CN104523897A - Enteroclysis medicine composition for treating piglet epidemic diarrhea - Google Patents

Abstract

The invention discloses an enteroclysis medicine composition for treating piglet epidemic diarrhea. The composition is prepared from the following components in parts by weight: 40-60 parts of sowthistle tasselflower herb, 40-60 parts of sargentodoxa cuneata, 40-60 parts of roughhaired holly root, 30-50 parts of phoenix-tail fern, 30-50 parts of euphorbia humifusa, 30-50 parts of agrimonia pilosa ledeb, 30-50 parts of pulsatilla chinensis regel, 30-50 parts of kudzu vine root, 30-50 parts of rhizoma atractylodis macrocephalae, 20-40 parts of senecio scandens, 20-40 parts of semen plantaginis, 15-25 parts of coptis chinensis, 15-25 parts of fructus mume, 3-5 parts of smecta and 3-5 parts of lactobacillin tablets. The medicinal materials are organically mixed, dialectically combined and mutually assisted to reinforce the effect of clearing heat, drying dampness and relieving diarrhea so as to achieve the aim of curing piglet diarrhea. The composition for treating piglet epidemic diarrhea in an enteroclysis manner has a cure rate of 90.23 percent and an effective rate of 98.70 percent. The medicine composition prepared by adopting the preparation has a remarkable effect.

Description

A kind of enema medicament compositions for the treatment of piglet epidemic diarrhea

Technical field

The present invention relates to the pharmaceutical composition for the treatment of Animal diseases, particularly a kind of enema medicament compositions for the treatment of piglet diarrhea.

Background technology

Piglet diarrhea clinically sickness rate, mortality rate is all higher, is the disease of a class serious harm pig industry development.Very general at China's primary disease, it is reported, the piglet of below 30kg, average of the whole year sickness rate 46.5%, mortality rate reaches 15%, every year to the more than one hundred million unit of direct economic loss that industrial belt of raising pigs is come.Primary disease is also higher at the M & M of the countries such as the more flourishing America and Europe of pig industry, and primary disease all brings great puzzlement to poultry feeders, especially Compact Develop both at home and abroad.Piglet, once suffer from diarrhoea, except making medication expense and rising, also causes that the survival rate of piglet declines, poor growth or stagnation, thus affects the price of deed, reduction fertility performance, causes huge economic loss to pig farm.Cause the cause of disease of morbidity of a great variety, characteristic of disease is complicated, wherein has virus (transmissible gastroenteritis, epidemic diarrhea, rotavirus etc.), antibacterial (escherichia coli, clostridieum welchii, Salmonella, vibrio etc.), parasite (coccidiosis, pouch ciliate etc.).According to the emergency of morbidity, show different symptoms.Large frequently-occurring disease is anxious, body temperature raises, be afraid of cold, like and bore careless nest or crowdedly to flock together, and spirit is depressed, big-eared ear of bowing, be reluctant activity, loss of appetite or do not eat, dyspnea, water sample is had loose bowels, feces is yellow-white or canescence, stench, be mingled with not digested feedstuff or ziega in some feces, backward dehydro, enophthalmos impatient by hair; Chronic disease body temperature does not generally raise even lower than room temperature, and spirit is poor, loss of appetite, and walking is slow or stand transfixed to the ground, and repeatedly has loose bowels, and dehydration is serious, has pica, likes gnawing pad grass, drinking addle, severe anemia, and visual mucosa is pale, last exhaustion death.

Current control piglet diarrhea adopts antibacterial, the antiviral agents of chemosynthesis to feed or drug administration by injection usually, although temporarily can delay the state of an illness, cures the symptoms, not the disease, drops into large quantities of fund, reduces benefit of raising pigs.And some antiviral chemical drugs (as moroxydine, virazole etc.) is used for the treatment of Animal diseases by domestic having forbidden at present, and antimicrobial DP finish easily causes drug residue again, there is the drawback that treatment thoroughly can not cause secondary disease or slow virus infection.And Integrated TCM is applied in antibacterial, anti-virus aspect, there is original advantage, cheap, toxic and side effects is little, source is wide.Not only cost-saving, and interior symptom management can be asked when shorter, reduce piglet dead, and then improve culture benefit.Therefore, a kind of Chinese and western drugs compositions for piglet diarrhoea is badly in need of, for clinical practice.

