CN103750060B - Feed for treating pig influenza and preparation method thereof - Google Patents
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- CN103750060B CN103750060B CN201410040063.XA CN201410040063A CN103750060B CN 103750060 B CN103750060 B CN 103750060B CN 201410040063 A CN201410040063 A CN 201410040063A CN 103750060 B CN103750060 B CN 103750060B
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Abstract
The invention discloses a feed for treating pig influenza and a preparation method thereof. The feed comprises the following raw materials: corn, wheat, fermented soybean pulp, whey powder, carrot powder, choline chloride, calcium hydrophosphate, soybean oil, salt and Chinese medicine additives. The feed has the benefits that as the feed contains Chinese medicine additives based on the treatment principles of exterior-interior syndrome relieving, heat clearing, detoxication, gloominess expelling, summer heat removing and dampness expelling, and the additives cooperate and interact with other raw materials in the feed to enhance the organism immunity of pigs, the feed has the advantages of rapid effect, good curative effect, no medicine residue and uneasiness of relapse after the disease is treated when being used for treating pig influenza, and has the health effect on a human body eating pork fed with the feed.
Description
Technical field
The present invention relates to pig feed technical field, particularly a kind of feed being used for the treatment of swine influenza and preparation method thereof.
Background technology
Swine influenza (English: swine influenza English abbreviation: swine flu) is that the one of pig is acute, infectiousness respiratory illness.It is characterized by burst, cough, expiratory dyspnea, generate heat and lapse to rapidly.Swine flu is the respiratory disease that pig body internal cause virus causes.Swine flu is caused by influenza A virus (influenza A), usually breaks out between pig, and infectiousness is very high but usually can not cause death.Autumn and winter belongs to the high-incidence season, but the whole year can propagate.One of swine flu is recognized as influenza virus C (C type influenza virus) more, or the subspecies of influenza A virus.This virus can cause Influenza Outbreak in swinery.The mankind little infected pigs influenza virus under normal circumstances.
The incidence of disease of this disease is high, and incubation period is 2 ~ 7 days, the course of disease about 1 week.Sick pig early stage generates heat suddenly, lassitude, anorexia or absolutely useless, and normal accumbency together, is reluctant activity, and expiratory dyspnea, fierce cough, eye nose flows out mucus.If in period of disease treatment not in time, then easy concurrent bronchitis, pneumonia and pleurisy etc., increase the case fatality rate of pig.Sick temperature of pig body raises and reaches 40 DEG C ~ 41.5 DEG C, and spirit is depressed, anorexia or do not eat, myalgia, is reluctant to stand, and eye and nose have viscous liquid to flow out, conjunctival congestion, indivedual sick pig expiratory dyspnea, breathes, cough, in abdominal respiration, there is sitting position of dog gesture, disease pig whoop can be heard at night, indivedual sick pig arthralgia, especially the morbidity of the growth of livestock good pig is more serious.Sow infected in period of pregnancy, and the piglet given birth to is very heavy in morbidity in 2 ~ 5 days postpartum, and some is dead before and after lactation and wean.Cuing open inspection visible larynx, tracheae and bronchus is full of containing alveolate mucus, and mucous membrane is congested, swelling, time and be mixed with blood, interstitial lung is broadening, enlargement of lymph nodes, congested, splenomegaly, gastrointestinal mucosa has catarrh hemorrhagic inflammation, the liquid of splanchnocoel, cavum pericardiale accumulation cellulose-containing mass.The pig of each age, sex and kind has neurological susceptibility to this virus.The popular of this disease has obvious seasonality, and the winter of weather changeable autumn Mo, early spring and cold easily occurs.This disease is propagated rapidly, normal in endemic conditions or be very popular.This sick incidence of disease is high, the death rate low (4% ~ 10%).Sick pig and the malicious pig of band are the infections sources of swine flu, pig band poison 6 ~ 8 weeks after ill recovery from illness.
