CN105012472A - Effervescent granules for treating poultry colibacillosis and preparation method thereof - Google Patents
Effervescent granules for treating poultry colibacillosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses effervescent granules for treating poultry colibacillosis and a preparation method thereof. The effervescent granules for treating the poultry colibacillosis are prepared from, by weight, the active pharmaceutical ingredients of 380-420 parts of Chinese pulsatilla roots, 380-420 parts of Chinese goldthread rhizome, 380-420 parts of cortex phellodendri, 180-220 parts of rheum officinale, 380-420 parts of radix scutellariae, 380-420 parts of isatis roots, 380-420 parts of humifuse euphorbia herbs and 180-220 parts of licorice roots, and the auxiliary materials of 216-264 parts of alkaline agents, 180-220 parts of acidic agents, 1100-1340 parts of diluents, 36-44 parts of flavoring agents and 0.2-240 parts of binding agents. The preparation method comprises the steps that the eight traditional Chinese medicines of Chinese pulsatilla roots, Chinese goldthread rhizome, cortex phellodendri, rheum officinale, radix scutellariae, isatis roots, humifuse euphorbia herbs and licorice roots are decocted through water, then decompress concentration is conducted on extract to prepare an extract cream, and compounding of the extract cream with the diluents, the flavoring agents, the binding agents and the alkaline agents or the acidic agents is conducted to prepare the granules. According to the effervescent granules for treating the poultry colibacillosis and the preparation method thereof, the prepared effervescent granules are good in stability and significant in curative effect.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, be specifically related to a kind of effervescent granule being used for the treatment of poultry colibacillosis and preparation method thereof.
Background technology
Along with the continuous expansion of poultry scale, the Blight control also more difficult of poultry, the especially outburst of the colibacillosis of poultry is the problem of the most headache of current poultry feed lot.One is that sickness rate is high, especially 18-22 days, the broiler chicks of 28-33 days; Two is once ehec infection, and the mortality rate of poultry is higher, loses larger; Three be infect after all along with toxaemic outburst, larger inflammatory reaction is also caused to other organs of poultry, has a strong impact on the growth in poultry later stage.Because colibacillosis takes place frequently, the antibiotic addition controlling colibacillosis is increasing, to such an extent as to a variety of antibiotic produces drug resistance all, very undesirable for colibacillary control effects.In addition, the antibiotic residual and health of drug resistance to people causes and has a strong impact on, people improve constantly for the cry of food safety, the supervision of state food safety is also increasingly strict, especially for antibiotic abuse, impose and keep under strict control and heavy punishment, significantly reduce antibiotic consumption imperative (European Union forbids to add antibiotic in feedstuff).And Chinese medicine effervescent granule is not containing antibiotic, and it is soluble, good absorbing, it is the medicine that a class has fine development prospect, but the ratio shared by Chinese medicine effervescent granule Chinese medicine extractum is great, having difficulties in the selection of drug extract and pharmaceutic adjuvant kind and ratio, there is the common problems such as disintegration time is slow, poor stability, palatability difference in existing Chinese medicine effervescent granule mostly.Simultaneously effervescent granule is because of the acid-base reaction of disintegrating agent itself in preservation process, and the impact of ambient moisture in storage process in addition, very easily produces gas, thus cause the product obtained to occur the unfavorable conditions such as swollen bag, air-blowing.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of good stability, disintegration time is short, and the evident in efficacy effervescent granule being used for the treatment of poultry colibacillosis and preparation method thereof.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
The invention provides a kind of effervescent granule being used for the treatment of poultry colibacillosis, prepared by following raw material by weight: crude drug: the Radix Pulsatillae 380 ~ 420, Rhizoma Coptidis 380 ~ 420, Cortex Phellodendri 380 ~ 420, Radix Et Rhizoma Rhei 180 ~ 220, Radix Scutellariae 380 ~ 420, Radix Isatidis 380 ~ 420, Herba Euphorbiae Humifusae 380 ~ 420, Radix Glycyrrhizae 180 ~ 220; Adjuvant: alkaline agent 216 ~ 264, acidizer 180 ~ 220, diluent 1100 ~ 1340, correctives 36 ~ 44, adhesive 0.2 ~ 240.
