CN101543601B - Compound pharmaceutical composition for preventing and curing respiratory diseases in animals and preparation method thereof - Google Patents
Compound pharmaceutical composition for preventing and curing respiratory diseases in animals and preparation method thereof Download PDFInfo
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Abstract
The invention provides a compound pharmaceutical composition for preventing and curing respiratory diseases in animals and a preparation method thereof. The pharmaceutical composition comprises the following components of Chinese ephedra, bitter almond, stenona root, dark plum, scutellaria root, yellow-corktree bark, chuanxiong rhizome, gypsum, liquorice, terramycin-type medicine and/or Maquinox and/or florfenicol. The compound pharmaceutical composition has the functions of preventing asthma and relieving cough and superactive antibiosis, can be used for preventing and curing the respiratory diseases in animals, has remarkable effect, complete treatment and short treatment course, and meanwhile, the compound pharmaceutical composition also has good action of growth promotion as well as the effect of promoting the utilization ratio of feeding stuff. The compound pharmaceutical composition can be powder preparation formulation. The invention also provides a feeding stuff including the compound pharmaceutical composition.
Description
Technical field
The present invention relates to a kind of compound medicament composition of preventing and treating livestock and birds respiratory disease and preparation method thereof that is used to.
Background technology
The generation of livestock and birds respiratory disease and popular complicated day by day, serious, serious harm the sound development of livestock breeding industry.
Livestock and birds respiratory disease is many to be caused by pathogenic bacterium, and with respiratory symptoms such as cough, asthma.When the treatment respiratory tract disease, the antibacterials of use mainly are at diseases induced pathogenic bacterium, and powerless to respiratory symptoms such as cough, asthma, and only after eliminating pathogenic bacterium, respiratory symptom just can fade away; In addition, along with antibacterials long-term, be extensive use of, drug-resistance of bacteria strengthens gradually, causes the curative effect of antibacterial drug therapy respiratory tract disease more and more undesirable.Though Chinese medicine has the advantage of alleviating respiratory symptom, the effectiveness of its anti-pathogenic bacterium is more weak and the course of treatment is long, thereby is restricted in the use.
Summary of the invention
The object of the present invention is to provide a kind of compound medicament composition of control livestock and birds respiratory disease of efficient, quick-acting, treating both the principal and secondary aspects of a disease, this compound medicament composition Chinese medicine and western medicine combination makes up for each other's deficiencies and learn from each other the two.Chinese medicine takes stopgap measures, and relievings asthma, lung moistening, cough-relieving; Western medicine effects a permanent cure, and directly kills pathogenic bacterium; The two combination, thus reach treating both the principal and secondary aspects of a disease, heighten the effect of a treatment, shorten the course of treatment, prevent the purpose that drug resistance produces.
The feedstuff that another object of the present invention is to provide the preparation method of this compound medicament composition and comprise this compound medicament composition.
The objective of the invention is to be achieved through the following technical solutions:
The invention provides a kind of compound medicament composition of preventing and treating livestock and birds respiratory disease, it is characterized in that comprising Herba Ephedrae, Semen Armeniacae Amarum, the Radix Stemonae, Fructus Mume, Radix Scutellariae, Cortex Phellodendri, Rhizoma Chuanxiong, Gypsum Fibrosum, Radix Glycyrrhizae, oxytetracycline class medicine, the weight proportion of mentioned component is: Herba Ephedrae 3-30 part, Semen Armeniacae Amarum 3-30 part, Radix Stemonae 3-30 part, Fructus Mume 3-30 part, Radix Scutellariae 5-30 part, Cortex Phellodendri 5-30 part, Rhizoma Chuanxiong 3-30 part, Gypsum Fibrosum 5-50 part, Radix Glycyrrhizae 3-30 part, oxytetracycline class medicine 5-50 part.
Wherein, the weight proportion optimal technical scheme of each composition is in this compound medicament composition: Herba Ephedrae 5-20 part, Semen Armeniacae Amarum 5-20 part, Radix Stemonae 5-20 part, Fructus Mume 5-20 part, Radix Scutellariae 5-20 part, Cortex Phellodendri 5-20 part, Rhizoma Chuanxiong 5-20 part, Gypsum Fibrosum 10-30 part, Radix Glycyrrhizae 5-20 part, oxytetracycline class medicine 10-30 part.
