CN101879171A - Oral liquid preventing and curing gallinaceous leucocyto zoonosis and preparation method thereof - Google Patents
Oral liquid preventing and curing gallinaceous leucocyto zoonosis and preparation method thereof Download PDFInfo
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- CN101879171A CN101879171A CN2009100687728A CN200910068772A CN101879171A CN 101879171 A CN101879171 A CN 101879171A CN 2009100687728 A CN2009100687728 A CN 2009100687728A CN 200910068772 A CN200910068772 A CN 200910068772A CN 101879171 A CN101879171 A CN 101879171A
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Abstract
The invention provides an oral liquid preventing and curing gallinaceous leucocyto zoonosis and a preparation method thereof. The oral liquid comprises sulfadiazine, TMP, aluminum stearate, alcohol, sodium carboxymethyl cellulose, and Tween -80. The concrete preparation method comprises the following steps that: (1) the aluminum stearate is porphyrized, to which the alcohol is added, (2) the sulfadiazine and the TMP are added to the solution of the step (1), (3) distilled water is taken and stirred evenly, (4) the Tween -80 is added and stirred evenly, (5) the sodium carboxymethyl cellulose is taken and is mixed into paste with the distilled water and the paste is added to the solution of the step (4) to be mixed well, and (6) anhydrous sodium sulfate is added and dissolved, the distilled water is added and stirred evenly, the pH value is adjusted to 9.5 to 11.5 with 0.5 percent of sodium hydroxide water solution and the product is obtained. The oral liquid adopts the suspension technology. The slightly soluble sulfadiazine and TMP are made into suspension liquid. The procedure of stirring feed is left out. The use is convenient and the efficacy is obvious.
Description
Technical field
The present invention relates to a kind of oral liquid and preparation method thereof, especially a kind of control chicken whitecomb oral liquid and preparation method thereof.
Background technology
Chicken whitecomb claims chicken Ka Shi to live the leukocyte parasitosis again, be to live a kind of cytozoicus protozoacide that coccidium syphilidis causes by Ka Shi, the erythrocyte that this protozoon can be destroyed in the blood causes bleeding, and cause the chicken anemia to cause the laying hen anemia, laying rate sharply descends, dealer's heavy losses cause raising chickens, especially at overcast and rainy moist southern area, this disease sickness rate height, its sickness rate accounts for more than 70% of total incidence, and the active drug of preventing and treating this disease is a sulfa drugs, commonly used have a Xin Nuomin, sulfamonomethoxine sodium, the new promise people are because of spice working costs effort, be extensive use of and be subjected to certain limitation, sulfamonomethoxine sodium then persister is extensive, is easy to generate drug resistance, therefore seeks a kind of easy to use, evident in efficacy, the product of with strong points and cheap chicken whitecomb is significant for southern area.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of control chicken whitecomb oral liquid, described oral liquid prescription advantages of simple, can effectively prevent and treat chicken whitecomb.
Another technical problem to be solved by this invention is to provide the preparation method of above-mentioned control chicken whitecomb oral liquid.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by its parts by weight sulfadiazine 1-40 part, trimethoprim 1-10 part, aluminium stearate 1-10 part, ethanol 15-30 part, sodium carboxymethyl cellulose 0.1-1 part, tween 80 1-5 part.
Preferably, above-mentioned control chicken whitecomb oral liquid is by its parts by weight sulfadiazine 1-30 part, trimethoprim 1-6 part, aluminium stearate 1-4 part, ethanol 15-30 part, sodium carboxymethyl cellulose 0.1-0.5 part, tween 80 1-4 part.
Preferably, above-mentioned control chicken whitecomb oral liquid is by 40 parts of its parts by weight sulfadiazines, 10 parts of trimethoprims, 10 parts of aluminium stearate, 30 parts of ethanol, 1 part of sodium carboxymethyl cellulose, 5 parts of tween 80s.
Preferably, above-mentioned control chicken whitecomb oral liquid is by 20 parts of its parts by weight sulfadiazines, 4 parts of trimethoprims, 4 parts of aluminium stearate, 20 parts of ethanol, 0.3 part of sodium carboxymethyl cellulose, 3 parts of tween 80s.
