CN101015619A - Chinese medicine composition for treating avian cholera and preparing method thereof - Google Patents
Chinese medicine composition for treating avian cholera and preparing method thereof Download PDFInfo
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- CN101015619A CN101015619A CNA2007100567981A CN200710056798A CN101015619A CN 101015619 A CN101015619 A CN 101015619A CN A2007100567981 A CNA2007100567981 A CN A2007100567981A CN 200710056798 A CN200710056798 A CN 200710056798A CN 101015619 A CN101015619 A CN 101015619A
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Abstract
The invention relates to a traditional Chinese pharmaceutical composition for treating avian cholera and process for preparation, wherein the composition is prepared from the following Chinese medicinal herbs (by weight portions): baikal skullcap root 5-15 parts, purslane 5-15 parts, green chiretta 18-22 parts, haw 4-6 parts, garden burnet root 9-13 parts, dandehon herb 9-13 parts, licorice root 4-6 parts and cordate houttuynia 18-22 parts.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of fowl cholera and preparation method thereof, in particular, relating to a kind of is the pharmaceutical composition and preparation method thereof of the treatment fowl cholera made of raw material with the vegetable Chinese herbal medicine.
Background technology
Fowl cholera claims fowl pasteurellosis or fowl bovine pasteurellosis again.It is the acute fatal infectious disease of the fowl that causes by pasteurella multocida.Pathogen extensively parasitizes on fowl respiratory tract and the gastrointestinal mucosal, with the birds symbiosis, is conditioned pathogen, and birds is at stress state, especially falls ill during the heat stress state.Acute case shows as the whole body mucosa little petechia, rapid onset, mortality rate height.Chronic case mainly shows as cockscomb, meat whisker edema, joint inflammation.Primary disease often is acute septic process and violent dysentery, and the M ﹠ M height is sporadic in various places or endemicity takes place, and is commonly encountered diseases and frequently-occurring disease that current serious influences China's aviculture development.The annual aviculture of China of giving causes very big loss.The multiple methods of preventing and treating such as present fowl cholera adopts that vaccine and chemical antibacterial are thrown something and fed.Adopt vaccine control fowl cholera, have problems such as duration of immunity weak point, weak effect, be difficult to promote.Adopt Tri-Biocin control fowl cholera, have the problem of Drug resistance and drug residue.Owing to take antibiotics for a long time, caused the drug-fast generation of pathogenic microorganism, make common antibiotics usefulness reduce.In addition, drug residue, remote-effects people's is healthy, and effect is all undesirable.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, and it is raw material that a kind of employing Chinese herbal medicine is provided, and avoids pathogenic microorganism to develop immunity to drugs, the pharmaceutical composition of the treatment fowl cholera of noresidue.
Another object of the present invention provides a kind of preparation of drug combination method that can improve the treatment fowl cholera of product drug effect.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of fowl cholera is characterized in that the Chinese herbal medicine by the following portions by weight proportioning is that preparation of raw material forms: Radix Scutellariae 5-15 part, Herba Portulacae 5-15 part, Herba Andrographis 18-22 part, Fructus Crataegi 4-6 part, Radix Sanguisorbae 9-13 part, Herba Taraxaci 9-13 part, Radix Glycyrrhizae 4-6 part, Herba Houttuyniae 18-22 part.
A kind of preparation method for the treatment of the Chinese medicine composition of fowl cholera, it is characterized in that, take by weighing Radix Scutellariae 5-15 part, Herba Portulacae 5-15 part, Herba Andrographis 18-22 part, Fructus Crataegi 4-6 part, Radix Sanguisorbae 9-13 part, Herba Taraxaci 9-13 part, Radix Glycyrrhizae 4-6 part, Herba Houttuyniae 18-22 part by weight, carry out micronizing, sieve, mix homogeneously gets final product.
Wherein, the granularity after sieving is the 200-300 order.
