CN104222651A - Preparation method for ascites syndrome-prevention feed for raising broiler chickens - Google Patents

Abstract

The invention provides a preparation method for an ascites syndrome-prevention feed for raising broiler chickens. The method comprises the following steps: the basic material of the feed comprises 54 to 61 percent of corn, 27 to 32 percent of bean pulp, 1 to 1.5 percent of calcium bicarbonate, 1 to 1.2 percent of mountain flour, 2 to 3 percent of edible oil, 2 to 3 percent of fish meal, 3 to 5 percent of wheat bran, and 2 to 3 percent of shell powder; the auxiliary material of the feed comprises any one or more of calcium hydrophosphate, monocalcium phosphate or calcium superphosphate, as well as salt, a urease inhibitor, sodium bicarbonate, vitamin C and prevention and treatment medicines; after all the components of the basic material are uniformly smashed, the components are uniformly stirred through a stirrer, clear water is added at room temperature until the water content is adjusted to 34 to 38 percent, the auxiliary material is added and uniform stirring is performed, pelleting is performed through a disk pelletizer, and the size of each granule is 1 to 2 mm. The feed is simple in proportioning, convenient to use, and good in ascites syndrome prevention and treatment effect, and can effectively reduce the loss of farmers caused by the ascites syndrome.

Description

A kind of manufacture method of feed of cultivation anti-chicken fowl ascites use of broiler chicken

technical field:

The present invention relates to technical field of pharmaceuticals, the manufacture method of the feed that the cultivation anti-chicken fowl ascites particularly relating to a kind of broiler chicken uses.

 

background technology:

In the breeding process of broiler chicken, easily because ascites symptoms causes the large quantities of death of chicken fowl, cause heavy losses to raiser.This illness is generally infect peak period when 15-20 days.Dorking abdominal dropsy, (Ascites syndrome, AS), also known as pulmonary hypertension syndrome (Pulmonary hypertension syndrome, PHS), be a kind of syndrome Hou Qun mainly betiding commercial generation Broiler chicks being formed as feature with hypertrophy of right heart-ascites.(seventies is to the mid-80) is mainly reported in High aititude anoxic area at first, and the report nearly ten years in low altitude area about this disease also increases increasingly, and the broiler breeding industry of China in serious harm.The risk factor of dorking abdominal dropsy: definitely the partial pressure of oxygen of anoxic high altitude localities is low, Broiler chicks makes the incidence of disease of AS increase substantially because of atmospheric anoxic.When thoracic deformity during Ca,P metabolism obstacle and the serious mycotic infection of respiratory system, the incidence of disease of AS can be made to raise because of respiratory hypoxia.Relatively hypoxia: the AS incidence of disease can be made obviously to increase because increasing weight fast when feeding particulate material.Male broiler chicken metabolic rate is higher, and oxygen demand is large, and the AS incidence of disease is high.Cold makes animal oxygen demand increase (test shows, increases by 93% when Broiler chicks oxygen demand is than 23 DEG C when 7 DEG C), and the incidence of disease of AS can increase considerably.The factor of broiler chicken to be the basis that AS occurs: AS be modern goods itself is for the product of Broiler chicks structure and function contradiction.The heredity of broiler chicken is selected mainly to concentrate on meat production in the past, the aspect such as the price of deed and the speed of growth, and ignoring the concern that each organ is developed in harmony, result causes the breathing of commercial generation Broiler chicks and the circulatory system greatly to reduce the adaptability that the poor environment such as anoxic, cold stimulates.Particularly often bring out hypertrophy of right heart and exhaustion-Ascites because of right cardiac load increase.Paragonimus cyst (lung weight/body weight) as Broiler chicks only has 60% of laying hen of the same age, therefore it is lower to the compensatory adaptive capacity of anoxic; Under the stimulation of cold and anoxic, cardiac muscle easily damages (the burst size increase of the Cardiac troponin T NT of specificity reflection cardiac structure infringement).This factor is in the main cause of plains region cultivation chicken fowl.As: diet excessive concentration, grows too fast, causes anoxic, cause the generation of Ascites to the increase in demand of oxygen; Sodium salt content in feed is too high, the osmotic pressure between body tissue cell and blood can be made obviously to strengthen Humoral immunity hypodynamia, thus cause the generation of Ascites.The clinical symptoms of AS and pathological change can summarize three aspects: (1) whole body hemostasis and congestive liver malnutrition (cirrhosis).It is that belly expands that AS suffers from the typical clinical symptoms of chicken, and skin of abdomen is shinny, has fluctuation when pressing with hand, and sick chicken is fluffy by hair, is reluctant to stand, slow in action, walks about like penguin shape.Expiratory dyspnea, several cases cockscomb, wattle is aubergine, skin cyanosis.Cut open the visible liver hemostasis of inspection, enlargement and fibroid sclerosis, a large amount of limpid or bale of straw liquid is amassed in abdominal cavity, can be mixed with cellulose mass or floccule in liquid.(2) right cardiomegaly, expansion, heart valve occurs that pathologic changes.(3) lungs hemostasis oedema.These are all the characteristic features of cor pulmonale.Therefore, generally at present explain the morbidity link of AS with the pathogenesis of cor pulmonale: namely risk factor → pulmonary hypertension (namely right cardiac load increases) → hypertrophy of right heart and exhaustion → whole body hemostasis and congestive liver malnutritive, posterior vena cava backflow obstruction and ascites formation.

