AU2021100021A4

AU2021100021A4 - Plant feed additive for preventing and treating diarrhea of weaned piglets and preparation method

Info

Publication number: AU2021100021A4
Application number: AU2021100021A
Authority: AU
Inventors: Heshu Chen; Yanzhong FENG; Haijuan He; Xinmiao He; Di LIU; Ziguang Liu; Meiyu QI; Ming Tian; Liang Wang; Wentao Wang; Saihui Wu; Jiqiao Xia; Xiaolong Yu; Haifeng Zhang
Original assignee: Institute of Animal Husbandry of Heilongjiang Academy of Agricultural Sciences
Current assignee: Institute of Animal Husbandry of Heilongjiang Academy of Agricultural Sciences
Priority date: 2020-12-10
Filing date: 2021-01-04
Publication date: 2021-03-18
Anticipated expiration: 2029-01-04
Also published as: CN112544809A

Abstract

The present invention discloses a plant feed additive for preventing and treating diarrhea of weaned piglets and a preparation method, and belongs to the technical field of feed additives. The plant feed additive comprises the following components in parts by mass: 100-150 parts of Radix codcnopsitis pilosulas, 100-200 parts of Radix astragali, 100-200 parts of Atractylodes, 100-200 parts of Acanthopanax, 200-300 parts of malt, 50-200 parts of hawthorn, 100-200 parts of tangerine peel, 50-150 parts of dandelion, 50-100 parts of pulsatilla and 100-200 parts of honeysuckle. Compared with the prior art, the present invention has the beneficial effects of enhancing the disease resistance and immunity of piglets, promoting digestion and absorption of the piglets, promoting growth, and effectively preventing diarrhea. Raw materials interact and have a synergistic effect. Medical effects are greatly improved through a fermentation technology. After fermentation, the activity and the palatability of effective substances of natural plants are improved; and the effective substances are safe and have no toxic or side effect. 10005 2006.7

Description

PLANT FEED ADDITIVE FOR PREVENTING AND TREATING DIARRHEA OF WEANED PIGLETS AND PREPARATION METHOD

Technical Field The present invention relates to the technical field of feed additives, and particularly relates to a plant feed additive for preventing and treating diarrhea of weaned piglets and a preparation method.

Background In the modem pig industry, with large-scale breeding, timely weaning of piglets has become an important link of pig production because weaning is related to the reproductive potential of sows and the growth and development of piglets and also influences the production cycle and overall economic benefits of the pig industry. At weaning, the digestive tract of the piglet has not been fully developed, the own immune system has not been fully developed, and the level of maternal antibodies is gradually decreased. Therefore, early weaning influences the digestive function of the piglet, decreases immunity, and easily leads to diarrhea. Without nutrition regulation, the feed intake of the piglet may be reduced, a feed conversion rate is low and organ development is poor. Not only the health of live pigs is influenced, but also a lot of economic losses may be caused. In production practice, chemicals such as antibiotics have been often added to pig ration to prevent piglet diarrhea for a long time. However, the disadvantages (such as drug residues and drug resistance) of long-term use of chemicals such as antibiotics are well known. To sum up, the problem to be urgently solved by those skilled in the art is how to provide a feed additive for preventing and treating diarrhea of weaned piglets having good effect and safety and having no side effect.

Summary 10004 2006.7

Description

In view of this, the present invention provides a plant feed additive for

preventing and treating diarrhea of weaned piglets and a preparation method.

To achieve the above purpose, the present invention adopts the following

technical solution:

The plant feed additive for preventing and treating diarrhea of weaned piglets

comprises the following components in parts by mass: 100-150 parts of Radix

codcnopsitis pilosulas, 100-200 parts of Radix astragali, 100-200 parts of

Atractylodes, 100-200 parts of Acanthopanax, 200-300 parts of malt, 50-200 parts

of hawthorn, 100-200 parts of tangerine peel, 50-150 parts of dandelion, 50-100

parts of pulsatilla and 100-200 parts of honeysuckle.