Preferably, described raw material medicaments in part by weight is counted: the Radix Pulsatillae 400, Rhizoma Coptidis 400, Cortex Phellodendri 400, Radix Et Rhizoma Rhei 200, Radix Scutellariae 400, Radix Isatidis 400, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200.
Preferably, described alkaline agent is the one in sodium bicarbonate and/or carbon element hydrogen potassium.
Preferably, described acidizer is fumaric acid, citric acid, tartaric acid, one or more in malic acid.
Preferably, described diluent is one or more in sucrose, glucose, lactose, mannitol, soluble starch, dextrin and sorbitol.
Preferably, described correctives is one or more in aspartame, steviosin, xylitol, vanillin, saccharin sodium, Calcium o-benzolsulfimide, glycyrrhizin, radix asparagi sweet extract.
Preferably, described adhesive is one or more in polyvidone, hydroxypropyl emthylcellulose, pregelatinized Starch, gelatin, sucrose, methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, Macrogol 4000, polyethylene glycol 6000 and polyvinyl alcohol.
Present invention also offers a kind of preparation method being used for the treatment of the effervescent granule of poultry colibacillosis, it is characterized in that, comprise the following steps:
(1) Radix Pulsatillae of described weight portion, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Herba Euphorbiae Humifusae and Radix Glycyrrhizae is taken respectively, after adding the water soaking 1 ~ 3h of medical material total amount 4 ~ 12 times of weight, heating decocts, first time decocts 2 ~ 4h, second time adds the soak by water 1 ~ 2h of medical material total amount 5 ~ 8 times of weight in medicinal residues, collecting decoction, filters, and getting supernatant concentration to relative density after leaving standstill is the extractum of 1.30 ~ 1.35;
(2) preparation of alkali grain: the alkaline agent taking described weight portion, a meromict of diluent described in one half-sum of the extractum prepared in step (1), the half adding described adhesive makes soft material, crosses 15 ~ 20 mesh sieves and granulates, 75 ~ 85 DEG C of dryings, for subsequent use after granulate;
(3) preparation of acid particles: the acidizer taking described weight portion, a meromict of diluent described in one half-sum of the extractum prepared in step (1), the half adding described adhesive makes soft material, crosses 15 ~ 20 mesh sieves and granulates, 75 ~ 85 DEG C of dryings, for subsequent use after granulate;
(4) by acid in step (2) and step (3) and alkali grain mixing, add correctives and stir, subpackage, obtained described effervescent granule.
The pharmacological action of the various crude drug of the present invention:
The Radix Pulsatillae: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; For toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.
Rhizoma Coptidis: bitter, cold; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication; For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Cortex Phellodendri: bitter, cold; Return kidney, urinary bladder channel; Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment; For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Radix Et Rhizoma Rhei: bitter, cold; Return spleen, stomach, large intestine, liver, pericardium channel; Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation; For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.
Radix Scutellariae: bitter, cold; Return lung, gallbladder, spleen, large intestine, small intestine meridian; Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive; For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Isatidis: bitter, cold; GUIXIN, stomach warp; Heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Herba Euphorbiae Humifusae: pungent, flat; Return liver, large intestine channel; Heat-clearing and toxic substances removing, cooling blood for hemostasis; For dysentery, have loose bowels, hemoptysis, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.
Radix Glycyrrhizae: sweet, flat; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
This eight tastes Chinese crude drug, all has effect of clearing away heat-fire, dysentery relieving above, and the composite use of this eight tastes Chinese crude drug, can be used in the treatment of damp-heat dysentery and chicken colibacillosis.
The invention has the beneficial effects as follows:
1. the present invention is used for the treatment of the effervescent granule of poultry colibacillosis, has effect of clearing away heat-fire, dysentery relieving, high to the cure rate of poultry colibacillosis, can reach 100%.
2. the present invention uses the composite diluent of natural Chinese medicine raw material, correctives and adhesive etc. to prepare effervescent granule, not containing antibiotic, does not have antibiotic remains after use, prevention and therapy is effective, have no side effect, and cheap, and market application scenarios is wide.
3. the present invention adopts the method that soda acid is separately granulated, and reduces the contact of soda acid in storage process.The effervescent granule prepared, in storage process, does not produce the unfavorable conditions such as swollen bag, air-blowing; And preparation technology is simple, easy-formation, not easily moisture absorption, rate of effervescence is fast, and effervescent is effective, and this effervescent granule to dissolve performance good, stability is good, evident in efficacy.
