CN101297858B - Oral liquid for treating infection by avian viruses mixed with salmonella and preparation - Google Patents
Oral liquid for treating infection by avian viruses mixed with salmonella and preparation Download PDFInfo
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- CN101297858B CN101297858B CN200810053101XA CN200810053101A CN101297858B CN 101297858 B CN101297858 B CN 101297858B CN 200810053101X A CN200810053101X A CN 200810053101XA CN 200810053101 A CN200810053101 A CN 200810053101A CN 101297858 B CN101297858 B CN 101297858B
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Abstract
The invention discloses an oral liquor for treatment for avian viral mixed salmonella infection and a preparation method, which aims at providing the oral liquor that has rapid onset of action for the treatment for secondary salmonella diseases caused by avian viral infection, effectivity and high efficiency and can ease the stress reactions of the affected chickens, treat both manifestation and root causes of diseases and reduce the times and dosage of drug administration, and the preparation method that has simple technology and easy realization. Each 100L of the oral liquor contains: 0.1 to 5kg of astragalus polysaccharide extract, 3 to 15kg of neomycin sulfate, 0.05 to 0.5kg of atropine sulfate, 0.01kg of EDTA-2Na, 0.6kg of sodium benzoate, 30kg of glycerol and the rest of water. The oral liquor is a compound preparation which combines traditional Chinese medicine anti-virus drugs and anti-microbial drugs, the astragalus polysaccharide, the neomycin sulfate and the atropine sulfate are combined for usage, which has rapid onset of action for the treatment for the secondary salmonella diseases caused by avian moderate viral infection, effectivity, high efficiency and can ease the stress reactions of the affected chicken and increase the weight of the chicken.
Description
Technical field
The present invention relates to a kind of birds virus that is used for the treatment of and mix compound Radix Astragali polysaccharide oral liquid of Salmonella infection and preparation method thereof.
Background technology
It is the class commonly encountered diseases of chicken that the fowl disease poison mixes Salmonella mixed infection, mainly be because the comparatively gentle viral infection of some causes health to propose resistance decline, and the secondary Salmonella infection, chicken diarrhea caused, dehydration, undergrowth, even cause death.
At present, the trend of the oriented mixed type of disease, complicated development adds long-term breed, does not have the special aquaculture management of producing, and the probability that the common temperate virus of chicken is infected increases, thereby causes that Abwehrkraft des Koepers descends, easily the secondary infection Salmonella.The single therapy schemes that adopt in the existing treatment more, as treating with astragalus polysaccharides oral liquid or neomycin sulfate oral solution, owing to can not be used aspect antiviral and the antibacterium two, and do not reach therapeutic effect or weak effect, and common both share, and bring inconvenience in the use to the raiser.And clinical mixed infection has certain interference, brings certain difficulty to the clinical application diagnosis, brings puzzlement when the raiser is selected medicine.
Other birds, there is same problem as the breed aspects of duck, goose etc.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provides a kind of avian viruses of can treating to mix Salmonella mixed infection, and instant effect can prevent to infect, and the fowl for the treatment of both the principal and secondary aspects of a disease is used the compound Radix Astragali polysaccharide oral liquid.
It is simple that another object of the present invention provides a kind of technology, and the above-mentioned fowl of realizing is easily used the preparation method of compound Radix Astragali polysaccharide oral liquid.
The present invention is achieved through the following technical solutions:
A kind of oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella, it is characterized in that, consisting of of every 100L oral liquid: astragalus polysaccharide extract 0.1～5kg, polygynax 3～15kg, atropine sulfate 0.05～0.5kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, glycerol 30kg, surplus is a water.
A kind of above-mentioned preparation method that is used for the treatment of the oral liquid of infection by avian viruses mixed with salmonella is characterized in that, comprises the steps:
(1) water intaking 20L adds astragalus polysaccharides 0.1～5kg; Be stirred to whole dissolvings;
(2) water intaking 30L adds EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 3～15kg, atropine sulfate 0.05～0.5kg, is stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds glycerol 30kg again, and moisturizing stirs to 100L, keeps 15-20min, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
The preferable of wherein every 100L oral liquid consists of: astragalus polysaccharide extract 0.5～3kg, and polygynax 5～12kg, atropine sulfate 0.1～0.3kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, glycerol 30kg, surplus is a water.