The beneficial effects are: natural plants with effects of resisting viruses and

bacteria, enhancing immunity, promoting digestion and strengthening the spleen

and stomach are selected and combined with compound additives; the non-specific

immunity of piglets can be improved to a certain extent, and diarrhea of the

weaned piglets can be prevented. The additives of malt and hawthorn in the present

invention have the functions of invigorating the spleen and appetizing, promoting

qi and promoting digestion, and are beneficial to the digestion, absorption and

utilization of nutrients by the gastrointestinal tract. Radix astragali, Radix

codcnopsitis pilosulas and Acanthopanax have the effects of invigorating qi, invigorating the spleen and enhancing immunity. The compatibility of Atractylodes

and tangerine peel has the effects of regulating qi-flowing for strengthening spleen,

and drying dampness and resolving phlegm. Dandelion and honeysuckle can clear

heat and remove toxicity. In modern pharmacological research, dandelion and

honeysuckle have the effects of clearing heat and resisting inflammation, bacteria

and viruses. The additive provided by the present invention contains various

antibacterial Chinese medicinal plants (honeysuckle, dandelion, pulsatilla, Radix

astragali and Atractylodes) which increase antibacterial types to form a

broad-spectrum antibacterial effect, but has no antagonistic effect with probiotics.

The additive of the present invention has the functions of effectively promoting 10004 2006.7

Description

digestion, strengthening the spleen and stomach, improving immunity, and

resisting bacteria and viruses, also has the effect of probiotics for promoting health,

and has a better effect on preventing and treating diarrhea of weaned piglets.

Preferably, the plant feed additive also comprises the following components

in parts by mass: 9.5-38 parts of molasses, 1-2 parts of coarse salt, 1-2 parts of urea

and 10-60 parts of composite bacterial liquid.

The beneficial effects are: the molasses, the coarse salt and the urea are added

in the present invention to play the role of starting fermentation.

A plant feed additive for preventing and treating diarrhea of weaned piglets

comprises the following components in parts by mass: 120 parts of Radix

codcnopsitispilosulas,180 parts of Radix astragali, 155 parts of Atractylodes, 175 parts of Acanthopanax, 247 parts of malt, 75 parts of hawthorn, 105 parts of

tangerine peel, 86 parts of dandelion, 72 parts of pulsatilla, 115 parts of

honeysuckle, 20 parts of molasses, 1.5 parts of coarse salt, 1.5 parts of urea and 33

parts of composite bacterial liquid.

Preferably, the composite bacterial liquid comprises lactobacillus plantarum

liquid and saccharomyces cerevisiae liquid according to a mass ratio of 1:1.

Preferably, the viable count of the lactobacillus plantarum liquid and the

saccharomyces cerevisiae liquid is 1X107-5x108 CFU/mL.

Preferably, the viable count in the feed additive is 100 million to 1 billion/g.

A preparation method of the plant feed additive for preventing and treating

diarrhea of weaned piglets comprises the following steps:

(1) weighing Radix codcnopsitis pilosulas, Radix astragali, Atractylodes,

Acanthopanax, malt, hawthorn, tangerine peel, dandelion, pulsatilla and

honeysuckle according to mass parts; then crushing the materials to an 80-mesh

sieve; and uniformly mixing the materials to obtain a fermentation substrate;

(2) weighing molasses, coarse salt and urea according to the mass parts; then

uniformly mixing the materials; and adding the materials to the composite bacterial

liquid for later use to obtain mixture A; 10004 2006.7 |||||||||||1||

Description

(3) uniformly mixing the fermentation substrate with the mixture A and then

fermenting;

(4) after fermentation is completed, drying the materials to obtain a finished

product.

The beneficial effects are: the fermentation of the traditional Chinese

medicine changes the traditional technologies of decocting, boiling, stewing,

refining, steaming and soaking, and greatly improves the medical effects.

Preferably, in the step (3), after the fermentation substrate is mixed with the

mixture A, water content needs to be adjusted to 35%-40%.

Preferably, in the step (3), fermentation temperature is 30-35°C and

fermentation time is 5-7 days.

