CN101468025A - Soluble powder for preventing and treating colibacillosis of fowl - Google Patents
Soluble powder for preventing and treating colibacillosis of fowl Download PDFInfo
- Publication number
- CN101468025A CN101468025A CNA2007100602294A CN200710060229A CN101468025A CN 101468025 A CN101468025 A CN 101468025A CN A2007100602294 A CNA2007100602294 A CN A2007100602294A CN 200710060229 A CN200710060229 A CN 200710060229A CN 101468025 A CN101468025 A CN 101468025A
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- Prior art keywords
- trimethoprim
- soluble powder
- colibacillosis
- prinzone
- squibb
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Abstract
The invention relates to soluble powder for preventing and treating colibacillosis of poultry, comprising sulfachlorpyridazine sodium, trimethoprim and auxiliary materials. The inventive medicament is mainly used to prevent and treat colibacillosis of poultry. The sulfachlorpyridazine sodium and trimethoprim have compatibility when used together. The trimethoprim is used as an antisepsis synergist of sulfonamides when resisting bacteria, thus strengthening medicament effect of sulfachlorpyridazine sodium. The sulfachlorpyridazine sodium and trimethoprim cooperate to effectively treat colibacillosis. The soluble powder has good absorption and relatively high safety when orally taken.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of soluble powder that is used to prevent and treat avian colibacillosis.
Background technology
Along with the continuous development of modern farming, the approach that poultry catch also becomes increasingly complex.The most common with the microbial various infectious disease of sensitivity, the current main medicine that is used for the treatment of such disease is an antibiotics, owing to use the shortage of user's relevant knowledge, the phenomenon of antibacterials abuse is of common occurrence, and drug resistance is ubiquity then.Because current fowl bacterial disease mostly is various bacteria mixed infection or secondary infection, a kind of antibiotic therapy of single use can not reach ideal therapeutic effect, simultaneously also make a lot of antibacterials become multi-drug resistant easily, meat product has also been caused a large amount of drug residues from single drug resistance.
Summary of the invention
Based on above-mentioned situation, the object of the present invention is to provide a kind of soluble powder that is used to prevent and treat avian colibacillosis
The object of the present invention is achieved like this: represent to be respectively Prinzone (Squibb) 9%-11% with percentage by weight, trimethoprim 1%-3%, adjuvant 86%-90%.
Described adjuvant comprises: anhydrous glucose, oral glucose etc. are preferably anhydrous glucose.
In order to obtain better effect, preferred ingredient is: Prinzone (Squibb) 10%, trimethoprim 2%, adjuvant 88%.
The present invention can adopt the general process of industry, equipment preparation.The following method preparation of preferred employing comprises step:
Earlier Prinzone (Squibb), trimethoprim are pulverized with used adjuvant, pulverized back mistake 60 mesh sieves; The adjuvant of getting Prinzone (Squibb), trimethoprim and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly.
Prinzone (Squibb): antimicrobial spectrum is similar to sulfamonomethoxine, and most of gram positive bacterias and negative bacterium are all had stronger inhibitory action, and it is slower that antibacterial produces drug resistance to this medicine.Post-absorption for oral administration is good, the blood level height, and the acetylation rate is low, is difficult for taking place crystalluria.
Trimethoprim: antimicrobial spectrum is similar and active to sulfa drugs stronger.Multiple gram positive bacteria and negative bacterium all there is antibacterial action.This drug mechanism is to suppress dihydrofolate reductase, makes dihydrofoilic acid can not be reduced into tetrahydrofolic acid, thereby hinders sensitive organism folic acid metabolism and utilization, thereby hinders thalline nucleic acid synthetic.When this medicine share with sulfonamides, can block folic acid metabolism simultaneously and the double blocking effect, make antibacterial action strengthen several times, even make bacteriostasis become bactericidal action, and can reduce the generation of Resistant strain to nearly a hundred times from two different links.
Medicine of the present invention is mainly used in the prevention and the treatment of poultry colibacillosis.
In order to verify the therapeutic effect of medicine of the present invention, get medicine of the present invention and do the clinical efficacy test at Jinghai county chicken house.Get the chicken that suffers from colibacillosis, use medicine of the present invention to treat, 20 milligrams of per 1 kg body weight daily doses, logotype 5 days was a course of treatment.Most ofly after the course of treatment suffer from chicken and cured, clinical symptom disappearance or effectively alleviated, effective percentage all reaches more than 95%.
Beneficial effect: by clinical trial as can be seen, medicine of the present invention curative effect aspect the treatment poultry colibacillosis is certain, is suitable for applying in herding is produced.The present invention fills a prescription and adopts trimethoprim and two kinds of compatibility of drugss of Prinzone (Squibb) to use, at the Trimethoprim of antimicrobial while trimethoprim as sulfa drugs, can strengthen the drug effect of Prinzone (Squibb), the two can produce synergism, effectively reach the purpose of treatment colibacillosis, oral absorption is good, is difficult for producing drug resistance, has higher safety.