Swine influenza is caused by swine influenza virus, many sudden onset, body temperature 40-41 DEG C, expiratory dyspnea, cough, and eye nose flows out slurry property liquid.Current treatment use antibiotic, the medicine such as antiviral, drug residue is large, and easily produce drug resistance, the state of an illness easily repeatedly, has certain adverse effect for body health after people eat this type of pork.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed being used for the treatment of swine influenza and preparation method thereof, containing Chinese medicine additive in feed, the defect of prior art Chinese and Western medicine can be overcome, to the treatment strengthening vital QI to eliminate pathogenic factors of pig suffering from swine influenza, cure rate is high, has no side effect, evident in efficacy, have no drug resistance, drug residue free, the advantage not easily recurred.
In order to realize foregoing invention object, the invention provides the feed being used for the treatment of swine influenza, described feed comprises following raw material: corn, wheat, fermented bean dregs, whey powder, carrot meal, Choline Chloride, calcium monohydrogen phosphate, soybean oil, salt and Chinese medicine additive.
Described feed is made up of the raw material of following parts by weight: corn 30-50 weight portion, wheat 30-40 weight portion, fermented bean dregs 20-40 weight portion, whey powder 10-20 weight portion, carrot meal 10-20 weight portion, Choline Chloride 5-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 1-5 weight portion and Chinese medicine additive 3-7 weight portion.
Described feed is made up of the raw material of following parts by weight: corn 35-45 weight portion, wheat 33-38 weight portion, fermented bean dregs 25-35 weight portion, whey powder 12-18 weight portion, carrot meal 12-18 weight portion, Choline Chloride 6-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 2-5 weight portion and Chinese medicine additive 4-6 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Poria cocos, hare's-lettuce, the capsule of weeping forsythia, the red sage root, polyporus lucidus, caecum grass, folium isatidis, champion wood fern rhizome, mulberry leaf, root of Compact Incarvillea, Chinese alpine rush and Radix Glycyrrhizae.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion and Radix Glycyrrhizae 10-20 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion and Radix Glycyrrhizae 13-17 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portion, Radix Codonopsis 17 weight portion, Poria cocos 20 weight portion, hare's-lettuce 13 weight portion, the capsule of weeping forsythia 17 weight portion, the red sage root 15 weight portion, polyporus lucidus 13 weight portion, caecum grass 15 weight portions, folium isatidis 20 weight portion, champion wood fern rhizome 15 weight portion, mulberry leaf 15 weight portion, root of Compact Incarvillea 13 weight portion, Chinese alpine rush 18 weight portion and Radix Glycyrrhizae 15 weight portion.
Described feed also comprises ginger, Kiwi berry, the bletilla striata, schizonepeta, Sha Peng and dried orange peel, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, ginger 10-20 weight portion, Kiwi berry 10-15 weight portion, bletilla striata 12-20 weight portion, schizonepeta 15-20 weight portion, husky fluffy 10-15 weight portion and dried orange peel 10-20 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion, Radix Glycyrrhizae 13-17 weight portion, ginger 13-16 weight portion, Kiwi berry 12-15 weight portion, bletilla striata 14-17 weight portion, schizonepeta 15-17 weight portion, husky fluffy 12-15 weight portion and dried orange peel 13-17 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portion, Radix Codonopsis 17 weight portion, Poria cocos 20 weight portion, hare's-lettuce 13 weight portion, the capsule of weeping forsythia 17 weight portion, the red sage root 15 weight portion, polyporus lucidus 13 weight portion, caecum grass 15 weight portions, folium isatidis 20 weight portion, champion wood fern rhizome 15 weight portion, mulberry leaf 15 weight portion, root of Compact Incarvillea 13 weight portion, Chinese alpine rush 18 weight portion, Radix Glycyrrhizae 15 weight portion, ginger 15 weight portion, Kiwi berry 13 weight portion, the bletilla striata 16 weight portion, schizonepeta 16 weight portion, husky fluffy 13 weight portions and dried orange peel 16 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 2 ~ 4 hours, and the amount of the water added and the mass ratio of mixture are 6 ~ 9:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, the dregs of a decoction after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 2 ~ 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 6 ~ 10:1, decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain the clear cream of mixture, under 60 DEG C of conditions, the relative density of clear cream is 1.10 ~ 1.20;
5th step, adds the ethanol that determining alcohol is 95% in the clear cream of mixture, and obtain containing the clear cream of alcohol, the mass ratio of the ethanol added and clear cream is 2 ~ 3:1;
6th step, at room temperature will leave standstill 12 ~ 24h containing the clear cream of alcohol, get supernatant, clear cream residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, be ground into powder, obtain pulvis.