In this compound medicament composition the weight proportion of various compositions more preferably technical scheme be: Herba Ephedrae 6-15 part, Semen Armeniacae Amarum 5-15 part, Radix Stemonae 5-15 part, Fructus Mume 5-15 part, Radix Scutellariae 5-15 part, Cortex Phellodendri 5-15 part, Rhizoma Chuanxiong 5-15 part, Gypsum Fibrosum 15-30 part, Radix Glycyrrhizae 5-15 part, oxytetracycline class medicine 10-20 part.
Wherein, described oxytetracycline class medicine is selected from any in oxytetracycline or its hydrochlorate, doxycycline (claiming doxycycline again) or its hydrochlorate, chlortetracycline or its hydrochlorate, tetracycline or its hydrochlorate.
The compound medicament composition of control livestock and birds respiratory disease of the present invention can also further comprise LIJUNJING and/or florfenicol, and the content of above-mentioned two kinds of compositions in compound medicament composition is: LIJUNJING 2-30 part, florfenicol 2-30 part.
In the weight proportion optimal technical scheme of compound medicament composition of the present invention, can also further comprise LIJUNJING and/or florfenicol, the content of above-mentioned two kinds of compositions in compound medicament composition is: LIJUNJING 5-15 part, florfenicol 5-15 part.
More preferably in the technical scheme, can also further comprise LIJUNJING and/or florfenicol at the weight proportion of compound medicament composition of the present invention, the content of above-mentioned two kinds of compositions in compound medicament composition is: LIJUNJING 5-10 part, florfenicol 5-10 part.
Compound medicament composition of the present invention can be the other medicines dosage form, but the preferred powder of the present invention.
The present invention also provides the preparation method of the compound medicament composition of this control livestock and birds respiratory disease, it is characterized in that comprising the steps:
(1) taking by weighing following medicine is raw material: Herba Ephedrae, Semen Armeniacae Amarum, the Radix Stemonae, Fructus Mume, Radix Scutellariae, Cortex Phellodendri, Rhizoma Chuanxiong, Gypsum Fibrosum, Radix Glycyrrhizae, oxytetracycline class medicine and/or LIJUNJING and/or florfenicol;
(2) with each component oven dry, sieve after crushed, take by weighing the back by proportioning and mix, stir, make powder, promptly.
The present invention also provides the feedstuff that comprises this compound medicament composition, and 1000-4000 gram compound medicament composition of the present invention is joined in 1000 kilograms of feedstuffs, can treat or prevent the respiratory tract disease of poultry.
Compound medicament composition of the present invention has following advantage:
1) compound medicament composition of the present invention is the Chinese medicine and western medicine compound preparation, complement each other, and treating both the principal and secondary aspects of a disease, effect is remarkable;
2) Chinese medicine and western medicine compound preparation, antibacterial action is strong, presses down sterilization rapidly, thoroughly, and short treating period does not recur, and is difficult for producing drug resistance;
3) have good growth promoting function and the effect that promotes efficiency of feed utilization;
4) reasonable, the science of prescription;
, it should be understood that described embodiment only is for the present invention is described, rather than limit the scope of the invention by any way more specific description the present invention by the following example.
The specific embodiment
Embodiment 1
3 parts in Herba Ephedrae, 3 parts of Semen Armeniacae Amarums, 3 parts of the Radixs Stemonae, 3 parts of Fructus Mumes, 5 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 3 parts of Rhizoma Chuanxiongs, 5 parts in Gypsum Fibrosum, 3 parts in Radix Glycyrrhizae, 5 parts of tetramycin hydrochlorides, oven dry is pulverized, and sieves, and takes by weighing the back by proportioning and mixes, and stirs, and makes powder, promptly.
Embodiment 2
30 parts in Herba Ephedrae, 30 parts of Semen Armeniacae Amarums, 30 parts of the Radixs Stemonae, 30 parts of Fructus Mumes, 30 parts of Radix Scutellariaes, 30 parts of Cortex Phellodendris, 30 parts of Rhizoma Chuanxiongs, 50 parts in Gypsum Fibrosum, 30 parts in Radix Glycyrrhizae, 50 parts of tetramycin hydrochlorides, oven dry is pulverized, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Embodiment 3
5 parts in Herba Ephedrae, 5 parts of Semen Armeniacae Amarums, 5 parts of the Radixs Stemonae, 5 parts of Fructus Mumes, 5 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Chuanxiongs, 10 parts in Gypsum Fibrosum, 5 parts in Radix Glycyrrhizae, 10 parts of tetramycin hydrochlorides, oven dry is pulverized, and sieves, and takes by weighing the back by proportioning and mixes, and stirs, and makes powder, promptly.
