CN103203004B - Medicinal composition with dysentery stopping effect and preparation method thereof - Google Patents
Medicinal composition with dysentery stopping effect and preparation method thereof Download PDFInfo
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- CN103203004B CN103203004B CN201310127920.5A CN201310127920A CN103203004B CN 103203004 B CN103203004 B CN 103203004B CN 201310127920 A CN201310127920 A CN 201310127920A CN 103203004 B CN103203004 B CN 103203004B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a medicinal composition with a dysentery stopping effect and a preparation method thereof, and belongs to the technical field of livestock medicaments. The medicinal composition is prepared from mahonia, majoram, Chinese pulsatilla root, hawthorn, terminalia fruit, ginger, pomegranate husk charcoal and the like serving as raw medicaments, wherein the raw medicaments are treated by water extraction, 60 percent ethanol reflux and extraction and direct crushing respectively according to different properties of the medicaments and prepared into powder or granules. The medicinal composition has the effects of clearing away heat, cooling blood, detoxifying and stopping dysentery, and is mainly used for treating the dysentery of livestock infection.
Description
Technical field
The invention belongs to veterinary medicine thing technical field, be specifically related to a kind of pharmaceutical composition with dysentery relieving effect and preparation method thereof.
Background technology
Clinical common dysentery is mainly bacillary dysentery and causes, bacillary dysentery is called for short bacillary dysentery, is the infectious intestinal disease being caused by dysentery bacterium, take colon suppurative inflammation as major lesions.Main clinical manifestation is heating, stomachache, diarrhoea, tenesmus, evacuation of pus blood sample stool.One of frequently-occurring disease of the current Reng Wei of bacillary dysentery China.Dysentery bacterium is Grain-negative brevibacterium, is divided into 4 groups of 39 serotypes, each group and various between many without cross immunity.
Animal dysentery is a kind of serious infectious intestinal disease that endangers, as diarrhea of pigs, yellow and white dysentery of piglet, lamb diarrhoea, calf diarrhea, calf paratyphoid fever, the four seasons have loose bowels, transmissible gastroenteritis, antibacterial and virus mixed infection cause diarrhoea, enteritis etc.
China is the big country of stock raising poultry, and the sickness rate of these animal diarrhoeas is high every year, and the infectiousness of particularly raising base is faster, as treated and can cause death in enormous quantities not in time.For the control of animal dysentery, the common way of animal husbandry is when dysentery is popular, directly to feed various Western medicine antibiotic.Although its antidiarrheal of Western medicine antibiotic is fast, cure rate is high, because of the animal of dysentery death less, but the antibiotic drug residue of feeding is heavier, research shows that the edible antibiotic drug residue of beast fowl can not excrete, and easily causes enteric flora disturbance, affects the domestic birds and animals farrowing of laying eggs.Particularly, in dysentery epidemic season, some raises family for fear of a large amount of infection dysentery, and tens of days, even the several months was admixed antibiotic in feedstuff, and its consequence directly has a strong impact on the safety of the edible brutish meat of the mankind and egg product.For fear of the formation of endurance strain with reduce residual harm, selection have wide spectrum, antimicrbial power strong, be difficult for producing drug resistance, medicine that toxic and side effects is little, it is veterinary's circle problem anxious to be resolved, development and exploitation China Chinese herbal medicine resource are prevented and treated livestock and poultry, have caused that domestic and international experts and scholars greatly pay attention to.
We constantly sum up and grope in long-term clinical research, have obtained this and have had the pharmaceutical composition of stronger dysentery relieving effect.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition with dysentery relieving effect and preparation method thereof, pharmaceutical composition clinical application effect prepared by the present invention is good, cost is low, pure Chinese medicinal preparation, noresidue, has good application prospect.
The present invention makes after adopting Mahonia fortunei (Lindl.) Fedde, dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Fructus Chebulae, Rhizoma Zingiberis Recens, Pericarpium Granati charcoal according to certain compatibility processing, according to medicine heterogeneity, adopt respectively the mode of water extraction, 60% alcohol reflux, directly pulverizing to be used as medicine, and make powder or granule.This pharmaceutical composition has the effect of clearing away heat and cooling blood, removing toxic substances dysentery relieving, is mainly used in treating the dysentery that fowl poultry infects, clinical remarkable for livestock dysentery effect.