In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the feed of swine influenza, described preparation method comprises the following steps:
Take corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Raw material after pulverizing and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive are all dropped into mixer, and mix, incorporation time is 3 minutes;
Drop into granulator to granulate, pelleting temperature is 75-85 DEG C.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contain with relieving exterior-interior syndrome, clearing heat and detoxicating, a surname Xie Yangyu, eliminate summer heat and remove dampness as the Chinese medicine additive of principle of reatment, cooperatively interact with other feedstuffs, acting in conjunction, pig body resistance can be strengthened, have rapid-action in treatment swine influenza, good effect, drug residue free, the advantage not easily recurred after being ill, and people also can play certain health-care effect to body after eating this type of pork.
Detailed description of the invention
Chinese veterinarian's theory is thought, swine influenza is because the outer heresy of the six external factors which cause diseases causes the evil pig body of invading of epidemic disease poison to defend table, so that it is disharmony between ying and wei, lung is defended and is lost admittedly, the present invention is with relieving exterior-interior syndrome, clearing heat and detoxicating, a surname Xie Yangyu, eliminate summer heat and remove dampness as principle of reatment, provide a kind of feed being used for the treatment of swine influenza, the Chinese medicine additive in feed comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Poria cocos, hare's-lettuce, the capsule of weeping forsythia, the red sage root, polyporus lucidus, caecum grass, folium isatidis, champion wood fern rhizome, mulberry leaf, root of Compact Incarvillea, Chinese alpine rush and Radix Glycyrrhizae.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Admittedly de-for invigorating qi for consolidating superficies, arrest sweating, to hold in the palm sore myogenic, inducing diuresis for removing edema effect." book on Chinese herbal medicine meets former " carries: all void of Radix Astragali energy tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rushes down yin fire, remove lung heat, lossless, sends out, has sweat then to stop.Be used for the treatment of the deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The bowl spares of astragalus root benefit gas, raw by solid table holder sore.The Radix Astragali is the good medicine promoting resistance and defence disease.
Radix Codonopsis: property is put down, sweet, the micro-acid of taste.Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy tonifying spleen nourishing the stomach, and moistening lung is promoted the production of body fluid, and gas in tendon fortune, this is very mutually not far away with ginseng.Its outstanding valuable person, then invigorating the spleen fortune and not dry, grow stomach-Yin and not wetting, moistening lung and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration, and without just dry fraud.Radix Astragali tonifying Qi, can enriching spleen-QI be risen, can admittedly show by beneficial lung again.Radix Codonopsis tonifying Qi, can only invigorating the spleen tonifying Qi, and without the power of solid table, but Radix Codonopsis can also nourishing generate fluid, and the Radix Astragali is then without the effect of promoting the production of body fluid, and the Radix Astragali double energy Li Shui, Radix Codonopsis acts on without Li Shui.This two tastes medicine share can tonifying middle-Jiao and Qi, improves resistance.
Poria cocos: sweet, light is flat.The thoughts of returning home, lung, spleen, kidney channel.Function clearing damp and promoting diuresis, the peaceful heart of invigorating the spleen.For oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, has loose bowels in loose stool, confused and worried, palpitation with fear insomnia.Eliminating dampness and diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, and the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful." herbal classic " carries it: " the inverse gas of the main chest side of body, sorrow is angerd frightened heresy and probably throbbed with fear, knot pain under the heart, and fever and chills dysphoria, coughs inverse, and the burnt tongue of mouth is done, diuresis." " not Lu ": " only quench one's thirst, like to sleep, large abdomen, drench drop, phlegm water in diaphragm, oedema drenches knot.Open chest internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, beneficial strength, during guarantor god keeps." " property of medicine opinion ": " appetizing, preventing or arresting vomiting is inverse, kind tranquilizing mind.Main consumptive lung disease phlegm is stopped up.Control pediatric epilepsy scared, trusted subordinate's turgor, married woman's heat is drenched.”