Embodiment 4
20 parts in Herba Ephedrae, 20 parts of Semen Armeniacae Amarums, 20 parts of the Radixs Stemonae, 20 parts of Fructus Mumes, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 20 parts of Rhizoma Chuanxiongs, 30 parts in Gypsum Fibrosum, 20 parts in Radix Glycyrrhizae, 30 parts of tetramycin hydrochlorides, oven dry is pulverized, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Embodiment 5
15 parts in Herba Ephedrae, 15 parts of Semen Armeniacae Amarums, 15 parts of the Radixs Stemonae, 15 parts of Fructus Mumes, 15 parts of Radix Scutellariaes, 15 parts of Cortex Phellodendris, 15 parts of Rhizoma Chuanxiongs, 30 parts in Gypsum Fibrosum, 15 parts in Radix Glycyrrhizae, 20 parts of tetramycin hydrochlorides, oven dry is pulverized, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Embodiment 6
10 parts in Herba Ephedrae, 8 parts of Semen Armeniacae Amarums, 8 parts of the Radixs Stemonae, 8 parts of Fructus Mumes, 8 parts of Radix Scutellariaes, 8 parts of Cortex Phellodendris, 8 parts of Rhizoma Chuanxiongs, 25 parts in Gypsum Fibrosum, 10 parts in Radix Glycyrrhizae, 15 parts of oxytetracyclines, oven dry is pulverized, and sieves, and takes by weighing the back by proportioning and mixes, and stirs, and makes powder, promptly.
Embodiment 7
6 parts in Herba Ephedrae, 5 parts of Semen Armeniacae Amarums, 5 parts of the Radixs Stemonae, 5 parts of Fructus Mumes, 5 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Chuanxiongs, 15 parts in Gypsum Fibrosum, 5 parts in Radix Glycyrrhizae, 10 parts of doxycycline hyclate, oven dry is pulverized, and sieves, and takes by weighing the back by proportioning and mixes, and stirs, and makes powder, promptly.
Embodiment 8
15 parts in Herba Ephedrae, 15 parts of Semen Armeniacae Amarums, 15 parts of the Radixs Stemonae, 15 parts of Fructus Mumes, 15 parts of Radix Scutellariaes, 15 parts of Cortex Phellodendris, 15 parts of Rhizoma Chuanxiongs, 30 parts in Gypsum Fibrosum, 15 parts in Radix Glycyrrhizae, 20 parts of chlortetracycline hydrochlorides, oven dry is pulverized, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Embodiment 9
15 parts in Herba Ephedrae, 10 parts of Semen Armeniacae Amarums, 10 parts of the Radixs Stemonae, 10 parts of Fructus Mumes, 10 parts of Radix Scutellariaes, 10 parts of Cortex Phellodendris, 15 parts of Rhizoma Chuanxiongs, 15 parts in Gypsum Fibrosum, 15 parts in Radix Glycyrrhizae, 20 parts of tetramycin hydrochlorides, 10 parts of LIJUNJING, oven dry is pulverized, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Embodiment 10
3 parts in Herba Ephedrae, 3 parts of Semen Armeniacae Amarums, 3 parts of the Radixs Stemonae, 3 parts of Fructus Mumes, 5 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 3 parts of Rhizoma Chuanxiongs, 5 parts in Gypsum Fibrosum, 3 parts in Radix Glycyrrhizae, 5 parts of tetramycin hydrochlorides, 5 parts of florfenicols, oven dry is pulverized, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Embodiment 11
6 parts in Herba Ephedrae, 5 parts of Semen Armeniacae Amarums, 5 parts of the Radixs Stemonae, 5 parts of Fructus Mumes, 5 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Chuanxiongs, 15 parts in Gypsum Fibrosum, 5 parts in Radix Glycyrrhizae, 5 parts of tetramycin hydrochlorides, 8 parts of LIJUNJING, 8 parts of florfenicols, oven dry is pulverized, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Embodiment 12
This traditional Chinese compound medicine compositions is prepared as follows and obtains:
1) takes by weighing following raw materials according: 6 parts in Herba Ephedrae, 5 parts of Semen Armeniacae Amarums, 5 parts of the Radixs Stemonae, 5 parts of Fructus Mumes, 5 parts of Radix Scutellariaes, 5 parts of Cortex Phellodendris, 5 parts of Rhizoma Chuanxiongs, 15 parts in Gypsum Fibrosum, 5 parts in Radix Glycyrrhizae, 5 parts of tetramycin hydrochlorides, 8 parts of LIJUNJING, 8 parts of florfenicols
2) with each component after crushed, sieve, take by weighing the back by proportioning and mix, stir, make powder, promptly.
