CN104547735B - A kind of pharmaceutical composition for treating piglet transmissible gastroenteritis and preparation method thereof - Google Patents
A kind of pharmaceutical composition for treating piglet transmissible gastroenteritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis, its composition by weight is：50 70 parts of granatum, 50 70 parts of Ciliatenerve Knotweed Root, 50 70 parts of shrub althea flower, 40 60 parts of the Chinese bulbul, 40 60 parts of Sargent gloryvine, 40 60 parts of Patrinia villosa Juss, coix seed（It fries）40 60 parts, 30 50 parts of wild chrysanthemum, 30 50 parts of acalypha copperleaf, 20 40 parts of hairyvein agrimony, 37 parts of berberine powder, 37 parts of piglet special bacterium, 37 parts of vitamin B compound.Said medicine is through organic assembling, dialectical compatibility and the effect of mutually assist, enhance party's heat-clearing and damp-drying drug antidiarrheal, so as to achieve the purpose that cure grice diarrhoea.Piglet transmissible gastroenteritis can be more effectively prevented, curative effect really is again safe and non-toxic, enhances the immunity of animal, improves raise benefit.Clinical Treatment Test proves that we treat the cure rate 93.15% of grice diarrhoea, effective percentage 98.97%.
Description
Technical field：
The present invention relates to the pharmaceutical composition for the treatment of Animal diseases, more particularly to a kind of piglet transmissible gastroenteritis for the treatment of
Pharmaceutical composition and preparation method thereof.
Background technology：
Transmissible gastroenteritis of swine (transmissible gastroenteritis of swine, TGE) is by coronal disease
Malicious section, the transmissible gastro-enteritis virus of coronavirus genus（Transmissible gastroenteritis virus of
Swine, TGEV）A kind of caused high degree in contact intestines problem.Characterized by vomiting, severe diarrhea, dehydration.Morbidity season
Significantly, cold winter, spring are mainly in, the pig at each age is all susceptible, several with the newborn piglet death rate highest in two week old
Reachable 100%, more than 5 week old, then the death rate is low, even if but more depauperations after piglet rehabilitation, growth retardation, production performance
Decline, price of deed rate is low, and larger economic loss is caused to pig breeding industry.
At present, this disease has the tendency that prevalence, and normal and other bacteria mixed infections in national some places, is caused to pig breeding industry
It seriously endangers.With regard to clinical findings, vomit within 12-24 hours after the Infection in Piglets within 2 week old, serious water sample then occur
Or paste diarrhea, excrement are in yellow, often accompany indigested ziega, stench.Weight declines rapidly, and piglet is significantly dehydrated, more
2-7 days after morbidity dead, and the death rate is up to 100%；In the piglet of 2-3 week old, the death rate is in 0-10%.2- after pig of weaning infects
It falls ill within 4 days, shows watery diarrhea, in spurting, excrement gray or brown, indivedual pig vomitings, diarrhea stops after 5-8 days, seldom
Death, but weight loss, often show depauperation, become cad pig.Some sows and illness piglet close contact repeated infection, disease
Shape is heavier, and body temperature raising, lactation stops, vomiting, loss of appetite and diarrhea, and also some milking sows do not show clinical symptom.This
Full of curdling block, the hyperemia of stomach bottom mucous membrane, bleeding, serous coat bleeding in the visible stomach of pathology dissect；Small intestine air-blowing, intestinal wall are visible more
Unrestrained property is congested, bleeding, the thinning shape that is translucent of intestinal wall, and interior full of watery stools, lymphonodi mesenterici is congested, swelling.Sick pig disappears
Thin, dehydration is apparent.