Preferably, above-mentioned control chicken whitecomb oral liquid is by 20 parts of its parts by weight sulfadiazines, 5 parts of trimethoprims, 2 parts of aluminium stearate, 20 parts of ethanol, 0.2 part of sodium carboxymethyl cellulose, 3 parts of tween 80s.
Preferably, above-mentioned control chicken whitecomb oral liquid is by its parts by weight sulfadiazine 10-30 part, trimethoprim 2-5 part, aluminium stearate 3-4 part, 25 parts of ethanol, sodium carboxymethyl cellulose 0.3-0.6 part, tween 80 3-4 part.
Above-mentioned control chicken whitecomb oral liquid is white or faint yellow suspension.
Above-mentioned control chicken whitecomb oral liquid, relative density is 1.18-1.22, described relative density is meant the proportion of this solution.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) gets the aluminium stearate porphyrize by above-mentioned parts by weight, cross 200 mesh sieves, add ethanol, stir while adding evenly;
(2) get in sulfadiazine and trimethoprim adding step (1) solution by above-mentioned parts by weight;
(3) adding distilled water stirs; Make it be uniform pasty state;
(4) adding tween 80 by above-mentioned parts by weight stirs;
(5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight and be deployed into pasty state, add in step (4) solution, fully stirred 5-10 minute with distilled water;
(6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by above-mentioned parts by weight 4-30 part stirs is between the 9.5-11.5 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product.
The consumption of above-mentioned control chicken whitecomb oral liquid is a chicken 0.3ml-0.5ml.
The invention has the beneficial effects as follows:
1, above-mentioned control chicken whitecomb oral liquid adopts suspendible technology, and insoluble drug sulfadiazine and trimethoprim are made suspension, saves the program that spice uses;
2, use anhydrous sodium sulfate to increase stability of drug, effectively improve bioavailability and reduce drug dose, make blood drug level steady, thereby improve curative effect, improved the convenience that insoluble medicine uses greatly, be widely used as antioxidant.
3, sulfadiazine is for oral administration absorbs easily, strengthens greatly with trimethoprim coupling antibacterial activity, gives full play to the protozoacide advantage of medicine, is not easy to produce drug resistance.
The specific embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is further described.
Embodiment 1
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by 20 parts of its parts by weight sulfadiazines, 5 parts of trimethoprims, 2 parts of aluminium stearate, 20 parts of ethanol, 0.2 part of sodium carboxymethyl cellulose, 3 parts of tween 80s.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) gets the aluminium stearate porphyrize by above-mentioned parts by weight, and cross 200 mesh sieves, add ethanol, stir while adding evenly; (2) get in sulfadiazine, trimethoprim adding step (1) solution by above-mentioned parts by weight; (3) add distilled water and stir, make it be uniform pasty state; (4) adding tween 80 by above-mentioned parts by weight stirs; (5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight, be deployed into pasty state, add in step (4) solution, fully stirred 5 minutes with distilled water; (6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by 20 parts of above-mentioned parts by weight stirs is 10.2 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product, and relative density is 1.20.
Embodiment 2
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by 30 parts of its parts by weight sulfadiazines, 6 parts of trimethoprims, 4 parts of aluminium stearate, 30 parts of ethanol, 0.5 part of sodium carboxymethyl cellulose, 4 parts of tween 80s.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) gets the aluminium stearate porphyrize by above-mentioned parts by weight, and cross 200 mesh sieves, add ethanol, stir while adding evenly; (2) get in sulfadiazine, trimethoprim adding step (1) solution by above-mentioned parts by weight; (3) add distilled water and stir, make it be uniform pasty state; (4) adding tween 80 by above-mentioned parts by weight stirs; (5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight, be deployed into pasty state, add in step (4) solution, fully stirred 8 minutes with distilled water; (6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by 15 parts of above-mentioned parts by weight stirs is 9.5 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product, and relative density is 1.21.