Observing the therapeutic effect of 1 pair of swine enzootic pneumonia of example observes
Adopt the compound medicament composition treatment swine enzootic pneumonia of the embodiment of the invention 1.The pig of natural infection asthma is divided into 6 groups at random, and 60 every group, the 1-3 group gives the compound medicament composition of embodiment 1, gives high, medium and low dosage respectively, promptly adds 4,2,1 kilograms of compound medicament compositions respectively by feedstuff per ton; The 4th group of compositions (not hydrochloric oxytetracycline) that the division of traditional Chinese drugs that gives embodiment 1 compound medicament composition is grouped into added 2 kilograms of Chinese medicine compositions by feedstuff per ton; The 5th group is the tetramycin hydrochloride group, adds 150 gram tetramycin hydrochlorides by feedstuff per ton, is free choice feeding, successive administration 7 days.The 6th group is the blank group, does not add any medicine in the feedstuff.Result of the test sees Table 1 and table 2.
The result of the test of table 1 treatment swine enzootic pneumonia
The result of the test of table 2. treatment swine enzootic pneumonia
| Group | Experimental animal quantity | A cough number before the medication | The 7th day rehabilitation number of medication | The 7th day rehabilitation rate of medication | The 15th day rehabilitation number of medication | The 15th day rehabilitation rate of medication | Untoward reaction |
| The 1st group | 60? | 60? | 60? | 100％? | 60? | 100％? | Do not have |
| The 2nd group | 60? | 60? | 59? | 98.3％? | 60? | 100％? | Do not have |
| The 3rd group | 60? | 60? | 53? | 88.3％? | 60? | 100％? | Do not have |
| The 4th group | 60? | 60? | 21? | 35％? | 48? | 80％? | Do not have |
| The 5th group | 60? | 60? | 38? | 63.3％? | 53? | 88.3％? | Do not have |
| The 6th group | 60? | 60? | 0? | 0? | 12? | 20％? | Do not have |
Result of the test shows that the high, medium and low dosage that gives the compound medicament composition of embodiment 1 all has excellent curative to swine enzootic pneumonia, significantly better than pure Chinese medicine composition group of independent use or tetramycin hydrochloride group, significant difference.
Observing the preventive effect of 2 pairs of swine enzootic pneumonias of example observes
Select Beijing to have the large-scale pig farm of swine enzootic pneumonia morbidity history to prevent the swine enzootic pneumonia test.220 pigs of just having weaned are divided into two groups at random, one group is the trial drug group, at 31-37 age in days, 84-90 age in days and 119-125 age in days, comprise the feedstuff of the compound medicament composition of the embodiment of the invention 2 respectively, add the compound medicament composition of 1 kilogram of embodiment 2 by feedstuff per ton; Another group is the blank group, gives not add the feedstuff of any medicine.Two groups of feedings and managements under identical condition, experimental observation to fattening period finishes.Test is initial and all adopt the method for weighing on an empty stomach morning to weigh in when finishing, and calculates the experimental period weightening finish, and a situation arises to write down two groups of swine enzootic pneumonias of duration of test simultaneously, and calculate the swine enzootic pneumonia sickness rate.Result of the test sees Table 3.
The result of the test of table 3 prevention swine enzootic pneumonia
| Group | Experimental animal quantity | Initial stage counterpoise (kg) | Whole last counterpoise (kg) | Weightening finish (kg) | A swine enzootic pneumonia morbidity animal number | The swine enzootic pneumonia sickness rate |
| The trial drug group | 110? | 10.2? | 95.3? | 85.1? | 0? | 0? |
| The blank group | 110? | 10.3? | 89.1? | 78.8? | 63? | 57.3％? |
But result of the test shows the feedstuff good preventing swine enzootic pneumonia of the compound medicament composition that comprises the embodiment of the invention 2 and has growth promoting function, has compared utmost point significant difference with the blank group.
