CN101596309A - The pharmaceutical composition and the effervescent prepared therefrom of control animal viral disease - Google Patents

Abstract

The invention discloses a kind of pharmaceutical composition of preventing and treating animal viral disease, said composition is composed of the following components by weight percentage: astragalus polysaccharides 5～14%, thymosin 2～4%, Radix Glycyrrhizae extractum 9～23%, amoxicillin 23～46%, acetaminophen 27～46%; The invention also discloses a kind of bubble Teng agent by said composition preparation and preparation method thereof.This pharmaceutical composition combines immunostimulant and antibiotic, and the performance medicine is advantage separately, learns from other's strong points to offset one's weaknesses, and coordinates mutually.

Description

The pharmaceutical composition and the effervescent prepared therefrom of control animal viral disease

Technical field

The present invention relates to a kind of veterinary drug, be specifically related to a kind of preparation method that can prevent and treat pharmaceutical composition and the effervescent prepared therefrom and the effervescent of animal viral disease, human body immunity improving power.

Background technology

Along with the development of China's livestock breeding industry, animal viral disease and a great problem that has become puzzlement animal husbandry by its hypoimmunity that causes.Fowl poultry immune failure, hypoimmunity often cause livestock and poultry complicated and changeable, and single infection is fewer and feweri, and the disease of mixed infection is more and more, and particularly children's poultry M ﹠ M in age increases year by year.The chronic illness new disease that do not eliminate constantly occurs again, especially some immunosuppressive disease such as the circovirus disease of infectious bursal disease of chicken and pig, high-pathogenicity blue ear disease, the immune system of body is destroyed, caused immunity of poultry and resistance to reduce, the responsibility of vaccine, the resistivity of disease are reduced, sickness rate obviously rises, the disease treatment difficulty, general medicine is difficult to receive ideal effect, and feedstuff-meat ratio, feedstuff-egg ratio are improved, cause and culture difficulty, aquaculture cost height.The hazardness of animal viral disease is very big, has a strong impact on growth of animal, makes animal products downgrade such as breast, meat, hair, and quantity reduces; Prevent and treat untimelyly, easily cause large quantities of poultry death, cause the tremendous economic loss to the raiser.Some zoonosis can also directly threaten human beings'health and life security.

At present, the medicine that veterinary clinic is used to prevent and treat animal viral disease seldom and is generally single preparations of ephedrine, can not satisfy the veterinary clinic needs.For this reason, develop and a kind ofly can prevent and treat animal viral disease, new veterinary drug compound preparation that again can human body immunity improving power has meaning of crucial importance.

Immunostimulant claims immunological adjuvant again, is that a class improves the material of animal body to antigen or microorganism specific reaction by non-specific approach.It helps strengthening the function of immune system of body, improves the immunne response of body, the immune level of enhancing body.Nineteen twenty-five France immunologist Caston Ramon has found since the nonspecific immunity potentiation; the research of immunostimulant causes people's attention gradually; its field is constantly expanded; research progressively deeply; find and synthesized many materials that immunological enhancement is arranged,, strengthen vaccine protection effect in the immune serum manufacturing; the aspects such as generation that prevent and treat infectious disease have obtained extensive use, and have brought into play positive effect.At present, to Chinese herbal medicine immunostimulant research more be the Radix Astragali and Fructus Ligustri Lucidi.But the Chinese herbal medicine immunostimulant is many to be used with powder, powder spice, and dosage form is single, uses inconvenience, and the product that can use on veterinary clinic is few, and more lacking with the livestock and poultry species is unit, is the immunostimulant of target with multiple disease.

Summary of the invention

The objective of the invention is to solve medicine that the veterinary clinic that exists in the prior art is used to prevent and treat animal viral disease seldom, and be generally single preparations of ephedrine, can not satisfy the veterinary clinic needs, the Chinese herbal medicine immunostimulant is many to be used with powder, powder spice, the single technical problem of dosage form, a kind of pharmaceutical composition that can prevent and treat animal viral disease, human body immunity improving power is provided, this pharmaceutical composition combines immunostimulant and antibiotic, the performance medicine is advantage separately, learn from other's strong points to offset one's weaknesses, coordinate mutually.

It is effervescent of making of primary raw material and preparation method thereof with the said composition that another object of the present invention provides a kind of.