Hare's-lettuce: bitter; Cold in nature.Function cures mainly: clearing heat and detoxicating.Main jaundice; Gastritis; Dysentery; Cough with lung heat; Intestines produce swollen; Orchitis; Parent's sore; Carbuncle swells; Impetigo.
The capsule of weeping forsythia: bitter, cold nature, enters the heart, liver, courage, small intestinl channel, have clearing heat and detoxicating, the effect of dispersing swelling and dissipating binds, for ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease from the beginning of, warmly to join the army, high hot polydipsia, coma sends out spot, and heat drenches the treatment of the cards such as renal shutdown, has very strong inhibitory action to shigella dysenteriae, staphylococcus aureus.
The red sage root: bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect.. " detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
Polyporus lucidus: sweet, flat.Function cures mainly: control consumptive disease, cough, asthma, insomnia, indigestion.
Caecum grass: taste is sweet; Micro-hardship; Cool in nature.Function cures mainly: heat-clearing; Removing toxic substances; Dampness removing; Invigorating the spleen.Main influenza; Abscess of throat; Icterohepatitis; Summer-heat and damp is vomited and diarrhoea; Enteritis; Dysentery; Acute appendicitis; Infantile malnutrition; Deficiency of blood Huang is swollen; Hemorrhoid; Snake bite and insect sting.
Folium isatidis: be mainly used in heat poison and send out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.This medicine extensive use clinically in recent years, controls except above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, Huang of coughing up phlegm is thick; Especially be usually used in popular second encephalitis, both can be applied to prevention by single, and radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, the dried rhizome of rehmannia etc. can be coordinated again, can removing summer-heat gas divide, the heat of seek point is malicious, availablely control various encephalitis, and comparatively suitable with partial heat type." detailed outline ": " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi separates Chinese blister beetle, Yuan green grass or young crops, tree of heaven chicken, cinnabar, arsenolite poison." " book on Chinese herbal medicine is just ": " control the hot poison of pestilence to go mad, wind-heat macula, large carbuncle swells and ache, relieving thirst and restlessness, only nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.Allly to hold concurrently malicious person with heat, all should smash juice and use it by blue leaf.”
Champion wood fern rhizome: bitter is flat, nontoxic.Return lung; Large intestine channel.Function cures mainly: clearing heat and detoxicating; Relieving asthma; Arresting bleeding and treating cutaneous pyogenic infection; Expelling parasite.Main flu; Hot eyes catches pain; Asthma; Have blood in stool; Sore festers; Scald; Hookworm disease.
Mulberry leaf: sweet, bitter, cold.Return lung, Liver Channel.Function cures mainly: dispelling wind and heat from the body, and clearing away the lungheat and moisturizing is clear liver and improved vision.For anemopyretic cold, lung-heat type cough, dizziness headache, hot eyes is dim-sighted.
Root of Compact Incarvillea: bitter; Micro-sweet; Property is put down.Return liver, spleen, lung, stomach four warp.Function cures mainly: heat-clearing; Fresh poison; Eliminating dampness; Help digestion.Main heating; Jaundice; Tympanitis; Indigestion; Stomachache; Abdominal distention constipation.
Chinese alpine rush: sweet, light, flat.Function cures mainly: heat clearing and inflammation relieving, flat liver improving eyesight, hemostasis.Cure mainly flu, hepatitis, infantile pneumonia, mastitis, urticaria, puerperal fever, stomachache, traumatism and bleeding.
Radix Glycyrrhizae: property is put down, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Chinese medicine additive of the present invention also comprises: ginger, Kiwi berry, the bletilla striata, schizonepeta, Sha Peng and dried orange peel.