Treatment for this disease, clinically mostly at present is to use Western medicine, although can temporarily delay the state of an illness, effect is not
Ideal, and large quantities of funds are put into, reduce pig raising benefit.In addition, drug resistance and residue problem are also easy to produce using antibiotic, it is unfavorable
In the diagnose and treat of disease, the outlet of China's animal food is hindered.Therefore a kind of safely and effectively prevention pig is developed to pass
The combination of Chinese tradiational and Western medicine drug of metachromia gastroenteritis is extremely urgent.Chinese herbal medicine has original advantage in terms of viral disease is treated,
It can not only influence the duplication of virus, it can also be by adjusting immunity of organisms, non-specific anti-inflammatory playing its antiviral work
With.And Chinese herbal medicine has toxic side effect small, and residual is few, and resourceful, therefore the advantages such as cheap, select suitable medium-height grass
Medicine coordinates Western medicine, and the advantage treatment transmissible gastroenteritis of swine for playing Integrated TCM is not only cost-effective, but also can be shorter
When ask the interior control state of an illness, reduce animal dead, and then improve culture efficiency.
Invention content：
The technical problem to be solved by the present invention is to overcome in the shortcoming for the treatment of piglet transmissible gastroenteritis, provide at present
A kind of materials are easily, preparation is convenient, reduce medicament residue and toxic side effect, and the treatment grice diarrhoea that cheap curative effect is higher
Pharmaceutical composition.We have many advantages, such as whole curative effect height, are not likely to produce that drug resistance, residual is low, toxic side effect is small, to son
The growth of transmissible gastro-enteritis virus has significant inhibiting effect or even can reach the viral pharmacology of killing with breeding imitates
Fruit has highly important economy and social effect for the sound development for promoting pig breeding industry.
The present invention provides following technical solutions：
A kind of pharmaceutical composition for treating piglet transmissible gastroenteritis, it is formed by gavaging medicine and spice medicine, the filling
Medication bulk pharmaceutical chemicals composition by weight be：50-70 parts of granatum, 50-70 parts of Ciliatenerve Knotweed Root, 50-70 parts of shrub althea flower, Chinese bulbul 40-60
Part, 40-60 parts of Sargent gloryvine, 40-60 parts of Patrinia villosa Juss, coix seed（It fries）40-60 parts, 30-50 parts of wild chrysanthemum, acalypha copperleaf 30-50
Part, 20-40 parts of hairyvein agrimony, 3-7 parts of berberine powder;
Spice medicine composition by weight is piglet is probiotics 3-7 parts special, 3-7 parts of vitamin B compound；
Gavaging the preferred composition by weight of medicine is：
70 parts of granatum, 70 parts of Ciliatenerve Knotweed Root, 70 parts of shrub althea flower, 60 parts of the Chinese bulbul, 60 parts of Sargent gloryvine, 60 parts of Patrinia villosa Juss,
Coix seed（It fries）60 parts, 50 parts of wild chrysanthemum, 50 parts of acalypha copperleaf, 40 parts of hairyvein agrimony, 7 parts of berberine powder；
Or it is：
50 parts of granatum, 50 parts of Ciliatenerve Knotweed Root, 50 parts of shrub althea flower, 40 parts of the Chinese bulbul, 40 parts of Sargent gloryvine, 40 parts of Patrinia villosa Juss,
Coix seed（It fries）40 parts, 30 parts of wild chrysanthemum, 30 parts of acalypha copperleaf, 20 parts of hairyvein agrimony, 3 parts of berberine powder；
Or it is：
60 parts of granatum, 60 parts of Ciliatenerve Knotweed Root, 60 parts of shrub althea flower, 50 parts of the Chinese bulbul, 50 parts of Sargent gloryvine, 50 parts of Patrinia villosa Juss,
Coix seed（It fries）50 parts, 40 parts of wild chrysanthemum, 40 parts of acalypha copperleaf, 30 parts of hairyvein agrimony, 5 parts of berberine powder, the special probiotics 5 of piglet
Part, 5 parts of vitamin B compound；
A further object of the present invention is to provide a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis and gavages medicine, is
It is prepared by following methods：
1）Gavage medicine：By Chinese medicine granatum, Ciliatenerve Knotweed Root, shrub althea flower, the Chinese bulbul, Sargent gloryvine, Patrinia villosa Juss, coix seed
（It fries）, wild chrysanthemum, acalypha copperleaf, hairyvein agrimony crush, be uniformly mixed, water impregnate, decoct, filter out the dregs of a decoction, take filtrate；Again by the coptis
Plain piece pulverization is added in filtrate；
Contained crude drug 0.73-0.77g/ml in the filtrate.