The best group of every 100L oral liquid becomes: astragalus polysaccharide extract 1kg, and polygynax 10kg, atropine sulfate 0.15kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, glycerol 30kg, surplus is a water.
Wherein, institute's water preferably adopts purified water.
The present invention has following technique effect:
The compound preparation of the present invention for adopting Chinese medicine antiviral agents and antimicrobial agents to share, astragalus polysaccharides and polygynax are united use, adopt double effects, the astragalus polysaccharides antiviral, the enhancing body resistance, the polygynax antibacterium, to Salmonella, gram negative bacterias such as escherichia coli are effective, cooperate the inhibition glandular secretion of atropine sulfate, reduce the intestinal contents moisture and reach quick therapeutic effect, and by the rational proportion to each amounts of components, the birds temperate virus is infected the secondary Salmonella infection respond well to treatment soon, effectively also efficient, can alleviate and suffer from birds health stress, treating both the principal and secondary aspects of a disease can prevent secondary infection, increases the body weight of birds.Simultaneously, the present invention has reduced medication number of times and dosage because therapeutic process is accelerated, and can reduce drug residue to occur and exceed standard.
The preparation method technology of the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) gets purified water 20L, add astragalus polysaccharides 0.1kg; Be stirred to whole dissolvings.
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 15kg, atropine sulfate 0.05kg, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds glycerol 30kg again, mends purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
Embodiment 2
(1) gets purified water 20L, add astragalus polysaccharides 5kg; Stirring and dissolving
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 3kg, atropine sulfate 0.5kg, stirring and dissolving;
(3) the prepared solution of combining step 1 and step 2 adds glycerol 30kg again, mends purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
Embodiment 3
(1) gets purified water 20L, add astragalus polysaccharides 0.5kg; Stirring and dissolving
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 12kg successively, atropine sulfate 0.1kg, stirring and dissolving;
(3) the prepared solution of combining step 1 and step 2 adds glycerol 30kg again, mends purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
Embodiment 4
(1) gets purified water 20L, add astragalus polysaccharides 3kg; Stirring and dissolving
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 5kg, atropine sulfate 0.3kg, stirring and dissolving;
(3) the prepared solution of combining step 1 and step 2 adds glycerol 30kg again, mends purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
Embodiment 5
(1) gets purified water 20L, add astragalus polysaccharides 0.8kg; Stirring and dissolving
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 8kg, atropine sulfate 0.15kg, stirring and dissolving;
(3) the prepared solution of combining step 1 and step 2 adds glycerol 30kg again, mends purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
Embodiment 6
(1) gets purified water 20L, add astragalus polysaccharides 1kg; Stirring and dissolving
(2) get purified water 30L, add EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 10kg, atropine sulfate 0.15kg, stirring and dissolving;
(3) the prepared solution of combining step 1 and step 2 adds glycerol 30kg again, mends purified water to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
Clinical trial:
Compound Radix Astragali polysaccharide oral liquid of the present invention both can be used for the chicken class, also can be used for duck, goose etc.Be laboratory animal below with the chicken, the effect that is used for the treatment of the oral liquid of infection by avian viruses mixed with salmonella of the present invention is experimentized.
1. laboratory animal:
1000 of the ill one-tenth of picked at random chickens, body weight is at 1～2kg.
2. experiment medicine
The oral liquid our unit development that is used for the treatment of infection by avian viruses mixed with salmonella of the embodiment of the invention 6 preparations;
1% astragalus polysaccharides oral liquid solution our unit prepared in laboratory;
10% neomycin sulphate solution our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 1% astragalus polysaccharides oral liquid: drinking-water, every 1kg body weight 0.1ml, 2 times on the one, logotype 4 days.
The C group is treated usage with 10% neomycin sulfate oral solution: drinking-water, every 1kg body weight 0.1ml, 2 times on the one, logotype 4 days.