The objective of the invention is to be achieved through the following technical solutions:

The pharmaceutical composition of control animal viral disease of the present invention, said composition is composed of the following components by weight percentage:

Astragalus polysaccharides 5～14%

Thymosin 2～4%

Radix Glycyrrhizae extractum 9～23%

Amoxicillin 23～46%

Acetaminophen 27～46%.

By the effervescent of preparation of pharmaceutical compositions of the present invention, this effervescent is composed of the following components by weight percentage:

Astragalus polysaccharides 1～3%

Thymosin 0.4～0.8%

Radix Glycyrrhizae extractum 2～5%

Amoxicillin 5～10%

Acetaminophen 6～10%

Acidizer 8～10%

Alkaline agent 7～12%

Diluent 50～65%

Adhesive 3～5%

Correctives 1～2%.

The used acidizer of the present invention is selected from a kind of in tartaric acid, citric acid, maleic acid, Fumaric acid, malic acid, adipic acid, succinic acid, lactic acid, hydroxyacetic acid, a-hydroxy acid, ascorbic acid, the aminoacid or the mixture of any two kinds or any two or more materials in the middle of them, is preferably citric acid.

Used alkaline agent is selected from a kind of in the carbonate of potassium, lithium, sodium, calcium, ammonium or sesquicarbonate or the bicarbonate or the mixture of any two kinds or any two or more materials in the middle of them, is preferably sodium bicarbonate.

Used diluent is a kind of in lactose, starch, dextrin, Icing Sugar or the mannitol or the mixture of any two kinds or any two or more materials in the middle of them.

Used adhesive is a kind of in the copolymer of polyvinylpyrrolidone ethanol liquid, polyvinylpyrrolidone and polyvinyl acetate or the PEG ethanol liquid.

The used correctives of the present invention is selected from a kind of in steviosin, vanillin, sugar, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid sodium, agedoite, dihydro Check ear ketone, glycyrrhizin, alcohol sugar or the radix asparagi sweet extract or the mixture of any two kinds or any two or more materials in the middle of them.

The preparation method of effervescent of the present invention, it carries out according to the following steps:

(1) preparation of acid particles: acidizer is worn into fine powder, in 50～60 ℃ of dryings 5～6 hours, take by weighing thymosin, amoxicillin, acetaminophen and acidizer respectively in the prescription ratio, mix homogeneously, add adhesive and make soft material, granulate, drying is 2～3 hours under 50～60 ℃ of conditions, granulate, standby.

(2) preparation of alkali grain: get astragalus polysaccharides, Radix Glycyrrhizae extractum, alkaline agent and proper amount of diluting in the prescription ratio, it is even to be mixed to color and luster, makes alkali grain, and drying is 2～3 hours under 60～70 ℃ of conditions, and granulate is standby.

(3), add correctives, drying, packing with qualified soda acid granule mix homogeneously.

Astragalus polysaccharides is a macromolecular compound in the Radix Astragali extract, contains polysaccharide, several amino acids, protein, choline, betanin, folic acid, flavonoid, riboflavin isoreactivity composition.As ideal immunostimulant, astragalus polysaccharides can make animal spleen increase, the hyperplasia of spleen entoplasm, enhancing antibody is synthetic, antibody forming cell's number (being haemolysis plaque number) and haemolysis measured value are significantly increased, serum immune globulin IgA, IgM, IgG level obviously increase, and can resist the influence of immunosuppressant such as meticortelone, and humoral immune function is had facilitation; Simultaneously, astragalus polysaccharides can strengthen the cell physiological metabolism, improves macrophage activity, increases macrophage quantity in the body, increases macrophage phagocytic function; Astragalus polysaccharides can also promote the cell transformation of body endolymph, promote the function of immunocytes such as T cell, B cell, NK cell, improve the ability that leukocyte oozes out interferon, improve the content of immunoglobulin, suppress the breeding of virus, panimmunity defective disease is all had good preventive and therapeutic effect.

Thymosin is as the most effective immune molecule of enhancing immunity, can specific adjusting immunity of organism imbalance state, can induce and promote the differentiation of T lymphocyte, maturation, but the special T cellular immunization of enhancing body strengthens the T cell virus is produced special, scavenging action efficiently; Simultaneously, the thymus Toplink improves the NK cell viability, recovers low, immune, the humoral immune function of damaged cells, recovers body specific immunity ability, particularly cellular immunization; And the raising nonspecific immunity, the immune anti-infection ability of transfer body, prevention and treatment severe infections improve the vaccine antibody titre, increase the vaccination response rate.