Summary of the invention

The technical problem to be solved in the present invention overcomes at present in the weak point for the treatment of piglet diarrhea, provide one draw materials easy, easy to prepare, reduce drug residue and toxic and side effects, and the pharmaceutical composition of the higher treatment piglet diarrhea of cheap curative effect.

Treat an enema medicament compositions for piglet diarrhea, its composition by weight is: Herba Emiliae 40-60 part, Caulis Sargentodoxae 40-60 part, Herba Andrographis 40-60 part, Herba Pteridis Multifidae 30-50 part, Herba Euphorbiae Humifusae 30-50 part, Herba Agrimoniae 30-50 part, Radix Pulsatillae 30-50 part, Radix Puerariae 30-50 part, Rhizoma Atractylodis Macrocephalae 30-50 part, Herba Senecionis Scandentis 20-40 part, Semen Plantaginis 20-40 part, Rhizoma Coptidis 15-25 part, Fructus Mume 15-25 part, dioctahedral smectite 3-5 part, lactein tablet 3-5 part.

Preferred composition by weight is:

Herba Emiliae 60 parts, Caulis Sargentodoxae 60 parts, Herba Andrographis 60 parts, Herba Pteridis Multifidae 50 parts, Herba Euphorbiae Humifusae 50 parts, Herba Agrimoniae 50 parts, the Radix Pulsatillae 50 parts, Radix Puerariae 50 parts, the Rhizoma Atractylodis Macrocephalae 50 parts, Herba Senecionis Scandentis 40 parts, Semen Plantaginis 40 parts, Rhizoma Coptidis 25 parts, Fructus Mume 25 parts, dioctahedral smectite 5 parts, lactein tablet 5 parts.

Or be:

Herba Emiliae 40 parts, Caulis Sargentodoxae 40 parts, Herba Andrographis 40 parts, Herba Pteridis Multifidae 30 parts, Herba Euphorbiae Humifusae 30 parts, Herba Agrimoniae 30 parts, the Radix Pulsatillae 30 parts, Radix Puerariae 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Herba Senecionis Scandentis 20 parts, Semen Plantaginis 20 parts, Rhizoma Coptidis 15 parts, Fructus Mume 15 parts, dioctahedral smectite 3 parts, lactein tablet 3 parts.

Or be:

Herba Emiliae 50 parts, Caulis Sargentodoxae 50 parts, Herba Andrographis 50 parts, Herba Pteridis Multifidae 40 parts, Herba Euphorbiae Humifusae 40 parts, Herba Agrimoniae 40 parts, the Radix Pulsatillae 40 parts, Radix Puerariae 40 parts, the Rhizoma Atractylodis Macrocephalae 40 parts, Herba Senecionis Scandentis 30 parts, Semen Plantaginis 30 parts, Rhizoma Coptidis 20 parts, Fructus Mume 20 parts, dioctahedral smectite 4 parts, lactein tablet 4 parts.

Another object of the present invention is to provide a kind of preparation method for the treatment of the enema medicament compositions of piglet diarrhea:

1) component is taken by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea, Chinese medicine Herba Emiliae, Caulis Sargentodoxae, Herba Andrographis, Herba Pteridis Multifidae, Herba Euphorbiae Humifusae, Herba Agrimoniae, the Radix Pulsatillae, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Herba Senecionis Scandentis, Semen Plantaginis, Rhizoma Coptidis, Fructus Mume are pulverized, decoct with water, filter medicinal residues, get filtrate, concentrated filtrate is to containing crude drug 0.68-0.72g/ml;

2) when using, middle drug filtrate is heated to 37-42 ⁰c, is mixed into dioctahedral smectite and lactein.