For avoiding this illness, in existing cultural method, usually adopt following means: 1, add selenium pellet 500 grams in every double centner feed, and add vitamin E in right amount.The method of this microelement-supplementing, preventive effect is good, but too late for the then treatment of having fallen ill.2 pairs of sick severe one can gavage with Aquarium every chicken half, vitamin C 10 milligrams.To the available hydrochlorothiazide tablet of chicken group 100 milligrams, add glucose 125 grams, after mixing, add water 20 kilograms, every day 2 times, serve on 3 days, use No. 16 syringe needles to carry out abdominocentesis to the obvious sick chicken of ascites, release hydrops, the death time can be made 2 ~ 4 days to postpone.This method can only be pushed into the death time, for treatment broiler chicken leaves the time.3, Chinese medicinal formulae is with two ugly, rhizoma alismatis, akebi, pokeberry root, rhizoma atractylodis, umbellate pore furgus, millet, each 500 grams of rush, and 250 grams, the leaf of bamboo, grinds to the powder altogether, and every chicken feeds 1 gram at every turn, is used in conjunction 3 days.This method has certain effect for dorking abdominal dropsy, but, find through overtesting, be efficiently only 60% about, be i.e. effect deficiency.

The present invention on the basis of existing technology, aim to provide a kind of proportioning simple, easy to use, prevention and cure dorking abdominal dropsy is effective, the manufacture method of the feed that the cultivation anti-chicken fowl ascites that obviously can reduce the broiler chicken of the loss that therefore illness is brought to raiser uses.

 

summary of the invention:

The object of the invention is to overcome the shortcoming existed in prior art, there is provided a kind of proportioning simple, easy to use, prevention and cure dorking abdominal dropsy is effective, the manufacture method of the feed that the cultivation anti-chicken fowl ascites that obviously can reduce the broiler chicken of the loss that therefore illness is brought to raiser uses.

To achieve these goals, the manufacture method of the feed that the cultivation anti-chicken fowl ascites that the invention provides a kind of broiler chicken uses, wherein, operates in accordance with the following steps:

A broiler chicken during 15-28 age in days in, supply of forage amount reduce 15%; Normal supply of forage amount is recovered after 28 ages in days,

Keep coop ventilation during the whole cultivation of B, reduce the content of inner CO2 and NH3 of hen house,

The Dietary phosphorus content of the daily feeding of C is not less than 0.05%, and salt content is not more than 0.5%, and urease inhibitors content is not less than 0.13%, and sodium acid carbonate content is not less than 1%, and vitamin C is not less than 0.5%;

D broiler chicken during 15-28 age in days in, the content of the protective agents of interpolation is not less than 3%, and between period of disease, the content of the protective agents of interpolation is not less than 5%.

The component of described protective agents is: Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, each 50-80g of Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, each 40-50g of cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, each 20-40g of wartwort, each 10-30g of balloonflower root, honey-fried licorice root.

The component of described protective agents is: Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, each 50-70g of Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, each 40-45g of cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, each 20-30g of wartwort, each 10-20g of balloonflower root, honey-fried licorice root.

The component of described protective agents is: Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, each 70-80g of Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, each 45-50g of cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, each 30-40g of wartwort, each 20-30g of balloonflower root, honey-fried licorice root.