Preferably, in the step (4), after fermentation is completed, the materials are

dried to water content of 15%-20%.

It can be known from the above technical solution that compared with the

prior art, the present invention has the beneficial effects that: (1) the feed additive

prepared by the present invention can enhance the disease resistance and immunity

of piglets, promote digestion and absorption of the piglets, promote growth, and

effectively prevent diarrhea. (2) Raw materials interact and have a synergistic

effect. (3) Medical effects are greatly improved through a fermentation technology.

(4) The feed additive is safe and has no toxic or side effect.

Detailed Description The technical solution in embodiments of the present invention will be clearly

and fully described below. Apparently, the described embodiments are merely part

of the embodiments of the present invention, not all of the embodiments. Based on

the embodiments in the present invention, all other embodiments obtained by those

ordinary skilled in the art without contributing creative labor will belong to the

protection scope of the present invention. 10004 2006.7

Description

The drug required by the present invention is a conventional experimental

drug purchased from commercially available channels; experimental methods not

mentioned are conventional experimental methods and will not be repeated herein.

Embodiment 1 (I) Formula of feed additive

100kg of Radix codcnopsitis pilosulas, 100kg of Radix astragali, 100kg of Atractylodes, 100kg of Acanthopanax, 200kg of malt, 50kg of hawthorn, 100kg of tangerine peel, 50kg of dandelion, 50kg of pulsatilla, 100kg of honeysuckle, 9.5kg of molasses, 1kg of coarse salt, 1kg of urea, 5kg of lactobacillus plantarum liquid

and 5kg of saccharomyces cerevisiae liquid.

The viable count of the lactobacillus plantarum liquid and the saccharomyces

cerevisiae liquid is 1x107 CFU/mL. (II) Preparation method

(1) weighing Radix codcnopsitis pilosulas, Radix astragali, Atractylodes,

Acanthopanax, malt, hawthorn, tangerine peel, dandelion, pulsatilla and

honeysuckle according to mass parts; then crushing the materials to an 80-mesh

sieve; and uniformly mixing the materials to obtain a fermentation substrate;

(2) weighing molasses, coarse salt and urea according to the mass parts; then

liquid for later use to obtain mixture A;

(3) mixing the fermentation substrate with the mixture A and then adjusting

water content to 35%; and fermenting, wherein fermentation temperature is 30°C

and fermentation time is 5 days;

(4) after fermentation is completed, drying the materials to water content of

% obtain a finished product.

Embodiment 2 (I) Formula of feed additive

150kg of Radix codcnopsitis pilosulas, 200kg of Radix astragali, 200kg of Atractylodes, 200kg of Acanthopanax, 300kg of malt, 200kg of hawthorn, 200kg 10004 2006.7

Description

of tangerine peel, 150kg of dandelion, 100kg of pulsatilla, 200kg of honeysuckle, 38kg of molasses, 2kg of coarse salt, 2kg of urea, 30kg of lactobacillus plantarum

liquid and 30kg of saccharomyces cerevisiae liquid.

The viable concentration of the lactobacillus plantarum liquid and the

saccharomyces cerevisiae liquid is 5x107 CFU/mL.

(II) Preparation method

(1) weighing Radix codcnopsitis pilosulas, Radix astragali, Atractylodes,

Acanthopanax, malt, hawthorn, tangerine peel, dandelion, pulsatilla and

honeysuckle according to mass parts; then crushing the materials to an 80-mesh

sieve; and uniformly mixing the materials to obtain a fermentation substrate;

(2) weighing molasses, coarse salt and urea according to the mass parts; then

liquid for later use to obtain mixture A;

(3) mixing the fermentation substrate with the mixture A and then adjusting

water content to 40%; and fermenting, wherein fermentation temperature is 35°C

and fermentation time is 7 days;

(4) after fermentation is completed, drying the materials to water content of

% obtain a finished product.

