CN103341151A - Traditional Chinese medicine for treating chronic bronchitis - Google Patents
Traditional Chinese medicine for treating chronic bronchitis Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating chronic bronchitis. The traditional Chinese medicine comprises the following active pharmaceutical ingredients: white mustard seed, membranous milkvetch root, bitter apricot seed, cassia twig, honeysuckle flower, inula flower, manchurian wildginger, Chinese date, saffron, cattail pollen, amur corktree bark, radish seed, mulberry leaf, common macrocarpium fruit, coix seed, immature bitter orange, tangerine peel, dried ginger and rubus corchorifolius leaf. Compared with western medicine treatment, the traditional Chinese medicine can be used for treatment on the whole, and has the advantages of no toxicity, no side effect, no medicament resistance, good effect and no recurrence of diseases.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine that is used for the treatment of chronic bronchitis.
Background technology
Chronic bronchitis is by infecting or the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue that non-infective agent causes, being common clinical, frequently-occurring disease.Good sending out in winter and spring, outbreak repeatedly, touching difficulty is more.
Current social tobacco and wine culture in vogue for people's doings provide auxiliary element, but also brought threat for people healthy simultaneously, and tobacco and wine also are one of factors of bringing out chronic bronchitis.Life stress causes work fatigue, and overtired also is to bring out one of this sick reason, and courses of infection, virus, irritative gas, cold weather etc. all can cause bronchial mucosa impaired in addition, bring out the generation of chronic bronchitis diseases.
This disease is clinical in cough, and companion's expectoration, panting is feature, can concurrent obstructive emphysema even pulmonary heart disease when serious, cause patient respiratory difficulty or heart failure.Any ages crowd all can fall ill, be more common in middle-aged and elderly people, show that according to interrelated data the sickness rate of China's crowd's chronic bronchitis more than 50 years old is about 15%, along with the increasing the weight of day by day of aged tendency of population and environmental pollution, its sickness rate is more and more higher in recent years.The patient has allergies, and prolonged and repeated virus and bacterial infection, immunity of organisms reduce and some chemical factors etc. can be brought out primary disease, with multiple when cold season autumn and winter or the temperature cataclysm.Patient Chang Yin outbreak repeatedly, protracted course of disease, the course of disease are long and hospitalization repeatedly not only can have a strong impact on patient's quality of life, and can increase the burden of patient family and society.
Western medical treatment is all selected antiinflammatory, apophlegmatisant for use, generally uses antibiotic therapy, and symptom can be alleviated, but cough, expectoration easily recurs, and side effect is more.Treatment causes curative effect to descend easily to antibiotic and antiviral agents deposits yields drug resistance repeatedly.Western medical treatment biases toward anti symptom treatment more, for the patient that shows effect repeatedly, often is difficult to obtain effect preferably.
Chronic bronchitis patient has cough, white, the uncomfortable in chest asthma of expectorant more and meets the heavy performance of cold rnning, the many genus of Chinese medical discrimination are suffered from a deficiency of the kidney and are not received, stagnation of phlegm-damp so be the Therapeutic Principle with " organic conception " " treatment must aim at the pathogenesis of disease " " treating both the principal and secondary aspects of a disease ", has the advantage that western medical treatment does not have.
Summary of the invention
Technical problem to be solved by this invention provides a kind of Chinese medicine that is used for the treatment of chronic bronchitis,
With respect to western medical treatment, it can be treated on the whole, has no side effect and drug resistance, and is respond well, and the state of an illness is not repeatedly.
Accordingly, the invention provides a kind of Chinese medicine that is used for the treatment of chronic bronchitis, its crude drug comprises:
Semen Sinapis Albae, the Radix Astragali, Semen Armeniacae Amarum, Ramulus Cinnamomi, Flos Lonicerae, Flos Inulae, Herba Asari, Fructus Jujubae, Stigma Croci, Pollen Typhae, Cortex Phellodendri, Semen Raphani, Folium Mori, Fructus Corni, Semen Coicis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and compound in rubus corchorifolius leaf.
Wherein, described Chinese medicine only is made of above-mentioned raw materials medicine component.
Wherein, the weight portion of each crude drug is respectively Semen Sinapis Albae 22 ~ 28 weight portions in the described Chinese medicine, the Radix Astragali 41 ~ 53 weight portions, Semen Armeniacae Amarum 27 ~ 35 weight portions, Ramulus Cinnamomi 37 ~ 46 weight portions, Flos Lonicerae 18 ~ 26 weight portions, Flos Inulae 12 ~ 19 weight portions, Herba Asari 19 ~ 25 weight portions, Fructus Jujubae 27 ~ 33 weight portions, Stigma Croci 21 ~ 28 weight portions, Pollen Typhae 18 ~ 23 weight portions, Cortex Phellodendri 30 ~ 40 weight portions, Semen Raphani 32 ~ 37 weight portions, Folium Mori 22 ~ 29 weight portions, Fructus Corni 35 ~ 41 weight portions, Semen Coicis 20 ~ 29 weight portions, Fructus Aurantii Immaturus 30 ~ 36 weight portions, Pericarpium Citri Reticulatae 26 ~ 30 weight portions, Rhizoma Zingiberis 27 ~ 33 weight portions and compound in rubus corchorifolius leaf 15 ~ 23 weight portions.