Embodiment 3
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by 10 parts of its parts by weight sulfadiazines, 2 parts of trimethoprims, 3 parts of aluminium stearate, 25 parts of ethanol, 0.3 part of sodium carboxymethyl cellulose, 3 parts of tween 80s.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) get aluminium stearate by above-mentioned parts by weight, porphyrize, and cross 200 mesh sieves, add ethanol and stir while adding evenly; (2) get in sulfadiazine, trimethoprim adding step (1) solution by above-mentioned parts by weight; (3) add distilled water and stir, make it be uniform pasty state; (4) adding tween 80 by above-mentioned parts by weight stirs; (5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight, be deployed into pasty state, add in step (4) solution, fully stirred 6 minutes with distilled water; (6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by 20 parts of above-mentioned parts by weight stirs is 10.4 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product, and relative density is 1.19.
Embodiment 4
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by 1 part of its parts by weight sulfadiazine, 1 part of trimethoprim, 1 part of aluminium stearate, 15 parts of ethanol, 0.1 part of sodium carboxymethyl cellulose, 1 part of tween 80.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) get aluminium stearate by above-mentioned parts by weight, porphyrize, and cross 200 mesh sieves, add ethanol and stir while adding evenly; (2) get in sulfadiazine, trimethoprim adding step (1) solution by above-mentioned parts by weight; (3) add distilled water and stir, make it be uniform pasty state; (4) adding tween 80 by above-mentioned parts by weight stirs; (5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight, be deployed into pasty state, add in step (4) solution, fully stirred 6 minutes with distilled water; (6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by 4 parts of above-mentioned parts by weight stirs is 9.7 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product, and relative density is 1.18.
Embodiment 5
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by 30 parts of its parts by weight sulfadiazines, 5 parts of trimethoprims, 4 parts of aluminium stearate, 25 parts of ethanol, 0.6 part of sodium carboxymethyl cellulose, 5 parts of tween 80s.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) get aluminium stearate by above-mentioned parts by weight, porphyrize, and cross 200 mesh sieves, add ethanol and stir while adding evenly; (2) get in sulfadiazine, trimethoprim adding step (1) solution by above-mentioned parts by weight; (3) add distilled water and stir, make it be uniform pasty state; (4) adding tween 80 by above-mentioned parts by weight stirs; (5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight, be deployed into pasty state, add in step (4) solution, fully stirred 8 minutes with distilled water; (6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by 30 parts of above-mentioned parts by weight stirs is 10.2 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product, and relative density is 1.22.
Embodiment 6
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by 40 parts of its parts by weight sulfadiazines, 10 parts of trimethoprims, 10 parts of aluminium stearate, 30 parts of ethanol, 1 part of sodium carboxymethyl cellulose, 5 parts of tween 80s.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) get aluminium stearate by above-mentioned parts by weight, porphyrize, and cross 200 mesh sieves, add ethanol and stir while adding evenly; (2) get in sulfadiazine, trimethoprim adding step (1) solution by above-mentioned parts by weight; (3) add distilled water and stir, make it be uniform pasty state; (4) adding tween 80 by above-mentioned parts by weight stirs; (5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight, be deployed into pasty state, add in step (4) solution, fully stirred 10 minutes with distilled water; (6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by 30 parts of above-mentioned parts by weight stirs is 11.5 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product, and relative density is 1.22.
Embodiment 7
A kind of control chicken whitecomb oral liquid, comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by 20 parts of its parts by weight sulfadiazines, 4 parts of trimethoprims, 4 parts of aluminium stearate, 20 parts of ethanol, 0.3 part of sodium carboxymethyl cellulose, 3 parts of tween 80s.
The preparation method of above-mentioned control chicken whitecomb oral liquid, concrete preparation process is as follows:
(1) get aluminium stearate by above-mentioned parts by weight, porphyrize, and cross 200 mesh sieves, add ethanol and stir while adding evenly; (2) get in sulfadiazine, trimethoprim adding step (1) solution by above-mentioned parts by weight; (3) add distilled water and stir, make it be uniform pasty state; (4) adding tween 80 by above-mentioned parts by weight stirs; (5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight, be deployed into pasty state, add in step (4) solution, fully stirred 7 minutes with distilled water; (6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by 26 parts of above-mentioned parts by weight stirs is 10.5 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product, and relative density is 1.20.
