CN112451589A - Pharmaceutical composition for treating pullorum disease and preparation method thereof - Google Patents
Pharmaceutical composition for treating pullorum disease and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention relates to a pharmaceutical composition for treating pullorum disease and a preparation method thereof, and belongs to the field of traditional Chinese veterinary medicine preparations. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 5-25 parts of coptis chinensis, 10-50 parts of phellodendron, 10-50 parts of scutellaria baicalensis, 10-50 parts of astragalus membranaceus, 5-25 parts of rheum officinale, 5-25 parts of rehmannia, 6-30 parts of sweet wormwood, 10-60 parts of humifuse euphorbia herb, 5-30 parts of common andrographis herb, 5-25 parts of Chinese pulsatilla root and 10-50 parts of liquorice. The pharmaceutical composition prepared by the invention has the effects of clearing heat, drying dampness, cooling blood, stopping dysentery and the like, is prepared by crushing and mixing through 80-mesh and 200-mesh sieves, has simple preparation process, convenient use and high bioavailability, and has special effect on treating pullorum disease proved by clinical application.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese veterinary medicine preparations, and particularly relates to a pharmaceutical composition for treating pullorum disease and a preparation method thereof.
Background
Pullorum disease is a frequently-occurring infectious disease with high harm in the chicken industry, and the disease is susceptible to chicks, young chicks are frequently outbreaked, and the morbidity and mortality of chicks within 10 months are the highest, and the mortality can reach 50% -60%.
At present, the common method for preventing and treating pullorum disease depends on the prevention and treatment of western medicines such as florfenicol and the like, and the occurrence of salmonella global drug resistance is caused by unreasonable use of antibiotics (such as long-term use, blind use, overdose use and the like of low-dose antibacterial growth promoters), and is increasingly serious, and most pathogenic bacteria generate multiple drug resistance to antibiotics. Therefore, the search for a drug-resistant inhibitor with good efficacy and no public nuisance for preventing and treating the chicken salmonellosis has been increasingly regarded as the achievement of safe poultry products.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide the pharmaceutical composition for treating pullorum disease and the preparation method thereof.
In order to achieve the purpose, the invention adopts the specific scheme that:
the pharmaceutical composition for treating pullorum disease is prepared from the following components in parts by weight: 5-25 parts of coptis chinensis, 10-50 parts of phellodendron, 10-50 parts of scutellaria baicalensis, 10-50 parts of astragalus membranaceus, 5-25 parts of rheum officinale, 5-25 parts of rehmannia, 6-30 parts of sweet wormwood, 10-60 parts of humifuse euphorbia herb, 5-30 parts of common andrographis herb, 5-25 parts of Chinese pulsatilla root and 10-50 parts of liquorice.
As a further optimization of the scheme, the preferable proportion of the components is as follows: 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia, 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 20 parts of liquorice.
The invention also provides a preparation method of the pharmaceutical composition for treating pullorum disease, which comprises the following steps:
step one, respectively carrying out superfine grinding on coptis chinensis, phellodendron, scutellaria baicalensis, astragalus mongholicus, rheum officinale and rehmannia glutinosa in the formula, and then sieving the mixture by a 80-mesh sieve; respectively carrying out superfine grinding on sweet wormwood, humifuse euphorbia herb, common andrographis herb, Chinese pulsatilla root and liquorice in the formula, and then sieving the mixture by a 200-mesh sieve;
step two, weighing 5-25 parts of coptis chinensis, 10-50 parts of phellodendron, 10-50 parts of scutellaria baicalensis, 10-50 parts of astragalus membranaceus, 5-25 parts of rheum officinale, 5-25 parts of rehmannia and 5-25 parts of liquorice according to weight, and mixing for 5-10 minutes until the mixture A is obtained;
weighing 6-30 parts of sweet wormwood, 10-60 parts of humifuse euphorbia herb, 5-30 parts of common andrographis herb, 5-25 parts of Chinese pulsatilla root and 5-25 parts of liquorice according to the weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture B;
and step four, combining the mixture A prepared in the step two and the mixture B prepared in the step three, and mixing for 10-20 minutes until the mixture is uniform.
The invention also claims application of the pharmaceutical composition for treating pullorum disease in preparation of medicines for treating bacterial diseases of poultry. Further, the bacterial disease of the poultry is pullorum disease.