Wherein, the weight portion of each crude drug is respectively Semen Sinapis Albae 26 weight portions, the Radix Astragali 46 weight portions, Semen Armeniacae Amarum 31 weight portions, Ramulus Cinnamomi 41 weight portions, Flos Lonicerae 22 weight portions, Flos Inulae 16 weight portions, Herba Asari 22 weight portions, Fructus Jujubae 30 weight portions, Stigma Croci 25 weight portions, Pollen Typhae 20 weight portions, Cortex Phellodendri 35 weight portions, Semen Raphani 35 weight portions, Folium Mori 26 weight portions, Fructus Corni 38 weight portions, Semen Coicis 25 weight portions, Fructus Aurantii Immaturus 33 weight portions, Pericarpium Citri Reticulatae 29 weight portions, Rhizoma Zingiberis 30 weight portions and compound in rubus corchorifolius leaf 20 weight portions in the described Chinese medicine.
Wherein, described Chinese medicine can be prepared into syrup and granule.
Preparation method of Chinese medicine provided by the invention when the dosage form of described Chinese medicine is granule, is specially:
Above-mentioned raw materials medicine component is mixed in proportion; decoct with water twice, the 1 time and add with respect to 6～8 times of water gagings of mixture quality, decocted 2 hours; add for the 2nd time with respect to 4～6 times of water gagings of mixture quality; decocted 1 hour, and filtered merging filtrate; be concentrated into the clear paste that every 1ml contains the 1g medical material approximately; adding hydrochloric acid accent pH is 1, and the limit edged stirs, and leaves standstill; with siphonage sucking-off supernatant; the precipitate sucking filtration washes with water to there not being obviously acidity to doing, and takes out drying precipitate; pulverize; obtaining dry powder, add subsequently with respect to dry powder quality 20% ~ 30% cane sugar powder (mass percent), is 75% ~ 85% ethanol soft material processed with determining alcohol; granulate with oscillating granulator; 60 ℃ of oven dry down, granulate gets granule.
Preparation method of Chinese medicine provided by the invention when the dosage form of described Chinese medicine is syrup, is specially:
Above-mentioned raw materials medicine component is mixed in proportion, decocts with water twice, the 1 time and add with respect to 6～8 times of water gagings of mixture quality, decocted 2 hours, add for the 2nd time with respect to 4～6 times of water gagings of mixture quality, decocted 1 hour, filter, merging filtrate, be concentrated into the clear paste that every 1ml contains the 1g medical material approximately, adding hydrochloric acid accent pH is 1, and the limit edged stirs, leave standstill, with siphonage sucking-off supernatant, the precipitate sucking filtration washes with water to not having obviously acid to doing, take out drying precipitate, pulverize, obtain dry powder, get 100 weight portion dry powder, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, the sucrose of 30 weight portions ~ 50 weight portions, 0.5 the sodium benzoate of weight portion ~ 1 weight portion is dispersed in the water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boils to make dissolving, filters, sterilization back packing namely gets syrup.
Beneficial effect of the present invention:
Chinese medicine provided by the invention is aspect the treatment chronic bronchitis, and with respect to western medical treatment, it can be treated on the whole, has no side effect and drug resistance, and is respond well, and the state of an illness is not repeatedly.
The specific embodiment
Motherland's medical science thinks that chronic tracheitis belongs to categories such as " cough ", " phlegm retention ", " the syndrome of dyspnea ", and how because of the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, owing to the course of disease is longer, latent phlegm hinders in lung, injures lungs, and pathogenesis is that yang deficiency is drunk and stopped,
The cough that chronic bronchitis patient is permanent, often and outbreak repeatedly, cause disease and spleen kidney,
Thereby make spleen-kidney vacuity cold, old complaint and disease originally do not reach firmly, purplish tongue or light, arteries and veins many and heavy thin, tongue is white.The invasion of the deficiency of healthy energy and exopathogen had relation during the morbidity of chronic bronchitis and the lung kidney in the body were insufficiency of the spleen etc.The cardinal symptom of chronic bronchitis shows as repeatedly and coughs up phlegm, coughs, and the basis of its cause of disease is mainly the interior volt of phlegm retention and the imbalance of internal organs.