Detailed description of the invention
Adopt soak, heating decocts, filter, the technique of concentrated extractum extracts the ingredients such as the Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Herba Euphorbiae Humifusae, Radix Glycyrrhizae, factor affect extraction efficiency mainly contains immersion water consumption, soak time, decoction water consumption, decocting time, decoction number of times.Take yield of extract as leading indicator to immersion water consumption, the water consumption that heating decocts and decocting time are investigated.
The mensuration of yield of extract: the medical material taking recipe quantity, soaks by described scheme, decocts, and filters, and filtrate merges, and leaves standstill, gets supernatant and be evaporated to the extractum that relative density is 1.30 ~ 1.35.Take appropriate, be placed in the evaporating dish being dried to constant weight, water bath method, 105 DEG C are dried to constant weight, are calculated as follows yield of extract:
Yield of extract (%)=W/W0 × 100%
W: the weight of extractum;
W0: the weight of medical material.
1. soak the screening of water consumption
Accurately take a certain amount of Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Herba Euphorbiae Humifusae and Radix Glycyrrhizae, soak by immersion water consumptions different in table 1, after soaking 2h, heating decocts, and first time decocts 2 hours, second time medicinal residues add the soak by water 1 hour of 6 times of medical material total amounts, collecting decoction, filters, and filtrate merges, leave standstill, get supernatant and be evaporated to the extractum that relative density is 1.30 ~ 1.35.Sampling measures, and the results are shown in Table 1.
Table 1 soaks the investigation result of water consumption
| Soak water consumption | 4 times | 6 times | 8 times | 10 times | 12 times |
| Yield of extract (%) | 11.3 | 14.0 | 14.9 | 15.3 | 15.0 |
As shown in Table 1, adopt the water of 8 times of medical material total amounts, when medical material being soaked with the water of 10 times of medical material total amounts and the water of 12 times of medical material total amounts in other conditions always, extraction ratio is close, without significantly improving, therefore adopts the water of 8 times of medical material total amounts to carry out soak extraction to can be used as a preferred scheme.
2. the screening of decocting time
Accurately take a certain amount of Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Herba Euphorbiae Humifusae and Radix Glycyrrhizae, the water of 8 times of medical material total amounts is used to soak, decoct by the time different in table 2, collecting decoction, filter, filtrate merges, and leaves standstill, gets supernatant and be evaporated to the extractum that relative density is 1.30 ~ 1.35.Sampling measures, and the results are shown in Table 2:
The investigation result of table 2 extraction time
As shown in Table 2, decoct 2 hours by first time, the soak by water 1 hour of 6 times of medical material total amounts is added in second time medicinal residues, after prolongation decocting time, extraction ratio is without significant difference, consider to produce reality, with 2 hours first times, the soak by water that second time medicinal residues add 6 times of medical material total amounts 1 hour was the best.
Therefore the Optimized extraction techniques of extractum is: accurately take a certain amount of Radix Pulsatillae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Herba Euphorbiae Humifusae and Radix Glycyrrhizae, by the water soaking 2h of 8 times of medical material total amounts, heating decocts, 2 hours first times, second time medicinal residues add the soak by water 1 hour of 6 times of medical material total amounts, collecting decoction, filter, filtrate merges, and leaves standstill, gets supernatant and be evaporated to the extractum that relative density is 1.30 ~ 1.35.
3. the screening of acidizer
Adopt sodium bicarbonate as alkaline agent, in the preparation technology's utilization table selecting identical diluent identical, different acidizers is granulated respectively, tests, the results are shown in Table 3.
The different acidizer of table 3 investigates result
| Alkaline agent | Acidizer | Result | |
| 1 | Sodium bicarbonate | Fumaric acid | Easy granulation, effervescent is good, dissolving is complete |
| 2 | Sodium bicarbonate | Citric acid | Not easily granulate, granule is hard |
| 3 | Sodium bicarbonate | Tartaric acid | Easy granulation, dissolving are not exclusively |
| 4 | Sodium bicarbonate | Malic acid | Easy caking, the moisture absorption |
Therefore, contrast acidizer citric acid, tartaric acid and malic acid, fumaric acid is more excellent as the effect of acidizer.