Ginger: warm in nature, its distinctive " gingerol " energy stimulating gastrointestinal mucous membrane, make gastrointestinal redness, digestion power strengthens, and effectively can treat the abdominal distension, stomachache, diarrhoea, vomiting etc. of eating cold and cool food and too much causing.After eating ginger, people has the sensation of body heat, this is because it can distend the blood vessels, blood circulation is accelerated, and impels pore with it to open, so not only the unnecessary torrid zone can be walked, also the germ in body, cold air are together taken out of simultaneously.When health has eaten cold and cool thing, be subject to drench with rain or stay in air-conditioned room long afterwards, eaten ginger and just can eliminate in time because human body is trembled with fear the various discomforts remake.For the pungent stomachic tonic of armaticity, have the effects such as warm, excited, sweating, preventing or arresting vomiting, removing toxic substances, warm lung cough-relieving, especially for fish crab poison, the drug poisoning such as the tuber of pinellia, rhizoma arisaematis has detoxication.Be applicable to catch cold, have a headache, phlegm and retained fluid, cough, gastrofrigid vomiting; After suffering wet, the cold invasion and attack of ice and snow, water, suddenly drink it with ginger decoction, can blood be promoted, disperse cold-evil.
Kiwi berry: sweet; Acid; Cold.Return kidney; Stomach; Courage; The spleen channel.Function cures mainly: antipyretic; Quench the thirst; Stomach invigorating; Treating stranguria.Main dysphoria with smothery sensation; Quench one's thirst; Lung heat dry cough; Indigestion; Jaundice with damp-heat pathogen; Urolithiasis; Hemorrhoid.
The bletilla striata: bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatism and bleeding, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle swells, dislike sore, lose subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach " Compendium of Material Medica: " smell (root) is bitter, flat, nontoxic.
Schizonepeta: taste is pungent, slightly warm in nature, enters lung, Liver Channel, has inducing sweat and dispelling exogenous evils, declares malicious promoting eruption, and the effect of blood hemostasis, and no matter the fever and headache that the wind-heat that is mainly used in catching cold is caused, have sweat lossless, all can apply; The headache that wind-heat is attacked is dizzy, and rash goes out not saturating; Postpartum anemic fainting apoplexy, the cards such as discharging fresh blood stool.
Sha Peng: sweet is cool.Function cures mainly: deliver antipyretic.Cure mainly cat fever, ephritis.
Dried orange peel: regulating the flow of Qi and the middle Jiao, eliminating dampness and eliminating phlegm, sharp water defaecation.Cure mainly incoordination between the spleen and the stomach, abdominal distention, do not feel like eating, vomiting hiccup; Phlegm-damp obstructing lung, coughing with a lot of sputum, chest diaphragm is full vexed, vertigo; Oedema, difficult urination, constipation; Acute mastitis sore tinea, middle fish crab poison, wine are malicious.For diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, for lung qi gather around stagnant, chest diaphragm ruffian full and the disease such as the taste stagnation of the circulation of vital energy, abdominal fullness and distention.Temperature eliminating dampness and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Being good at again eliminating dampness and eliminating phlegm, stopping up the conventional key medicine of lung, the many coughs of phlegm for controlling wet phlegm, often use together with the tuber of pinellia, Poria cocos.Reduce for insufficiency of the spleen diet, indigestion, and the disease such as n and V, eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizings, indigestion, stool diarrhea, often and the fit applications such as ginseng, the bighead atractylodes rhizome, Poria cocos.Because it can invigorating the spleen, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect.In addition, orange peel again can with in, stomach Qi rising, n and V can be controlled.
Embodiment 1 feed 1
Embodiments provide a kind of feed being used for the treatment of swine influenza, be made up of the raw material of following parts by weight: corn 32 weight portion, wheat 40 weight portion, fermented bean dregs 37 weight portion, whey powder 12 weight portion, carrot meal 20 weight portion, Choline Chloride 5 weight portion, calcium monohydrogen phosphate 3 weight portion, soybean oil 3 weight portion, salt 2 weight portion and Chinese medicine additive 4 weight portion.
Wherein, Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portion, Radix Codonopsis 17 weight portion, Poria cocos 20 weight portion, hare's-lettuce 13 weight portion, the capsule of weeping forsythia 17 weight portion, the red sage root 15 weight portion, polyporus lucidus 13 weight portion, caecum grass 15 weight portions, folium isatidis 20 weight portion, champion wood fern rhizome 15 weight portion, mulberry leaf 15 weight portion, root of Compact Incarvillea 13 weight portion, Chinese alpine rush 18 weight portion and Radix Glycyrrhizae 15 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 4 hours, and the amount of the water added and the mass ratio of mixture are 8:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, the dregs of a decoction after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 10:1, decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain the clear cream of mixture, under 60 DEG C of conditions, the relative density of clear cream is 1.20;
5th step, adds the ethanol that determining alcohol is 95% in the clear cream of mixture, and obtain containing the clear cream of alcohol, the mass ratio of the ethanol added and clear cream is 3:1;
6th step, at room temperature will leave standstill 20h containing the clear cream of alcohol, get supernatant, clear cream residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, be ground into powder, obtain pulvis.