The component of feed is: corn 54-61%, dregs of beans 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone flour 1-1.2%, edible oil 2-3%, fish meal 2-3%, wheat bran 3-5%, oyster shell whiting 2-3%.

The P elements composition that the Dietary phosphorus content of daily feeding described in step C is not less than 0.05% interpolation be in calcium monohydrogen phosphate, calcium dihydrogen phosphate or calcium superphosphate any or several.

Urease inhibitors described in step C is preferably vinegar hydroxyamino.

 

The preparation method of protective agents: by Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, wartwort, balloonflower root, honey-fried licorice root use water extract method lixiviate three times, after three times leaching liquor merges, boiling, to thick, adds modified starch and CMC, flavouring; The mass ratio of modified starch and CMC, flavouring is 2:1:0.5, the quality of modified starch, CMC and flavouring and be protective agents raw material (Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, wartwort, balloonflower root, honey-fried licorice root) the 2-3% of quality.Also cross 80 mesh sieves in pulvis after dry, the pulvis after sieving, after ultraviolet irradiation is sterilized 10 seconds, adds ampicillin, and the quality of the ampicillin added is the 1-2% of pulvis quality, mixes the protective agents that rear obtained the present invention is used.

This protective agents, with, the bighead atractylodes rhizome yellow to drug anesthesia of purging the lung of pathogenic fire row water, lung-heat clearing and detoxification be monarch drug in a prescription to medicine Radix Isatidis, Lasiosphaera fenzlii, with the cordate houttuynia of the motherwort of the cattail pollen of stagnation resolvation diuresis, root tuber of aromatic turmeric promoting blood circulation and removing blood stasis, the sharp aquation stasis of blood, the purple perilla of dispelling dampness and promoting diuresis, the root of kudzu vine of bringing down a fever, lophatherum gracile, removing toxic substances for ministerial drug, with the diuresis that clears away heart-fire to drug anesthesia Huang, the bighead atractylodes rhizome, beneficial gas astringe yin to medicine ginseng, the fruit of Chinese magnoliavine, the Phytolacca acinosa of relieving oedema or abdominal distension through diuresis or purgation, the wartwort of clearing damp and promoting diuresis is adjutant, with the balloonflower root stimulated the menstrual flow and Radix Glycyrrhizae for making medicine.After restricted-access media active ingredient, mix with anti-inflammation drugs ampicillin, strengthen prevention effect.

 

The manufacture method of feed:

Feed is expected substantially: corn 54-61%, dregs of beans 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone flour 1-1.2%, edible oil 2-3%, fish meal 2-3%, wheat bran 3-5%, oyster shell whiting 2-3%.

Auxiliary material: in calcium monohydrogen phosphate, calcium dihydrogen phosphate or calcium superphosphate any or several; Salt, urease inhibitors, sodium acid carbonate, vitamin C, protective agents.

Feed expects that each component is pulverized evenly substantially, and use mixer to stir, add clear water at ambient temperature, being adjusted to water content is 34-38%,

Stir after adding auxiliary material, use granulating disc granulation, gained granular size is 1-2mm.

 

Such as:

Feed: corn 54.2%, dregs of beans 32%, carbonic acid fine particle calcium carbonate 1.2%, stone flour 1%, edible oil 2%, fish meal 3%, wheat bran 4%, oyster shell whiting 2.6%.

The addition of auxiliary material is be all reference basis with feed.

Such as, feed expects to configure 100kg substantially, and add auxiliary material, the auxiliary material added is calcium superphosphate 0.06kg, salt 0.4kg, urease inhibitors 0.15kg, sodium acid carbonate 1kg, vitamin C 0.6kg, protective agents 3.5kg.

Vitamin C can substitute with compound vitamin element.

 

Advantage of the present invention is: proportioning is simple, and easy to use, prevention and cure dorking abdominal dropsy is effective, obviously can reduce the loss that therefore illness is brought to raiser, be specially:

Vitamin C is added in feed, or compound vitamin element, maintain cylinder electrolyte balance, to relax stress reaction.

The method of early silicosis, takes early stage appropriate limit to raise and can effectively reduce later ascites.Reduce by 15% feeding in the 3rd surrounding (15 days ~ 28 days) period of feeding of broiler, during 28 days normal feedings of later recovery, feed intake increases, and can make up to lose early stage to weigh, and delivers Normal-weight for sale.Material reducing mode can use night light turning off timing or timing dead slot, the generation of ascites symptoms can be reduced thus.