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
The effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 380g, Rhizoma Coptidis 420g, Cortex Phellodendri 420g, Radix Et Rhizoma Rhei 180g, Radix Scutellariae 420g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 380, Radix Glycyrrhizae 220g;
Adjuvant: potassium bicarbonate 216g, citric acid 200g, diluent: sucrose 550g, sorbitol 550g, correctives: steviosin 36g, adhesive: polyvidone 240g.
The preparation method of this effervescent granule:
(1) take Radix Pulsatillae 380g respectively, Rhizoma Coptidis 420g, Cortex Phellodendri 420g, Radix Et Rhizoma Rhei 180g, Radix Scutellariae 420g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 380, Radix Glycyrrhizae 220g, add 11280g water soaking 1h, heating decocts, and first time filters after decocting 2h; Second time adds the soak by water 1h of 14100g, collecting decoction in medicinal residues, filters, and getting supernatant after leaving standstill, to be evaporated to 60 DEG C of relative densities be the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take potassium bicarbonate 216g, the half of the extractum weight of preparation in step (1), sucrose 275g, sorbitol 275g mix homogeneously, then adds 120g polyvidone and makes soft material, crosses 15 mesh sieves and granulates, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take citric acid 200g, the half of the extractum weight of preparation in step (1), sucrose 275g, sorbitol 275g mix homogeneously, then adds 120g polyvidone and makes soft material, crosses 15 mesh sieves and granulates, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) acid in step (2) and step (3) and alkali grain are mixed, add 36g steviosin and stir and namely prepare effervescent granule, subpackage.
Embodiment 2
The effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 410g, Rhizoma Coptidis 380g, Cortex Phellodendri 410g, Radix Et Rhizoma Rhei 220g, Radix Scutellariae 380g, Radix Isatidis 420g, Herba Euphorbiae Humifusae 420, Radix Glycyrrhizae 180g;
Adjuvant: potassium bicarbonate 264g, tartaric acid 180g, diluent: sucrose 1000g, glucose 200g, correctives: Calcium o-benzolsulfimide 40g, adhesive: hydroxypropyl emthylcellulose 120g.
The preparation method of this effervescent granule:
(1) take Radix Pulsatillae 410g respectively, Rhizoma Coptidis 380g, Cortex Phellodendri 410g, Radix Et Rhizoma Rhei 220g, Radix Scutellariae 380g, Radix Isatidis 420g, Herba Euphorbiae Humifusae 420, Radix Glycyrrhizae 180g, add 33840g water soaking 3h, heating decocts, and first time filters after decocting 4h; Second time adds the soak by water 2h of 22560g, collecting decoction in medicinal residues, filters, and getting supernatant after leaving standstill, to be evaporated to 60 DEG C of relative densities be the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take potassium bicarbonate 264g, the half of the extractum weight of preparation in step (1), sucrose 500g, glucose 100g mix homogeneously, then add 60g hydroxypropyl emthylcellulose and make soft material, cross 20 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take tartaric acid 180g, the half of the extractum weight of preparation in step (1), sucrose 500g, glucose 100g mix homogeneously, then add 60g hydroxypropyl emthylcellulose and make soft material, cross 20 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) acid in step (2) and step (3) and alkali grain are mixed, add 40g Calcium o-benzolsulfimide and stir and namely prepare effervescent granule, subpackage.
Embodiment 3
The effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 420g, Rhizoma Coptidis 410g, Cortex Phellodendri 380g, Radix Et Rhizoma Rhei 190g, Radix Scutellariae 410g, Radix Isatidis 380g, Herba Euphorbiae Humifusae 410, Radix Glycyrrhizae 210g;
Adjuvant: sodium bicarbonate 240g, malic acid 220g, diluent: dextrin 1300g, correctives: radix asparagi sweet extract 44g, adhesive: pregelatinized Starch 0.2g.