Embodiment of the present invention Chinese medicine additive can be used alone, soluble in water by Chinese medicine additive, and each 5-8g Chinese medicine additive, every day gavages for 1-3 time.
The preparation method of the feed of the embodiment of the present invention comprises the following steps:
Take corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 30 orders;
Raw material after pulverizing and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive are all dropped into mixer, and mix, incorporation time is 3 minutes;
Drop into granulator to granulate, pelleting temperature is 80 DEG C.
Embodiment 2 feed 2
Embodiments provide a kind of feed being used for the treatment of swine influenza, described feed is made up of the raw material of following parts by weight: corn 41 weight portion, wheat 35 weight portion, fermented bean dregs 30 weight portion, whey powder 15 weight portion, carrot meal 15 weight portion, Choline Chloride 7 weight portion, calcium monohydrogen phosphate 4 weight portion, soybean oil 4 weight portion, salt 3 weight portion and Chinese medicine additive 5 weight portion.
Wherein, Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portion, Radix Codonopsis 17 weight portion, Poria cocos 20 weight portion, hare's-lettuce 13 weight portion, the capsule of weeping forsythia 17 weight portion, the red sage root 15 weight portion, polyporus lucidus 13 weight portion, caecum grass 15 weight portions, folium isatidis 20 weight portion, champion wood fern rhizome 15 weight portion, mulberry leaf 15 weight portion, root of Compact Incarvillea 13 weight portion, Chinese alpine rush 18 weight portion, Radix Glycyrrhizae 15 weight portion, ginger 15 weight portion, Kiwi berry 13 weight portion, the bletilla striata 16 weight portion, schizonepeta 16 weight portion, Sha Peng 13 weight portion and dried orange peel 16 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 3 hours, and the amount of the water added and the mass ratio of mixture are 7:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, the dregs of a decoction after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 3 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 8:1, and decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain the clear cream of mixture, under 60 DEG C of conditions, the relative density of clear cream is 1.10;
5th step, adds the ethanol that determining alcohol is 95% in the clear cream of mixture, and obtain containing the clear cream of alcohol, the mass ratio of the ethanol added and clear cream is 3:1;
6th step, at room temperature will leave standstill 18h containing the clear cream of alcohol, get supernatant, clear cream residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, be ground into powder, obtain pulvis.
Embodiment of the present invention Chinese medicine additive can be used alone, soluble in water by Chinese medicine additive, and each 5-8g Chinese medicine additive, every day gavages for 1-3 time.
The preparation method of the feed of the embodiment of the present invention comprises the following steps:
Take corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 40 orders;
Raw material after pulverizing and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive are all dropped into mixer, and mix, incorporation time is 3 minutes;
Drop into granulator to granulate, pelleting temperature is 85 DEG C.
Challenge test
1, acute toxicity test
Require to carry out prerun according to acute toxicity test, find that test medicine cannot measure LD50.Therefore carry out maximum dosage-feeding test in a day.Get above-mentioned mouse 40, fasting can't help water after 12 hours, administration group and water control group is divided at random by body weight, often organize 20, administration group gives the liquid 0.4ml/10g of the crude drug amount 2.4g/ml concentration of the Chinese medicine additive prepared containing embodiment 1, gavage one day 2 times, make dosage in a day reach symphysis dose 192.0g/kg, water control group is to the water of equal volume.After each treated animal administration, 5, every box, normal raising, close observation, equal Continuous Observation seven days, the toxic reaction that record may occur and death condition, after administration, mouse outward appearance hair color light, behavioral activity is normal, pathologic neural reflex without exception occurs, in seven days, feed is good, and other Novel presentation is seen at end, changes of weight no significant difference and none animal dead compared with water control group, visually observe the main organs such as the heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, the test result of result as embodiment 1 Chinese medicine additive is identical.