The total pathogenesis of this disease is because diseases caused by exogenous pathogenic factor six evil causes impairment of purifying and descending function of the lung, coughs, expectorant, breathes heavily all diseases and occur in succession, with the passing of time injures the spleen kidney, and it is marked on lung, and it is at the spleen kidney.The branch that the diseases caused by exogenous pathogenic factor internal injury is arranged, diseases caused by exogenous pathogenic factor person takes advantage of for six climate exopathogens and attacks, and internal injury is many to injure the spleen kidney because of prolonged illness.The Shen Jin of Qing Dynasty huge legendary turtle is pointed out in " miscellaneous diseases source and course rhinoceros candle cough, asthma source and course ": " the lid lung is not hindered and is not coughed, and spleen is not hindered not chronic cough, and it is not vehement that kidney is not hindered fire, coughs not very, and it greatly more also." illustrate lung spleen kidney three dirty be the major lesions place of cough, spleen insufficiency water liquid, accumulation and obstruction of sputum causes impairment of dispersing and descending function of the lung, abnormal rising of lung-QI and falls ill.Suffer from a deficiency of the kidney and not improving inspiration by invigorating kidney-QI frequently do to panting.
Therefore, the primary disease treatment should be main with " invigorating the spleen and benefiting QI the kidney invigorating, relieving cough and resolving phlegm is relievingd asthma ".
Accordingly, the invention provides a kind of Chinese medicine that is used for the treatment of chronic bronchitis, its crude drug comprises:
Semen Sinapis Albae, the Radix Astragali, Semen Armeniacae Amarum, Ramulus Cinnamomi, Flos Lonicerae, Flos Inulae, Herba Asari, Fructus Jujubae, Stigma Croci, Pollen Typhae, Cortex Phellodendri, Semen Raphani, Folium Mori, Fructus Corni, Semen Coicis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and compound in rubus corchorifolius leaf.
In the side, Semen Sinapis Albae has the usefulness of warming the lung eliminating phlegm promoting the circulation of QI, the Radix Astragali, return liver spleen kidney three warps, the effect of benefiting QI for strengthening the superficies is arranged, the Semen Armeniacae Amarum relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, it can control the maincenter of cough, the Ramulus Cinnamomi warming yang for resolving fluid retention, Flos Lonicerae has good antibiotic, antiviral efficacy, can also suppress the acute lung injury of endotaxin induction, treatment to chronic bronchitis has help, thereby Flos Inulae can be alleviated bronchial spasm and relievings asthma, Herba Asari, Stigma Croci contains the secretion of reduction bronchus and antianaphylactic spasmolysis, and Fructus Jujubae can increase its hemoglobin, and can promote the regeneration of hemocyte, Pollen Typhae has reasonable microthrombus and antianaphylactic effect unique of removing in the diseased region, Cortex Phellodendri is good at part of the body cavity above the diaphragm housing the heart and lungs lung-fire clearly, and expectorant promoting the circulation of QI Dingchuan is coughed, Semen Raphani energy lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, You Yizhi cough expectorant is stopped up, and Folium Mori have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, the effect of clearing away lung-heat to relieve cough, Fructus Corni, Galla Chinensis the kidney warming improving inspiration by invigorating kidney-QI, relieving cough and asthma, the strong taste that turn round and look at of Semen Coicis, the source of living extremely expectorant, Fructus Aurantii Immaturus can stimulate the throat mucosa, reflexive causes the respiratory mucosa hypersecretion, tangible phlegm-dispelling functions is arranged, and Pericarpium Citri Reticulatae has the peace of regulating the flow of vital energy stomach, the effect of drying dampness to eliminate phlegm, the Rhizoma Zingiberis warming spleen and stomach for dispelling cold, warming the lung to resolve fluid-retention, the compound in rubus corchorifolius leaf relieving sore-throat by clearing away heat, skin ulcer is held back in detoxifcation, and all medicines share, realize the invigorating the spleen and benefiting QI the kidney invigorating, the treatment that relieving cough and resolving phlegm is relievingd asthma.
Each crude drug pharmacology is as follows:
Semen Sinapis Albae: the dry mature seed of crucifer Caulis et Folium Sinapis albee, latin name
Sinapis Semen, acrid in the mouth, hot in nature, have warming the lung eliminating phlegm promoting the circulation of QI, the effect of resolving mass and removing the obstruction of the collateral pain relieving is used for cold-phlegm and breathes with cough, distending pain in the chest and hypochondrium, the expectorant cards such as meridians, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling that stagnate.
The Radix Astragali: sweet in the mouth, warm in nature, go into spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effects such as holder skin ulcer granulation promoting are mainly used in the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, cards such as insufficiency of vital energy and blood.
Semen Armeniacae Amarum: bitter in the mouth, suffering, slightly warm in nature is gone into spleen, lung two warps, has the lung qi dispersing cough-relieving, lowering the adverse-rising QI to subdue asthma, loosening bowel to relieve constipation, the effect of parasite killing detoxifcation cures mainly cough, the dyspnea with rapid and short breath fullness in the chest, the sore throat pharyngalgia, the dryness of the intestine constipation, cards such as insect poison skin infection, Compendium of Material Medica: earnestly Semen Armeniacae Amarum can loose and can fall, so expelling pathogenic factors from muscles, loose wind, sending down the abnormal ascending QI, moisturize, removing food stagnancy, cure the wound to decrease in the medicine and use it.Control the skin ulcer parasite killing, with its poison also.Control in the wind and cold pectoral, the gross weight point person of using is also arranged, get it and disperse also.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel have the diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, the Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere is used for the affection of exogenous wind-cold exterior syndrome, no matter antiperspirant is arranged, losslessly all can use, also be used for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, phlegm retention syndromes such as cough with dyspnea dizziness.
