CN104208089B - Gastric floating preparation for treating poultry proventriculitis and preparation method thereof - Google Patents
Gastric floating preparation for treating poultry proventriculitis and preparation method thereof Download PDFInfo
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- CN104208089B CN104208089B CN201410450429.0A CN201410450429A CN104208089B CN 104208089 B CN104208089 B CN 104208089B CN 201410450429 A CN201410450429 A CN 201410450429A CN 104208089 B CN104208089 B CN 104208089B
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Abstract
The invention discloses a gastric floating preparation for treating poultry proventriculitis. The preparation comprises major medicines and excipients, wherein the major medicines are amoxicillin and astragalus polysaccharide. The preparation comprises the following raw materials in percentage by weight: 5-30% of amoxicillin, 2-10% of astragalus polysaccharide, 10-20% of an adsorbent, 20-50% of a hydrophilic gel material, 5-20% of a bleaching aid, 1-30% of a thinner and 0.2-5% of a foaming agent. The gastric floating preparation disclosed by the invention is an intra-gastric floating preparation which is prepared by combining amoxicillin and astragalus polysaccharide, so that medicines can stay in the stomach for a relatively long time to take efficacies. Compared to a normal preparation, the preparation disclosed by the invention can keep stable plasma concentration of the medicines in a body for a long time and improve bioavailability of the medicines; meanwhile, administration frequency and dosage are reduced; and toxic and side effects of the medicines as well as antibiotic residue are relieved.
Description
Technical field
The invention belongs to poultry technical field of pharmaceuticals is and in particular to a kind of stomach for treating poultry proventriculitis floats system
Agent and preparation method thereof.
Background technology
At present, the proventriculitis of poultry is a kind of common frdquently encountered disease of poultry especially broiler.Predisposing factorss are gastric juice first
Ph value decline leads to helicobacter pylori to be bred in a large number, and acidity is burnt by force very much glandular stomach and muscular stomach, and then causes inflammation, leads when serious
Cause bleeding and ulcer；Secondly it is viral factor, such as avian infectious bronchitis virus, bird flu viruss etc. all can cause glandular stomach to send out
Disease；In addition candida albicans infection and some immunosuppressive diseases are also this sick inducement.The mortality rate of poultry proventriculitis is up to
10-28%, and the course of disease persistent period is long.Amoxicillin has preferable killing action to the pathogenic bacteria causing proventriculitis, but due to
The gastric emptying time of chicken is shorter, causes the drug effect of medicine to be difficult to give full play to, and the medicine of discharge leads to waste and environmental pollution, and
Therapeutic effect is poor, is easily caused growth promoter slowly, feed conversion rate reduces, and sick fowl feed intake and resistance decline, and becomes stiff
Chicken, the other various diseases of easy secondary, bring very big economic loss to raiser.Therefore, research and development one kind being capable of effectively treatment man
The medicine of fowl proventriculitis has very important production meaning.
Content of the invention
Present invention aim at providing a kind of stomach floating preparation for treating poultry proventriculitis, said preparation passes through to extend medicine
Thing makes medicine slowly discharge in the holdup time of stomach, thus improving the bioavailability of medicine.
Present invention also offers the preparation method of the above-mentioned stomach floating preparation for treating poultry proventriculitis.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of stomach floating preparation for treating poultry proventriculitis, said preparation includes principal agent and adjuvant, and the composition of principal agent is
Amoxicillin and astragalus polysaccharidess；Each raw material weight percentage ratio of described preparation is: amoxicillin 5-30%, astragalus polysaccharidess 2-
10%th, adsorbent 10-30%, hydrophilic gel material 20-50%, bleach activator 5-20%, diluent 1-30%, foaming agent 0.2-
5%.Wherein, astragalus polysaccharidess directly buy ordinary commercial products, and astragalus polysaccharidess of the present invention are purchased from Sichuan letter ring vegetable products to be had
Limit company, lot number: 140608.
Specifically, described adsorbent is one of micropowder silica gel, Microcrystalline Cellulose, calcium phosphate and aluminium hydroxide or two kinds
More than.
Described hydrophilic gel material is hydroxypropyl methyl cellulose, Carbomer, hydroxyethyl cellulose, polyvinyl pyrrole
Alkanone, Polyethylene Glycol, carboxymethyl starch are received, sodium carboxymethyl cellulose, sodium alginate, xanthan gum, acacin and tamarind gum
One of or two or more.
Described bleach activator be one of glyceryl monostearate, cetyl alcohol, positive octadecanol, Cera Flava and stearic acid or
Two or more.
Described diluent is one of medicinal dextrin, corn starch, Lactose and Mannitol or two or more.
Described foaming agent be one of magnesium carbonate, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid or two kinds with
On.
The preparation method of the above-mentioned stomach floating preparation for treating poultry proventriculitis, particularly as follows: weigh A Moxi in proportion
Woods, astragalus polysaccharidess, adsorbent, hydrophilic gel material, bleach activator, diluent and foaming agent, after mixing, conventional according to this area
Technology makes tablet, microspheres agent or pellet.Wherein, preferred pellet.