2, long term toxicity test
The Chinese medicine additive of the embodiment of the present invention 1 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mouse, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat of Chinese medicine additive to mouse of the embodiment of the present invention 1 all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the Chinese medicine additive of the embodiment of the present invention 1 is little to toxicity after mouse long-term prescription, also there is no difference reaction after drug withdrawal, application safety.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, the test result of result as embodiment 1 Chinese medicine additive is identical.
Clinical testing
(1) animal used as test
In by the end of November, 2011, certain pig farm finds the pig anorexia or absolutely useless of nearly about 20, avoirdupoisly sleeping be reluctant activity, expiratory dyspnea together, eye nose flows out mucus, after one week, find that pig farm has 400 pigs nearly all to occur above-mentioned symptom, ill temperature of pig body is increased to more than 40 DEG C, conjunctival congestion, the higher pig state of an illness of body weight is existing to seriously.Random choose ill pig is cutd open inspection and finds, ill pig larynx, tracheae and bronchus are full of containing alveolate mucus, and mucous membrane is congested, swelling, enlargement of lymph nodes, congested, the liquid of splanchnocoel, cavum pericardiale accumulation cellulose-containing mass.Being diagnosed as swinery and suffering from influenza, choosing 180 ill pigs as supplying examination animal.
(2) test method
Adopt random device to be divided into three groups by 180 for examination animal, often organize 60 ill pigs, adopt the feed (embodiment group 1) of the embodiment of the present invention 1, the feed (embodiment group 2) of embodiment 2 and Panadinum parenteral solution (control group) to treat respectively.Wherein, the feed of embodiment group 1 and 2 conveniently feed mode feed; The Panadinum parenteral solution 4-6ml intramuscular injection of control group, once a day, conventional feed of feeding.Test period is 3-5 days.
(3) criterion of therapeutical effect
Recovery from illness: spirit, body temperature and appetite all recover normal, respiratory symptom disappears, and eye nose flows out without mucus, is judged to be recovery from illness;
Effective: spirit, body temperature and appetite recover normal substantially, and respiratory symptom is clearly better, eye nose mucus flows out symptom and alleviates, and is judged to be effectively;
Invalid: after medication, symptom does not alleviate and even increases the weight of.
Wherein, recovery from illness and effective percentage sum are counted efficient.
(4) treatment results
Result for the treatment of is as shown in table 1, from result for the treatment of, adopts feed of the present invention to be more than 95% to the treated effect of swine influenza, higher than control group.
The table 1 result for the treatment of table of comparisons
Data as can be seen from table 1: compared with control group, use the feed of the embodiment of the present invention 1 and embodiment 2 treatment swine influenza to have evident in efficacy, that cure rate is high advantage.Often group selects recovery from illness pig 5 as experimental subjects, and pig is mixed in ill pigsty after label respectively, feeds according to normal feed mode, through bimestrial observation, find embodiment group 1 and embodiment group 2 pig again the incidence of disease be starkly lower than the pig of control group.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. be used for the treatment of the feed of swine influenza, it is characterized in that, described feed is made up of the raw material of following parts by weight: corn 30-50 weight portion, wheat 30-40 weight portion, fermented bean dregs 20-40 weight portion, whey powder 10-20 weight portion, carrot meal 10-20 weight portion, Choline Chloride 5-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 1-5 weight portion and Chinese medicine additive 3-7 weight portion;
Described Chinese medicine additive comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Poria cocos, hare's-lettuce, the capsule of weeping forsythia, the red sage root, polyporus lucidus, caecum grass, folium isatidis, champion wood fern rhizome, mulberry leaf, root of Compact Incarvillea, Chinese alpine rush and Radix Glycyrrhizae;
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion and Radix Glycyrrhizae 10-20 weight portion;
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 2 ~ 4 hours, and the amount of the water added and the mass ratio of mixture are 6 ~ 9:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, the dregs of a decoction after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 2 ~ 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 6 ~ 10:1, decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain the clear cream of mixture, under 60 DEG C of conditions, the relative density of clear cream is 1.10 ~ 1.20;
5th step, adds the ethanol that determining alcohol is 95% in the clear cream of mixture, and obtain containing the clear cream of alcohol, the mass ratio of the ethanol added and clear cream is 2 ~ 3:1;
6th step, at room temperature will leave standstill 12 ~ 24h containing the clear cream of alcohol, get supernatant, clear cream residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, be ground into powder, obtain pulvis.