Has the advantages that:
the medicine composition prepared by the invention has the effects of clearing heat, drying dampness, cooling blood, stopping dysentery and the like.
The pharmaceutical composition provided by the invention is safe and nontoxic, has no toxicity to livestock bodies and environment, is simple in preparation process, convenient to use and high in bioavailability, and clinical application proves that the pharmaceutical composition has a special effect of treating pullorum disease.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention.
Example 1
A pharmaceutical composition for treating pullorum disease comprises raw materials of, by weight, 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia glutinosa, 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 20 parts of liquorice.
Respectively micronizing Coptidis rhizoma, cortex Phellodendri, Scutellariae radix, radix astragali, radix et rhizoma Rhei, and rehmanniae radix in the composition, and sieving with 80 mesh sieve; the sweet wormwood, the humifuse euphorbia herb, the common andrographis herb, the Chinese pulsatilla root and the liquorice in the formula are respectively subjected to superfine grinding and then sieved by a 200-mesh sieve.
Weighing 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia and 10 parts of liquorice by weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture A;
weighing 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 10 parts of liquorice according to the weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture B;
and mixing the mixture A and the mixture B obtained in the previous step, and continuously mixing for 10-20 minutes until the mixture is uniform to obtain the pharmaceutical composition.
Example 2
A pharmaceutical composition for treating pullorum disease comprises raw materials of, by weight, 5 parts of coptis chinensis, 10 parts of golden cypress, 10 parts of scutellaria baicalensis, 10 parts of astragalus membranaceus, 5 parts of rheum officinale, 5 parts of rehmannia glutinosa, 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 20 parts of liquorice.
Respectively micronizing Coptidis rhizoma, cortex Phellodendri, Scutellariae radix, radix astragali, radix et rhizoma Rhei, and rehmanniae radix in the composition, and sieving with 80 mesh sieve; the sweet wormwood, the humifuse euphorbia herb, the common andrographis herb, the Chinese pulsatilla root and the liquorice in the formula are respectively subjected to superfine grinding and then sieved by a 200-mesh sieve.
Weighing 5 parts of coptis chinensis, 10 parts of phellodendron, 10 parts of scutellaria baicalensis, 10 parts of astragalus membranaceus, 5 parts of rheum officinale, 5 parts of rehmannia and 10 parts of liquorice according to weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture A;
weighing 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 10 parts of liquorice according to the weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture B;
and mixing the mixture A and the mixture B obtained in the previous step, and continuously mixing for 10-20 minutes until the mixture is uniform to obtain the pharmaceutical composition.
Example 3
A pharmaceutical composition for treating pullorum disease comprises raw materials of, by weight, 25 parts of coptis chinensis, 50 parts of phellodendron, 50 parts of scutellaria baicalensis, 50 parts of astragalus membranaceus, 25 parts of rheum officinale, 25 parts of rehmannia, 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 50 parts of liquorice.
Respectively micronizing Coptidis rhizoma, cortex Phellodendri, Scutellariae radix, radix astragali, radix et rhizoma Rhei, and rehmanniae radix in the composition, and sieving with 80 mesh sieve; the sweet wormwood, the humifuse euphorbia herb, the common andrographis herb, the Chinese pulsatilla root and the liquorice in the formula are respectively subjected to superfine grinding and then sieved by a 200-mesh sieve.
Weighing 25 parts of coptis chinensis, 50 parts of phellodendron, 50 parts of scutellaria baicalensis, 50 parts of astragalus membranaceus, 25 parts of rheum officinale, 25 parts of rehmannia and 40 parts of liquorice by weight, and uniformly mixing for 5-10 minutes to obtain a mixture A;
weighing 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 10 parts of liquorice according to the weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture B;
and mixing the mixture A and the mixture B obtained in the previous step, and continuously mixing for 10-20 minutes until the mixture is uniform to obtain the pharmaceutical composition.
Example 4
A pharmaceutical composition for treating pullorum disease comprises raw materials of, by weight, 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia glutinosa, 6 parts of sweet wormwood, 10 parts of humifuse euphorbia herb, 5 parts of common andrographis herb, 5 parts of Chinese pulsatilla root and 20 parts of liquorice.