Flos Lonicerae: sweet in the mouth, cold in nature, go into the heart, lung, stomach, large intestine channel, the effect of heat-clearing and toxic substances removing is arranged, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity and contain, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; The fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of, inflammation heat person of swelling and ache etc., Flos Lonicerae has antipyretic effect preferably, the energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria are had stronger bacteriostasis, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., Flos Lonicerae is all effective to the pyretic toxicity of QI and blood battalion branch, and broad-spectrum antibacterial action is arranged.
Flos Inulae: its first system of flavor with salty, relaxing the bowels with lubricant drugs is done salty, salty energy softening the hard mass; " not Lu " be to sweet taste in the mouth, among the Gan Nenghuan; Tepor, temperature can be passed through, so main stagnation of QI fullness in the hypochondrium; Heart spleen latent fluid-retention is sick palpitation with fear then, and drink disappears then multiple normal.Dewater, remove cold and heat between the five internal organs, and expectorant knot on the breast that disappears, saliva such as shellac varnish, heart side of body expectorant water, wing is prolonged fluid-retention all of a sudden, the pathogenic wind arthralgia chiefly caused by damp pathogen, dead flesh is opened in the order between skin, sharp large intestine person, all the merit that dewaters of softening the hard mass, cold profit, relaxing the bowels with lubricant drugs, expectorant drink is also.It says invigorating middle warmer therapeutic method to keep the adverse QI flowing downwards person, and in delaying with sweet energy, so salty energy relaxing the bowels with lubricant drugs is also.Promoting blood circulation, beneficial color and luster person, lid refers to that the drink spleen that disappears then is strong, and is strong then can move, spleen is wrapped up in the blood blood of uniting again and is died also.
Herba Asari: latin name
Asari Radix et Rhizoma, acrid in the mouth, warm in nature, return lung, kidney channel, have the expelling wind and cold pain relieving, the effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma due to the cold fluid-retention, nasal obstruction nasal sinusitis, the wind-eye corneal nebula, the deafness pharyngalgia, cards such as aphtha halitosis, Herba Asari has the obvious suppression effect to cellular immunization and humoral immunization.
Fructus Jujubae: sweet in the mouth, slightly warm in nature, have invigorating the spleen and replenishing QI, the effect of nourishing blood to tranquillize the mind is returned spleen, stomach warp, cures mainly weakness of the spleen and stomach, deficiency of QI in middle-JIAO, fatigue and lack of strength, anorexia and loose stool; Blood deficiency fistula Huang, become thin, or the women is dirty dry, cards such as spiritual uneasiness.
Stigma Croci: sweet in the mouth, property is flat, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, the chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, and is frightened fear in a trance, women's amenorrhea, and the stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, cards such as traumatic injury.
Pollen Typhae: sweet in the mouth, property is flat, goes into liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.Be used for spitting blood epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, cards such as blood strangury and dry pain.
Cortex Phellodendri: latin name
Phellodendri Chinensis Cortex,Bitter in the mouth, cold in nature, go into kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, the hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, cards such as eczema pruritus, Cortex Phellodendri has good antibacterial action to multiple gram-positive bacterium.
Semen Raphani: property is flat, and acrid in the mouth, sweet is returned lung, spleen, stomach warp, having to help digestion except expanding, and the effect of lowering the adverse-rising QI to resolve phlegm cures mainly retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant and stops up card such as breath with cough.
Folium Mori: sweet in the mouth, hardship; Cold in nature.Return lung, Liver Channel has dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, and suppressing liver-YANG, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis is used for anemopyretic cold and conjunctival congestion and swelling pain, wind-fire order disease, dryness-heat impairing the lung, the few expectorant of dry cough, " Bencao Jingshu ": " herbal classic " odorlessness.Detailed its cures mainly, and should be that sweet in the mouth gas is cold nontoxic.So sweet beneficial blood, so cold removing heat from blood, so sweet cold being harmonious is the therapeutic method to keep the adverse QI flowing downwards and tonifying YIN.Be with the main deficiency of YIN cold and heat of energy, and because of the interior-heat perspiration.Its property is held concurrently dry, so can remove beriberi edema, sharp intestine and small intestine again.The golden gas of former official report is so can remove wind again.Through frost the respectful clearly of the world that then get both, quench the thirst so can make eye bright again.Send out the person, after the blood, so beneficial blood is again can long hair, and so removing heat from blood is emesis blood again.Close the carbuncle mouth, net for catching birds or fish is worn the palm, treats the soup fire, and all refrigerant merit of enriching blood also.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature is returned liver, kidney channel, has liver and kidney tonifying, the effect of essence astringing and desertion stemming.Be used for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.Interior-heat card such as quench one's thirst.
Semen Coicis: cool in nature, sweet in the mouth, light is returned spleen, stomach, lung meridian.Function with spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic is used for weakness of the spleen and stomach, loose stool diarrhoea, or vaginal discharge diseases of women, and the insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache.