Radix Glycyrrhizae extractum has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, alleviation asthma, coordinating the actions of various ingredients in a prescription, and for the dry mouth and tougue that viral disease causes, tracheal secretion increases phenomenon very high mitigation, can also regulate palatability of drugs simultaneously.

The amoxicillin is semi-synthetic penbritin class medicine, and antimicrobial spectrum and antibacterial activity and ampicillin are basic identical, but its acid resistance is strong than the ampicillin, and its bactericidal action is better than the ampicillin.The amoxicillin bactericidal action is strong, and the ability of penetration cell wall is also strong.Lactam group hydrolysis immediately in the drug molecule of oral back generates peptide bond, rapid and endobacillary transpeptidase is in conjunction with making it inactivation, cut off the unique channel that thalline relies on the synthetic glycopeptide of transpeptidase to be used for building cell wall, make bacterial cell become spheroplast and the dissolving of breaking rapidly, thalline decreases water, constantly infiltration spalling death because of cell wall finally.Most of morbific G+ bacterium and G-bacterium (comprising coccus and bacillus) all there is powerful antibacterial and bactericidal action.Streptococcus pneumoniae, Hemolytic streptococcus are belonged to, do not produce aerobic gram positive bacterias such as penicillin staphylococcus, enterococcus faecalis, and aerobic gram-negative bacterias such as escherichia coli, proteus mirabilis, Salmonella have good antibacterial action.

Acetaminophen is the active metabolite of phenacetin, has antipyretic effect, and refrigeration function is similar to aspirin, and relatively more lasting.Acetaminophen is mainly by suppressing the synthetic of prostaglandin among the central nervous system, and the conduction of impulse of blocking-up pain nerve tip produces analgesic activity; Reach refrigeration function by the generation that suppresses hypothalamus thermotaxic centre prostaglandin.The acetaminophen dissolubility is good, rapid through gastrointestinal absorption, can remove due to illness malaise symptoms such as heating that poison and bacterial infection and vaccination etc. cause, pain quickly and effectively, and this medicine is safer, platelet and clotting mechanism there is not influence, do not have the cross allergy reaction with aspirin, toxic and side effects is little, does not cause gastrointestinal hemorrhage.

The present invention is with plant source immunostimulant-astragalus polysaccharides and animal immune enhancer-thymosin use in conjunction; not only inhibited to multiple virus; and bring into play immunoregulation effect from different perspectives; the immunocompromised that immunosuppressant is caused has significant protective effect, thereby reaches the effect of two-ways regulation.Simultaneously, ingredients such as amoxicillin and acetaminophen have also been added in the medicament composing prescription, to alleviate and to treat the complication and the secondary infection of various viral diseases initiations.

The effervescent of the present invention's preparation is compared with common granule, uses cold water can make clarifying Liquid drug preparation, taking convenience, good absorbing, bioavailability of medicament height at short notice; Can contact rapidly with the pathological tissues of poultry, strengthen the anti-adversity ability of human body, can suppress duplicating of viral DNA and RNA, evident in efficacy to various infection, the hypoimmunity of various viral diseases and initiation thereof, use very extensive.

The specific embodiment:

Below by embodiment the present invention is elaborated, therefore do not limit the present invention among the described scope of embodiments.

Embodiment 1

Control animal viral disease pharmaceutical composition, said composition is composed of the following components by weight percentage:

Astragalus polysaccharides 5%

Thymosin 4%

Radix Glycyrrhizae extractum 9%

Amoxicillin 36%

Acetaminophen 46%.

Embodiment 2

The pharmaceutical composition of control animal viral disease, said composition is composed of the following components by weight percentage:

Astragalus polysaccharides 14%

Thymosin 2%

Radix Glycyrrhizae extractum 23%

Amoxicillin 23%

Acetaminophen 38%.

Embodiment 3

The pharmaceutical composition of control animal viral disease, said composition is composed of the following components by weight percentage:

Astragalus polysaccharides 12%

Thymosin 3.5%

Radix Glycyrrhizae extractum 18%

Amoxicillin 39.5%

Acetaminophen 27%.