A kind of enema medicament compositions for the treatment of piglet diarrhea of the present invention, in side, Herba Emiliae has another name called Herba Duchesneae Indicae, and herb is medicinal, mildly bitter flavor, cool in nature.Function heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling antidiarrheal.Cure mainly the disease such as upper respiratory tract infection, laryngopharynx swelling and pain, demonstrate,proving acute enteritis, bacillary dysentery, have blood in stool etc. also has good curative effect.Caulis Sargentodoxae has another name called Caulis Sargentodoxae, bitter in the mouth, and property is put down.Return large intestine, Liver Channel.Tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, disinsection efficiency.Cure mainly acute appendicitis, the diseases such as dysentery.Two medicines are harmonious, heat-clearing and toxic substances removing, eliminating carbuncle antidiarrheal; Herba Andrographis nature and flavor are bitter, cold.Return lung, stomach, large intestine, small intestine meridian.There is heat-clearing and toxic substances removing, the merit of dampness removing and diarrhea-relieving.Radix Pulsatillae nature and flavor bitter cold, enters large intestine, stomach warp, can heat-clearing and toxic substances removing, and can enter again blood system and removing heat from blood antidiarrheal, especially kind clearing stomach intestinal is damp and hot.Two medicines are the key medicine controlling dysentery, its heat-clearing and toxic substances removing of mutual compatibility, and the effect of dampness removing and diarrhea-relieving is especially aobvious.The research of modern medicine proves, punching Nelumbo broad spectrum antibiotic, has killing action to multiple pathogenic microorganisms, and energy antiviral and raising leukocyte are to the phagocytic activity of antibacterial.The Radix Pulsatillae has astriction to intestinal mucosa, energy antidiarrheal, hemostasis.There is inhibitory action to dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus, bacillus subtilis, and amoeba trophozoite can be suppressed to grow.The monarch drug of above-mentioned four medicines jointly in the side of composition.Herba Pteridis Multifidae is bitter, cold.Return liver, stomach, lung, large intestine, urinary bladder channel.Herb, for medicine, has clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, the strong active equivalence of muscle, for cards such as dysentery, gastroenteritis, hepatitis, urinary system infections.The research of modern medicine proves, Herba Pteridis Multifidae all has inhibitory action to staphylococcus aureus, Hemolytic streptococcus, shigella flexneri, Bacillus typhi.Herba Euphorbiae Humifusae nature and flavor are pungent flat, and have heat-clearing and toxic substances removing, the merit of cooling blood for hemostasis, is used for dysentery, has loose bowels, spitting of blood, hematuria, the card such as to have blood in stool.With bracken, the better effects if of its antidiarrheal.Herba Agrimoniae is put down, bitter in the mouth, puckery.Return stomach, liver, spleen, lung, large intestine channel.There is astringing to arrest bleeding, dysentery relieving, the merit of removing toxic substances.There is puckery property of holding back, can relieving diarrhea with astringents dysentery relieving, because of this product mild in medicine property and, holding concurrently can tonify deficiency, can stop blooding again, thus for dysentery and prolonged illness dysentery particularly suitable.Pharmacological evaluation shows, its water extraction becomes silted up in vitro to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, shigella flexneri, and Bacillus typhi, Bacillus tuberculosis's increasing have inhibitory action.Herba Senecionis Scandentis bitter in the mouth is cold in nature, returns lung, liver, large intestine channel.Energy heat-clearing and toxic substances removing; Liver heat removing and eyesight improving.Cure mainly acute enteritis; Bacillary dysentery, pneumonia; The disease such as hepatitis and skin pruritus; Particularly the merit of the clear sharp damp-heat in the large intestine of Herba Senecionis Scandentis is especially aobvious, and for damp-heat in the large intestine, stomachache is had loose bowels, or dysentery pus and blood, tenesmus.Herba Senecionis Scandentis has stronger broad spectrum antibiotic activity, has obvious inhibitory action to Gram-positive and negative bacteria, wherein particularly responsive to shigella flexneri, dysentery bacterium and mucositis Nai Shi coccus.The ministerial drug of above-mentioned four medicines jointly in the side of composition.Radix Puerariae is sweet, pungent, cool, returns spleen, stomach two warp.Having induces sweat brings down a fever, the merit of promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal, especially treats visible peristalsis visible intestinal peristalsis cold, fever diarrhoea, is equal to use with Rhizoma Coptidis, can play bring down a fever, the effect such as antibacterial, antiinflammatory.Particularly simmering can the lucid yang sending up antidiarrheal after using.Rhizoma Atractylodis Macrocephalae sweetness and bitterness and warm, spleen reinforcing dampness is to hold up soil empty.Herba Plantaginis heat-clearing and toxic substances removing, invigorating the spleen to clear away damp pathogen antidiarrheal; Rhizoma Coptidis bitter cold, has the merit of heat clearing and damp drying, eliminating fire and detoxication, consolidating YIN only profit.Fructus Mume is astringed the lung astringing intestine to stop diarrhea, is equal to the better effects if with its relieving diarrhea with astringents with Rhizoma Coptidis, conventionally controls chronic diarrhea chronic dysentery.Modern medicine study proves, Fructus Mume has inhibitory action to escherichia coli, dysentery bacterium, Bacillus typhi etc. and multiple coccus, fungus.Dioctahedral smectite has another name called montmorillonite powder, is a kind of aluminosilicate.There is good anti-diarrhea effect, be clinically applicable to the acute and chronic diarrhoea of people and animals.Dioctahedral smectite research shows, it has good adsorption to escherichia coli, vibrio cholera, campylobacter jejuni, staphylococcus aureus and rotavirus and cholate; Fixation is have to bacterial poison; Dioctahedral smectite only adsorbs, fixed surface with the pathogenic charged pathogen of grain encoding proteins (CS31 A), the normal flora of effects on surface not with CS31 A is without fixing scavenging action, and the uneven charging property of dioctahedral smectite makes it can adsorb various digestive tract virulence factor.Dioctahedral smectite and digestive tract mucus protein electrostatical binding, can increase mucus amount and improve cohesiveness and the elasticity of mucus Quality advance mucus, thus playing protection and repair to gastrointestinal mucosal.The diarrhoea that dioctahedral smectite causes the various cause of disease is all effective, is that bacillary, viral, lienteric, dysbiosis and intestinal poison bowel syndrome diarrhoea all has good curative effect.Dioctahedral smectite does not enter blood, gets rid of external completely, never residual, and any bacterial virus does not produce drug resistance to it, is green animal health product.Lactein tablet, this product forms protective layer at intestinal, stops the invasion and attack of pathogen, virus; Stimulate intestinal secretion antibody, improve intestinal immunity; Selectivity kills pathogenic entero becteria, and protection promotes the growth of probiotics; Regulate intestinal mucosa electrolyte, water balance; Promote gastric secretion, strengthen digestive function.