A kind of pharmaceutical composition for treating piglet transmissible gastroenteritis of the present invention, granatum is warm-natured, sour, puckery.Enter large intestine,
Lung, kidney channel.With relieving diarrhea with astringents, hemostasis, expelling parasite work(.Chronic diarrhea is controlled, protracted dysentery is had blood in stool, the illnesss such as rectum abjection.Modern veterinary science
Research has shown that granatum has extraordinary curative effect to chronic bacillary dysentery, amoebic dysentery and multi-infection inflammation, has well
Astriction because it is mostly containing mixing matter, after the contacts such as mucous membrane, the surface of a wound, can precipitate or solidify local protein, make in surface shape
Into comparatively dense protective layer, local woanded surface is contributed to heal or protects part from stimulation.To a variety of pathogens and virus all
There are killing and inhibiting effect.Ciliatenerve Knotweed Root also known as Wilson Begonia Rhizome, cold in nature, acrid flavour is bitter, the thoughts of returning home, lung, Liver Channel.With clearing heat and detoxicating, detumescence
The work(of analgesic.Enteritis, diarrhea abdominal pain, indigestion, abscess of throat etc. are had a better effect.Particularly to bacterium, disease
Virus diarrhea curative effect really has convergence, analgesic effect well.White shrub althea flower nature and flavor sweetness and bitterness, it is cool.Enter spleen, lung, Liver Channel.Tool
There is heat-clearing and damp-drying drug, the work(to remove heat from the blood and relieve diarrhea.The Chinese bulbul is bitter in taste, trembles with fear.Enter large intestine, stomach.With clearing heat and detoxicating, it is removed heat from the blood and relieve diarrhea
Work(.It is mainly used for intestines Huang rush down, is diarrhea purulence blood, tenesmus etc..Modern pharmacological research proves that the Chinese bulbul has convergence to intestinal mucosa
Effect, therefore can antidiarrheal, hemostasis.There is inhibiting effect to Pseudomonas aeruginosa, staphylococcus aureus, hay bacillus, shigella dysenteriae, to control
The key medicine of dysentery.Four medicine phases 5 can enhance clearing heat and detoxicating, the effect of dampness-eliminating and dysentery-stopping, be chiefly used in damp-heat dysentery or diarrhea, collectively constitute
Monarch drug in a prescription in side.Sargent gloryvine also known as sargentodoxa cuneata, bitter are mild-natured.Return large intestine, Liver Channel.Has removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain and other effects.It is main
Control the cards such as acute appendicitis, dysentery.Patrinia villosa Juss is cool in nature, acrid flavour, hardship, pungent energy dissipating bind, cold to expel the heat-evil.There is clearing heat and detoxicating, removing blood stasis and expelling pus
And other effects.For cards such as dysentery, enteritis, hepatitis, postpartum blood stasis abdominal pain.Modern veterinary science research has shown that have preferable disease-resistant
Pathogenic microorganism acts on, and can eliminate local inflammation, improves diseased region microcirculation, promotes the effect of ulcer reparation.Coix seed is micro-
It is cold, it is sweet in flavor, light.Enter spleen, lung, kidney channel.Effect removing damp-heat, invigorating the spleen to arrest diarrhea.The heat of clearing lung-heat gold in this product, it is lower profit stomach and intestine it is wet.
Property slightly sweet flavor, strengthens the spleen and stomach.It fries preferable with splenasthenic diarrhea effect is controlled.Clinically Patrinia villosa Juss is often matched with Sargent gloryvine, the seed of jog's tears etc.