Fructus Aurantii Immaturus: bitter in the mouth, suffering, cold nature is gone into spleen, stomach warp, and the dispelling the stagnated QI removing food stagnancy is arranged, and expectorant is except the effect of painful abdominal mass, is mainly used in stopping in stagnant, the excess syndrome of YANG MING FU-organ card of distension and fullness in the abdomen, constipation.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, the hot logical temperature of loosing, fragrant odour is longer than and is regulated the flow of vital energy, and can go into the spleen lung, thus can go diffusing sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, be used for lung qi and gather around cards such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen.
Rhizoma Zingiberis: acrid in the mouth, hot in nature, return spleen, stomach, the heart, lung meridian; Have warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, the dampness expectorant, and the effect of warming the lung to resolve fluid-retention is used for coldness and pain in the epigastrium, and vomiting is had loose bowels, and YANG-depletion is fainted contrary, and cold fluid-retention is breathed with cough, cards such as arthralgia due to cold-dampnes.
Compound in rubus corchorifolius leaf: bitter in the mouth, puckery, property is flat, has relieving sore-throat by clearing away heat, and the effect of skin ulcer is held back in detoxifcation, cures mainly laryngopharynx swelling and pain, carbuncle sore furuncle and phyma, mastitis, cards such as eczema.
Preferably, described Chinese medicine only is made of above-mentioned raw materials medicine component.
The weight portion of each crude drug is respectively Semen Sinapis Albae 22 ~ 28 weight portions in the described Chinese medicine, the Radix Astragali 41 ~ 53 weight portions, Semen Armeniacae Amarum 27 ~ 35 weight portions, Ramulus Cinnamomi 37 ~ 46 weight portions, Flos Lonicerae 18 ~ 26 weight portions, Flos Inulae 12 ~ 19 weight portions, Herba Asari 19 ~ 25 weight portions, Fructus Jujubae 27 ~ 33 weight portions, Stigma Croci 21 ~ 28 weight portions, Pollen Typhae 18 ~ 23 weight portions, Cortex Phellodendri 30 ~ 40 weight portions, Semen Raphani 32 ~ 37 weight portions, Folium Mori 22 ~ 29 weight portions, Fructus Corni 35 ~ 41 weight portions, Semen Coicis 20 ~ 29 weight portions, Fructus Aurantii Immaturus 30 ~ 36 weight portions, Pericarpium Citri Reticulatae 26 ~ 30 weight portions, Rhizoma Zingiberis 27 ~ 33 weight portions and compound in rubus corchorifolius leaf 15 ~ 23 weight portions.
Further preferred, the weight portion of each crude drug is respectively Semen Sinapis Albae 26 weight portions, the Radix Astragali 46 weight portions, Semen Armeniacae Amarum 31 weight portions, Ramulus Cinnamomi 41 weight portions, Flos Lonicerae 22 weight portions, Flos Inulae 16 weight portions, Herba Asari 22 weight portions, Fructus Jujubae 30 weight portions, Stigma Croci 25 weight portions, Pollen Typhae 20 weight portions, Cortex Phellodendri 35 weight portions, Semen Raphani 35 weight portions, Folium Mori 26 weight portions, Fructus Corni 38 weight portions, Semen Coicis 25 weight portions, Fructus Aurantii Immaturus 33 weight portions, Pericarpium Citri Reticulatae 29 weight portions, Rhizoma Zingiberis 30 weight portions and compound in rubus corchorifolius leaf 20 weight portions in the described Chinese medicine.
The Chinese medicine that is used for the treatment of chronic bronchitis provided by the invention can be prepared into any regular dosage form, and preferred for preparation becomes syrup and granule.
Preparation method of Chinese medicine provided by the invention when the dosage form of described Chinese medicine is granule, is specially:
Above-mentioned raw materials medicine component is mixed in proportion; decoct with water twice, the 1 time and add with respect to 6～8 times of water gagings of mixture quality, decocted 2 hours; add for the 2nd time with respect to 4～6 times of water gagings of mixture quality; decocted 1 hour, and filtered merging filtrate; be concentrated into the clear paste that every 1ml contains the 1g medical material approximately; adding hydrochloric acid accent pH is 1, and the limit edged stirs, and leaves standstill; with siphonage sucking-off supernatant; the precipitate sucking filtration washes with water to there not being obviously acidity to doing, and takes out drying precipitate; pulverize; obtaining dry powder, add subsequently with respect to dry powder quality 20% ~ 30% cane sugar powder (mass percent), is 75% ~ 85% ethanol soft material processed with determining alcohol; granulate with oscillating granulator; 60 ℃ of oven dry down, granulate gets granule.