All medicines share the agent becoming heat clearing and damp drying antidiarrheal altogether.

The side's of system feature: we are with heat-clearing and toxic substances removing, and dampness removing and diarrhea-relieving use, hold concurrently with harmonizing the functional activities of vital QI, dispel pathogenic factor in the exterior, treating both the exterior and interior.Said medicine is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country, enhances effect of the party's heat clearing and damp drying antidiarrheal, thus reaches the object of curing piglet diarrhea.The present invention passes through scientific compatibility, Chinese medicine compound decoction and the medicine such as dioctahedral smectite, lactein are achieved organic assembling, can more effectively prevent and treat the various piglet diarrhea caused by bacillary and viral etc., curative effect safety non-toxic again really, strengthen the immunity of animal, improve raise benefit.Clinical Treatment Test proves, the cure rate 90.23% of we's treatment piglet diarrhea, effective percentage 98.70%.

We have overall curative effect high, not easily produce drug resistance, residual low, the advantage such as toxic and side effects is little, it has significant inhibitory action to the growth and reproduction of many pathogenic microorganisms, even can reach the pharmacological effect killing cause of disease, for promoting that the sound development of pig industry has very important economy and social meaning.

Detailed description of the invention

embodiment 1

1) No. 1, antidiarrheal: take each Chinese medicine component by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea, Herba Emiliae 60 parts, Caulis Sargentodoxae 60 parts, Herba Andrographis 60 parts, Herba Pteridis Multifidae 50 parts, Herba Euphorbiae Humifusae 50 parts, Herba Agrimoniae 50 parts, the Radix Pulsatillae 50 parts, Radix Puerariae 50 parts, the Rhizoma Atractylodis Macrocephalae 50 parts, Herba Senecionis Scandentis 40 parts, Semen Plantaginis 40 parts, Rhizoma Coptidis 25 parts, Fructus Mume 25 parts.Add water by 6 times of total dose, both 3660 parts of water, become 896 parts of medicinal liquids after decocting, both every milliliter of medicinal liquid was containing crude drug about 0.68 gram.