Urease inhibitor, significantly can reduce the death rate, its mechanism is to broiler feeding urease inhibitor, both inhibit the urease activity in small intestine and large intestine, again reduce the content of ammonia in small intestine and large intestine, thus reduce mucous membrane tissue turnover rate and the oxygen demand of portal vein row blood organ, so just there is more oxygen to utilize for body, eliminate the motive power causing ascites symptoms and death.

Sodium acid carbonate, in alkalescence, can reduce the incidence of dorking abdominal dropsy.For neutralizing acid intoxication conditions in feed, distend the blood vessels and pulmonary artery is reduced, thus reducing the incidence of disease of ascites symptoms

And by adding protective agents, protection liver lung, protect the heart and enrich blood, diuresis is relieved oedema or abdominal distension through diuresis or purgation simultaneously promoting blood circulation and removing blood stasis, simultaneously antibacterial, and control secondary disease, greatly reduces incidence probability, reduces raiser's loss.

detailed description of the invention:

Example 1:

A broiler chicken during 15-28 age in days in, supply of forage amount reduce 15%; Normal supply of forage amount is recovered after 28 ages in days,

Keep coop ventilation during the whole cultivation of B, reduce the content of inner CO2 and NH3 of hen house,

The Dietary phosphorus content of the daily feeding of C is not less than 0.05%, and salt content is not more than 0.5%, and urease inhibitors content is not less than 0.13%, and sodium acid carbonate content is not less than 1%, and vitamin C is not less than 0.5%;

D broiler chicken during 15-28 age in days in, the content of the protective agents of interpolation is not less than 3%, and between period of disease, the content of the protective agents of interpolation is not less than 5%.

The component of described protective agents is: Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, each 80g of Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, each 50g of cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, each 40g of wartwort, each 30g of balloonflower root, honey-fried licorice root.

The component of feed is: corn 54-61%, dregs of beans 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone flour 1-1.2%, edible oil 2-3%, fish meal 2-3%, wheat bran 3-5%, oyster shell whiting 2-3%.

The P elements composition that the Dietary phosphorus content of daily feeding is not less than 0.05% interpolation is calcium superphosphate.

Urease inhibitors is preferably vinegar hydroxyamino.

 

Preferred:

Feed: corn 54.2%, dregs of beans 32%, carbonic acid fine particle calcium carbonate 1.2%, stone flour 1%, edible oil 2%, fish meal 3%, wheat bran 4%, oyster shell whiting 2.6%.

The addition of auxiliary material is be all reference basis with feed.

Such as, feed expects to configure 100kg substantially, and add auxiliary material, the auxiliary material added is calcium superphosphate 0.06kg, salt 0.4kg, urease inhibitors 0.15kg, sodium acid carbonate 1kg, vitamin C 0.6kg, protective agents 3kg.

Vitamin C can substitute with compound vitamin element.

Said method uses cultivation broiler chicken man of Jimo Qin raiser, delivers for sale to becoming chicken from baby chick, and cultivate 3500 broiler chicken, the morbidity number of elements of ascites symptoms is 253, and the incidence of disease is only 7.2%, and 253 merely hit healing 227, and efficient 89.7%.

 

Example 2

A broiler chicken during 15-28 age in days in, supply of forage amount reduce 15%; Normal supply of forage amount is recovered after 28 ages in days,

Keep coop ventilation during the whole cultivation of B, reduce the content of inner CO2 and NH3 of hen house,

The Dietary phosphorus content of the daily feeding of C is not less than 0.05%, and salt content is not more than 0.5%, and urease inhibitors content is not less than 0.13%, and sodium acid carbonate content is not less than 1%, and vitamin C is not less than 0.5%;

D broiler chicken during 15-28 age in days in, the content of the protective agents of interpolation is not less than 3%, and between period of disease, the content of the protective agents of interpolation is not less than 5%.

The component of described protective agents is: Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, each 70g of Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, each 45g of cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, each 30g of wartwort, each 20g of balloonflower root, honey-fried licorice root.

The component of feed is: corn 54-61%, dregs of beans 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone flour 1-1.2%, edible oil 2-3%, fish meal 2-3%, wheat bran 3-5%, oyster shell whiting 2-3%.

The P elements composition that the Dietary phosphorus content of daily feeding is not less than 0.05% interpolation is calcium dihydrogen phosphate.

