CN101297795B - Compound florfenicol powder for animals and preparation thereof - Google Patents
Compound florfenicol powder for animals and preparation thereof Download PDFInfo
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- CN101297795B CN101297795B CN2008100526454A CN200810052645A CN101297795B CN 101297795 B CN101297795 B CN 101297795B CN 2008100526454 A CN2008100526454 A CN 2008100526454A CN 200810052645 A CN200810052645 A CN 200810052645A CN 101297795 B CN101297795 B CN 101297795B
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- florfenicol
- doxofylline
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Abstract
The invention discloses a veterinary compound florfenicol powder and a preparation method thereof, which aims at providing the veterinary compound florfenicol powder that has rapid onset of action for the treatment for porcine infectious pleuropneumonia and mycoplasmal pneumonia and can treat both manifestation and root causes of the diseases, alleviate the stress reactions when having the attacks of diseases of the pigs and improve the weight gain rate, and the preparation method that has simple process and easy realization. The powder is composed of the components with the following weight percentages: 5 to 20 percent florfenicol, 0.5 to 5 percent doxophylline and the rest of starch. The powder of the invention is a compound preparation which combines anti-bacterial drugs and the drugs for relieving cough and asthma, the florfenicol and the doxophylline are combined for usage, thus having rapid onset of action for the treatment for infectious pleuropneumonia and mycoplasmal pneumonia, effectivity and high efficiency; furthermore, the power can ease the stress reactions of the affected animals, significantly ease the clinical symptoms caused by the infectious pleuropneumonia and the mycoplasmal pneumonia, treat both manifestation and root causes of diseases, reduce the suffering of the affected pigs and increase the weight of the pigs.
Description
Technical field
The present invention relates to a kind of compound florfenicol powder for animals and preparation method thereof.
Background technology
Porcine contagious pleuropneumonia and mycoplasma pneumonia are the commonly encountered diseases of pig, and porcine contagious pleuropneumonia can cause hyopneumoniae, pleuritis.Mycoplasma pneumonia shows as clinical symptoms such as cough, asthma, dyspnea, amalgamation bronchitis.Porcine contagious pleuropneumonia can cause pig death, and mycoplasma pneumonia can have a strong impact on the pig growth.This two disease is common respiratory diseases in pigs infectious disease, brings great loss to pig industry.
At present, because florfenicol can be killed cause of disease targetedly, the treatment porcine contagious pleuropneumonia usually adopts florfenicol to treat separately, but florfenicol does not have control action as cough, asthma etc., therefore for clinical symptoms, respond well to treatment slowly, influence growth and the rate of body weight gain of pig.And doxofylline can be treated the clinical symptoms that disease causes targetedly, as cough, asthma etc., therefore, mycoplasma pneumonia usually adopts the doxofylline treatment, but doxofylline does not have direct effect to cause of disease, cures the symptoms, not the disease, do not reach therapeutic effect, bounce-back rate height very yet.And both share, and take florfenicol powder and doxofylline powder combination therapy, and the raiser uses inconvenience, and it is too high and cause the phenomenon of drug waste to occur certain pharmaceutical quantities deficiency or dosage easily, and the user uses uneconomical.Simultaneously,, be difficult to clearly to distinguish porcine contagious pleuropneumonia or mycoplasma pneumonia, can not suit the remedy to the case, bring difficulty, sometimes even incur loss through delay golden hour to treatment of diseases for the raiser.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat porcine contagious pleuropneumonia and mycoplasma pneumonia, and therapeutic effect is good, instant effect, and can treating both the principal and secondary aspects of a disease, can alleviate the stress of pig when having an attack of one's old illness, improve the compound florfenicol powder for animals of rate of body weight gain.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned compound florfenicol powder for animals of realizing.
The present invention is achieved through the following technical solutions:
A kind of compound florfenicol powder for animals is characterized in that, is made by following component by weight percentage: florfenicol 5～20%, and doxofylline 0.5～5%, surplus is a starch.
Wherein the preferable content of each component is: florfenicol 8～15%, and doxofylline 1～4%, surplus is a starch.The optimum content of each component is: florfenicol 10%, and doxofylline 2%, surplus is a starch.
A kind of preparation method of compound florfenicol powder for animals is characterized in that, comprises the steps:
(1) florfenicol, doxofylline, starch are sieved respectively, standby;
(2) good florfenicol fully mixes in V word mixer with doxofylline to take by weighing sieve;
(3) will sieve good starch again joins in the mixture of above-mentioned florfenicol and doxofylline, in common batch mixer, fully mix, discharging, sieve and obtain compound florfenicol powder of the present invention, make by following component by weight percentage in the compound florfenicol powder wherein of the present invention: florfenicol 5～20%, doxofylline 0.5～5%, surplus are starch.