2) No. 2, antidiarrheal: take each 5 parts of dioctahedral smectite, lactein tablet by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea.By dioctahedral smectite and lactein red in pulv, and mix homogeneously.

embodiment 2

1) No. 1, antidiarrheal: take each Chinese medicine component by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea, Herba Emiliae 40 parts, Caulis Sargentodoxae 40 parts, Herba Andrographis 40 parts, Herba Pteridis Multifidae 30 parts, Herba Euphorbiae Humifusae 30 parts, Herba Agrimoniae 30 parts, the Radix Pulsatillae 30 parts, Radix Puerariae 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Herba Senecionis Scandentis 20 parts, Semen Plantaginis 20 parts, Rhizoma Coptidis 15 parts, Fructus Mume 15 parts, add water by 6 times of total dose, both 2256 parts of water, become 522 parts of medicinal liquids after decocting, both every milliliter of medicinal liquid was containing crude drug about 0.72 gram.

2) No. 2, antidiarrheal: take each 3 parts of dioctahedral smectite, lactein tablet by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea.By dioctahedral smectite and lactein red in pulv, and mix homogeneously.

embodiment 3

1) No. 1, antidiarrheal: take each Chinese medicine component by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea, Herba Emiliae 50 parts, Caulis Sargentodoxae 50 parts, Herba Andrographis 50 parts, Herba Pteridis Multifidae 40 parts, Herba Euphorbiae Humifusae 40 parts, Herba Agrimoniae 40 parts, the Radix Pulsatillae 40 parts, Radix Puerariae 40 parts, the Rhizoma Atractylodis Macrocephalae 40 parts, Herba Senecionis Scandentis 30 parts, Semen Plantaginis 30 parts, Rhizoma Coptidis 20 parts, Fructus Mume 20 parts, add water by 6 times of total dose, both 2520 parts of water, become 711 parts of medicinal liquids after decocting, both every milliliter of medicinal liquid was containing crude drug about 0.70 gram.

2) No. 2, antidiarrheal: take each 4 parts of dioctahedral smectite, lactein tablet by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea.By dioctahedral smectite and lactein red in pulv, and mix homogeneously.

embodiment 4

Another object of the present invention is to provide a kind of enema medicament compositions for the treatment of piglet diarrhea, is prepared by following method:

1) No. 1, antidiarrheal: gavage medicine 1 proportioning by embodiment 1,2 or 3 and weigh, Chinese medicine Herba Emiliae, Caulis Sargentodoxae, Herba Andrographis, Herba Pteridis Multifidae, Herba Euphorbiae Humifusae, Herba Agrimoniae, the Radix Pulsatillae, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Herba Senecionis Scandentis, Semen Plantaginis, Rhizoma Coptidis, Fructus Mume are crushed to particle diameter less than 2 millimeters, then mix homogeneously, adds the water soaking 40 minutes of 6 times of weight.Put into decoction pot, decoct 30 minutes, filter medicinal residues, get filtrate.Contained crude drug 0.68-0.72g/ml in filtrate.

Wherein

Embodiment 1 adds water 3660 parts, concentrated filtrate to 896 part;

Embodiment 2 adds water 2256 parts, concentrated filtrate to 522 part;

Embodiment 3 adds water 2520 parts, concentrated filtrate to 711 part;

2) No. 2, antidiarrheal: take dioctahedral smectite, lactein tablet by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea, by dioctahedral smectite and lactein red in pulv, mix homogeneously.

3) operational approach: facing the used time is heated to 40 by diarrhea No. 1 filtrate ⁰about C, adds No. 2, diarrhea, mix homogeneously.Concrete grammar is: two back legs holding piglet, transfusion organ pipe leading portion is cut, burns with lighter on the transfusion device tube head cut, and makes it not too sharp-pointed, to prevent from scratching intestinal.Then, be coated with a little paraffin oil, slowly insert anus, the degree of depth is about 20cm, and injected by medicinal liquid as transfusion, injection rate is per kilogram of body weight 4ml, and minimum stop 5min, then puts down, every day 2 times, within 5 days, is a course for the treatment of.

experimental example

Instructions of taking:

1, dose: by embodiment 1, embodiment 4, embodiment 2, embodiment 4, No. 1, the antidiarrheal that embodiment 3, embodiment 4 are obtained and No. 2, antidiarrheal press proportioning mix homogeneously, by 4ml/kg body weight coloclysis.