The specific embodiment
Embodiment 1: earlier Prinzone (Squibb) 90g, trimethoprim 10g and used adjuvant anhydrous glucose 900g are pulverized, pulverize back mistake 60 mesh sieves; The adjuvant of getting Prinzone (Squibb), trimethoprim and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly get the about 1000g of soluble powder, wherein contain Prinzone (Squibb) 90g, trimethoprim 10g.
Sulfonamides.Be mainly used in the prevention and the treatment of poultry colibacillosis.Usage and dosage: 24 milligrams of per 1 kg body weight daily doses, logotype 3-6 days is a course of treatment.
Embodiment 2: earlier Prinzone (Squibb) 100g, trimethoprim 20g and used adjuvant anhydrous glucose 880g are pulverized, pulverize back mistake 60 mesh sieves; The adjuvant of getting Prinzone (Squibb), trimethoprim and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly get the about 1000g of soluble powder, wherein contain Prinzone (Squibb) 100g, trimethoprim 20g.
Sulfonamides.Be mainly used in the prevention and the treatment of poultry colibacillosis.Usage and dosage: 20 milligrams of per 1 kg body weight daily doses, logotype 3-6 days is a course of treatment.
Embodiment 3: earlier Prinzone (Squibb) 110g, trimethoprim 30g and used adjuvant anhydrous glucose 860g are pulverized, pulverize back mistake 60 mesh sieves; The adjuvant of getting Prinzone (Squibb), trimethoprim and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly get the about 1000g of soluble powder, wherein contain Prinzone (Squibb) 110g, trimethoprim 30g.
Sulfonamides.Be mainly used in the prevention and the treatment of poultry colibacillosis.Usage and dosage: 14 milligrams of per 1 kg body weight daily doses, logotype 3-6 days is a course of treatment.
Claims (3)
1, a kind of soluble powder that is used to prevent and treat avian colibacillosis is characterized in that the medicine that medicine of the present invention comprises is: Prinzone (Squibb), trimethoprim, adjuvant.
2, a kind of soluble powder that is used to prevent and treat avian colibacillosis according to claim 1, it is characterized in that: represent to be respectively Prinzone (Squibb) 9%-11% with percentage by weight, trimethoprim 1%-3%, adjuvant 86%-90%, described adjuvant comprises: anhydrous glucose, oral glucose etc. are preferably anhydrous glucose.
3, a kind of soluble powder that is used to prevent and treat avian colibacillosis according to claim 1, it is characterized in that: preferred ingredient is: Prinzone (Squibb) 10%, trimethoprim 2%, adjuvant 88%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100602294A CN101468025A (en) | 2007-12-26 | 2007-12-26 | Soluble powder for preventing and treating colibacillosis of fowl |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100602294A CN101468025A (en) | 2007-12-26 | 2007-12-26 | Soluble powder for preventing and treating colibacillosis of fowl |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101468025A true CN101468025A (en) | 2009-07-01 |
Family
ID=40825987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100602294A Pending CN101468025A (en) | 2007-12-26 | 2007-12-26 | Soluble powder for preventing and treating colibacillosis of fowl |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101468025A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105903019A (en) * | 2016-05-17 | 2016-08-31 | 湖南泰谷生物兽药有限公司 | Compound sulfanilamide soluble powder and preparation method thereof |
| CN108578417A (en) * | 2018-01-03 | 2018-09-28 | 浙江万方生物科技有限公司 | A kind of compound sulfonamide chlorine pyridazine sodium dry suspensoid agent and preparation method thereof |
| CN109498577A (en) * | 2018-12-24 | 2019-03-22 | 宜昌三峡制药有限公司 | Ease of solubility Compound Sulfachorpyrdazine Sodium Powder |
| CN112137962A (en) * | 2020-10-27 | 2020-12-29 | 湖北龙翔药业科技股份有限公司 | Compound sulfachlorpyridazine sodium powder and preparation method thereof |
-
2007
- 2007-12-26 CN CNA2007100602294A patent/CN101468025A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105903019A (en) * | 2016-05-17 | 2016-08-31 | 湖南泰谷生物兽药有限公司 | Compound sulfanilamide soluble powder and preparation method thereof |
| CN108578417A (en) * | 2018-01-03 | 2018-09-28 | 浙江万方生物科技有限公司 | A kind of compound sulfonamide chlorine pyridazine sodium dry suspensoid agent and preparation method thereof |
| CN108578417B (en) * | 2018-01-03 | 2020-05-15 | 浙江万方生物科技有限公司 | Compound sulfachlorpyridazine sodium dry suspension and preparation method thereof |
| CN109498577A (en) * | 2018-12-24 | 2019-03-22 | 宜昌三峡制药有限公司 | Ease of solubility Compound Sulfachorpyrdazine Sodium Powder |
| CN112137962A (en) * | 2020-10-27 | 2020-12-29 | 湖北龙翔药业科技股份有限公司 | Compound sulfachlorpyridazine sodium powder and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090701 |