5, there is a promoting diuresis and pus discharge, the efficacy of removing toxicity for detumescence effect, with controlling the cards such as acute appendicitis, diarrhea.Ministerial drug in the side of collectively constituting.Wild chrysanthemum is cool in nature,
Acrid flavour, hardship；Return lung, Liver Channel.With clearing heat and detoxicating；The effect of dispelling wind soothing the liver.It is " broad-spectrum antibiotic " in Chinese herbal medicine, to majority
Fungi, staphylococcus aureus, shigella dysenteriae, Pseudomonas aeruginosa and influenza virus etc. have stronger inhibiting effect.Available for controlling
A variety of diseases such as coronary heart disease, hypertension, gastroenteritis are treated, it can anti-oxidant, raising immunity of organisms.Acalypha copperleaf is cool in nature, bitter, puckery.
With clearing heat and detoxicating, dampness removing, the work(of astringing to arrest bleeding.For enteritis, dysentery, have blood in stool, the cards such as hematuria.Hairyvein agrimony nature and flavor are mild-natured, taste
It is bitter, puckery, return stomach, liver, spleen, lung, large intestine channel.With astringing to arrest bleeding, stop dysentery removing toxic substances.To staphylococcus aureus, Escherichia coli, green
Purulence bacillus, shigella flexneri etc. have inhibiting effect.Halomine is called Berberine hydrochloride, and drug is cool in nature, can remove heresy
Heat or abnormal heat remove harmful poisonous substance, are exactly the good medicine clearing heat and detoxicating simply in traditional Chinese medical science hand since ancient times, have significant antibacterial work
With, there is inhibiting effect to various bacteria such as shigella dysenteriae, tubercle bacillus, pneumococcus, typhoid bacillus and corynebacterium diphtheriae etc.,
In shigella dysenteriae is acted on most strong, clinic is mainly used for treating bacillary dysentery and enterogastritis.In the above-mentioned four medicines side of collectively constituting
Adjuvant.Heat-clearing and damp-drying drug is played altogether by full side, and the work(of relieving diarrhea with astringents has a better effect piglet transmissible gastroenteritis tool.Piglet
Special probiotics is a kind of probiotics, contains a large amount of vegetalitas lactobacillus, Lactobacillus casei, streptococcus fecalis, aspergillus niger, meter Qu
Mould, bacillus subtilis, bacillus cereus, lactobacillus acidophilus, streptococcus lactis, vitamin, somatomedin etc. can maintain
Intestinal eubiosis inhibits harmful bacteria growth, prevents the diarrhea of delactational piglets, improves anti-adversity ability and anti-stress ability.It is made
It is that biology takes oxygen by force with mechanism, promotes the growth and breeding beneficial to anaerobe, maintain intestinal eubiosis, effectively prevention ablactation is young
The diarrhea of pig improves its survival rate, reduces the death rate so that the speed of growth of piglet is accelerated, and enhances immune function, promotes piglet
Intestinal growth enhances the activity of digestive ferment, improves feed intake, improves daily gain, reduces feedstuff-meat ratio.Vitamin B compound is soluble
Powder includes vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, calcium pantothenate, folic acid, vitamin A, vitamin
D3, vitamin E.The polyneuritis caused by illness piglet is lacked due to vitamin B complex can be supplemented, malnutrition, detested
The diseases such as food, gastricism, moreover it is possible to which resisting stress improves immunity, reduces the incidence of disease, enhances premunition, promotes sick body health
It is multiple.
All medicines share is altogether into the agent of heat-clearing and damp-drying drug antidiarrheal.
System side's feature：We with clearing heat and detoxicating, be used in combination by dampness removing and diarrhea-relieving, and with harmonizing the functional activities of vital QI, dispels table heresy, treating both the exterior and interior.