The preparation method of this effervescent granule:
(1) take Radix Pulsatillae 420g respectively, Rhizoma Coptidis 410g, Cortex Phellodendri 380g, Radix Et Rhizoma Rhei 190g, Radix Scutellariae 410g, Radix Isatidis 380g, Herba Euphorbiae Humifusae 410, Radix Glycyrrhizae 210g, add 22480g water soaking 2h, heating decocts, and first time filters after decocting 3h; Second time adds the soak by water 1h of 16860g, collecting decoction in medicinal residues, filters, and getting supernatant after leaving standstill, to be evaporated to 60 DEG C of relative densities be the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take sodium bicarbonate 240g, the half of the extractum weight of preparation in step (1), dextrin 650 g mix homogeneously, then add 0.1g pregelatinized Starch and make soft material, cross 18 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take malic acid 220g, the half of the extractum weight of preparation in step (1), dextrin 650 g mix homogeneously, then add 0.1g pregelatinized Starch and make soft material, cross 18 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) acid in step (2) and step (3) and alkali grain are mixed, add 44g radix asparagi sweet extract and stir and namely prepare effervescent granule, subpackage.
Embodiment 4
A kind of effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 400g, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g;
Adjuvant: sodium bicarbonate 240g, fumaric acid 200g, diluent: dextrin 100g, glucose 1120g, correctives: aspartame 40g, adhesive: polyvidone 100g, methylcellulose 20g.
The preparation method of this effervescent granule:
(1) take Radix Pulsatillae 400g respectively, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g, add 22400g water soaking 2h, heating decocts, and first time filters after decocting 2h; Second time adds the soak by water 1h of 16800g, collecting decoction in medicinal residues, filters, and getting supernatant after leaving standstill, to be evaporated to 60 DEG C of relative densities be the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take sodium bicarbonate 240g, the half of the extractum weight of preparation in step (1), dextrin 50g, glucose 560g mix homogeneously, then add polyvidone 50g, methylcellulose 10g makes soft material, crosses 16 mesh sieves and granulates, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take fumaric acid 200g, the half of the extractum weight of preparation in step (1), dextrin 50g, glucose 560g mix homogeneously, then add polyvidone 50g, methylcellulose 10g makes soft material, crosses 16 mesh sieves and granulates, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) acid in step (2) and step (3) and alkali grain are mixed, add 40g aspartame and stir and namely prepare effervescent granule, subpackage.
Embodiment 5
A kind of effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 400g, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g;
Adjuvant: sodium bicarbonate 216g, fumaric acid 180g, diluent: glucose 1200g, correctives: vanillin 40g, adhesive: gelatin 50g, sodium carboxymethyl cellulose 50g.
The preparation method of this effervescent granule:
(1) take Radix Pulsatillae 400g respectively, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g, add 22400g water soaking 2h, heating decocts secondary, and first time filters after decocting 2h; Second time adds the soak by water 1h of 16800g, collecting decoction in medicinal residues, filters, and getting supernatant after leaving standstill, to be evaporated to 60 DEG C of relative densities be the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take sodium bicarbonate 216g, the half of the extractum weight of preparation in step (1), glucose 600g mix homogeneously, then add gelatin 25g, Carboxymethyl cellulose sodium 25g makes soft material, crosses 16 mesh sieves and granulates, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take fumaric acid 180g, the half of the extractum weight of preparation in step (1), glucose 600g, then add gelatin 25g, Carboxymethyl cellulose sodium 25g makes soft material, crosses 16 mesh sieves and granulates, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) acid in step (2) and step (3) and alkali grain are mixed, add 40g vanillin and stir and namely prepare effervescent granule, subpackage.
Embodiment 6
The effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 400g, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g;
Adjuvant: sodium bicarbonate 232g, fumaric acid 190g, diluent: glucose 600g, lactose 400g, mannitol 198g, correctives: saccharin sodium 20g, glycyrrhizin 18g, adhesive: Macrogol 4000 50g, PVOH 6000 30g.
The preparation method of this effervescent granule:
(1) take Radix Pulsatillae 400g respectively, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g, add 22400g water soaking 2h, heating decocts secondary, and first time filters after decocting 2h; Second time adds the soak by water 1h of 16800g in medicinal residues, collecting decoction, filters, and get supernatant after leaving standstill, being evaporated to 60 DEG C of relative densities is the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take sodium bicarbonate 232g, the half of the extractum weight of preparation in step (1), glucose 300g, lactose 200g, mannitol 99g mix homogeneously, then adds 25g Macrogol 4000,15g PVOH 6000 makes soft material, cross 16 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take fumaric acid 190g, the half of the extractum weight of preparation in step (1), glucose 300g, lactose 200g, mannitol 99g, then add 25g Macrogol 4000,15g PVOH 6000 makes soft material, cross 16 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) by acid in step (2) and step (3) and alkali grain mixing, add 20g saccharin sodium, 18g glycyrrhizin stirs and namely prepares effervescent granule, subpackage.