Observing 3 pairs of porcine respiratory diseases of example syndrome prevention effect observes
Porcine respiratory disease syndrome is to be caused by multi-pathogenesis, except that virus, also has actinobacillus pleuropneumoniae, bronchus deteriorated blood bordetella bacilli, haemophilus parasuis, mycoplasma pneumoniae, pasteurella multocida, Streptococcus suis etc.Clinical symptoms shows as depressed, the feed intake minimizing of spirit, cough, dyspnea, poor growth, severe patient death, and sickness rate 40-70% has a strong impact on the productivity effect on pig farm.The pig farm that this test and Selection Beijing is threatened by the respiratory tract disease syndrome, the compound medicament composition prevention and control porcine respiratory disease syndrome of Application Example 5, embodiment 7, embodiment 8, embodiment 9, embodiment 10, embodiment 11, and observing effect.
In the test 420 child care piglets are divided into 7 groups at random, the 1-6 group gives the compound medicament composition group of embodiment 5, embodiment 7, embodiment 8, embodiment 9, embodiment 10, embodiment 11 respectively, add 1 kilogram of compound medicament composition, logotype 15 days by feedstuff per ton; The 7th group is the blank group, does not add any medicine, each group feeding and management under identical condition, experimental observation 30 days.Test is initial and all adopt the method for weighing on an empty stomach morning to weigh in when finishing, and calculates the experimental period weightening finish.Tract disease is inhaled in each group calling of record duration of test, and a situation arises, with respiratory tract disease head takes place and calculate, and it is 1 time that 1 pig has respiratory symptom phenomenons such as asthma, cough to continue 1 day.Result of the test sees Table 4.
The result of the test of table 4 control porcine respiratory disease syndrome
| Group | Size of animal | Initial stage counterpoise (kg) | Whole last counterpoise (kg) | Weightening finish (kg) | Rate of body weight gain (%) | Head takes place in respiratory tract disease |
| The 1st group | 60? | 13.1? | 33.2? | 20.1? | 153.4? | 0? |
| The 2nd group | 60? | 13.3? | 34.3? | 21.0? | 157.9? | 0? |
| The 3rd group | 60? | 13.0? | 33.9? | 20.9? | 160.8? | 0? |
| The 4th group | 60? | 12.8? | 33.5? | 20.7? | 161.7? | 0? |
| The 5th group | 60? | 13.4? | 33.5? | 20.1? | 150.0? | 0? |
| The 6th group | 60? | 13.2? | 33.3? | 20.1? | 152.3? | 0? |
| The 7th group | 60? | 13.4? | 30.9? | 17.5? | 130.6? | 420? |
Result of the test shows that the compound medicament composition of embodiment 5, embodiment 7, embodiment 8, embodiment 9, embodiment 10, embodiment 11 has remarkable prevention effect to porcine respiratory disease syndrome, and good growth promoting function is arranged.
Claims (10)
1. compound medicament composition of preventing and treating livestock and birds respiratory disease, it is characterized in that comprising Herba Ephedrae, Semen Armeniacae Amarum, the Radix Stemonae, Fructus Mume, Radix Scutellariae, Cortex Phellodendri, Rhizoma Chuanxiong, Gypsum Fibrosum, Radix Glycyrrhizae, oxytetracycline class medicine, the weight proportion of mentioned component is: Herba Ephedrae 3-30 part, Semen Armeniacae Amarum 3-30 part, Radix Stemonae 3-30 part, Fructus Mume 3-30 part, Radix Scutellariae 5-30 part, Cortex Phellodendri 5-30 part, Rhizoma Chuanxiong 3-30 part, Gypsum Fibrosum 5-50 part, Radix Glycyrrhizae 3-30 part, oxytetracycline class medicine 5-50 part.
2. the compound medicament composition of the described control livestock and birds respiratory disease of claim 1 is characterized in that the weight proportion of mentioned component is: Herba Ephedrae 5-20 part, Semen Armeniacae Amarum 5-20 part, Radix Stemonae 5-20 part, Fructus Mume 5-20 part, Radix Scutellariae 5-20 part, Cortex Phellodendri 5-20 part, Rhizoma Chuanxiong 5-20 part, Gypsum Fibrosum 10-30 part, Radix Glycyrrhizae 5-20 part, oxytetracycline class medicine 10-30 part.