2. the feed being used for the treatment of swine influenza according to claim 1, it is characterized in that, described feed is made up of the raw material of following parts by weight: corn 35-45 weight portion, wheat 33-38 weight portion, fermented bean dregs 25-35 weight portion, whey powder 12-18 weight portion, carrot meal 12-18 weight portion, Choline Chloride 6-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 2-5 weight portion and Chinese medicine additive 4-6 weight portion.
3
.the feed being used for the treatment of swine influenza according to claim 1, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion and Radix Glycyrrhizae 13-17 weight portion.
4
.the feed being used for the treatment of swine influenza according to claim 1, is characterized in that, described feed also comprises ginger, Kiwi berry, the bletilla striata, schizonepeta, Sha Peng and dried orange peel, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, ginger 10-20 weight portion, Kiwi berry 10-15 weight portion, bletilla striata 12-20 weight portion, schizonepeta 15-20 weight portion, husky fluffy 10-15 weight portion and dried orange peel 10-20 weight portion.
5
.the feed being used for the treatment of swine influenza according to claim 4, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion, Radix Glycyrrhizae 13-17 weight portion, ginger 13-16 weight portion, Kiwi berry 12-15 weight portion, bletilla striata 14-17 weight portion, schizonepeta 15-17 weight portion, husky fluffy 12-15 weight portion and dried orange peel 13-17 weight portion.
6
.the preparation method being used for the treatment of the feed of swine influenza as described in any one of claim 1-5, is characterized in that, described preparation method comprises the following steps:
Take corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate by ratio of weight and the number of copies, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Raw material after pulverizing and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive are all dropped into mixer, and mix, incorporation time is 3 minutes;
Drop into granulator to granulate, pelleting temperature is 75-85 DEG C.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104083691A (en) * | 2014-05-28 | 2014-10-08 | 青岛华仁技术孵化器有限公司 | Medicine feed additive for controlling pig influenza |
| CN104082538B (en) * | 2014-05-28 | 2016-05-11 | 张绪伟 | For preventing and treating the feed of swine influenza |
| CN104115993A (en) * | 2014-05-30 | 2014-10-29 | 安徽省正大源饲料集团有限公司 | Animal feed capable of preventing respiratory diseases of animals |
| CN104366018A (en) * | 2014-12-10 | 2015-02-25 | 叶红 | Feed for preventing swine influenza and method for manufacturing feed |
| CN105851595A (en) * | 2016-05-31 | 2016-08-17 | 李加义 | Piglet feed additive |
| CN105995094A (en) * | 2016-05-31 | 2016-10-12 | 李加义 | Feed additive for medium pigs |
| CN107136012A (en) * | 2017-05-19 | 2017-09-08 | 巍山县瑞丰牧业有限责任公司 | Feeding live pig management method |
| CN107198043A (en) * | 2017-06-20 | 2017-09-26 | 宁国市仙之居家庭农场 | A kind of Chinese medicine pig feed including the bletilla striata and preparation method thereof |
| CN107373057A (en) * | 2017-07-31 | 2017-11-24 | 百色金陵农牧有限公司 | A kind of diseases prevention pig feed |
| CN107279501A (en) * | 2017-08-04 | 2017-10-24 | 哈尔滨千合动物药品制造有限公司 | A kind of feed for animals with resisiting influenza virus and preparation method thereof |
| SG10201914042SA (en) * | 2019-12-31 | 2021-07-29 | Xj Bio Engineering Int Pte Ltd | Feed additive for preventing african swine fever disease or replacing antibiotic growth promoters and methods of making and using the same |
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| CN102038097A (en) * | 2010-09-14 | 2011-05-04 | 周剑峰 | Feed additive for preventing and treating swine influenza |
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