Embodiment 7
The effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 400g, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g;
Adjuvant: sodium bicarbonate 264g, fumaric acid 220g, diluent: mannitol 670g, soluble starch 670g, correctives: xylitol 40g, adhesive: polyvinyl alcohol 120g, sucrose 20g, methylcellulose 100g.
(1) take Radix Pulsatillae 400g respectively, Rhizoma Coptidis 400g, Cortex Phellodendri 400g, Radix Et Rhizoma Rhei 200g, Radix Scutellariae 400g, Radix Isatidis 400g, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200g, add 22400g water soaking 2h, heating decocts secondary, and first time filters after decocting 2h; Second time adds the soak by water 1h of 16800g, collecting decoction in medicinal residues, filters, and getting supernatant after leaving standstill, to be evaporated to 60 DEG C of relative densities be the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take sodium bicarbonate 264g, the half of the extractum weight of preparation in step (1), mannitol 335g, soluble starch 335g mix homogeneously, then adds 60g polyvinyl alcohol, 10g sucrose, 50g methylcellulose makes soft material, cross 16 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take fumaric acid 220g, the half of the extractum weight of preparation in step (1), mannitol 335g, soluble starch 335g mix homogeneously, then adds 60g polyvinyl alcohol, 10g sucrose, 50g methylcellulose makes soft material, cross 16 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) acid in step (2) and step (3) and alkali grain are mixed, add 40g xylitol and stir and namely prepare effervescent granule, subpackage.
Embodiment 8
The effervescent granule being used for the treatment of poultry colibacillosis is prepared by following raw material:
Raw material: Radix Pulsatillae 390g, Rhizoma Coptidis 400g, Cortex Phellodendri 390g, Radix Et Rhizoma Rhei 210g, Radix Scutellariae 410g, Radix Isatidis 380g, Herba Euphorbiae Humifusae 410, Radix Glycyrrhizae 210g;
Adjuvant: sodium bicarbonate 240g, fumaric acid 220g, diluent: dextrin 1300g, correctives: saccharin sodium 44g, adhesive: ethyl cellulose 60g.
The preparation method of this effervescent granule:
(1) take Radix Pulsatillae 390g respectively, Rhizoma Coptidis 400g, Cortex Phellodendri 390g, Radix Et Rhizoma Rhei 210g, Radix Scutellariae 410g, Radix Isatidis 380g, Herba Euphorbiae Humifusae 410, Radix Glycyrrhizae 210g, add 22480g water soaking 2h, heating decocts secondary, and first time filters after decocting 3h; Second time adds the soak by water 1h of 16860g, collecting decoction in medicinal residues, filters, and getting supernatant after leaving standstill, to be evaporated to 60 DEG C of relative densities be the extractum of 1.30 ~ 1.35.
(2) preparation of alkali grain: take sodium bicarbonate 240g, the half of the extractum weight of preparation in step (1), dextrin 650 g mix homogeneously, then add 30g ethyl cellulose and make soft material, cross 16 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(3) preparation of acid particles: take fumaric acid 220g, the half of the extractum weight of preparation in step (1), dextrin 650 g mix homogeneously, then add 30g ethyl cellulose and make soft material, cross 16 mesh sieves to granulate, 75 ~ 85 DEG C of forced air dryings, for subsequent use after granulate;
(4) acid in step (2) and step (3) and alkali grain are mixed, add 44g saccharin sodium and stir and namely prepare effervescent granule, subpackage.
Performance test
Get this product, simulation commercially available back, temperature 25 ± 2 DEG C, place under relative humidity 60% ± 10% condition, respectively at 0 month, March and June sampling investigate, investigate the results are shown in Table 4.
1. moisture: according to Chinese veterinary pharmacopoeia 2005 editions 2 aquametries (annex 57 pages).
2. melting: the product 10g getting above-mentioned 7 embodiments respectively, warm water 200ml observe the solubility property of product.
3. disintegration: effervescent granule to check in the time limit all disintegrates leach or become particle be dissolved in water needed for time.
4. stability: observe the stability of product at 6 months energy, observe and whether have caking or deterioration.