Mahonia fortunei (Lindl.) Fedde in pharmaceutical composition of the present invention has the effect of heat clearing and damp drying, removing toxic substances dysentery relieving, cures mainly the yellow dysentery of intestinal, jaundice due to damp-heat etc.; Dysentery relieving grass has the effect of heat clearing and inflammation relieving, inducing diuresis for treating stranguria syndrome, is mainly used in treating dysentery, nephritis, has sore throat etc.; The Radix Pulsatillae has the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, is mainly used in toxic-heat and blood stasis, amebic dysentery etc.; Fructus Chebulae have astringe the lung, the effect of astringing intestine to stop diarrhea, be mainly used in chronic diarrhea, chronic dysentery, proctoptosis etc.; Pericarpium Granati charcoal has the effect of relieving diarrhea with astringents, hemostasis, is mainly used in chronic diarrhea, chronic dysentery, has blood in stool etc.Above-mentioned all medicines share, reasonable recipe, gather altogether clearing away heat and cooling blood, removing toxic substances dysentery relieving effect.
The pharmaceutical composition for the treatment of livestock dysentery of the present invention, comprises the crude drug of following weight portion:
120～180 parts of Mahonia fortunei (Lindl.) Fedde, 120～180 parts of dysentery relieving grass, 90～150 parts of the Radix Pulsatillaes, 80～120 parts of Fructus Crataegis, 80～120 parts of Fructus Chebulaes, 80～120 parts, Rhizoma Zingiberis Recens, 15～25 parts of Pericarpium Granati charcoals.
The crude drug composition and ratio of pharmaceutical composition of the present invention is preferably:
150 parts of Mahonia fortunei (Lindl.) Fedde, 150 parts of dysentery relieving grass, 120 parts of the Radix Pulsatillaes, 100 parts of Fructus Crataegis, 100 parts of Fructus Chebulaes, 100 parts, Rhizoma Zingiberis Recens, 20 parts of Pericarpium Granati charcoals.
The concrete preparation method of the present invention is as follows: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, 60% ethanol that adds 4～8 times of amounts of medical material weight, reflux, extract, 1～3 time, each 1.5 hours, filter merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add the water of 8～12 times of amounts of medical material weight, extract 1～3 time, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add the conventional adjuvant of pharmaceutics, mix, make.
The dosage form that is applicable to medicine of the present invention is granule or powder.
Further optimizing the method is: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, add 60% ethanol of 6 times of amounts of medical material weight, reflux, extract, 2 times, each 1.5 hours, filter merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add the water of 10 times of amounts of medical material weight, extract 2 times, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add the conventional adjuvant of pharmaceutics, mix granulation agent or powder.
In the present invention, the conventional adjuvant of pharmaceutics described above is including but not limited to several below: starch, sucrose, dextrin, lactose, micropowder silica gel.
Pharmaceutical composition of the present invention is mainly used in treating livestock dysentery.
Pharmaceutical composition of the present invention have wide spectrum, antimicrbial power strong, be difficult for producing drug resistance, feature that toxic and side effects is little, treatment fowl poultry diarrhoeal diseases is had to good therapeutic effect, effectively avoid the formation of endurance strain and reduce residual harm.The present invention, by the method for the treatment of of heat clearing and damp drying, removing toxic substances dysentery relieving, has received satisfied curative effect to the prevention of the diseases such as damp-heat dysentery, dysentery pus and blood, tenesmus and treatment in clinical trial.Processing technology of the present invention is simple, and cost is low.
The specific embodiment
With specific embodiment, pharmaceutical composition prepared by the present invention is described again below, following examples are only for illustrating the present invention, and the present invention is not limited to this.
Embodiment 1
Prescription: Mahonia fortunei (Lindl.) Fedde 150g dysentery relieving grass 150g Radix Pulsatillae 120g Fructus Crataegi 100g Fructus Chebulae 100g Rhizoma Zingiberis Recens 100g Pericarpium Granati charcoal 20g
Method for making: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, add 1500ml60% ethanol, reflux, extract, 2 times, each 1.5 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add 4700ml water, extract 2 times, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add dextrin 60g, mix, dry-pressing is granulated, and obtains.(theoretical total amount 300g, the actual granule 289g that makes, finished granule rate 96.3%; Get this product 2g, the need testing solution preparation method preparation of measuring according to content of berberine under Cortex Phellodendri medical material item of < < Chinese Pharmacopoeia > > version in 2010, and carry out by the same method assay, recording content of berberine hydrochloride in this product is 4.4mg/g, recording content of berberine hydrochloride in Mahonia fortunei (Lindl.) Fedde is 1.2%, as calculated this product berberine hydrochloride rate of transform 71.5%)
Embodiment 2:
Prescription: Mahonia fortunei (Lindl.) Fedde 9kg dysentery relieving grass 6kg Radix Pulsatillae 4.5kg Fructus Crataegi 6kg Fructus Chebulae 4kg Rhizoma Zingiberis Recens 4kg Pericarpium Granati charcoal 1.25kg