Urease inhibitors is preferably vinegar hydroxyamino.

 

Preferred:

Feed: corn 56%, dregs of beans 30%, carbonic acid fine particle calcium carbonate 1.2%, stone flour 1.2%, edible oil 3%, fish meal 3%, wheat bran 3%, oyster shell whiting 2.6%.

The addition of auxiliary material is be all reference basis with feed.

Such as, feed expects to configure 100kg substantially, and add auxiliary material, the auxiliary material added is calcium dihydrogen phosphate 0.06kg, salt 0.4kg, urease inhibitors 0.15kg, sodium acid carbonate 1kg, vitamin C 0.6kg, protective agents 3.5kg.

Vitamin C can substitute with compound vitamin element.

Said method is opened a raiser and is used cultivation broiler chicken in Jiangzhou, deliver for sale to becoming chicken from baby chick, and cultivate 2000 broiler chicken, the morbidity number of elements of ascites symptoms is 120, and the incidence of disease is only 6%, and 120 merely hit healing 104, and efficient 86.7%.

 

Example 3

A broiler chicken during 15-28 age in days in, supply of forage amount reduce 15%; Normal supply of forage amount is recovered after 28 ages in days,

Keep coop ventilation during the whole cultivation of B, reduce the content of inner CO2 and NH3 of hen house,

The Dietary phosphorus content of the daily feeding of C is not less than 0.05%, and salt content is not more than 0.5%, and urease inhibitors content is not less than 0.13%, and sodium acid carbonate content is not less than 1%, and vitamin C is not less than 0.5%;

D broiler chicken during 15-28 age in days in, the content of the protective agents of interpolation is not less than 3%, and between period of disease, the content of the protective agents of interpolation is not less than 5%.

The component of described protective agents is: Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, each 60g of Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, each 40g of cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, each 20g of wartwort, each 15g of balloonflower root, honey-fried licorice root.

The component of feed is: corn 54-61%, dregs of beans 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone flour 1-1.2%, edible oil 2-3%, fish meal 2-3%, wheat bran 3-5%, oyster shell whiting 2-3%.

The P elements composition that the Dietary phosphorus content of daily feeding is not less than 0.05% interpolation is calcium monohydrogen phosphate.

Urease inhibitors is preferably vinegar hydroxyamino.

Feed: corn 61%, dregs of beans 28%, carbonic acid fine particle calcium carbonate 1%, stone flour 1%, edible oil 2%, fish meal 2%, wheat bran 3%, oyster shell whiting 2%.

The addition of auxiliary material is be all reference basis with feed.

Such as, feed expects to configure 100kg substantially, and add auxiliary material, the auxiliary material added is calcium monohydrogen phosphate 0.06kg, salt 0.4kg, urease inhibitors 0.15kg, sodium acid carbonate 1kg, vitamin C 0.6kg, protective agents 4kg.

Vitamin C can substitute with compound vitamin element.

Said method uses cultivation broiler chicken Laixi Chen Jia raiser, delivers for sale to becoming chicken from baby chick, and cultivate 3200 broiler chicken, the morbidity number of elements of ascites symptoms is 224, and the incidence of disease is only 7%, and 224 merely hit healing 197, and efficient 87.9%.

 

Pathological experiment:

1, model is set up

Select the broiler chicken between 300 ages week in 4 week age-5, bodyweight difference is less than 10g, is divided into 6 groups at random, and often organize 50,1-5 group is experimental group, and 6 groups is Normal group.

Experimental group modeling:

Be placed in small space by 1-5 group, the content of CO2 and NH3 in this space is 2 times of normal hen house, and simultaneously feeding adopts high protein, high-fat high oxygen consumption feed, salt content higher than 3%, without selenium element and injection Vitamin B_6 in feed, and P elements.Improve moisture degree in air, and cause lung's anoxic with stimulations such as formalin and occur.Continue after 10 days,

1-5 group broiler chicken performance lassitude, feather is fluffy and disorderly, has loose bowels, abdominal distention, spraddle, and behavior is blunt, expiratory dyspnea, and hat and wattle are aubergine, cuts open inspection visible chicken body tissue organ extravasated blood, oedema, whole body skeletal muscle extravasated blood, peony.Pulmonary congestion, oedema, hydropericardium, cardiac enlargement, liver is congested, edge is thickening, be covered with one deck half gel-shaped thing, the congested enlargement of kidney, and has lithate to deposit, and enteron aisle is extensively congested, has fibrin clot in abdominal cavity, and hydrops is usually limpid in brownish red.Model is set up.