Said medicine is through organic assembling, dialectical compatibility and the effect of mutually assist, enhance party's heat-clearing and damp-drying drug antidiarrheal, from
And achieve the purpose that cure piglet transmissible gastroenteritis.The present invention is by scientific compatibility, by Chinese medicine compound prescription decoction and berberine, son
The drugs such as the special probiotics of pig, vitamin B compound realize organic assembling, can more effectively prevent piglet transmissible gastroenteritis,
Curative effect really is again safe and non-toxic, enhances the immunity of animal, improves raise benefit.Clinical Treatment Test proves that we's treatment is young
The cure rate 93.15% of diarrhea of pigs, effective percentage 98.97%.
Specific embodiment
Embodiment 1
Gavage medicine composition by weight：70 parts of granatum, 70 parts of Ciliatenerve Knotweed Root, 70 parts of shrub althea flower, 60 parts of the Chinese bulbul, 60 parts of Sargent gloryvine,
60 parts of Patrinia villosa Juss, coix seed（It fries）60 parts, 50 parts of wild chrysanthemum, 50 parts of acalypha copperleaf, 40 parts of hairyvein agrimony.By 6 times of total dose
Water is added in, both 3540 parts of water, into 776 parts of liquids after decoction, both every milliliter of liquid was containing about 0.76 gram of crude drug.Face the used time addition coptis
Plain 7 parts of powder so that every milliliter of liquid contains about 0.77 gram of crude drug.
Spice medicine components by weight percent：7 parts of the special probiotic powder of piglet, 7 parts of vitamin B compound soluble powder mix two medicines
Uniformly, it admixes in 986 parts of feeds.
The special probiotics of piglet is the probiotics detached out of piglet enteron aisle, predominantly lactobacillus, existing market top grade
Kind is on the increase again.The special probiotic powder of this piglet is purchased from Su Kehan（Weifang）Bioengineering Co., Ltd
Embodiment 2
Gavage medicine composition by weight：50 parts of granatum, 50 parts of Ciliatenerve Knotweed Root, 50 parts of shrub althea flower, 40 parts of the Chinese bulbul, 40 parts of Sargent gloryvine,
40 parts of Patrinia villosa Juss, coix seed（It fries）40 parts, 30 parts of wild chrysanthemum, 30 parts of acalypha copperleaf, 20 parts of hairyvein agrimony.By 6 times of total dose
Water is added in, both 2340 parts of water, into 542 parts of liquids after decoction, both every milliliter of liquid was containing about 0.72 gram of crude drug.Face the used time addition coptis
Plain 3 parts of powder so that every milliliter of liquid contains about 0.73 gram of crude drug.
Spice medicine components by weight percent：3 parts of the special probiotic powder of piglet, 3 parts of vitamin B compound soluble powder mix two medicines
Uniformly, it admixes in 994 parts of feeds.
Embodiment 3
Gavage medicine composition by weight：60 parts of granatum, 60 parts of Ciliatenerve Knotweed Root, 60 parts of shrub althea flower, 50 parts of the Chinese bulbul, 50 parts of Sargent gloryvine,
50 parts of Patrinia villosa Juss, coix seed（It fries）50 parts, 40 parts of wild chrysanthemum, 40 parts of acalypha copperleaf, 30 parts of hairyvein agrimony.By 6 times of total dose
Water is added in, both 2940 parts of water, into 662 parts of liquids after decoction, both every milliliter of liquid was containing about 0.74 gram of crude drug.Face the used time addition coptis
Plain 5 parts of powder so that every milliliter of liquid contains about 0.75 gram of crude drug.
Spice medicine components by weight percent：5 parts of the special probiotic powder of piglet, 5 parts of vitamin B compound soluble powder mix two medicines
Uniformly, it admixes in 990 parts of feeds.