2, the coloclysis time: morning and afternoon every day, coloclysis once, 5 days was a course for the treatment of respectively.Within last hour, gavage feeding.

3, medicine temperature control: about 40 DEG C decoction being taken warmly.

Taboo item: treatment period in a medicine strengthens feeding and management to ill piglet, ensures sufficient drinking-water, feeds to soft digestible feedstuff.

Criterion of therapeutical effect: the medicine composite for curing piglet diarrhea for the treatment of piglet diarrhea, whether efficacy determination Main Basis piglet diarrhea symptom disappears.Taking medicine 5 days is a course for the treatment of, and concrete curative effect is divided into three grades:

Cure: piglet diarrhea symptom all disappears;

Take a turn for the better: piglet diarrhea symptom partial disappearance;

Invalid: piglet diarrhea symptom is not improved.

In recent years, we, in thousands of examples of single therapeutic piglet diarrhea such as multiple pig farm and veterinary hospitals, treat a course for the treatment of, cure rate 92.17%, effective percentage 99.40%.

clinical effect trial

1. method: four, the pig farm of publishing cub's diarrhea of pigs, selects piglet 1124 example that piglet diarrhea occurs, age 7-30 age in days altogether.Ill piglet is divided into four groups, is respectively of the present invention group, Radix Pulsatillae side's group, dioctahedral smectite add lactein group and matched group.

Of the present invention group is the pharmaceutical composition by the treatment piglet diarrhea obtained by embodiment 3,4.

Radix Pulsatillae Decoction group Radix Pulsatillae Decoction used derives from treatise on Febrile Diseases, and it consists of the Radix Pulsatillae 60 parts, Cortex Phellodendri 30 parts, Rhizoma Coptidis 45 parts, Cortex Fraxini 60 parts, is crushed to particle diameter less than 2 millimeters, then mix homogeneously, adds the water soaking 40 minutes of 6 times of weight.Put into decoction pot, decoct 30 minutes, filter medicinal residues, get filtrate.Contained crude drug 0.70g/ml in filtrate.

It had been both No. 2, antidiarrheal in of the present invention group that dioctahedral smectite adds lactein group, and it consists of montmorillonite powder 5 parts, cereobiogen sheet 5 parts, adds water by 3 times of total dose.

Matched group need not any Drug therapy.

Treatment time is a course for the treatment of, namely 5 days, and once, dosage presses 4ml/kg body weight to every day at upper and lower noon each coloclysis.

Table 1 suffers from poultry grouping and primary treatments

2. efficacy determination:

Criterion of therapeutical effect: whether the symptom of efficacy determination Main Basis piglet diarrhea disappears.Medication 5 days is a course for the treatment of, observe the curative effect after 5 days.Concrete curative effect is divided into three grades:

Cure: piglet diarrhea symptom all disappears;

Take a turn for the better: piglet diarrhea symptom partial disappearance;

Invalid: piglet diarrhea symptom is not improved.

3. result: 1124 routine ill piglets are by different dosage regimens, and after the treatment of a course for the treatment of, the therapeutic effect of each group is in table 2.

The various therapeutic scheme therapeutic effect of table 2

From table 2; three groups of drug enemas have different therapeutic effect to piglet diarrhea, and wherein best with of the present invention group of therapeutic effect, cure rate reaches 90.23%; total effective rate 98.70%, pole is significantly higher than other two groups (P < 0. 01); Radix Pulsatillae Decoction group is taken second place, and dioctahedral smectite adds lactein group again, and matched group does not have therapeutical effect.Statistical result shows, each group difference extremely significantly (P< 0. 01).