Sulfadiazine belongs to broad-spectrum antibacterial agent, it is the drug of first choice that is used for the treatment of the brain bacterial infection in the sulfa drugs, principal indication has mastitis, infectious coryza of chicken, Ka Shi leucocyte protozoon disease, toxoplasmosis, pig streptococcicosis etc., be applicable to the systemic infection due to the various animal sensitive organisms, absorption easily for oral administration, strengthen greatly with trimethoprim coupling antibacterial activity, be not easy to produce drug resistance.
Clinical trial:
Mianyang City Deyang, Sichuan Province one raiser, the blue brown kind in laying hen sea, 270 ages in days, laying rate descends, and cockscomb turns white, and cuts open inspection and is diagnosed as chicken whitecomb, and the sick chicken of 300 symptoms of picked at random divides into groups according to following table, uses this inventive embodiment 7 to treat:
To experimental group continuous use 3 days, not administration of matched group, contrast after finish a course of treatment.
The clinical experiment efficacy result sees the following form:
Experimental result and analysis:
Cure rate: after the medication, the clinical symptoms complete obiteration; Search for food, drink water and physical signs such as spirit recovers normal for curing fully, curing number, to account for the total percentage ratio of this group test be cure rate.
Inefficiency: clinical symptoms do not see and alleviates, even occurs worsening or death is invalid, respectively organizes inefficiency according to invalid computation.
Untoward reaction: press 0.5ml/kg and mix drink, test chicken is not observed any untoward reaction.
Oral liquid of the present invention is pressed high dose (0.5ml/ only), middle dosage (0.3ml/ only), three mixed drink treatments of dosage of low dosage (0.2ml/ only), organize, fall ill not medication (positive control) group in contrast with sulfamonomethoxine sodium soluble powder (medicine contrast).The result shows: high, medium and low dosage group of oral liquid of the present invention and sulfamonomethoxine sodium soluble powder group infect chicken whitecomb all higher curative effect, the effect of wherein high, middle dosage group and sulfamonomethoxine sodium soluble powder is best, but three's difference not significantly (P＞0.05); Each group of the present invention is significantly higher than the not medication group of falling ill (P＜0.01) with the relative weight gain rate of sulfamonomethoxine sodium soluble powder group.Studies show that disease obviously alleviates and recovers fast after height of the present invention, the medication of middle dosage group chicken.
This result of the test shows that control chicken whitecomb oral liquid of the present invention is used for the effect that chicken whitecomb infects highly significant, and antibacterial activity is strong, and is not easy to produce drug resistance.
Above-mentionedly this is is a kind ofly prevented and treated the detailed description that chicken whitecomb oral liquid and preparation method thereof carries out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (9)
1. prevent and treat the chicken whitecomb oral liquid for one kind, it is characterized in that: comprise sulfadiazine, trimethoprim, aluminium stearate, ethanol, sodium carboxymethyl cellulose and tween 80, by its parts by weight sulfadiazine 1-40 part, trimethoprim 1-10 part, aluminium stearate 1-10 part, ethanol 15-30 part, sodium carboxymethyl cellulose 0.1-1 part, tween 80 1-5 part.
2. a kind of control chicken whitecomb oral liquid according to claim 1 is characterized in that: by its parts by weight sulfadiazine 1-30 part, trimethoprim 1-6 part, aluminium stearate 1-4 part, ethanol 15-30 part, sodium carboxymethyl cellulose 0.1-0.5 part, tween 80 1-4 part.
3. a kind of control chicken whitecomb oral liquid according to claim 1 is characterized in that: by 40 parts of its parts by weight sulfadiazines, 10 parts of trimethoprims, 10 parts of aluminium stearate, 30 parts of ethanol, 1 part of sodium carboxymethyl cellulose, 5 parts of tween 80s.