Method for making: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, add 52L60% ethanol, reflux, extract, 2 times, each 1.5 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add 164L water, extract 2 times, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add dextrin 5kg, sucrose 1.5kg, mixes, and 80% alcohol granulation is dry, obtains.(theoretical total amount 18kg, the actual granule 17.2kg that makes, finished granule rate 95.8%; Get this product 2g, the need testing solution preparation method preparation of measuring according to content of berberine under Cortex Phellodendri medical material item of < < Chinese Pharmacopoeia > > version in 2010, and carry out by the same method assay, recording content of berberine hydrochloride in this product is 4.2mg/g, recording content of berberine hydrochloride in Mahonia fortunei (Lindl.) Fedde is 1.2%, as calculated this product berberine hydrochloride rate of transform 66.3%)
Embodiment 3:
Prescription: Mahonia fortunei (Lindl.) Fedde 1200g dysentery relieving grass 1200g Radix Pulsatillae 1500g Fructus Crataegi 800g Fructus Chebulae 1200g Rhizoma Zingiberis Recens 1200g Pericarpium Granati charcoal 150g
Method for making: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, add 19200ml60% ethanol, reflux, extract, 2 times, each 1.5 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add 56400ml water, extract 2 times, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add starch 800g, mix, dry-pressing is granulated, and obtains.(theoretical total amount 3kg, the actual granule 2.89kg that makes, finished granule rate 96.3%; Get this product 2g, the need testing solution preparation method preparation of measuring according to content of berberine under Cortex Phellodendri medical material item of < < Chinese Pharmacopoeia > > version in 2010, and carry out by the same method assay, recording content of berberine hydrochloride in this product is 3.4mg/g, recording content of berberine hydrochloride in Mahonia fortunei (Lindl.) Fedde is 1.2%, as calculated this product berberine hydrochloride rate of transform 68.1%)
Embodiment 4:
Prescription: Mahonia fortunei (Lindl.) Fedde 3000g dysentery relieving grass 2600g Radix Pulsatillae 1800g Fructus Crataegi 2200g Fructus Chebulae 1800g Rhizoma Zingiberis Recens 1800g Pericarpium Granati charcoal 400g
Method for making: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, add 28.8L60% ethanol, reflux, extract, 2 times, each 1.5 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add 67.2L water, extract 2 times, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add starch 600g, micropowder silica gel 100g, mixes, and obtains.(theoretical total amount 4.5kg, the actual granule 4.4kg that makes, powder yield rate 97.8%; Get this product 2g, the need testing solution preparation method preparation of measuring according to content of berberine under Cortex Phellodendri medical material item of < < Chinese Pharmacopoeia > > version in 2010, and carry out by the same method assay, recording content of berberine hydrochloride in this product is 5.8mg/g, recording content of berberine hydrochloride in Mahonia fortunei (Lindl.) Fedde is 1.2%, as calculated this product berberine hydrochloride rate of transform 70.4%)
Embodiment 5:
, there is dysentery on a large scale in 3500 of certain chicken farm poultry, heating anorexia etc., are used medicine of the present invention to treat.
(1) laboratory animal
Choose 3500 of disease chickens, main clinic symptoms is heating, tenesmus, and loose stool or be watery diarrhea, has blood in stool.
(2) Experimental agents
Totally 2000 for the treatment of groups, take the mixed drink of granule in the embodiment of the present invention 2, and usage: 5g adds 500ml water dissolution, and medication 3 days keeps environment ventilation sterilization simultaneously; Totally 1500 of matched groups, injection 0 Long-acting enrofloxacin injection (Wendeng City Yu Zeyinfeng animal pharmaceutical estate company limited), only, intramuscular injection,, is used in conjunction 3 to 0.2mL/ by 1 times/day.Above two groups are stopped observation post administration 5, analyze medication effect.
(3) evaluation criterion
1) observation index
Give the sick chicken manure of observation post administration just with body temperature situation, feces is divided into normally, water sample and 3 grades of hemafecia, rear 2 grades are all judged to be dysentery.
2) curative effect index
Mortality rate=(dead number of elements/this test group sum) * 100%;
Effective percentage=(each group survival number/this test group sum when experiment finishes) * 100%;
Cure rate=(number of elements that clinical symptoms disappears completely/this test group sum) * 100%
(4) experimental result and analysis
To 2 groups of sick chickens, by different scheme medications, the death toll of each group, healing number, significant figure, mortality rate, cure rate, effective percentage situation, the results are shown in Table 1.
The curative effect index of each medication group of table 1
| Group | Sum | Death toll | Cure number | Significant figure | Mortality rate | Cure rate | Effective percentage |
| Treatment group | 2000 | 44 | 1898 | 1956 | 2.2% | 94.9% | 97.8% |
| Matched group | 1500 | 173 | 1129 | 1327 | 11.5% | 75.3% | 88.5% |
Result shows, the effective percentage of medicine of the present invention reaches 97.8%, relatively has significant advantage with matched group.