Table 4 performance test
Clinical trial one
In March, 2015, the broiler morbidity of more than 15000 22 ages in days of poultry autotrophy field, Suqian, Jiangsu, draws canescence loose stool, flocks together, do not eat, dyspnea, sick chicken lassitude, lethargy, and disorderly, wing is sagging for Podocarpus imbricatus, starts dead.
Cut open inspection change: heart, liver are covered by colibacillary white rheuminess thing, intestinal diffuse hemorrhage, cecal tonsil and cloaca hemorrhage and have yellow loose stool; Be full of mucus in bronchus, tube wall thickening, air bag is muddy, inside has rheuminess thing; Heart hat fat is hemorrhage, has ecchymosis in cardiac muscle.
Lab testing: the liver that antibacterial culturing gets with aseptic manipulation the chicken that dies of illness is inoculated on plain agar and maconkey agar plating medium, cultivate 24h for 37 DEG C, plain agar flat board grows circle, smooth non-flanged, neat moistening translucent petite, maconkey agar plating medium grows translucent pink circular colonies.The single bacterium colony chosen in 3 culture medium makes gram stain microscopy, all the dialister bacterium of the blunt circle in visible Gram-negative two ends.Smear for microscopic examination, the blood smear of 6 sick chickens is got by sterile working, carries out gram and wright staining microscopy, is dispersed in the Gram-negative dialister bacterium of two single auspicious blunt circles all as seen.Through being diagnosed as colibacillosis.
Therapeutic Method:
Treatment group 1: use the product in embodiment 4, be watered the dosage of 1000kg according to 500g, successive administration 5 days.
Treatment group 2: use amoxicillin (100 g/ boxes, Zhengzhou Bary Animal Pharmaceutical Co., Ltd.), be watered the amount administration of 200 L by 100 g, successive administration 5 days.
Therapeutic effect:
Treatment group 1:(1) use 1 day after, dead to reduce; (2) death control after using 3 days, recovery of searching for food; (3) give to protect the liver after three days and protect kidney nutriment 3 days, the chicken group mental status is recovered, and other inflammation disappear.
Treatment group 2:(1) use 2 days after, dead to reduce; (2) death control after using 5 days, recovery of searching for food; (3) give to protect the liver after 5 days and protect kidney nutriment 3 days, the chicken group mental status is recovered, and other inflammation disappear.
Contrast the therapeutic effect of above-mentioned treatment group 1 and treatment group 2, the product in visible the present invention in embodiment 4 is better than amoxicillin for the effect for the treatment of chicken colibacillosis.
Clinical trial two
The large-scale chicken house in Shanxi, the commercial generation AA chicken in 42 week age about 10000, falls ill gradually, and dead more than 20 of every day, laying rate drops to 60% by 81%.
Clinical symptoms: depressed, the necking down of spirit, flock together, feather is fluffy, the faint yellow filth of crissum feather, breathe, night, death was more.
Cut open inspection change: cut open inspection 24 and only to die of illness chicken, there are a large amount of egg yolk or yellow fibers exudate in abdominal cavity, stench, typical yolk peritonitis, indivedual ovary degeneration necrosis, and ovum falls among abdominal cavity and becomes cheese shape.
Check according to incidence, clinical symptoms, pathological change and laboratory bacterial qualification, biochemical test etc., isolate pasteurella multocida and Salmonella, also have single cases to isolate escherichia coli.
Therapeutic Method:
Treatment group 1: use the product in embodiment 5, be watered the dosage of 1000kg according to 500g, successive administration 5 days.
Treatment group 2: use amoxicillin (100 g/ boxes, Zhengzhou Bary Animal Pharmaceutical Co., Ltd.), be watered the amount administration of 200 L by 100 g, successive administration 5 days.
Therapeutic effect:
Treatment group 1: use the 2nd day, diarrhoea disappears, dead minimizing; Use the 3rd day, death control, laying rate rises to some extent; Then be aided with to protect the liver and protect kidney nutriment, improve feedstuff level, be used in conjunction 3 ~ 5 days, mine massively food, spirit of chicken is recovered normally all gradually, and laying rate, eggshell color etc. also recover normally, without rebound phenomenon in one month.