Embodiment 4
Gavage medicine：Medicine proportioning is gavaged by embodiment 1,2 or 3 to weigh, is put into pot for boiling chinese traditional medicine, by proportional quantity plus water, is decocted
It is first impregnated 40 minutes before boiling；Then heating is boiled, and keeps temperature, is decocted 30 minutes, and slagging-off takes filtrate, then adds in berberine,
Be uniformly mixed is to gavage medicine.
Spice medicine：By embodiment 1,2 or 3 spice medicines proportioning weighs the special probiotic powder of piglet and vitamin B compound is solvable
Property powder, be uniformly mixed both as spice medicine, admix in feed, it is 1000 parts to make its total amount.
Wherein
Embodiment 1 gavages the medicine prepared slices of Chinese crude drugs and adds 3540 parts of water, and concentration filtrate is to 776 parts；
Embodiment 2 gavages the medicine prepared slices of Chinese crude drugs and adds 2340 parts of water, and concentration filtrate is to 542 parts；
Embodiment 3 gavages the medicine prepared slices of Chinese crude drugs and adds 2940 parts of water, and concentration filtrate is to 662 parts；
Experimental example
Instructions of taking：
1st, dose：Medicine will be gavaged made from embodiment 1, embodiment 4, by 4ml/kg body weight doses, be divided into two parts, above and below
Noon respectively gavages once；Medicine will be gavaged made from embodiment 2, embodiment 4, by 2ml/kg body weight doses, be divided into two parts, the upper and lower noon
It respectively gavages primary；Medicine will be gavaged made from embodiment 3, embodiment 4, by 3ml/kg body weight doses, be divided into two parts, the upper and lower noon is each
It gavages primary.It is gavaged in feeding previous hour.
Spice medicine made from embodiment 1, embodiment 2, embodiment 4 being added in feed so that total amount is 1000 parts,
Morning and afternoon respectively feeds once.The special probiotic powder of piglet is purchased from Su Kehan（Weifang）Bioengineering Co., Ltd.
2nd, medication time：One course for the treatment of totally 12 days, wherein preceding 5 day morning and afternoon twice using gavaging medicine, then stopping two days,
Daily morning and afternoon twice using spice medicine, was used in conjunction 5 days since the 8th day.
3rd, medicine temperature control system：40 DEG C or so warmly take.
Avoid item：Feeding management is strengthened to illness piglet during treatment medication, ensures sufficient drinking-water, is fed for softness easily
The feed of digestion.
Criterion of therapeutical effect：The medicine composite for curing piglet transmissible gastroenteritis of piglet transmissible gastroenteritis is treated, curative effect is sentenced
Determine whether Main Basiss piglet transmissible gastroenteritis symptom disappears.It takes medicine 12 days as a treatment course, specific curative effect is divided into three-level：
It cures：Piglet piglet transmissible gastroenteritis symptom all disappears；
It improves：Piglet piglet transmissible gastroenteritis symptom partial disappearance；
In vain：Piglet piglet transmissible gastroenteritis symptom is not improved.
In recent years, we are in the thousands of examples of the single therapeutics grice diarrhoea such as multiple pig farms and veterinary hospital, one treatment for the treatment of
Journey, cure rate 93.15%, effective percentage 98.97%.
Clinical effect trial
1. method:Seven, newborn's porkling transmissible gastroenteritis of swine pig farm is published, selects piglet transmissible gastroenteric occurs altogether
Scorching piglet 1123, age 7-35 age in days.Illness piglet is divided into four groups, respectively of the present invention group, Chinese bulbul side's group, cover it is de-
Stone adds cereobiogen group and control group.
Pharmaceutical composition of the present invention group for the treatment grice diarrhoea as obtained by embodiment 3,4.
Baitouweng decoction used in baitouweng decoction group derives from《The Treatise on Fevrile Diseases》, consisting of 60 parts of the Chinese bulbul, 30 parts of Cortex Phellodendri, Huang
Even 45 parts, 60 parts of the bark of ash, place the drug into decoction pot, add 1170 parts of water, decoct 30 minutes, and slagging-off takes filtrate, gained filtrate
It it is 264 parts, per 0.74 gram of milliliter contained.