Wherein preferable consisting of: florfenicol 8～15%, doxofylline 1～4%, surplus is a starch.
Best group becomes: florfenicol 10%, and doxofylline 2%, surplus is a starch.
The present invention has following technique effect:
The compound preparation of the present invention for adopting antimicrobial drug and treatment cough with asthma class medicine to share, florfenicol and doxofylline unite use, by rational proportion to florfenicol and doxofylline consumption, have double effects, can alleviate the clinical symptoms that porcine contagious pleuropneumonia and mycoplasma pneumonia cause fast, reduce the destruction that these two kinds of diseases cause body, reduce the misery of disease pig, alleviate and suffer from poultry health stress, make and recover to accelerate, improve rate of body weight gain.Can fundamentally kill pathogen again, contagious pleuropneumonia for the treatment of both the principal and secondary aspects of a disease pig and mycoplasma pneumonia, therapeutic effect is good, and instant effect avoids drug residue to exceed standard.And the user does not need clearly to distinguish that contagious pleuropneumonia or mycoplasma pneumonia can treat this two classes disease, uses more conveniently, because drug dose is little, instant effect has reduced use cost.
The preparation method technology of compound florfenicol powder for animals of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) florfenicol, doxofylline, starch are crossed the 24# sieve respectively, standby.
(2) good florfenicol 5kg fully mixed 30 minutes in V word mixer with doxofylline 5kg to take by weighing sieve.
(3) will sieve good starch 90kg again and join in the mixture of above-mentioned florfenicol and doxofylline, and fully mix 30 minutes in common batch mixer, discharging is crossed the 24# sieve and is obtained compound florfenicol powder of the present invention.
Embodiment 2
(1) florfenicol, doxofylline, starch are crossed the 24# sieve respectively, standby.
(2) good florfenicol 20kg fully mixed 30 minutes in V word mixer with doxofylline 0.5kg to take by weighing sieve.
(3) will sieve good starch 79.5kg again and join in the mixture of above-mentioned florfenicol and doxofylline, and fully mix 30 minutes in common batch mixer, discharging is crossed the 24# sieve and is obtained compound florfenicol powder of the present invention.
Embodiment 3
(1) florfenicol, doxofylline, starch are crossed the 24# sieve respectively, standby.
(2) good florfenicol 8kg fully mixed 30 minutes in V word mixer with doxofylline 4kg to take by weighing sieve.
(3) will sieve good starch 88kg again and join in the mixture of above-mentioned florfenicol and doxofylline, and fully mix 30 minutes in common batch mixer, discharging is crossed the 24# sieve and is obtained compound florfenicol powder of the present invention.
Embodiment 4
(1) florfenicol, doxofylline, starch are crossed the 24# sieve respectively, standby.
(2) good florfenicol 15kg fully mixed 30 minutes in V word mixer with doxofylline 1kg to take by weighing sieve.
(3) will sieve good starch 84kg again and join in the mixture of above-mentioned florfenicol and doxofylline, and fully mix 30 minutes in common batch mixer, discharging is crossed the 24# sieve and is obtained compound florfenicol powder of the present invention.
Embodiment 5
(1) florfenicol, doxofylline, starch are crossed the 24# sieve respectively, standby.
(2) good florfenicol 12kg fully mixed 30 minutes in V word mixer with doxofylline 2.5 to take by weighing sieve.
(3) will sieve good starch 85.5kg again and join in the mixture of above-mentioned florfenicol and doxofylline, and fully mix 30 minutes in common batch mixer, discharging is crossed the 24# sieve and is obtained compound florfenicol powder of the present invention.
Embodiment 6
(1) florfenicol, doxofylline, starch are crossed the 24# sieve respectively, standby.
(2) good florfenicol 10kg fully mixed 30 minutes in V word mixer with doxofylline 2kg to take by weighing sieve.
(3) will sieve good starch 88kg again and join in the mixture of above-mentioned florfenicol and doxofylline, and fully mix 30 minutes in common batch mixer, discharging is crossed the 24# sieve and is obtained compound florfenicol powder of the present invention.
Clinical trial:
1. laboratory animal:
Only 100 of the ill one-tenth of picked at random pigs, body weight is at 30～60kg.
2. experiment medicine
The compound florfenicol powder our unit development of the embodiment of the invention 6 preparations;
10% florfenicol powder our unit prepared in laboratory;
2% doxofylline powder our unit prepared in laboratory.
3. experimental technique:
Suffer from pig with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% florfenicol powder: spice is for oral administration, every 1kg body weight 0.2g, 2 times on the one, logotype 4 days.
The C group is treated usage with 2% doxofylline: spice is for oral administration, every 1kg body weight 0.2g, 2 times on the one, logotype 4 days.