Embodiment 3 (I) Formula of feed additive

120kg of Radix codcnopsitis pilosulas, 180kg of Radix astragali, 155kg of Atractylodes, 175kg of Acanthopanax, 247kg of malt, 75kg of hawthorn, 105kg of tangerine peel, 86kg of dandelion, 72kg of pulsatilla, 115kg of honeysuckle, 20kg of molasses, 1.5kg of coarse salt, 1.5kg of urea, 16.5kg of lactobacillus plantarum

liquid and 16.5kg of saccharomyces cerevisiae liquid.

The viable concentration of the lactobacillus plantarum liquid and the

saccharomyces cerevisiae liquid is 5x108 CFU/mL.

(II) Preparation method

10004 2006.7 |||||||||||1||

Description

(1) weighing Radix codcnopsitis pilosulas, Radix astragali, Atractylodes,

Acanthopanax, malt, hawthorn, tangerine peel, dandelion, pulsatilla and

honeysuckle according to mass parts; then crushing the materials to an 80-mesh

sieve; and uniformly mixing the materials to obtain a fermentation substrate;

(2) weighing molasses, coarse salt and urea according to the mass parts; then

liquid for later use to obtain mixture A;

(3) mixing the fermentation substrate with the mixture A and then adjusting

water content to 37%; and fermenting, wherein fermentation temperature is 33°C

and fermentation time is 6 days;

(4) after fermentation is completed, drying the materials to water content of

17% obtain a finished product.

Embodiment 4 (I) Formula of feed additive

120kg of Radix codcnopsitis pilosulas, 180kg of Radix astragali, 155kg of Atractylodes, 175kg of Acanthopanax, 247kg of malt, 75kg of hawthorn, 105kg of tangerine peel, 86kg of dandelion, 72kg of pulsatilla, 115kg of honeysuckle, 20kg of molasses, 1.5kg of coarse salt and 1.5kg of urea.

(II) Preparation method

The raw materials are mixed and then crushed.

Experiment 1

(1) Experimental site: a pig farm in the east of Heilongjiang Province.

(2) Experimental subjects: DurocxYorkshirexLandrace ternary castrated

boars with similar body weight and age in the same nursery house are selected.

(3) Experimental grouping: the pigs are randomly divided into four groups;

each group comprises 30 experimental pigs and is divided into 5 pens; and each

pen comprises 6 pigs. The control group is fed with basic corn-soybean meal ration;

the test group 1 is added with antibiotics (chlortetracycline) on the basis of the

basic ration; and the addition amount is in accordance with the instructions. The 10004 2006.7

Description

test group 2 is added with the feed additive prepared in embodiment 4 of the

present invention on the basis of the basic ration, and the addition amount is 0.3%.

The test group 3 is added with the feed additive prepared in embodiment 3 of the

present invention on the basis of the basic ration, and the addition amount is 0.2%.

The test period is 28 days.

(4) Standard: during the test, soft and shapeless feces, dilute feces and watery

spray feces of piglets are recorded as diarrhea. The number and states of piglets

with diarrhea, and continuous days of diarrhea are recorded every day, and each

pig is recorded.

Diarrhea rate = (number of piglets with diarrhea xdays of diarrhea)/(total

number of experimental pigs x total days of experiment) x 100%

(5) Experimental results: the experimental results are shown in Table 1.

Table 1 Experimental Results

Groups Control Group Test Group1 Test Group 2 Test Group 3 Diarrhea Rate 1.41 ±0.31a 0.95 ±0.14b 1.01 ±0.2 5b 0.61 ±0.19c

Through the analysis of the test results, compared with the control group, the

diarrhea rates of the test group 1 and the test groups 2 are obviously reduced

(P<0.05), and the diarrhea rate of the test group 3 group is extremely obviously

reduced (P<0.01); and compared with the test group 1 and the test group 2, the

diarrhea rate of the test group 3 is obviously reduced (P<0.05). It can be concluded

from the test that the fermented compound Chinese herbal medicine has the

strongest inhibitory effect on diarrhea of the pigs, followed by antibiotics, and

unfermented compound Chinese herbal medicine. It indicates that the fermented

compound Chinese herbal medicine group has the best effect on inhibiting

diarrhea.