3. the compound medicament composition of the described control livestock and birds respiratory disease of claim 1 is characterized in that weight proportion is: Herba Ephedrae 6-15 part, Semen Armeniacae Amarum 5-15 part, Radix Stemonae 5-15 part, Fructus Mume 5-15 part, Radix Scutellariae 5-15 part, Cortex Phellodendri 5-15 part, Rhizoma Chuanxiong 5-15 part, Gypsum Fibrosum 15-30 part, Radix Glycyrrhizae 5-15 part, oxytetracycline class medicine 10-20 part.
4. the compound medicament composition of the described control livestock and birds respiratory disease of claim 1 is characterized in that described oxytetracycline class medicine is selected from any in oxytetracycline or its hydrochlorate, doxycycline (claiming doxycycline again) or its hydrochlorate, chlortetracycline or its hydrochlorate, tetracycline or its hydrochlorate.
5. the compound medicament composition of the described control livestock and birds respiratory disease of claim 1, it is characterized in that can also further comprising LIJUNJING and/or florfenicol in this compound medicament composition, the content of above-mentioned two kinds of compositions in compound medicament composition is: LIJUNJING 2-30 part, florfenicol 2-30 part.
6. the compound medicament composition of the described control livestock and birds respiratory disease of claim 2, it is characterized in that can also further comprising LIJUNJING and/or florfenicol in this compound medicament composition, the content of above-mentioned two kinds of compositions in compound medicament composition is: LIJUNJING 5-15 part, florfenicol 5-15 part.
7. the compound medicament composition of the described control livestock and birds respiratory disease of claim 3, it is characterized in that can also further comprising LIJUNJING and/or florfenicol in this compound medicament composition, the content of above-mentioned two kinds of compositions in compound medicament composition is: LIJUNJING 5-10 part, florfenicol 5-10 part.
8. the compound medicament composition of each described control livestock and birds respiratory disease of claim 1-7 is characterized in that it is a kind of powder.
9. as the preparation method of the compound medicament composition of each described control livestock and birds respiratory disease of claim 1-8, it is characterized in that comprising the steps:
(1) taking by weighing following medicine by proportioning is raw material: Herba Ephedrae, Semen Armeniacae Amarum, the Radix Stemonae, Fructus Mume, Radix Scutellariae, Cortex Phellodendri, Rhizoma Chuanxiong, Gypsum Fibrosum, Radix Glycyrrhizae, oxytetracycline class medicine and/or LIJUNJING and/or florfenicol;
(2) with each component oven dry, sieve after crushed, take by weighing the back by proportioning and mix, stir, make powder, promptly.
10. feedstuff of preventing and treating livestock and birds respiratory disease, it is characterized in that containing in this feedstuff the compound medicament composition just like each described control livestock and birds respiratory disease of claim 1-8, its content is the compound medicament composition that contains the 1000-4000 gram in per 1000 kilograms of feedstuffs.
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Families Citing this family (7)
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| CN102640884B (en) * | 2012-05-22 | 2013-10-30 | 山东新希望六和集团有限公司 | Feed for treating mycoplasmal pneumonia of swine and preparation method |
| CN103655593B (en) * | 2013-12-12 | 2015-05-13 | 挑战（天津）动物药业有限公司 | Composite medicine preparation for prevention and treatment of bacterium and virus polyinfection diseases of livestock as well as preparation method and application thereof |
| CN105708910A (en) * | 2014-01-06 | 2016-06-29 | 四川德润通生物科技有限公司 | Preparation method of powder for clearing away heat and toxic materials of livestock and poultry |
| CN105168444B (en) * | 2015-10-10 | 2019-02-19 | 湖北武当动物药业有限责任公司 | One kind is for preventing and treating livestock and poultry respiratory syndrome drug |
| CN105748656A (en) * | 2016-03-02 | 2016-07-13 | 江西傲新生物科技有限公司 | Medicine preparation for preventing and treating bacterial respiratory diseases of livestock and poultry and preparation method thereof |
| CN105902626A (en) * | 2016-05-30 | 2016-08-31 | 宿州天雨养殖（集团）有限公司 | Chinese and Western composite medicine for treating chronic respiratory diseases of poultry |
| CN117379484B (en) * | 2023-12-13 | 2024-03-15 | 内蒙古自治区农牧业科学院 | Cattle and sheep pneumonia aerosol and preparation method and application thereof |
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| CN101143176A (en) * | 2007-08-25 | 2008-03-19 | 尹克华 | Traditional Chinese medicine for treating lung cancer |
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