The D group is treated usage with the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the embodiment of the invention 6 preparations: drinking-water, every 1kg body weight 0.1ml, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, chicken health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 5 days, wherein:
Invalid: as after referring to 5 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 5 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 5 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 5 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 is used for the treatment of oral liquid treatment group, 1% astragalus polysaccharides oral liquid treatment group and the 10% neomycin sulfate oral solution group of infection by avian viruses mixed with salmonella and matched group difference extremely significantly (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | Symptom chicken number is arranged during end | Dead number of elements | The relative weight gain rate % |
| A | Matched group | 250 | 0 | 0 | 132 | 118 | 0 |
| B | The treatment of 1% astragalus polysaccharides oral liquid | 185 | 65 | 50 | 140 | 60 | 20.5 |
| C | The treatment of 10% neomycin sulfate oral solution | 73 | 177 | 122 | 74 | 54 | 62.3 |
| D | The oral liquid treatment of the embodiment of the invention 6 | 27 | 223 | 204 | 27 | 19 | 80.0 |
Claims (2)
1. an oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella is characterized in that, the consisting of of every 100L oral liquid: astragalus polysaccharide extract 1kg, polygynax 10kg, atropine sulfate 0.15kg, EDTA-2Na 0.01kg, sodium benzoate 0.6kg, glycerol 30kg, surplus is a water.
2. the described preparation method that is used for the treatment of the oral liquid of infection by avian viruses mixed with salmonella of claim 1 is characterized in that, comprises the steps:
(1) water intaking 20L adds astragalus polysaccharide extract 1kg, is stirred to whole dissolvings;
(2) water intaking 30L adds EDTA-2Na 0.01kg, sodium benzoate 0.6kg, polygynax 10kg, and atropine sulfate 0.15kg is stirred to whole dissolvings;
(3) combining step (1) and the prepared solution of step (2) add glycerol 30kg again, and moisturizing stirs to 100L, keep 15-20min, treat that medicinal liquid promptly makes the oral liquid that is used for the treatment of infection by avian viruses mixed with salmonella of the present invention after clear and bright.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810053101XA CN101297858B (en) | 2008-05-13 | 2008-05-13 | Oral liquid for treating infection by avian viruses mixed with salmonella and preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810053101XA CN101297858B (en) | 2008-05-13 | 2008-05-13 | Oral liquid for treating infection by avian viruses mixed with salmonella and preparation |
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| CN101297858B true CN101297858B (en) | 2011-04-27 |
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| CN102813910B (en) * | 2012-08-09 | 2013-10-16 | 南京农业大学 | Medicine composition used for controlling poultry airsacculitis, and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850148A (en) * | 2006-05-19 | 2006-10-25 | 天津生机集团有限公司 | Medicine for increasing bird's immunity and treating immunity-inhibiting diseases, and preparing medicine therefor |
| CN1965846A (en) * | 2005-11-18 | 2007-05-23 | 天津市润拓生物技术有限公司 | Neomycin sulphate solution containing clustered water used for animal |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965846A (en) * | 2005-11-18 | 2007-05-23 | 天津市润拓生物技术有限公司 | Neomycin sulphate solution containing clustered water used for animal |
| CN1850148A (en) * | 2006-05-19 | 2006-10-25 | 天津生机集团有限公司 | Medicine for increasing bird's immunity and treating immunity-inhibiting diseases, and preparing medicine therefor |
Non-Patent Citations (1)
| Title |
|---|
| 郝艳霜.中药黄芪在家禽生产中的应用研究.中国家禽.2006,28(20),93-95. * |
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Denomination of invention: Oral liquid for treating infection by avian viruses mixed with salmonella and preparation Effective date of registration: 20120925 Granted publication date: 20110427 Pledgee: Bank of Shanghai Limited by Share Ltd Tianjin branch Pledgor: Tianjin Shengji Group Co., Ltd. Registration number: 2012990000565 |
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Date of cancellation: 20131202 Granted publication date: 20110427 Pledgee: Bank of Shanghai Limited by Share Ltd Tianjin branch Pledgor: Tianjin Shengji Group Co., Ltd. Registration number: 2012990000565 |
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Denomination of invention: Oral liquid for treating infection by avian viruses mixed with salmonella and preparation Effective date of registration: 20131202 Granted publication date: 20110427 Pledgee: Bank of Shanghai Limited by Share Ltd Tianjin branch Pledgor: Tianjin Shengji Group Co., Ltd. Registration number: 2013990000919 |
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Date of cancellation: 20151019 Granted publication date: 20110427 Pledgee: Bank of Shanghai Limited by Share Ltd Tianjin branch Pledgor: Tianjin Shengji Group Co., Ltd. Registration number: 2013990000919 |
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