The experimental results show that the feed additive of the present invention

has the effect of preventing and treating diarrhea of the weaned piglets, and can

replace the antibiotics in production.

10004 2006.7

Description

Each embodiment in the description is described in a progressive way. The

difference of each embodiment from each other is the focus of explanation. The

same and similar parts among all of the embodiments can be referred to each other.

The above description of the disclosed embodiments enables those skilled in

the art to realize or use the present invention. Many modifications to these

embodiments will be apparent to those skilled in the art. The general principle

defined herein can be realized in other embodiments without departing from the

spirit or scope of the present invention. Therefore, the present invention will not be

limited to these embodiments shown herein, but will conform to the widest scope

consistent with the principle and novel features disclosed herein.

10004 2006.7

Claims

1. A plant feed additive for preventing and treating diarrhea of weaned piglets, comprising the following components in parts by mass: 100-150 parts of Radix codcnopsitis pilosulas, 100-200 parts of Radix astragali, 100-200 parts of Atractylodes, 100-200 parts of Acanthopanax, 200-300 parts of malt, 50-200 parts of hawthorn, 100-200 parts of tangerine peel, 50-150 parts of dandelion, 50-100 parts of pulsatilla and 100-200 parts of honeysuckle.

2. The plant feed additive for preventing and treating diarrhea of weaned piglets according to claim 1, wherein the plant feed additive also comprises the following components in parts by mass: 9.5-38 parts of molasses, 1-2 parts of coarse salt, 1-2 parts of urea and 10-60 parts of composite bacterial liquid.

3. A plant feed additive for preventing and treating diarrhea of weaned piglets, comprising the following components in parts by mass: 120 parts of Radix codcnopsitispilosulas, 180 parts of Radix astragali, 155 parts of Atractylodes, 175 parts of Acanthopanax, 247 parts of malt, 75 parts of hawthorn, 105 parts of tangerine peel, 86 parts of dandelion, 72 parts of pulsatilla, 115 parts of honeysuckle, 20 parts of molasses, 1.5 parts of coarse salt, 1.5 parts of urea and 33 parts of composite bacterial liquid.

4. The plant feed additive for preventing and treating diarrhea of weaned piglets according to any one of claim 2 or 3, wherein the composite bacterial liquid comprises lactobacillus plantarum liquid and saccharomyces cerevisiae liquid according to a mass ratio of 1:1.

5. The plant feed additive for preventing and treating diarrhea of weaned piglets according to claim 4, wherein the viable count of the lactobacillus plantarum liquid and the saccharomyces cerevisiae liquid is1x107-5x108 CFU/mL.

6. The plant feed additive for preventing and treating diarrhea of weaned piglets according to any one of claim 2 or 3, wherein the viable count in the feed additive is 100 million to 1 billion/g.

Claims

7. A preparation method of the plant feed additive for preventing and treating diarrhea of weaned piglets of any one of claim 2 or 3, comprising the following steps: (1) weighing Radix codcnopsitis pilosulas, Radix astragali, Atractylodes, Acanthopanax, malt, hawthorn, tangerine peel, dandelion, pulsatilla and honeysuckle according to mass parts; then crushing the materials to an 80-mesh sieve; and uniformly mixing the materials to obtain a fermentation substrate; (2) weighing molasses, coarse salt and urea according to the mass parts; then uniformly mixing the materials; and adding the materials to the composite bacterial liquid to obtain mixture A; (3) uniformly mixing the fermentation substrate with the mixture A and then fermenting; (4) after fermentation is completed, drying the materials to obtain a finished product.

8. The preparation method according to claim 7, wherein in the step (3), after the fermentation substrate is mixed with the mixture A, water content needs to be adjusted to 35%-40% and then fermentation is conducted.

9. The preparation method according to claim 7, wherein in the step (3), fermentation temperature is 30-35°C and fermentation time is 5-7 days.

10. The preparation method according to claim 7, wherein in the step (4), after fermentation is completed, the materials are dried to water content of 15%-20%.

10006 2006.7