Preparation method of Chinese medicine provided by the invention when the dosage form of described Chinese medicine is syrup, is specially:
Above-mentioned raw materials medicine component is mixed in proportion, decocts with water twice, the 1 time and add with respect to 6～8 times of water gagings of mixture quality, decocted 2 hours, add for the 2nd time with respect to 4～6 times of water gagings of mixture quality, decocted 1 hour, filter, merging filtrate, be concentrated into the clear paste that every 1ml contains the 1g medical material approximately, adding hydrochloric acid accent pH is 1, and the limit edged stirs, leave standstill, with siphonage sucking-off supernatant, the precipitate sucking filtration washes with water to not having obviously acid to doing, take out drying precipitate, pulverize, obtain dry powder, get 100 weight portion dry powder, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, the sucrose of 30 weight portions ~ 50 weight portions, 0.5 the sodium benzoate of weight portion ~ 1 weight portion is dispersed in the water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boils to make dissolving, filters, sterilization back packing namely gets syrup.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
Embodiment 1
With Semen Sinapis Albae 26g, Radix Astragali 46g, Semen Armeniacae Amarum 31g, Ramulus Cinnamomi 41g, Flos Lonicerae 22g, Flos Inulae 16g, Herba Asari 22g, Fructus Jujubae 30g, Stigma Croci 25g, Pollen Typhae 20g, Cortex Phellodendri 35g, Semen Raphani 35g, Folium Mori 26g, Fructus Corni 38g, Semen Coicis 25g, Fructus Aurantii Immaturus 33g, Pericarpium Citri Reticulatae 29g, Rhizoma Zingiberis 30g and compound in rubus corchorifolius leaf 20g mix, decoct with water twice, add for the 1st time with respect to 8 times of water gagings of mixture quality, decocted 2 hours, add for the 2nd time with respect to 6 times of water gagings of mixture quality, decocted 1 hour, filter, merging filtrate, be concentrated into the clear paste that every 1ml contains the 1g medical material approximately, adding hydrochloric acid accent pH is 1, and the limit edged stirs, leave standstill, with siphonage sucking-off supernatant, the precipitate sucking filtration washes with water to not having obviously acid to doing, take out drying precipitate, pulverize, obtain dry powder, get 100g dry powder, the 4g sodium carboxymethyl cellulose, the sucrose of 50g, 0.5g sodium benzoate be dispersed in the water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 4g/ml, boils to make dissolving, filters, sterilization back packing namely gets syrup.
Embodiment 2
With Semen Sinapis Albae 22g, Radix Astragali 41g, Semen Armeniacae Amarum 27g, Ramulus Cinnamomi 37g, Flos Lonicerae 18g, Flos Inulae 12g, Herba Asari 19g, Fructus Jujubae 27g, Stigma Croci 21g, Pollen Typhae 18g, Cortex Phellodendri 30g, Semen Raphani 32g, Folium Mori 22g, Fructus Corni 35g, Semen Coicis 20g, Fructus Aurantii Immaturus 30g, Pericarpium Citri Reticulatae 26g, Rhizoma Zingiberis 27g and compound in rubus corchorifolius leaf 15g mix, decoct with water twice, add for the 1st time with respect to 8 times of water gagings of mixture quality, decocted 2 hours, add for the 2nd time with respect to 6 times of water gagings of mixture quality, decocted 1 hour, filter, merging filtrate, be concentrated into the clear paste that every 1ml contains the 1g medical material approximately, adding hydrochloric acid accent pH is 1, and the limit edged stirs, leave standstill, with siphonage sucking-off supernatant, the precipitate sucking filtration washes with water to not having obviously acid to doing, take out drying precipitate, pulverize, obtain dry powder, get 100g dry powder, the 4g sodium carboxymethyl cellulose, the sucrose of 50g, 0.5g sodium benzoate be dispersed in the water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 4g/ml, boils to make dissolving, filters, sterilization back packing namely gets syrup.
Embodiment 3
With Semen Sinapis Albae 28g, Radix Astragali 53g, Semen Armeniacae Amarum 35g, Ramulus Cinnamomi 46g, Flos Lonicerae 26g, Flos Inulae 19g, Herba Asari 25g, Fructus Jujubae 33g, Stigma Croci 28g, Pollen Typhae 23g, Cortex Phellodendri 40g, Semen Raphani 37g, Folium Mori 29g, Fructus Corni 41g, Semen Coicis 29g, Fructus Aurantii Immaturus 36g, Pericarpium Citri Reticulatae 30g, Rhizoma Zingiberis 33g and compound in rubus corchorifolius leaf 23g mix, decoct with water twice, add for the 1st time with respect to 8 times of water gagings of mixture quality, decocted 2 hours, add for the 2nd time with respect to 6 times of water gagings of mixture quality, decocted 1 hour, filter, merging filtrate, be concentrated into the clear paste that every 1ml contains the 1g medical material approximately, adding hydrochloric acid accent pH is 1, and the limit edged stirs, leave standstill, with siphonage sucking-off supernatant, the precipitate sucking filtration washes with water to not having obviously acid to doing, take out drying precipitate, pulverize, obtain dry powder, get 100g dry powder, the 4g sodium carboxymethyl cellulose, the sucrose of 50g, 0.5g sodium benzoate be dispersed in the water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 4g/ml, boils to make dissolving, filters, sterilization back packing namely gets syrup.