The special probiotics of piglet adds vitamin B compound soluble powder group, has both been the spice medicine in of the present invention group, composition
For the special probiotic powder of piglet and each 2.5 parts of vitamin B compound soluble powder, add in 995 feeds.
Control group does not have to any drug therapy.
Treatment time is as a treatment course, i.e., 12 days, and preceding use in 5 days gavages medicine, and upper and lower noon each medication is primary daily, dosage
By 3ml/kg weight.It is discontinued within 6th, 7 day, begins to use spice medicine within the 8th day, be used in conjunction 5 days.
1 affected animal of table is grouped and primary treatments
2. efficacy determination:
Criterion of therapeutical effect：The medicine composite for curing piglet transmissible gastroenteritis of piglet transmissible gastroenteritis is treated, curative effect is sentenced
Determine whether Main Basiss piglet transmissible gastroenteritis symptom disappears.It takes medicine 12 days as a treatment course, specific curative effect is divided into three-level：
It cures：Piglet piglet transmissible gastroenteritis symptom all disappears；
It improves：Piglet piglet transmissible gastroenteritis symptom partial disappearance；
In vain：Piglet piglet transmissible gastroenteritis symptom is not improved.
3. result：1123 illness piglets are by different dosage regimens, and after the treatment by a course for the treatment of, each group is controlled
Therapeutic effect is shown in Table 2.
2 various therapeutic scheme therapeutic effects of table
From table 2, three groups of drugs have grice diarrhoea different therapeutic effects, wherein organizing treatment effect with the present invention
Fruit is best, and for cure rate up to 93.15%, total effective rate 98.97%, pole is significantly higher than other two groups of (P< 0. 01);The Chinese bulbul
Soup group is taken second place, and piglet special bacterium adds compound VB groups again, and control group does not have therapeutic effect.Statistical result shows, each group
Between difference extremely significantly (P< 0. 01) .
It was verified that drug of the present invention is through organic assembling, dialectical compatibility and mutually assist, it is clearing heat and detoxicating to enhance the party,
The effect of dampness removing and diarrhea-relieving, has a better effect piglet piglet transmissible gastroenteritis tool, so as to achieve the purpose that healing.Using
A kind of preparation method for the pharmaceutical composition for treating piglet piglet transmissible gastroenteritis of present invention treatment piglet piglet obtained passes
The pharmaceutical composition of metachromia gastroenteritis has at low cost, preparation easily, has no toxic side effect and significant in efficacy.It should for clinical treatment
Disease provides a kind of practicable new drug.Clinical practice proves, the cure rate 93.15% of the medicine, effective percentage 98.97%.
It is above-mentioned with reference to embodiment to pharmaceutical composition of the treatment piglet piglet transmissible gastroenteritis and preparation method thereof into
Capable detailed description is illustrative rather than limited, can enumerate several embodiments according to limited range, therefore
Change and modification in the case where not departing from present general inventive concept should belong within protection scope of the present invention.
Claims (6)
1. a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis, it is formed by gavaging medicine and spice medicine, and described gavages
The components by weight percent of medicine bulk pharmaceutical chemicals is：50-70 parts of granatum, 50-70 parts of Ciliatenerve Knotweed Root, 50-70 parts of shrub althea flower, 40-60 parts of the Chinese bulbul,
40-60 parts of Sargent gloryvine, 40-60 parts of Patrinia villosa Juss fry 40-60 parts of coix seed, 30-50 parts of wild chrysanthemum, 30-50 parts of acalypha copperleaf, celestial being
20-40 parts of crane grass, 3-7 parts of berberine powder；
The spice medicine composition by weight is piglet is probiotics 3-7 parts special, 3-7 parts of vitamin B compound soluble powder.