Embodiment 4

The pharmaceutical composition of control animal viral disease, said composition is composed of the following components by weight percentage:

Astragalus polysaccharides 8%

Thymosin 3%

Radix Glycyrrhizae extractum 14%

Amoxicillin 46%

Acetaminophen 29%.

Embodiment 5

The pharmaceutical composition of control animal viral disease, said composition is composed of the following components by weight percentage:

Astragalus polysaccharides 14%

Thymosin 2.5%

Radix Glycyrrhizae extractum 26%

Amoxicillin 26%

Acetaminophen 31.5%

Embodiment 6

1. by the effervescent of preparation of pharmaceutical compositions of the present invention, composed of the following components:

Astragalus polysaccharides 3%

Thymosin 0.5%

Radix Glycyrrhizae extractum 5%

Amoxicillin 5%

Acetaminophen 6%

Acidizer: citric acid 9%

Alkaline agent: sodium bicarbonate 9%

Diluent: lactose 58.5%

Adhesive: polyvinylpyrrolidone ethanol liquid 3%

Correctives: vanillin 1%.

2. the preparation method of effervescent is carried out according to the following steps:

(1) preparation of acid particles: citric acid is worn into fine powder, in 50 ℃ of dryings 6 hours, take by weighing thymosin, amoxicillin, acetaminophen and citric acid according to the above ratio respectively, mix homogeneously, add 5% polyvinylpyrrolidone (dehydrated alcohol) and make soft material, granulate, drying is 3 hours under 50 ℃ of conditions, granulate, standby.

(2) preparation of alkali grain: get astragalus polysaccharides, Radix Glycyrrhizae extractum, sodium bicarbonate and an amount of Icing Sugar in the prescription ratio, it is even to be mixed to color and luster, makes alkali grain, and drying is 3 hours under 60 ℃ of conditions, and granulate is standby.

(3) with qualified soda acid granule mix homogeneously, spray vanillin alcoholic solution with 1%, drying, packing, promptly.

Embodiment 7

1. by the effervescent of preparation of pharmaceutical compositions of the present invention, composed of the following components:

Astragalus polysaccharides 1%

Thymosin 0.4%

Radix Glycyrrhizae extractum 2%

Amoxicillin 10%

Acetaminophen 10%

Acidizer: maleic acid 4%

Malic acid 4%

Alkaline agent: sodium carbonate 7%

Potassium carbonate 2%

Calcium carbonate 2%

Diluent: lactose 24.6%

Starch 10%

Dextrin 5%

Icing Sugar 5%

Mannitol 10%

Adhesive: the copolymer 5% of polyvinylpyrrolidone and polyvinyl acetate

Correctives: steviosin 0.5%

Saccharin sodium 0.5%

Cyclohexane sulfamic acid sodium 0.5%

Agedoite 0.5%.

2. the preparation method of effervescent is carried out according to the following steps:

(1) preparation of acid particles: acidizer is worn into fine powder,, take by weighing thymosin, amoxicillin, acetaminophen and acidizer respectively in the prescription ratio in 60 ℃ of dryings 5 hours, mix homogeneously adds adhesive and makes soft material, granulates, drying is 2 hours under 60 ℃ of conditions, and granulate is standby.

(2) preparation of alkali grain: get astragalus polysaccharides, Radix Glycyrrhizae extractum, alkaline agent and proper amount of diluting in the prescription ratio, it is even to be mixed to color and luster, makes alkali grain, and drying is 2 hours under 70 ℃ of conditions, and granulate is standby.

(3), add correctives, drying, packing with qualified soda acid granule mix homogeneously.

Embodiment 8

1. by the effervescent of preparation of pharmaceutical compositions of the present invention, composed of the following components:

Astragalus polysaccharides 2%

Thymosin 0.8%

Radix Glycyrrhizae extractum 3%

Amoxicillin 6%

Acetaminophen 7%

Acidizer: tartaric acid 1%

Citric acid 1%

Maleic acid 1%

Fumaric acid 1%

Malic acid 1%

Adipic acid 1%

Succinic acid 1%

Lactic acid 1%

Hydroxyacetic acid 0.5%

Alkaline agent: sesquialter calcium carbonate 6%

Sodium carbonate 6%

Diluent: lactose 55.3%

Adhesive: PEG ethanol liquid 4%

Correctives: vanillin 1.4%.