Embodiment 4 granules
Semen Sinapis Albae 26g; Radix Astragali 46g; Semen Armeniacae Amarum 31g; Ramulus Cinnamomi 41g; Flos Lonicerae 22g; Flos Inulae 16g; Herba Asari 22g; Fructus Jujubae 30g; Stigma Croci 25g; Pollen Typhae 20g; Cortex Phellodendri 35g; Semen Raphani 35g; Folium Mori 26g; Fructus Corni 38g; Semen Coicis 25g; Fructus Aurantii Immaturus 33g; Pericarpium Citri Reticulatae 29g; Rhizoma Zingiberis 30g and compound in rubus corchorifolius leaf 20g mix; decoct with water twice; add for the 1st time with respect to 8 times of water gagings of mixture quality; decocted 2 hours; add for the 2nd time with respect to 6 times of water gagings of mixture quality, decocted 1 hour, filter; merging filtrate; be concentrated into the clear paste that every 1ml contains the 1g medical material approximately, adding hydrochloric acid accent pH is 1, and the limit edged stirs; leave standstill; with siphonage sucking-off supernatant, the precipitate sucking filtration washes with water to not having obviously acid to doing; take out drying precipitate; pulverize, obtain dry powder, get dry powder 100g; add the 25g cane sugar powder subsequently; be 75% ethanol soft material processed with determining alcohol, granulate with oscillating granulator, 60 ℃ of oven dry down; granulate gets granule.
Embodiment 5 clinical datas
Physical data
Select for use be object of study the 172 routine patients that the author place hospital carries out the chronic bronchitis treatment in April, 2010～2011 year April.Man's 95 examples, woman's 77 examples, 13～75 years old age, average (45.0 ± 9.2) year, all patients all have certain cough, have sore throat before being admitted to hospital, sputum is sticky and be white in color, have wheezing sound, symptom such as the difficulty of breathing, health are weak, heating, the course of disease 2 months～8 years.172 routine patients are divided into matched group and treatment group by its therapeutic modality difference.90 examples are organized in treatment, matched group 82 examples.Two groups of patients are learning processing by statistics aspect age, sex, the course of disease, the risk factor, difference not statistically significant (P＞0.05) has comparability.
Therapeutic Method
The treatment group adopts the syrup of the embodiment of the invention 1 preparation to treat, every day 3 times, each 1 bottle, every bottle of 10ml is in treatment, give patient's adjustment in life and nursing and spiritual encouragement and comfort more, the nutrition that is careful in one's diet, the suction of mist, dust and irritative gas is eliminated and avoided to the food of polyphagia moistening the lung and resolving phlegm and high protein, homovitamin food, the enhancing body resistance improves clinical efficacy.
It is each that matched group gives CEFUROXIME AXETIL capsule 0.25g, and every day 2 times is oral, and 100 ㎎ are each for the aminophylline sheet, and every day 3 times is oral.
All treat 2 courses for the treatment of for two groups.
Efficacy determination
Cure: transference cures such as cough, expectoration, wheezing sound, it is normal substantially to breathe, and X line sheet is normal substantially; Produce effects: symptoms such as cough, expectoration, wheezing sound have clear improvement, and breathing has slight difficulty once in a while, and X line sheet recovery situation reaches more than 85%; Effectively: symptoms such as cough, expectoration, wheezing sound make moderate progress, some difficulty of breathing, and X line sheet recovery situation reaches more than 60%; Invalid: symptoms such as cough, expectoration, wheezing sound do not have improvement, the difficulty of breathing, and X line sheet recovery situation is below 60%.
Include standard in
(1) meets " diagnostic criteria that Chinese Medical Association's Pneumology Department meeting is determined "; (2) 10～80 years old age; (3) can accept the doctor and carry out every detection; (4) there are not other primary diseases or psychosis medical history.
Statistical procedures
Adopt SPSS17.0 statistics software to analyze, two groups of patients' cough, expectoration, wheezing sound and X line sheet recovery situation compared, there is statistical significance P＜0.05 for difference.
Therapeutic outcome
Each condition of illness contrast the results are shown in Table 1 before and after two groups of patient treatments.
Each condition of illness compares (n) before and after the table 1 liang group patient treatment
Two groups of patients' curative effect relatively the results are shown in Table 2 after two courses for the treatment of.
Table 2 liang group patient's curative effect relatively
| Group | n | Cure | Produce effects | Effectively | Invalid | Total effective rate |
| The treatment group | 90 | 52 | 26 | 10 | 2 | 97.8% |
| Matched group | 82 | 32 | 27 | 13 | 10 | 87.8% |
By table 1 and table 2 as can be seen, adopt Chinese materia medica syrup of the present invention having good curative effect aspect the treatment chronic bronchitis.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (7)
1. Chinese medicine that is used for the treatment of chronic bronchitis, it is characterized in that the crude drug of described Chinese medicine comprises: Semen Sinapis Albae, the Radix Astragali, Semen Armeniacae Amarum, Ramulus Cinnamomi, Flos Lonicerae, Flos Inulae, Herba Asari, Fructus Jujubae, Stigma Croci, Pollen Typhae, Cortex Phellodendri, Semen Raphani, Folium Mori, Fructus Corni, Semen Coicis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and compound in rubus corchorifolius leaf.