Treatment group 2: use the 3rd day, diarrhoea disappears, dead minimizing; Use the 5th day, death control, laying rate rises to some extent; Then be aided with to protect the liver and protect kidney nutriment, improve feedstuff level, be used in conjunction 5 ~ 6 days, mine massively food, spirit of chicken is recovered normally all gradually, and laying rate, eggshell color etc. also recover normal.
From above-mentioned therapeutic effect, treatment group 1 and treatment group 2, through the administration of 5 days, can reach a desirable therapeutic effect, but the product curative effect in the present invention in embodiment 5 are better than amoxicillin.
Claims (8)
1. one kind is used for the treatment of the effervescent granule of poultry colibacillosis, it is characterized in that, prepared by following raw material by weight: crude drug: the Radix Pulsatillae 380 ~ 420, Rhizoma Coptidis 380 ~ 420, Cortex Phellodendri 380 ~ 420, Radix Et Rhizoma Rhei 180 ~ 220, Radix Scutellariae 380 ~ 420, Radix Isatidis 380 ~ 420, Herba Euphorbiae Humifusae 380 ~ 420, Radix Glycyrrhizae 180 ~ 220; Adjuvant: alkaline agent 216 ~ 264, acidizer 180 ~ 220, diluent 1100 ~ 1340, correctives 36 ~ 44, adhesive 0.2 ~ 240.
2. the effervescent granule being used for the treatment of poultry colibacillosis according to claim 1, is characterized in that, described raw material medicaments in part by weight is counted: the Radix Pulsatillae 400, Rhizoma Coptidis 400, Cortex Phellodendri 400, Radix Et Rhizoma Rhei 200, Radix Scutellariae 400, Radix Isatidis 400, Herba Euphorbiae Humifusae 400, Radix Glycyrrhizae 200.
3. the effervescent granule being used for the treatment of poultry colibacillosis according to claim 1 and 2, is characterized in that, described alkaline agent is the one in sodium bicarbonate and/or carbon element hydrogen potassium.
4. the effervescent granule being used for the treatment of poultry colibacillosis according to claim 1 and 2, is characterized in that, described acidizer is fumaric acid, citric acid, tartaric acid, one or more in malic acid.
5. the effervescent granule being used for the treatment of poultry colibacillosis according to claim 1 and 2, is characterized in that, described diluent is one or more in sucrose, glucose, lactose, mannitol, soluble starch, dextrin and sorbitol.
6. the effervescent granule being used for the treatment of poultry colibacillosis according to claim 1 and 2, it is characterized in that, described correctives is one or more in aspartame, steviosin, xylitol, vanillin, saccharin sodium, Calcium o-benzolsulfimide, glycyrrhizin, radix asparagi sweet extract.
7. the effervescent granule being used for the treatment of poultry colibacillosis according to claim 1 and 2, it is characterized in that, described adhesive is one or more in polyvidone, hydroxypropyl emthylcellulose, pregelatinized Starch, gelatin, sucrose, methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, Macrogol 4000, polyethylene glycol 6000 and polyvinyl alcohol.
8. be used for the treatment of a preparation method for the effervescent granule of poultry colibacillosis as claimed in claim 1, it is characterized in that, comprise the following steps:
(1) Radix Pulsatillae of described weight portion, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Herba Euphorbiae Humifusae and Radix Glycyrrhizae is taken respectively, after adding the water soaking 1 ~ 3h of medical material total amount 4 ~ 12 times of weight, heating decocts, first time decocts 2 ~ 4h, second time adds the soak by water 1 ~ 2h of medical material total amount 5 ~ 8 times of weight in medicinal residues, collecting decoction, filters, and getting supernatant concentration to relative density after leaving standstill is the extractum of 1.30 ~ 1.35;
(2) preparation of alkali grain: the alkaline agent taking described weight portion, a meromict of diluent described in one half-sum of the extractum prepared in step (1), the half adding described adhesive makes soft material, crosses 15 ~ 20 mesh sieves and granulates, 75 ~ 85 DEG C of dryings, for subsequent use after granulate;
(3) preparation of acid particles: the acidizer taking described weight portion, a meromict of diluent described in one half-sum of the extractum prepared in step (1), the half adding described adhesive makes soft material, crosses 15 ~ 20 mesh sieves and granulates, 75 ~ 85 DEG C of dryings, for subsequent use after granulate;
(4) by acid in step (2) and step (3) and alkali grain mixing, add correctives and stir, subpackage, obtained described effervescent granule.
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