of chicken is characterized in that, comprises the steps:
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 1～2kg, after the stirring and dissolving, dissolve enrofloxacin 1～7kg successively, sulfamonomethoxine sodium 5～15kg.
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 1～3kg, the dissolving back adds 95% ethanol 20L, stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.1～0.5kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
Used water is purified water or water for injection.
The preferable content of each component is in wherein every 100L oral liquid: enrofloxacin 2～6kg, sulfamonomethoxine sodium 8～12kg, TMP 1.6～2.4kg, atropine sulfate 0.15～0.3kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1.2～1.8kg, surplus is a water.
The optimum content of each component is in every 100L oral liquid: enrofloxacin 5kg, and sulfamonomethoxine sodium 10kg, TMP 2kg, atropine sulfate 0.2kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1.5kg, surplus is a water.
The present invention has following technique effect:
The present invention is a compound preparation, adopt enrofloxacin and sulfamonomethoxine sodium as antimicrobial component, double inhibition causes the Salmonella of the white scour of chicken, and can reduce the drug resistance probability of antibacterial, improve the sensitivity of cause of disease, and enrofloxacin and sulfamonomethoxine sodium have broad spectrum activity, and the bacterial infections such as escherichia coli of white scour of chicken secondary are also had control action; TMP has the antibacterial action that strengthens sulfamonomethoxine sodium, improve its antibacterial effect, atropine sulfate has the glandular secretion of the intestinal of inhibition, reduce the effect of intestinal contents moisture, reduce the loss of moisture in the ill chickling body, improve therapeutic effect, all medicines share and pass through rational proportion, the white scour of chicken had multi-faceted effect, treating both the principal and secondary aspects of a disease, and this product is compound preparation, a drug, reach the effect of multiple medications, easy to use, can alleviate the clinical symptoms of ill chickling when ill, and under normal conditions, can reduce the chemical sproof generation of pathogen, the prevention secondary infection.This product is an oral liquid, can dissolve each other by any ratio with water, but the jumpbogroup medication.The oral liquor technology of the treatment white scour of chicken of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
The water that the present invention uses is purified water or water for injection.
Embodiment 1
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 1kg, after the stirring and dissolving, dissolve enrofloxacin 1kg, sulfamonomethoxine sodium 15kg successively.
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 3kg, the dissolving back adds 95% ethanol 20L, stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.1kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
Embodiment 2
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 2kg, after the stirring and dissolving, dissolve enrofloxacin 7kg, sulfamonomethoxine sodium 5kg successively.
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 1kg, the dissolving back adds 95% ethanol 20L, stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.5kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
Embodiment 3
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 1.2kg, after the stirring and dissolving, dissolve enrofloxacin 2kg, sulfamonomethoxine sodium 12kg successively.
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 2.4kg, the dissolving back adds 95% ethanol 20L, stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.15kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
Embodiment 4
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 1.8kg, after the stirring and dissolving, dissolve enrofloxacin 6kg, sulfamonomethoxine sodium 8kg successively.
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 1.6kg, the dissolving back adds 95% ethanol 20L, stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.3kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
Embodiment 5
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 1.6kg, after the stirring and dissolving, dissolve enrofloxacin 4kg, sulfamonomethoxine sodium 11kg successively.
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 2.2kg, the dissolving back adds 95% ethanol 20L, stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.18kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
Embodiment 6
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 1.5kg, after the stirring and dissolving, dissolve enrofloxacin 5kg, sulfamonomethoxine sodium 10kg successively.
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 2kg, the dissolving back adds 95% ethanol 20L, stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.2kg.
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
Clinical trial:
1. laboratory animal:
1000 of the ill chickling of picked at random.
2. experiment medicine
The oral liquid our unit development that is used for the treatment of the white scour of chicken of the embodiment of the invention 6 preparations;
10% sulfamonomethoxine sodium oral liquid our unit prepared in laboratory;
5% enrofloxacin oral liquid our unit prepared in laboratory.
3. experimental technique:
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% sulfamonomethoxine sodium oral liquid: drinking-water, every 1L water 1ml, 2 times on the one, logotype 3 days.