2. the preparation method of effervescent is carried out according to the following steps:

(1) preparation of acid particles: acidizer is worn into fine powder,, take by weighing thymosin, amoxicillin, acetaminophen and acidizer respectively in the prescription ratio in 54 ℃ of dryings 5.6 hours, mix homogeneously adds adhesive and makes soft material, granulates, drying is 2.8 hours under 54 ℃ of conditions, and granulate is standby.

(2) preparation of alkali grain: get astragalus polysaccharides, Radix Glycyrrhizae extractum, alkaline agent and proper amount of diluting in the prescription ratio, it is even to be mixed to color and luster, makes alkali grain, and drying is 2.8 hours under 64 ℃ of conditions, and granulate is standby.

(3), add correctives, drying, packing with qualified soda acid granule mix homogeneously.

Embodiment 9

1. by the effervescent of preparation of pharmaceutical compositions of the present invention, composed of the following components:

Astragalus polysaccharides 1.5%

Thymosin 0.6%

Radix Glycyrrhizae extractum 4%

Amoxicillin 9%

Acetaminophen 9%

Acidizer: hydroxyacetic acid 3%

A-hydroxy acid 3%

Ascorbic acid 3.5%

Alkaline agent: ammonium bicarbonate 10%

Diluent: mannitol 25%

Starch 25%

Adhesive: polyvinylpyrrolidone ethanol liquid 4.6%

Correctives: vanillin 1%

Calcium o-benzolsulfimide 0.8%.

2. the preparation method of effervescent is carried out according to the following steps:

(1) preparation of acid particles: acidizer is worn into fine powder,, take by weighing thymosin, amoxicillin, acetaminophen and acidizer respectively in the prescription ratio in 58 ℃ of dryings 5.2 hours, mix homogeneously adds adhesive and makes soft material, granulates, drying is 2.2 hours under 58 ℃ of conditions, and granulate is standby.

(2) preparation of alkali grain: get astragalus polysaccharides, Radix Glycyrrhizae extractum, alkaline agent and proper amount of diluting in the prescription ratio, it is even to be mixed to color and luster, makes alkali grain, and drying is 2.5 hours under 65 ℃ of conditions, and granulate is standby.

(3), add correctives, drying, packing with qualified soda acid granule mix homogeneously.

Embodiment 10

1. by the effervescent of preparation of pharmaceutical compositions of the present invention, composed of the following components:

Astragalus polysaccharides 1%

Thymosin 0.4%

Radix Glycyrrhizae extractum 2%

Amoxicillin 5%

Acetaminophen 6%

Acidizer: malic acid 1%

Adipic acid 1%

Succinic acid 1%

Lactic acid 1%

Hydroxyacetic acid 4%

Alkaline agent: sodium bicarbonate 7%

Diluent: lactose 65%

Adhesive: polyvinylpyrrolidone ethanol liquid 4.2%

Correctives: vanillin 1.4%.

2. the preparation method of effervescent is carried out according to the following steps:

(1) preparation of acid particles: acidizer is worn into fine powder,, take by weighing thymosin, amoxicillin, acetaminophen and acidizer respectively in the prescription ratio in 55 ℃ of dryings 5.5 hours, mix homogeneously adds adhesive and makes soft material, granulates, drying is 2.5 hours under 55 ℃ of conditions, and granulate is standby.

(2) preparation of alkali grain: get astragalus polysaccharides, Radix Glycyrrhizae extractum, alkaline agent and proper amount of diluting in the prescription ratio, it is even to be mixed to color and luster, makes alkali grain, and drying is 2.5 hours under 66 ℃ of conditions, and granulate is standby.

(3), add correctives, drying, packing with qualified soda acid granule mix homogeneously.

Embodiment 11

Repeat the preparation method of embodiment 6, except that acidizer, other component is identical with embodiment 6, and the consumption of each component is also identical with embodiment 6, and used acidizer and ratio thereof are as follows:

Tartaric acid 0.5%

Citric acid 0.5%

Maleic acid 0.5%

Fumaric acid 0.5%

Malic acid 0.5%

Adipic acid 0.5%

Succinic acid 1%

Lactic acid 1%

Hydroxyacetic acid 1%

A-hydroxy acid 1%

Ascorbic acid 1%

Aminoacid 0.5%

Embodiment 12

Repeat the preparation method of embodiment 6, except that alkaline agent, other component is identical with embodiment 6, and the consumption of each component is also identical with embodiment 6, and used alkaline agent and ratio thereof are as follows:

Sodium carbonate 0.5%

Potassium carbonate 0.5%

Calcium carbonate 0.5%

Carbonic acid reason 0.5%

Ammonium carbonate 0.5%

Sodium sesquicarbonate 0.5%

Sesquialter potassium carbonate 0.5%

Sesquialter calcium carbonate 0.5%

Sesquialter carbonic acid reason 0.5%

Sesquialter ammonium carbonate 0.5%

Sodium bicarbonate 0.5%

Potassium bicarbonate 1%

Calcium bicarbonate 1%

Bicarbonate reason 1%

Ammonium bicarbonate 1%

Embodiment 13

Repeat the preparation method of embodiment 7, except that alkaline agent, other component is identical with embodiment 7, and the consumption of each component is also identical with embodiment 7, and used alkaline agent and ratio thereof are as follows:

Steviosin 0.1%

Vanillin 0.1%

Sugar 0.1%

Saccharin sodium 0.1%

Calcium o-benzolsulfimide 0.1%

Cyclohexane sulfamic acid sodium 0.2%

Agedoite 0.2%

Dihydro Check ear ketone 0.2%

Glycyrrhizin 0.2%

Alcohol sugar 0.2%

Radix asparagi sweet extract 0.5%.

Application example 1

Chicken house meat assorted chicken scale in Wen County, Jiaozhuo turns to 5000, finds during 14 ages in days that chicken beats stack up, lethargy, the necking down of bowing, wing are drooped, feed intake reduces, diarrhoea appears in sick chicken, discharge white thickness and water sample loose stool, cloaca feather on every side is by fecal pollution.Discovery in the 3rd day has chicken death, about 50.

Cuing open the inspection symptom is: dead chicken dehydration is serious, and shank and chest muscle are hemorrhage, kidney swelling, and there is the strip petechia glandular stomach and muscular stomach junction, and mucus increases in the fabricius bursa, fabricius bursa edema and hemorrhage, mucous membrane surface has petechial hemorrhage or fills the air hemorrhage.Tentative diagnosis is an infectious bursal disease.Be diagnosed as infectious bursal disease through viral isolation identification, serological test.

Treatment: select for use this product to add drinking-water, every 100g converts water 200Kg, logotype 3 days, and chicken group's the symptom of having loose bowels disappears substantially, the no phenomena of mortality.Press every 100g spice 200Kg then, logotype 3～4 days, it is normal that chicken group mental status recovers, and it is normal that the feed intake of chicken is also recovered substantially.

Application example 2

Pig farm, Xinxiang, Henan is when purchasing piglet, and sale person says and beaten the swine fever Seedling do not have timely immune swine fever Seedling after therefore buying.Soon occur successively after buying that fever, health are rubescent, asthma, feces have does or symptom such as rare, with antibiotic therapy after 2 weeks, commentariess on classics of not getting better, and the state of an illness has repeatedly only death successively of pig subsequently.Diagnose suspection that swine fever is arranged through the veterinary, have the mild swine fever after look into swinery.The owner worries that this moment, vaccinate can increase the weight of the state of an illness, and does not inject the swine fever Seedling.

Select for use this product to add drinking-water, every 100g converts water 200Kg, logotype 3 days, and the clinical symptoms of swinery is alleviated to some extent, does not have death condition again and takes place.Press every 100g spice 100Kg then, logotype 3～4 days, it is normal that the swinery mental status recovers, and pig feed intake is only also recovered normally substantially.

When adopting the present invention that the morbidity pig is only treated, other pigs on pig farm are only prevented every 100g spice 400Kg, logotype 5～7 days.According to owner's reflection, other pigs are only since this product of feeding, not because of infecting the swine fever morbidity.

Application example 3

A Nanyang growing and fattening pigs 100 bulls (about 120 jin) have 50 hair diseases approximately.Clinical symptoms: more than the morbidity pig fervescence to 41 ℃, feces is done, and skin rubefaction has the hemorrhage point in the pore, and the ventral breathing aggravation is not eaten, inguinal lymph nodes enlargement, the erythema of purple point of abdominal part and comparison rule etc.