Respectively micronizing Coptidis rhizoma, cortex Phellodendri, Scutellariae radix, radix astragali, radix et rhizoma Rhei, and rehmanniae radix in the composition, and sieving with 80 mesh sieve; the sweet wormwood, the humifuse euphorbia herb, the common andrographis herb, the Chinese pulsatilla root and the liquorice in the formula are respectively subjected to superfine grinding and then sieved by a 200-mesh sieve.
Weighing 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia and 10 parts of liquorice by weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture A;
weighing 6 parts of sweet wormwood, 10 parts of humifuse euphorbia herb, 5 parts of common andrographis herb, 5 parts of Chinese pulsatilla root and 10 parts of liquorice according to the weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture B;
and mixing the mixture A and the mixture B obtained in the previous step, and continuously mixing for 10-20 minutes until the mixture is uniform to obtain the pharmaceutical composition.
Example 5
A pharmaceutical composition for treating pullorum disease comprises raw materials of, by weight, 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia, 30 parts of sweet wormwood, 60 parts of humifuse euphorbia herb, 30 parts of common andrographis herb, 25 parts of Chinese pulsatilla root and 50 parts of liquorice.
Respectively micronizing Coptidis rhizoma, cortex Phellodendri, Scutellariae radix, radix astragali, radix et rhizoma Rhei, and rehmanniae radix in the composition, and sieving with 80 mesh sieve; the sweet wormwood, the humifuse euphorbia herb, the common andrographis herb, the Chinese pulsatilla root and the liquorice in the formula are respectively subjected to superfine grinding and then sieved by a 200-mesh sieve.
Weighing 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia and 10 parts of liquorice by weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture A;
weighing 30 parts of sweet wormwood, 60 parts of humifuse euphorbia herb, 30 parts of common andrographis herb, 25 parts of Chinese pulsatilla root and 40 parts of liquorice according to the weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture B;
and mixing the mixture A and the mixture B obtained in the previous step, and continuously mixing for 10-20 minutes until the mixture is uniform to obtain the pharmaceutical composition.
And (3) clinical trials: clinical tests are carried out according to the technical guidance principle of clinical practical tests of traditional Chinese medicines and natural medicines for veterinary use.
Test materials and methods
1.1 test drugs
The tested drugs are: composition one sample, derived from example 1. Mixed feeding, 5g of chicken per 1kg of feed, and continuously taking for 3-5 days.
Control drugs: florfenicol soluble powder. Taking florfenicol as a reference, drinking the mixture, wherein each 1L of water contains 100 mg of chicken and 200mg of chicken, and the drinking time is continuously 3-5 days.
1.2 test animals
300 sick chickens infected with the pullorum salmonellosis at the age of 7 +/-1 day. The feed during the test period was a basal diet without any antibiotics, formulated with reference to the standard of nutritional requirements of livestock, with free access to food and water.
1.3 test methods
1.3.1 test grouping and administration
300 chickens infected with the pullorum disease salmonellosis are randomly divided into a first group, a second group and a third group, wherein each group comprises 100 chickens, and the groups respectively correspond to a tested drug group (a sample of a first group prescription), a control drug group (florfenicol soluble powder) and an untreated control group.
1.3.2 Observation index
The cure, obvious effect, effective and ineffective conditions of the medicines on the sick chicken infected with the pullorum salmonellosis are calculated.
And (3) healing: during the test period, after the administration, the mental state, the food intake and diet and the like are recovered to be normal, the feces are normal, the feathers are normal, the respiration is normal, the health and the activity are normal, or the number of living bacteria in the blood is counted by a flat-plate pouring method, the number of bacterial colonies has the trend of being obviously reduced, and the recovery is judged.
The effect is shown: during the test period, after the drug is administered, the mental state is basically recovered, the food intake and diet are basically recovered, the feces are normal or obviously improved, the feathers are basically normal, the respiration is basically normal, the feces are basically healthy and active, or the number of viable bacteria in the blood is counted by a flat-plate pouring method, the number of bacterial colonies has the trend of decreasing, and the effect is judged to be obvious.
The method has the following advantages: during the trial period, clinically cured and not cured after administration, mental state, diet did not return to normal completely or there was still a small amount of diarrhea symptoms. But the patient does not die, the number of viable bacteria in the blood does not rise any more, and the patient does not relapse after 7 days, so the patient is judged to be effective;
the total effective counts are the sum of the cure counts, the obvious effective counts and the effective counts, and the protection rate is calculated according to the proportion of the total effective counts to the total number of the group.