The C group is treated usage with 5% enrofloxacin oral liquid: drinking-water, every 1L water 1ml, 2 times on the one, logotype 3 days.
The D group is treated usage with the white scour of chicken oral liquid that is used for the treatment of of the embodiment of the invention 6 preparations: drinking-water, every 1L water 1ml, 2 times on the one, logotype 3 days.
After the treatment beginning, write down ill chickling health situation of change every day and distribute, treat and add up therapeutic effect after 7 days, wherein:
Invalid: after referring to 7 days, ill chickling symptom does not have obvious change, still keeps the preceding symptom of treatment.
Effectively: after referring to 7 days, ill chickling symptom changes, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure, ill chickling gets well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, ill chickling still has certain symptom, and its symptom performance is better than before the treatment or does not have change, and ill chickling is not cured.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the oral liquid treatment group that is used for the treatment of the white scour of chicken of the embodiment of the invention 6 preparations and 10% sulfamonomethoxine sodium oral liquid treatment group, 5% enrofloxacin oral liquid group and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
Claims (6)
1. oral liquid that is used for the treatment of the white scour of chicken, it is characterized in that, consisting of of every 100L oral liquid: enrofloxacin 1～7kg, sulfamonomethoxine sodium 5～15kg, TMP 1～3kg, atropine sulfate 0.1～0.5kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1～2kg, surplus is a water.
2. the oral liquid that is used for the treatment of the white scour of chicken according to claim 1, it is characterized in that, consisting of of every 100L oral liquid: enrofloxacin 2～6kg, sulfamonomethoxine sodium 8～12kg, TMP1.6～2.4kg, atropine sulfate 0.15～0.3kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1.2～1.8kg, surplus is a water.
3. the oral liquid that is used for the treatment of the white scour of chicken according to claim 1, it is characterized in that, consisting of of every 100L oral liquid: enrofloxacin 5kg, sulfamonomethoxine sodium 10kg, TMP 2kg, atropine sulfate 0.2kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1.5kg, surplus is a water.
4. the described preparation method that is used for the treatment of the oral liquid of the white scour of chicken of claim 1 is characterized in that, comprises the steps:
(1) gets 70～80 ℃ water 30L, add sodium hydroxide 1～2kg, after the stirring and dissolving, dissolve enrofloxacin 1～7kg, sulfamonomethoxine sodium 5～15kg successively;
(2) get dimethyl formamide 30L, heating in water bath dissolving TMP 1～3kg, the dissolving back adds 95% ethanol 20L and stirs;
(3) water intaking 2L, dissolving atropine sulfate 0.1～0.5kg;
(4) combining step (1), step (2) and the prepared solution of step (3), after stirring, add water to 100L, stir, keep 15-20min, with mass percent concentration is that 40% sodium hydroxide solution or concentration of volume percent are that 10% hydrochloric acid solution is regulated pH value to 10.0～13.00, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of the white scour of chicken after clear and bright.
5. the preparation method that is used for the oral liquid of the white scour of chicken according to claim 4, it is characterized in that, in every 100L oral liquid, enrofloxacin 2～6kg, sulfamonomethoxine sodium 8～12kg, TMP1.6～2.4kg, atropine sulfate 0.15～0.3kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1.2～1.8kg, surplus is a water.
6. the preparation method that is used for the treatment of the oral liquid of the white scour of chicken according to claim 4, it is characterized in that, enrofloxacin 5kg in every 100L oral liquid, sulfamonomethoxine sodium 10kg, TMP 2kg, atropine sulfate 0.2kg, dimethyl formamide 30L, 95% ethanol 20L, sodium hydroxide 1.5kg, surplus is a water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100417726A CN102151266A (en) | 2011-02-21 | 2011-02-21 | Oral liquid for treating white scour of chicken and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100417726A CN102151266A (en) | 2011-02-21 | 2011-02-21 | Oral liquid for treating white scour of chicken and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102151266A true CN102151266A (en) | 2011-08-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011100417726A Pending CN102151266A (en) | 2011-02-21 | 2011-02-21 | Oral liquid for treating white scour of chicken and preparation method thereof |
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2011
- 2011-02-21 CN CN2011100417726A patent/CN102151266A/en active Pending
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Application publication date: 20110817 |