Embodiment 6:
6 of self-employed entrepreneurs milch cows, cause diarrhoea and dysentery because eating microbiological contamination food by mistake, color depth palm fibre blood, and band blood has dense.Get the made Granules in Treating of embodiment 3, scheme: after grain dissolution, drink water, a 40g/ head, three times on the one.Administration is observed for 3 days afterwards, all without symptom of diarrhea, and recovery from illness.
Embodiment 7:
Certain pig farm is 12 of pig house porklings wherein, bacterial infection dysentery, and rare aquiform stool, has tenesmus.Get the treatment of the made powder of embodiment 4, scheme: mix food and feed, a 5g/ only, three times on the one, administration 3 days.Take observation post administration, 11 porklings are all without symptom of diarrhea, recovery from illness, another individually dosed a day again, symptom of diarrhea completely without.
Above-described embodiment shows, its yield rate of the medicine that pharmaceutical composition of the present invention is made is all higher than 95%, and in Mahonia fortunei (Lindl.) Fedde, the rate of transform of index components berberine hydrochloride is all higher than 65%.The reasonable recipe of visible pharmaceutical composition of the present invention, its preparation technology is reasonable, feasible, has the prospect of stronger practical application.
Through a plurality of healing cases, show the diarrhoea class disease that pharmaceutical composition prepared by the present invention can effectively be treated domestic animal, rather than because the case that the difference on individuality or Therapeutic Method causes.Pharmaceutical composition of the present invention has good application and popularization value.
Claims (8)
1. a pharmaceutical composition with dysentery relieving effect, is characterized in that, comprises following crude drug: Mahonia fortunei (Lindl.) Fedde, dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Fructus Chebulae, Rhizoma Zingiberis Recens, Pericarpium Granati charcoal;
Wherein: 120～180 parts of Mahonia fortunei (Lindl.) Fedde, 120～180 parts of dysentery relieving grass, 90～150 parts of the Radix Pulsatillaes, 80～120 parts of Fructus Crataegis, 80～120 parts of Fructus Chebulaes, 80～120 parts, Rhizoma Zingiberis Recens, 15～25 parts of Pericarpium Granati charcoals.
2. pharmaceutical composition as claimed in claim 1, is characterized in that, comprises the crude drug of following weight portion: 150 parts of Mahonia fortunei (Lindl.) Fedde, 150 parts of dysentery relieving grass, 120 parts of the Radix Pulsatillaes, 100 parts of Fructus Crataegis, 100 parts of Fructus Chebulaes, 100 parts, Rhizoma Zingiberis Recens, 20 parts of Pericarpium Granati charcoals.
3. the preparation method of pharmaceutical composition as claimed in claim 1 or 2, it is characterized in that: by crude drug such as Mahonia fortunei (Lindl.) Fedde, dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Fructus Chebulae, Rhizoma Zingiberis Recens, Pericarpium Granati charcoals, according to medicine heterogeneity, adopt respectively the mode of water extraction, 60% alcohol reflux, directly pulverizing to be used as medicine; Be specially: Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae are adopted to 60% alcohol reflux, dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens are adopted to water extraction, Pericarpium Granati charcoal is directly pulverized.
4. the preparation method of pharmaceutical composition as claimed in claim 3, it is characterized in that: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, 60% ethanol that adds 4～8 times of amounts of medical material weight, reflux, extract, 1～3 time, each 1.5 hours, filters, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add the water of 8～12 times of amounts of medical material weight, extract 1～3 time, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add the conventional adjuvant of pharmaceutics, mix, make medicament.
5. the preparation method of pharmaceutical composition as claimed in claim 4, it is characterized in that: get Mahonia fortunei (Lindl.) Fedde, Fructus Chebulae, 60% ethanol that adds 6 times of amounts of medical material weight, reflux, extract, 2 times, each 1.5 hours, filters, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get dysentery relieving grass, the Radix Pulsatillae, Fructus Crataegi, Rhizoma Zingiberis Recens, add the water of 10 times of amounts of medical material weight, extract 2 times, each 2 hours, filter, merging filtrate, the thick paste that when filtrate decompression is concentrated into 60 ℃, relative density is 1.30～1.35, drying under reduced pressure, is ground into fine powder; Get Pericarpium Granati charcoal, be ground into fine powder; Get above-mentioned three kinds of fine powders, add the conventional adjuvant of pharmaceutics, mix, make medicament.
6. the preparation method as described in claim 4 or 5, is characterized in that: the type of the medicament of making is granule or powder.
7. the preparation method as described in claim 4 or 5, is characterized in that: the conventional adjuvant of described pharmaceutics is any one or several in starch, sucrose, dextrin, lactose, micropowder silica gel.
8. the pharmaceutical composition described in claim 1 or 2 is in the application for the preparation of in treatment livestock dysentery disease medicament.
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