And (4) invalidation: when the mental, appetite and feces of the sick chicken are not obviously improved in the test period, the typical symptoms such as white loose feces and the like in clinic are not relieved or die, the typical pathological changes of the viscera are judged to be invalid by the autopsy, and the death rate is calculated according to the proportion of dead number to the number of the group; inefficiency is calculated based on the proportion of invalid counts to the set of counts.
Results
The results are shown in Table 1 below. The test result shows that the treatment effect of the tested drug group (formula I sample) on the chicken infected with the salmonella pullorum disease is similar to that of the florfenicol soluble powder, and the clinical application proves that the drug group has special effect on treating the pullorum disease.
Table 1: the therapeutic effect is shown in the comparison table.
| Group of | Total number (only) | Recovery number (only) | Number of effect display (only) | Effective number (only) | Invalid number (only) | Death number (only) | Protective Rate (%) | Mortality (%) | Inefficiency (%) |
| First group of test drug groups | 100 | 66 | 23 | 5 | 6 | 2 | 94 | 2 | 6 |
| Second group of control drug groups | 100 | 70 | 19 | 7 | 4 | 3 | 96 | 3 | 4 |
| Third group untreated control group | 100 | - | - | - | 100 | 6 | - | 6 | - |
It should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, which is defined by the appended claims. It will be apparent to those skilled in the art that certain insubstantial modifications and adaptations of the present invention can be made without departing from the spirit and scope of the invention.
Claims (5)
1. A pharmaceutical composition for treating pullorum disease is characterized in that: the pharmaceutical composition is prepared from the following components in parts by weight: 5-25 parts of coptis chinensis, 10-50 parts of phellodendron, 10-50 parts of scutellaria baicalensis, 10-50 parts of astragalus membranaceus, 5-25 parts of rheum officinale, 5-25 parts of rehmannia, 6-30 parts of sweet wormwood, 10-60 parts of humifuse euphorbia herb, 5-30 parts of common andrographis herb, 5-25 parts of Chinese pulsatilla root and 10-50 parts of liquorice.
2. The pharmaceutical composition for treating pullorum disease according to claim 1, wherein: the pharmaceutical composition is prepared from the following components in parts by weight: 10 parts of coptis chinensis, 20 parts of phellodendron, 20 parts of scutellaria baicalensis, 20 parts of astragalus membranaceus, 10 parts of rheum officinale, 10 parts of rehmannia, 10 parts of sweet wormwood, 20 parts of humifuse euphorbia herb, 10 parts of common andrographis herb, 10 parts of Chinese pulsatilla root and 20 parts of liquorice.
3. The preparation method of the pharmaceutical composition for treating pullorum disease according to claim 1 or 2, wherein: the method comprises the following steps:
step one, respectively carrying out superfine grinding on coptis chinensis, phellodendron, scutellaria baicalensis, astragalus mongholicus, rheum officinale and rehmannia glutinosa in the formula, and then sieving the mixture by a 80-mesh sieve; respectively carrying out superfine grinding on sweet wormwood, humifuse euphorbia herb, common andrographis herb, Chinese pulsatilla root and liquorice in the formula, and then sieving the mixture by a 200-mesh sieve;
step two, weighing 5-25 parts of coptis chinensis, 10-50 parts of phellodendron, 10-50 parts of scutellaria baicalensis, 10-50 parts of astragalus membranaceus, 5-25 parts of rheum officinale, 5-25 parts of rehmannia and 5-25 parts of liquorice according to weight, and mixing for 5-10 minutes until the mixture A is obtained;
weighing 6-30 parts of sweet wormwood, 10-60 parts of humifuse euphorbia herb, 5-30 parts of common andrographis herb, 5-25 parts of Chinese pulsatilla root and 5-25 parts of liquorice according to the weight, and mixing for 5-10 minutes until the mixture is uniform to obtain a mixture B;
and step four, combining the mixture A prepared in the step two and the mixture B prepared in the step three, and mixing for 10-20 minutes until the mixture is uniform.
4. The use of the pharmaceutical composition according to claim 1 for the manufacture of a medicament for the treatment of bacterial disease in poultry.
5. Use according to claim 4, characterized in that: the poultry bacterial disease is pullorum disease.
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