 

2, contrast test

1 group of feeding example 3 of the present invention, every feeding 50g.Remove protective agents after recovery from illness and continue feeding feed of the present invention.

2 groups of feeding examples 1 of the present invention, every feeding 50g.Remove protective agents after recovery from illness and continue feeding feed of the present invention.

3 groups of feedings are by the Chinese medicinal formulae in the background technology of inventing with two ugly, rhizoma alismatis, akebi, pokeberry root, rhizoma atractylodis, umbellate pore furgus, millet, each 500 grams of rush, and 250 grams, the leaf of bamboo, grinds to the powder altogether, every feeding 1g.

4 groups are used alone ampicillin, mix fodder feeding.

5 groups, after extracting ascites, carry out 2 1g/L sodium selenitethe intramuscular injection of 0.1mL, takes simultaneously diuretics.

6 groups is Normal group.

Above-mentioned each group of comparative effectiveness is as follows:

Histological examination:

Each group core, liver, lung, spleen, stomach, intestines, kidney, brain, thymus gland, the tissue such as the bursa of farbricius, drench fixing with 10% formal, routine paraffin wax is cut into slices, and HE dyes, microscopy.

2 results

Broiler chicken abdominal distention dead in 1-5 group, touch and have fluctuation, skin of abdomen is thinning shinny, and serious is rubescent.Cut belly open, from abdominal cavity, flow out the faint yellow or limpid transparent liquid of volume, what have is mixed with fibrin deposition thing; Heart enlargement, distortion, softness, especially atrium dextrum expansion significantly.Right cardiac muscle is thinning, and myocardium look is talked and with white stripes, the chambers of the heart is long-pending a large amount of sludged blood, and the extremely expansion of pulmonary artery and sustainer, is full of blood in tube chamber.Part heart bag is long-pending weak yellow liquid; Liver enlargement or atrophy, matter are hard, extravasated blood, hemorrhage, gollbladder dilation, and outstanding liver surface, is inside full of bile; Pulmonary venous pleonaemia, oedema, in graniphyric, quality is slightly tough and tensile, and interstitial has canescence striped, and tangent plane flows out the blood sample liquid of volume with minute bubbles; Spleen is kermesinus, and tangent plane acini lienalis structure is unclear; Kidney is slightly swollen, extravasated blood, hemorrhage.Meningovascular anger is opened, hyperemia; Stomach is slightly swollen, extravasated blood, hemorrhage; Mesenterium and serosa congestion, intestinal mucosa has hemorrhage on a small quantity, and intestines wall oedema thickens.

1-2 group and the Normal group sign of healing are basically identical.

In 3-5 group, hydropericardium has thrown away existence, and stomach is hemorrhage, and intestinal mucosa bleeding still has 17% existence.

Kidney in the 1-5 group of dying of illness: glomerulus is congested, plexus vasculosus endotheliocytic swelling, renal cells swelling, and granular degeneration, vacuolar degeneration, steatosis are even downright bad, visible hyalina in tube chamber; Interstitial edema, loose, the congestion of blood vessel,

1-2 group and the Normal group sign of healing are basically identical.

In 3-5 group, steatosis and tube chamber interstitial edema have 22% existence.

The 1-5 group spleen of dying of illness: the lymphocyte of whole spleen reduces, and acini lienalis reduces, and deposit in medullary sinus a large amount of red blood cell and edematous fluid, has also been dispersed in red blood cell, sinusoidal endothelial cells swelling in medullary cord and acini lienalis lymphocyte.

1-2 group and the Normal group sign of healing are basically identical.

3-5 group medium size lymphocyte quantity is still lower than normal value.

 

Experimental data: the secondary pathogens such as salmonellosis or some virus cause lung, the heart, liver pathological changes, and cause a large amount of ascites to occur.

With the inhibition test for salmonella.