2. a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis according to claim 1, which is characterized in that described
The medicine components by weight percent that gavages be：70 parts of granatum, 70 parts of Ciliatenerve Knotweed Root, 70 parts of shrub althea flower, 60 parts of the Chinese bulbul, 60 parts of Sargent gloryvine, white flower
60 parts of field pennycress fries 60 parts of coix seed, 50 parts of wild chrysanthemum, 50 parts of acalypha copperleaf, 40 parts of hairyvein agrimony, 7 parts of berberine powder;Described
Spice medicine composition by weight is 7 parts of the special probiotics of piglet, 7 parts of vitamin B compound soluble powder.
3. a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis according to claim 1, which is characterized in that described
The medicine components by weight percent that gavages be：50 parts of granatum, 50 parts of Ciliatenerve Knotweed Root, 50 parts of shrub althea flower, 40 parts of the Chinese bulbul, 40 parts of Sargent gloryvine, white flower
40 parts of field pennycress fries 40 parts of coix seed, 30 parts of wild chrysanthemum, 30 parts of acalypha copperleaf, 20 parts of hairyvein agrimony, 3 parts of berberine powder;Described
Spice medicine composition by weight is 3 parts of the special probiotics of piglet, 3 parts of vitamin B compound soluble powder.
4. a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis according to claim 1, which is characterized in that described
The medicine components by weight percent that gavages be：60 parts of granatum, 60 parts of Ciliatenerve Knotweed Root, 60 parts of shrub althea flower, 50 parts of the Chinese bulbul, 50 parts of Sargent gloryvine, white flower
50 parts of field pennycress fries 50 parts of coix seed, 40 parts of wild chrysanthemum, 40 parts of acalypha copperleaf, 30 parts of hairyvein agrimony, 5 parts of berberine powder;Described
Spice medicine composition by weight is 5 parts of the special probiotics of piglet, 5 parts of vitamin B compound soluble powder.
5. according to a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis in claim 1,2,3 or 4, which is characterized in that institute
The medicine that gavages stated is prepared by following methods：
By Chinese medicine granatum, Ciliatenerve Knotweed Root, shrub althea flower, the Chinese bulbul, Sargent gloryvine, Patrinia villosa Juss, fry coix seed, wild chrysanthemum, acalypha copperleaf,
The proportioning of hairyvein agrimony crushes, and is uniformly mixed, and water impregnates, and decocts, filters out the dregs of a decoction, takes filtrate, then berberine powder is added in filtrate
In, the berberine powder is the smalls that berberine tablet is ground into.
6. a kind of pharmaceutical composition for treating piglet transmissible gastroenteritis according to claim 5, it is characterised in that：It is described
Middle drug filtrate in contained crude drug 0.73-0.77g/ml.
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| CN201410813334.0A CN104547735B (en) | 2014-12-24 | 2014-12-24 | A kind of pharmaceutical composition for treating piglet transmissible gastroenteritis and preparation method thereof |
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| CN104547735B true CN104547735B (en) | 2018-06-08 |
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| CN1435220A (en) * | 2002-11-26 | 2003-08-13 | 贵州神奇制药有限公司 | Medicine for treating intestinal diseases |
| CN102698123A (en) * | 2012-01-05 | 2012-10-03 | 刘霞 | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof |
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| CN1435220A (en) * | 2002-11-26 | 2003-08-13 | 贵州神奇制药有限公司 | Medicine for treating intestinal diseases |
| CN102698123A (en) * | 2012-01-05 | 2012-10-03 | 刘霞 | Traditional Chinese medicinal composition for treating transmissible gastroenteritis of swine, feed, preparation method and application thereof |
Non-Patent Citations (2)
| Title |
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| 中西药结合治疗仔猪传染性胃肠炎;焦耀祥;《河南畜牧兽医》;20061231;第27卷(第12期);第52页 * |
| 白头翁汤加减治疗家禽肠胃炎;宋永清;《中国兽医杂志》;20081231;第44卷(第3期);第83-84页 * |
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