2. Chinese medicine as claimed in claim 1, it is characterized in that: described Chinese medicine only is made of above-mentioned raw materials medicine component.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that: the weight portion of each crude drug is respectively Semen Sinapis Albae 22 ~ 28 weight portions in the described Chinese medicine, the Radix Astragali 41 ~ 53 weight portions, Semen Armeniacae Amarum 27 ~ 35 weight portions, Ramulus Cinnamomi 37 ~ 46 weight portions, Flos Lonicerae 18 ~ 26 weight portions, Flos Inulae 12 ~ 19 weight portions, Herba Asari 19 ~ 25 weight portions, Fructus Jujubae 27 ~ 33 weight portions, Stigma Croci 21 ~ 28 weight portions, Pollen Typhae 18 ~ 23 weight portions, Cortex Phellodendri 30 ~ 40 weight portions, Semen Raphani 32 ~ 37 weight portions, Folium Mori 22 ~ 29 weight portions, Fructus Corni 35 ~ 41 weight portions, Semen Coicis 20 ~ 29 weight portions, Fructus Aurantii Immaturus 30 ~ 36 weight portions, Pericarpium Citri Reticulatae 26 ~ 30 weight portions, Rhizoma Zingiberis 27 ~ 33 weight portions and compound in rubus corchorifolius leaf 15 ~ 23 weight portions.
4. as the described Chinese medicine of claim 1 to 3, it is characterized in that: the weight portion of each crude drug is respectively Semen Sinapis Albae 26 weight portions in the described Chinese medicine, the Radix Astragali 46 weight portions, Semen Armeniacae Amarum 31 weight portions, Ramulus Cinnamomi 41 weight portions, Flos Lonicerae 22 weight portions, Flos Inulae 16 weight portions, Herba Asari 22 weight portions, Fructus Jujubae 30 weight portions, Stigma Croci 25 weight portions, Pollen Typhae 20 weight portions, Cortex Phellodendri 35 weight portions, Semen Raphani 35 weight portions, Folium Mori 26 weight portions, Fructus Corni 38 weight portions, Semen Coicis 25 weight portions, Fructus Aurantii Immaturus 33 weight portions, Pericarpium Citri Reticulatae 29 weight portions, Rhizoma Zingiberis 30 weight portions and compound in rubus corchorifolius leaf 20 weight portions.
5. as the described Chinese medicine of claim 1 to 4, it is characterized in that: described Chinese medicine can be prepared into syrup and granule.
6. the described preparation method of Chinese medicine of claim 1 to 5 is characterized in that: when the dosage form of described Chinese medicine is granule, is specially,
Described crude drug component is mixed in proportion; decoct with water twice, the 1 time and add with respect to 6～8 times of water gagings of mixture quality, decocted 2 hours; add for the 2nd time with respect to 4～6 times of water gagings of mixture quality; decocted 1 hour, and filtered merging filtrate; be concentrated into the clear paste that every 1ml contains the 1g medical material approximately; adding hydrochloric acid accent pH is 1, and the limit edged stirs, and leaves standstill; with siphonage sucking-off supernatant; the precipitate sucking filtration washes with water to there not being obviously acidity to doing, and takes out drying precipitate; pulverize; obtaining dry powder, add subsequently with respect to dry powder quality 20% ~ 30% cane sugar powder (mass percent), is 75% ~ 85% ethanol soft material processed with determining alcohol; granulate with oscillating granulator; 60 ℃ of oven dry down, granulate gets granule.
7. the described preparation method of Chinese medicine of claim 1 to 5 is characterized in that: when the dosage form of described Chinese medicine is syrup, is specially,
Described crude drug component is mixed in proportion, decocts with water twice, the 1 time and add with respect to 6～8 times of water gagings of mixture quality, decocted 2 hours, add for the 2nd time with respect to 4～6 times of water gagings of mixture quality, decocted 1 hour, filter, merging filtrate, be concentrated into the clear paste that every 1ml contains the 1g medical material approximately, adding hydrochloric acid accent pH is 1, and the limit edged stirs, leave standstill, with siphonage sucking-off supernatant, the precipitate sucking filtration washes with water to not having obviously acid to doing, take out drying precipitate, pulverize, obtain dry powder, get 100 weight portion dry powder, 3 weight portions ~ 5 weight portion sodium carboxymethyl cellulose, the sucrose of 30 weight portions ~ 50 weight portions, 0.5 the sodium benzoate of weight portion ~ 1 weight portion is dispersed in the water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boils to make dissolving, filters, sterilization back packing namely gets syrup.
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| CN118286383A (en) * | 2024-06-04 | 2024-07-05 | 华龙圣爱中医集团有限公司 | Pharmaceutical composition for treating children cough, preparation and application thereof |
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