Get 3 parts of each 50g of pulvis, be respectively charged into 500ml small beaker, add the organic solvent methyl alcohol of pulvis 5 times of weight.Chloroform, benzinum.Soak 3 days under room temperature, filtering and concentrating, to paste, takes a certain amount of extract and adds Tween 80 and make emulsifying agent, 4 degrees Celsius of preservations,

Adopt growth rate method, the vigorous bacterial classification of 6mm colony edge is got with card punch, the PDA flat board being placed on dosing is cultivated, the sterilized water adding equivalent with culture medium contrasts, each repetition 3 times, is placed in 25 degrees Celsius of cultivations, surveys each colony diameter by right-angled intersection method, represent the diameter of bacterium colony with mean value, obtain growth rate=(contrast colony diameter-process colony diameter)/(contrast colony diameter-0.6) × 100% of anti-bacteria.

The extract of 3 kinds of organic solvents is made the PEA culture medium that final concentration is the extract of 1mg/ml, get the suspension 10ul prepared in advance, be inoculated into the culture dish central authorities that diameter is 9cm, logical spreader is smeared evenly, cultivate 48 hours in 25 degrees Celsius of incubators, calculate the growth rate of anti-bacteria.

Solvent	The colony diameter mm of 48h	Inhibiting rate	The colony diameter mm of 96h	Inhibiting rate
					Methyl alcohol	1.90	68.09	2.32	62.50
Chloroform	1.56	66.60	2.13	60.05
					Benzinum	2.32	44.81	3.47	41.20

Can find out that the Secondary cases pathogenic bacteria of protective agents of the present invention to salmonella and ascites have good inhibitory action by above-mentioned data

Toxicity is to the experiment of rat:

Acute oral (LD50) > 500mg/kg,

It is acute through skin (LD 50) > 2000mg/kg,

Belong to low toxicity.

 

Proportioning of the present invention is simple, and easy to use, prevention and cure dorking abdominal dropsy is effective, obviously can reduce the loss that therefore illness is brought to raiser, add vitamin C in feed, or compound vitamin element, maintains cylinder electrolyte balance, to relax stress reaction.The method of early silicosis, takes early stage appropriate limit to raise and can effectively reduce later ascites.Reduce by 15% feeding in the 3rd surrounding (15 days ~ 28 days) period of feeding of broiler, during 28 days normal feedings of later recovery, feed intake increases, and can make up to lose early stage to weigh, and delivers Normal-weight for sale.Material reducing mode can use night light turning off timing or timing dead slot, the generation of ascites symptoms can be reduced thus.

Urease inhibitor, significantly can reduce the death rate, its mechanism is to broiler feeding urease inhibitor, both inhibit the urease activity in small intestine and large intestine, again reduce the content of ammonia in small intestine and large intestine, thus reduce mucous membrane tissue turnover rate and the oxygen demand of portal vein row blood organ, so just there is more oxygen to utilize for body, eliminate the motive power causing ascites symptoms and death.

Sodium acid carbonate, in alkalescence, can reduce the incidence of dorking abdominal dropsy.For neutralizing acid intoxication conditions in feed, distend the blood vessels and pulmonary artery is reduced, thus reducing the incidence of disease of ascites symptoms.

And by adding protective agents, protection liver lung, protect the heart and enrich blood, diuresis is relieved oedema or abdominal distension through diuresis or purgation simultaneously promoting blood circulation and removing blood stasis, simultaneously antibacterial, and control secondary disease, greatly reduces incidence probability, reduces raiser's loss.

Claims (1)

1. a manufacture method for the feed of the cultivation of broiler chicken anti-chicken fowl ascites use, it is characterized in that, step is as follows:

Feed is expected substantially: corn 54-61%, dregs of beans 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone flour 1-1.2%, edible oil 2-3%, fish meal 2-3%, wheat bran 3-5%, oyster shell whiting 2-3%;

Auxiliary material: in calcium monohydrogen phosphate, calcium dihydrogen phosphate or calcium superphosphate any or several; Salt, urease inhibitors, sodium acid carbonate, vitamin C, protective agents are Chinese ephedra, the bighead atractylodes rhizome, Radix Isatidis, Lasiosphaera fenzlii, cattail pollen, root tuber of aromatic turmeric, motherwort, purple perilla, the root of kudzu vine, lophatherum gracile, cordate houttuynia, cape jasmine, akebi, ginseng, the fruit of Chinese magnoliavine, Phytolacca acinosa, wartwort, balloonflower root, honey-fried licorice root obtain pulvis;

Feed expects that each component is pulverized evenly substantially, and use mixer to stir, add clear water at ambient temperature, being adjusted to water content is 34-38%,

Stir after adding auxiliary material, use granulating disc granulation, gained granular size is 1-2mm.