4. a kind of control chicken whitecomb oral liquid according to claim 1 is characterized in that: by 20 parts of its parts by weight sulfadiazines, 4 parts of trimethoprims, 4 parts of aluminium stearate, 20 parts of ethanol, 0.3 part of sodium carboxymethyl cellulose, 3 parts of tween 80s.
5. a kind of control chicken whitecomb oral liquid according to claim 1 is characterized in that: by 20 parts of its parts by weight sulfadiazines, 5 parts of trimethoprims, 2 parts of aluminium stearate, 20 parts of ethanol, 0.2 part of sodium carboxymethyl cellulose, 3 parts of tween 80s.
6. a kind of control chicken whitecomb oral liquid according to claim 1 is characterized in that: by its parts by weight sulfadiazine 10-30 part, trimethoprim 2-5 part, aluminium stearate 3-4 part, 25 parts of ethanol, sodium carboxymethyl cellulose 0.3-0.6 part, tween 80 3-4 part.
7. according to the described a kind of control chicken whitecomb oral liquid of one of claim 1-6, it is characterized in that: be white or faint yellow suspension.
8. according to the described a kind of control chicken whitecomb oral liquid of one of claim 1-6, it is characterized in that: relative density is 1.18-1.22.
9. the described a kind of preparation method of preventing and treating the chicken whitecomb oral liquid of one of claim 1-8 is characterized in that: concrete preparation process is as follows:
(1) gets the aluminium stearate porphyrize by above-mentioned parts by weight, cross 200 mesh sieves, add ethanol, stir while adding evenly;
(2) get in sulfadiazine and trimethoprim adding step (1) solution by above-mentioned parts by weight;
(3) add distilled water and stir, make it be even pasty state;
(4) adding tween 80 by above-mentioned parts by weight stirs;
(5) get sodium carboxymethyl cellulose in addition by above-mentioned parts by weight and be deployed into pasty state, add in step (4) solution, fully stirred 5-10 minute with distilled water;
(6) add anhydrous sodium sulfate by 0.3 part of above-mentioned parts by weight, dissolving, and the distilled water that adds by above-mentioned parts by weight 4-30 part stirs is between the 9.5-11.5 with 0.5% sodium hydrate aqueous solution adjusting pH value at last, promptly gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100687728A CN101879171A (en) | 2009-05-08 | 2009-05-08 | Oral liquid preventing and curing gallinaceous leucocyto zoonosis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100687728A CN101879171A (en) | 2009-05-08 | 2009-05-08 | Oral liquid preventing and curing gallinaceous leucocyto zoonosis and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2500062A (en) * | 2012-03-09 | 2013-09-11 | B C B Internat Ltd | Alcohol composition for use as solid fuel or sanitising agent |
| CN104800229A (en) * | 2015-03-23 | 2015-07-29 | 四川成康动物药业有限公司 | Compound sulfadiazine suspension and preparation method thereof |
| US10273424B2 (en) | 2012-03-09 | 2019-04-30 | B.C.B. International Limited | Alcohol-containing compositions useful as solid fuels and processes for their manufacture |
-
2009
- 2009-05-08 CN CN2009100687728A patent/CN101879171A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2500062A (en) * | 2012-03-09 | 2013-09-11 | B C B Internat Ltd | Alcohol composition for use as solid fuel or sanitising agent |
| GB2500062B (en) * | 2012-03-09 | 2014-01-22 | B C B Internat Ltd | Alcohol-containing compositions |
| US10273424B2 (en) | 2012-03-09 | 2019-04-30 | B.C.B. International Limited | Alcohol-containing compositions useful as solid fuels and processes for their manufacture |
| EP2822607B1 (en) * | 2012-03-09 | 2023-06-07 | B.C.B. International Limited | Alcohol-containing compositions useful as solid fuels and processes for their manufacture |
| CN104800229A (en) * | 2015-03-23 | 2015-07-29 | 四川成康动物药业有限公司 | Compound sulfadiazine suspension and preparation method thereof |
| CN104800229B (en) * | 2015-03-23 | 2017-11-03 | 四川成康动物药业有限公司 | A kind of compound sulfadiazine suspension and preparation method thereof |
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Application publication date: 20101110 |