The D group is treated usage with the compound florfenicol powder of the embodiment of the invention 6 preparations: spice is for oral administration, every 1kg body weight 0.2g, 1 time on the one, logotype 2 times.
After the treatment beginning, every day, record trouble poultry health situation of change and dead animal distributed, and treat and add up therapeutic effect after 10 days, wherein:
Invalid: as after referring to 10 days, to suffer from the poultry symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 10 days, suffer from the poultry symptom and change, the effect before symptom is better than treating.
Cure: after referring to 10 days, transference cure is suffered from poultry and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 10 days, suffer from poultry and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from poultry and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, compound florfenicol powder treatment group, florfenicol treated powder group and doxofylline powder and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end | Good rotary head number on the secondth | Good rotary head number on the 3rd | The relative weight gain rate % |
| A | Matched group | 25 | 0 | 0 | 25 | 0 | 0 | 0 |
| B | 10% florfenicol powder | 3 | 22 | 18 | 7 | 5 | 10 | 75.2 |
| C | 2% doxofylline powder | 20 | 5 | 2 | 23 | 24 | 24 | 20.5 |
| D | Compound florfenicol powder | 2 | 23 | 22 | 3 | 24 | 24 | 90.0 |
Claims (6)
1. a compound florfenicol powder that is used for the treatment of porcine contagious pleuropneumonia and mycoplasma pneumonia is characterized in that, is made by following component by weight percentage: florfenicol 5～20%, and doxofylline 0.5～5%, surplus is a starch.
2. the compound florfenicol powder that is used for the treatment of porcine contagious pleuropneumonia and mycoplasma pneumonia according to claim 1 is characterized in that, is made by following component by weight percentage: florfenicol 8～15%, and doxofylline 1～4%, surplus is a starch.
3. the compound florfenicol powder that is used for the treatment of porcine contagious pleuropneumonia and mycoplasma pneumonia according to claim 1 is characterized in that, is made by following component by weight percentage: florfenicol 10%, and doxofylline 2%, surplus is a starch.
4. a preparation method that is used for the treatment of the compound florfenicol powder of porcine contagious pleuropneumonia and mycoplasma pneumonia is characterized in that, comprises the steps:
(1) florfenicol, doxofylline, starch are sieved respectively, standby;
(2) good florfenicol fully mixes in V word mixer with doxofylline to take by weighing sieve;
(3) will sieve good starch again joins in the mixture of above-mentioned florfenicol and doxofylline, in common batch mixer, fully mix, discharging, sieve and obtain the compound florfenicol powder that is used for the treatment of porcine contagious pleuropneumonia and mycoplasma pneumonia of the present invention, make by following component by weight percentage in the compound florfenicol powder that is used for the treatment of porcine contagious pleuropneumonia and mycoplasma pneumonia wherein of the present invention: florfenicol 5～20%, doxofylline 0.5～5%, surplus are starch.
5. the preparation method that is used for the treatment of the compound florfenicol powder of porcine contagious pleuropneumonia and mycoplasma pneumonia according to claim 4 is characterized in that, described florfenicol is 8～15%, doxofylline 1～4%, and surplus is a starch.
6. the preparation method that is used for the treatment of the compound florfenicol powder of porcine contagious pleuropneumonia and mycoplasma pneumonia according to claim 4 is characterized in that, described florfenicol is 10%, and doxofylline is 2%, and surplus is a starch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100526454A CN101297795B (en) | 2008-04-08 | 2008-04-08 | Compound florfenicol powder for animals and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100526454A CN101297795B (en) | 2008-04-08 | 2008-04-08 | Compound florfenicol powder for animals and preparation thereof |
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| Publication Number | Publication Date |
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| CN101297795A CN101297795A (en) | 2008-11-05 |
| CN101297795B true CN101297795B (en) | 2010-06-09 |
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| CN2008100526454A Expired - Fee Related CN101297795B (en) | 2008-04-08 | 2008-04-08 | Compound florfenicol powder for animals and preparation thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104173374A (en) * | 2014-07-25 | 2014-12-03 | 邳州正康生物技术有限公司 | Formula and preparation method of florfenicol powder |
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Owner name: TIANJIN HYNARD ANIMAL PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: TIANJIN SHENGJI GROUP CO., LTD. Effective date: 20101112 |
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Effective date of registration: 20101112 Address after: 301609. 2, Tianyu Science Park, Jinghai, Tianjin Patentee after: Tianjin Hynard Animal Pharmaceutical Co., Ltd. Address before: 301609. 2, Tianyu Science Park, Jinghai, Tianjin Patentee before: Tianjin Shengji Group Co., Ltd. |
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Granted publication date: 20100609 Termination date: 20130408 |