Amoxicillin has preferable killing action to the pathogenic bacteria causing proventriculitis, and astragalus polysaccharidess are that veterinary clinic is more common
Antiviral drugs, therefore, the present invention attempt by amoxicillin and astragalus polysaccharidess combination treatment poultry proventriculitis.Floating in stomach is given
Medicine system can maintain autologous density to be less than the density of gastric content after referring to be administered orally, and in gastric juice is in the system of floating state
Agent.Compared with ordinary preparation, the time of staying is longer in vivo for stomach floating preparation, and the bioavailability of medicine is of a relatively high.
Compared to the prior art, beneficial effects of the present invention: floating in stomach is made in amoxicillin and astragalus polysaccharidess combination
Preparation, allows medicament to long period stop and plays drug effect under one's belt.Compared with ordinary preparation, stomach floating preparation of the present invention can
The long period maintains stable blood drug level in vivo to make medicine, improves the bioavailability of medicine, decrease simultaneously to
Medicine number of times and dosage, reduce toxic and side effects and the antibiotic remainss of medicine.
Specific embodiment
The present invention is described further by the following examples, but protection scope of the present invention not limited to this.
Embodiment 1
A kind of stomach floating preparation for treating poultry proventriculitis, said preparation includes principal agent and adjuvant, and the composition of principal agent is
Amoxicillin and astragalus polysaccharidess；Each raw material weight proportioning of soup processed of described preparation is: amoxicillin 5g, astragalus polysaccharidess 2g, micropowder silica gel
10g, Polyethylene Glycol 30g, carboxymethyl starch sodium 20g, glyceryl monostearate 5g, corn starch 27.8g, sodium bicarbonate 0.1g,
Tartaric acid 0.1g.
The preparation method of the above-mentioned stomach floating preparation for treating poultry proventriculitis, particularly as follows: weighing each raw material in proportion,
After mixing, it is added in melt granulation machine and makes pellet according to this area routine techniquess.
Embodiment 2
A kind of stomach floating preparation for treating poultry proventriculitis, said preparation includes principal agent and adjuvant, and the composition of principal agent is
Amoxicillin and astragalus polysaccharidess；Each raw material weight proportioning of soup processed of described preparation is: amoxicillin 10g, astragalus polysaccharidess 4g, microcrystalline cellulose
Plain 30g, sodium alginate 15g, tamarind gum 15g, cetyl alcohol 10g, Lactose 14g, magnesium carbonate 1g, tartaric acid 1g.
The preparation method of the above-mentioned stomach floating preparation for treating poultry proventriculitis is with reference to embodiment 1.
Embodiment 3
A kind of stomach floating preparation for treating poultry proventriculitis, said preparation includes principal agent and adjuvant, and the composition of principal agent is
Amoxicillin and astragalus polysaccharidess；Each raw material weight proportioning of soup processed of described preparation is: amoxicillin 20g, astragalus polysaccharidess 6g, calcium phosphate
20g, Carbomer 20g, Cera Flava 15g, medicinal dextrin 16g, sodium bicarbonate 1.5g, citric acid 1.5g.
The preparation method of the above-mentioned stomach floating preparation for treating poultry proventriculitis is with reference to embodiment 1.
Embodiment 4
A kind of stomach floating preparation for treating poultry proventriculitis, said preparation includes principal agent and adjuvant, and the composition of principal agent is
Amoxicillin and astragalus polysaccharidess；Each raw material weight proportioning of soup processed of described preparation is: amoxicillin 30g, astragalus polysaccharidess 10g, hydroxide
Aluminum 30g, hydroxypropyl methyl cellulose 5g, Polyvinylpyrrolidone 15g, stearic acid 5g, Mannitol 3g, sodium bicarbonate 1g, winestone
Sour 1g.
The preparation method of the above-mentioned stomach floating preparation for treating poultry proventriculitis is with reference to embodiment 1.
Floating effect measures
Take the embodiment of the present invention 1 product to be obtained in right amount, put in water, product all swims on the water surface, play the drift time 15
Minute, the flotation time is more than 8 hours.
Drug release determination
Take the embodiment of the present invention 2 that product is obtained appropriate (being equivalent to amoxicillin 72mg), with reference to drug release determination method (China
Veterinary drug allusion quotation one annex of version in 2010), using dissolution determination subtraction unit, the hydrochloric acid solution (9 → 1000) with degassing process
900ml be release medium, rotating speed be 100 revs/min, operate in accordance with the law, 5 minutes, 20 minutes, 40 minutes, 1 hour, 2 hours, 4
Hour, take within 8 hours 20ml dissolution fluid respectively, after 0.45 μm of filtering with microporous membrane, take 1ml subsequent filtrate in 25ml volumetric flask,
Mobile phase (0.01mol/l phosphate buffer) is settled to scale, containing according to Syrups by HPLC amoxicillin after shaking up
Amount, simultaneously according to the content of astragalus polysaccharidess in phenol-sulphoacid colorimetric method for determining release liquid.