Cuing open inspection changes: pulmonary interstitial edema, and pleuritis, pericardial effusion, the spleen enlargement is hemorrhage, and liver has the canescence necrosis region, the lymph node severe haemorrhage, there is the petechia on the kidney surface, stomach bottom mucosal bleeding etc.Cut open inspection and pathogen separation testing result analysis-by-synthesis according to this sick epidemic characteristic, Clinical symptoms, pathology, be diagnosed as high-pathogenicity blue ear disease and Eperythrozoon mixed infection.

At the beginning of the disease, with partner treatments such as amoxicillin, doxycycline, dipyrone, but can not disease controlling and spread, pharmaceutical preparation of the present invention is adopted in the back, every 100g spice 100Kg, logotype 3～4 days, the state of an illness is controlled substantially; Continue subsequently to use pharmaceutical preparation of the present invention to carry out efficacy consolidation, logotype is after 5～7 days, and morbidity pig clinical symptoms only disappears substantially, and it is normal that feed intake is recovered.When the morbidity pig is only treated, adopt pharmaceutical preparation of the present invention that this other pigs are only prevented, every 100g spice 400Kg, logotype 5～7 days.According to owner reflection, other pigs are only since this product of feeding, not infected morbidity.

Claims (10)

1. pharmaceutical composition of preventing and treating animal viral disease is characterized in that said composition is composed of the following components by weight percentage:

Astragalus polysaccharides 5～14%

Thymosin 2～4%

Radix Glycyrrhizae extractum 9～23%

Amoxicillin 23～46%

Acetaminophen 27～46%.

2. one kind is the effervescent that primary raw material is made with the described pharmaceutical composition of claim 1, it is characterized in that this effervescent is composed of the following components by weight percentage:

Astragalus polysaccharides 1～3%

Thymosin 0.4～0.8%

Radix Glycyrrhizae extractum 2～5%

Amoxicillin 5～10%

Acetaminophen 6～10%

Acidizer 8～10%

Alkaline agent 7～12%

Diluent 50～65%

Adhesive 3～5%

Correctives 1～2%.

3. effervescent according to claim 2 is characterized in that: described acidizer is selected from a kind of in tartaric acid, citric acid, maleic acid, Fumaric acid, malic acid, adipic acid, succinic acid, lactic acid, hydroxyacetic acid, a-hydroxy acid, ascorbic acid, the aminoacid or the mixture of any two kinds or any two or more materials in the middle of them.

4. effervescent according to claim 3 is characterized in that: described acidizer is a citric acid.

5. according to claim 2 or 3 described effervescents, it is characterized in that: described alkaline agent is selected from a kind of in the carbonate of potassium, lithium, sodium, calcium, ammonium or sesquicarbonate or the bicarbonate or the mixture of any two kinds or any two or more materials in the middle of them.

6. effervescent according to claim 5 is characterized in that: described alkaline agent is a sodium bicarbonate.

7. according to claim 2 or 6 described effervescents, it is characterized in that: described diluent is a kind of in lactose, starch, dextrin, Icing Sugar or the mannitol or the mixture of any two kinds or any two or more materials in the middle of them.

8. effervescent according to claim 7 is characterized in that: described adhesive is a kind of in the copolymer of polyvinylpyrrolidone ethanol liquid, polyvinylpyrrolidone and polyvinyl acetate or the PEG ethanol liquid.

9. according to claim 2 or 7 described effervescents, it is characterized in that: described correctives is selected from a kind of in steviosin, vanillin, sugar, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid sodium, agedoite, dihydrochalcone, glycyrrhizin, alcohol sugar or the radix asparagi sweet extract or the mixture of any two kinds or any two or more materials in the middle of them.

10. the preparation method of effervescent as claimed in claim 2 is characterized in that it carries out according to the following steps:

(1) preparation of acid particles: acidizer is worn into fine powder, in 50～60 ℃ of dryings 5～6 hours, take by weighing thymosin, amoxicillin, acetaminophen and acidizer respectively in the prescription ratio, mix homogeneously, add adhesive and make soft material, granulate, drying is 2～3 hours under 50～60 ℃ of conditions, granulate, standby.

(2) preparation of alkali grain: get astragalus polysaccharides, Radix Glycyrrhizae extractum, alkaline agent and proper amount of diluting in the prescription ratio, it is even to be mixed to color and luster, makes alkali grain, and drying is 2～3 hours under 60～70 ℃ of conditions, and granulate is standby.

(3), add correctives, drying, packing with qualified soda acid granule mix homogeneously.