Facts have proved, medicine of the present invention is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country, enhances the party's heat-clearing and toxic substances removing, effect of dampness removing and diarrhea-relieving.And by coloclysis, medicine is directly contacted with intestinal, for piglet diarrhea, there is good curative effect, thus reach the object of healing.The enema medicament compositions of the treatment piglet diarrhea adopting the present invention a kind of preparation method for the treatment of the enema medicament compositions of piglet diarrhea to obtain has that cost is low, preparation easily, to have no side effect and evident in efficacy.For this disease of clinical treatment provides a kind of practicable new drug.Clinical practice proves, the cure rate 90.23% of this medicine, effective percentage 98.70%.

Above-mentioned detailed description of pharmaceutical composition of this treatment piglet diarrhea and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.

Claims (5)

1. treat an enema medicament compositions for piglet diarrhea, its composition by weight is: Herba Emiliae 40-60 part, Caulis Sargentodoxae 40-60 part, Herba Andrographis 40-60 part, Herba Pteridis Multifidae 30-50 part, Herba Euphorbiae Humifusae 30-50 part, Herba Agrimoniae 30-50 part, Radix Pulsatillae 30-50 part, Radix Puerariae 30-50 part, Rhizoma Atractylodis Macrocephalae 30-50 part, Herba Senecionis Scandentis 20-40 part, Semen Plantaginis 20-40 part, Rhizoma Coptidis 15-25 part, Fructus Mume 15-25 part, dioctahedral smectite 3-5 part, lactein tablet 3-5 part.

2. a kind of enema medicament compositions for the treatment of piglet diarrhea according to claim 1, is characterized in that: described Herba Emiliae 60 parts, Caulis Sargentodoxae 60 parts, Herba Andrographis 60 parts, Herba Pteridis Multifidae 50 parts, Herba Euphorbiae Humifusae 50 parts, Herba Agrimoniae 50 parts, the Radix Pulsatillae 50 parts, Radix Puerariae 50 parts, the Rhizoma Atractylodis Macrocephalae 50 parts, Herba Senecionis Scandentis 40 parts, Semen Plantaginis 40 parts, Rhizoma Coptidis 25 parts, Fructus Mume 25 parts, dioctahedral smectite 5 parts, lactein tablet 5 parts.

3. a kind of enema medicament compositions for the treatment of piglet diarrhea according to claim 1, is characterized in that: described Herba Emiliae 40 parts, Caulis Sargentodoxae 40 parts, Herba Andrographis 40 parts, Herba Pteridis Multifidae 30 parts, Herba Euphorbiae Humifusae 30 parts, Herba Agrimoniae 30 parts, the Radix Pulsatillae 30 parts, Radix Puerariae 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Herba Senecionis Scandentis 20 parts, Semen Plantaginis 20 parts, Rhizoma Coptidis 15 parts, Fructus Mume 15 parts, dioctahedral smectite 3 parts, lactein tablet 3 parts.

4. a kind of enema medicament compositions for the treatment of piglet diarrhea according to claim 1, is characterized in that: described Herba Emiliae 50 parts, Caulis Sargentodoxae 50 parts, Herba Andrographis 50 parts, Herba Pteridis Multifidae 40 parts, Herba Euphorbiae Humifusae 40 parts, Herba Agrimoniae 40 parts, the Radix Pulsatillae 40 parts, Radix Puerariae 40 parts, the Rhizoma Atractylodis Macrocephalae 40 parts, Herba Senecionis Scandentis 30 parts, Semen Plantaginis 30 parts, Rhizoma Coptidis 20 parts, Fructus Mume 20 parts, dioctahedral smectite 4 parts, lactein tablet 4 parts.

5. treat a preparation method for the enema medicament compositions of piglet diarrhea, it comprises:

1) component is taken by a kind of proportioning raw materials for the treatment of the enema medicament compositions of piglet diarrhea according to claim 1, Chinese medicine Herba Emiliae, Caulis Sargentodoxae, Herba Andrographis, Herba Pteridis Multifidae, Herba Euphorbiae Humifusae, Herba Agrimoniae, the Radix Pulsatillae, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Herba Senecionis Scandentis, Semen Plantaginis, Rhizoma Coptidis, Fructus Mume are pulverized, decoct with water, filter medicinal residues, get filtrate, concentrated filtrate is to containing crude drug 0.68-0.72g/ml;

2) when using, middle drug filtrate is heated to 37-42 ⁰c, is mixed into dioctahedral smectite and lactein.