Result shows, in different time sections, the average release of amoxicillin and astragalus polysaccharidess is: 5 minutes 4%, 20 minutes
8%, 40 minutes 15%, 1 hour 20%, 2 hours 40%, 4 hours 60%, 8 hours more than 85%.
The test of pesticide effectiveness
Experimental agents: the embodiment of the present invention 2 be obtained stomach floating pellet preparations (10%), amoxicillin soluble powder (10%, on
Hai Gongyi animal pharmaceutical factory).
(30 ~ 60 ages in days, clinical manifestation is proventriculitis morbidity laying hen 60: feed intake declines, lassitude, visual mucosa
Pale, propeller-like feather, become thin, weak), it is randomly divided into test group and two groups of matched group, every group 30, respectively using this
Bright embodiment 2 is obtained stomach floating pellet preparations (test group) and amoxicillin soluble powder (matched group) is treated.Test group
Using spice mode, every 100g medicine is incorporated in 200kg feedstuff, free choice feeding；Matched group is using mixed drink mode, every 100g medicine
Thing is added in 200kg water, free water.Two groups of equal continuous uses of diseased chicken 5 days, observe and record the rehabilitation situation of chicken daily,
The results are shown in Table 1.
Criterion: recovery from illness: diseased chicken clinical symptom disappearance, spirit and appetite recover normal；Effective: diseased chicken clinical symptoms are big
Part mitigates or disappears, and appetite has been recovered；Invalid: diseased chicken clinical symptoms do not mitigate or even increase.
Table 1. stomach of the present invention floats the therapeutic effect of pellet preparations and amoxicillin soluble powder
| Group | Recovery from illness (only) | Effectively (only) | Invalid (only) | Effective percentage (%) |
| Test group | 26 | 2 | 2 | 93% |
| Matched group | 17 | 7 | 6 | 80% |
As seen from Table 1, the cure rate of stomach floating pellet preparations of the present invention is higher by 30% than amoxicillin soluble powder, effectively
Rate is higher by 13% than amoxicillin soluble powder, and significant difference；Illustrate that stomach floating preparation of the present invention can make medicine longer in vivo
The blood drug level that it is fixed that time dimension keeps steady, improves the bioavailability of medicine, and therapeutic effect is notable.
Claims (7)
1. a kind of stomach floating preparation for treating poultry proventriculitis is it is characterised in that said preparation includes principal agent and adjuvant, principal agent
Composition be amoxicillin and astragalus polysaccharidess；Each raw material weight percentage ratio of described preparation is: amoxicillin 5-30%, the Radix Astragali are many
Sugared 2-10%, adsorbent 10-30%, hydrophilic gel material 20-50%, bleach activator 5-20%, diluent 1-30%, foaming agent
0.2-5%.
2. it is used for as claimed in claim 1 treating the stomach floating preparation of poultry proventriculitis it is characterised in that described adsorbent is micro-
One of powder silica gel, Microcrystalline Cellulose, calcium phosphate and aluminium hydroxide or two or more.
3. it is used for as claimed in claim 1 treating the stomach floating preparation of poultry proventriculitis it is characterised in that described hydrophilic coagulates
Glue material is hydroxypropyl methyl cellulose, Carbomer, hydroxyethyl cellulose, Polyvinylpyrrolidone, Polyethylene Glycol, carboxymethyl form sediment
Powder is received, one of sodium carboxymethyl cellulose, sodium alginate, xanthan gum, acacin and tamarind gum or two or more.
4. it is used for as claimed in claim 1 treating the stomach floating preparation of poultry proventriculitis it is characterised in that described bleach activator is
One of glyceryl monostearate, cetyl alcohol, positive octadecanol, Cera Flava and stearic acid or two or more.
5. it is used for as claimed in claim 1 treating the stomach floating preparation of poultry proventriculitis it is characterised in that described diluent is
One of medicinal dextrin, corn starch, Lactose and Mannitol or two or more.
6. it is used for as claimed in claim 1 treating the stomach floating preparation of poultry proventriculitis it is characterised in that described foaming agent is
One of magnesium carbonate, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid or two or more.
7. it is used for described in claim 1 treating the preparation method of the stomach floating preparation of poultry proventriculitis it is characterised in that in proportion
Weigh amoxicillin, astragalus polysaccharidess, adsorbent, hydrophilic gel material, bleach activator, diluent and foaming agent, after mixing, according to
This area routine techniquess make tablet, microspheres agent or pellet.
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| CN105343023B (en) * | 2015-12-02 | 2018-06-29 | 隆昌锐智恒创生物科技有限公司 | It is a kind of for albendazole ivermectin cud floating tablet of ruminant and preparation method thereof |
| CN107789362A (en) * | 2016-08-31 | 2018-03-13 | 瑞普（天津）生物药业有限公司 | A kind of gravel for treating birds ventriculitis and preparation method thereof |
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| CN101596309A (en) * | 2008-06-06 | 2009-12-09 | 河南惠通天下动物药业有限公司 | The pharmaceutical composition and the effervescent prepared therefrom of control animal viral disease |
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