The present invention has following technique effect:
This medicine belongs to pure Chinese medicinal preparation, can avoid the pathogenic microorganism Drug resistance, uses back medicine noresidue, and the guarantee people's is healthy.Radix Scutellariae in the prescription of the present invention, Herba Portulacae, Herba Andrographis, Fructus Crataegi, Radix Sanguisorbae, Herba Taraxaci, Radix Glycyrrhizae, Herba Houttuyniae are Chinese herbal medicine commonly used, and its main effect is as follows: Radix Scutellariae: the hot dampness that disappears, eliminating fire and detoxication.Be used for dysentery, the cough due to lung-heat.Herba Portulacae: Herba Portulacae has the obvious sterilization effect to the bus bacillus that causes fowl cholera.The Herba Andrographis heat-clearing and toxic substances removing, removing heat from blood, detumescence.The Radix Sanguisorbae cooling blood for hemostasis, skin ulcer is held back in detoxifcation.The Herba Taraxaci heat-clearing and toxic substances removing.The Herba Houttuyniae heat-clearing and toxic substances removing, clear carbuncle evacuation of pus.Set of guidelines is to the characteristics of incidence and the mechanism of fowl cholera, sterilization, heat-clearing and toxic substances removing, clear carbuncle evacuation of pus, the hot dampness that disappears, eliminating fire and detoxication, treating both the principal and secondary aspects of a disease.
On preparation technology, utilized superfine communication technique to carry out the processing of Chinese medicine, can break the cell wall (sporoderm-broken rate can reach more than 90%) of medical material, increased the availability of effective ingredient, the contact area of increasing and solvent, the overall availability of raising raw material of Chinese medicine.Simultaneously, because micronizing does not have the phenomenon of hot-spot, and pulverizing speed is fast, can also farthest keep bioactive substance and various nutritional labeling in the Chinese crude drug, effective ingredient is absorbed more fully, it is shorter to meet the fowl intestinal more, and medicine is digested and assimilated incomplete characteristics, has improved the drug effect of product widely.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
Take by weighing 10 parts of Radix Scutellariaes, 10 parts of Herba Portulacaes, 20 parts of Herba Andrographis, 5 parts of Fructus Crataegis, 10 parts of Radix Sanguisorbaes, 10 parts of Herba Taraxacis, 5 parts in Radix Glycyrrhizae, 20 parts of Herba Houttuyniae by weight, after carrying out micronizing, cross 200 mesh sieves, promptly make the Chinese medicine composition that the present invention treats fowl cholera after the mixing.
Embodiment 2
Take by weighing 15 parts of Radix Scutellariaes, 15 parts of Herba Portulacaes, 20 parts of Herba Andrographis, 4 parts of Fructus Crataegis, 13 parts of Radix Sanguisorbaes, 13 parts of Herba Taraxacis, 6 parts in Radix Glycyrrhizae, 20 parts of Herba Houttuyniae by weight, after carrying out micronizing, cross 300 mesh sieves, promptly make the Chinese medicine composition that the present invention treats fowl cholera after the mixing.
Embodiment 3
Take by weighing 5 parts of Radix Scutellariaes, 5 parts of Herba Portulacaes, 18 parts of Herba Andrographis, 6 parts of Fructus Crataegis, 11 parts of Radix Sanguisorbaes, 11 parts of Herba Taraxacis, 4 parts in Radix Glycyrrhizae, 18 parts of Herba Houttuyniae by weight, after carrying out micronizing, cross 200 mesh sieves, promptly make the Chinese medicine composition that the present invention treats fowl cholera after the mixing.
Embodiment 4
Take by weighing 12 parts of Radix Scutellariaes, 12 parts of Herba Portulacaes, 22 parts of Herba Andrographis, 5 parts of Fructus Crataegis, 9 parts of Radix Sanguisorbaes, 9 parts of Herba Taraxacis, 5 parts in Radix Glycyrrhizae, 22 parts of Herba Houttuyniae by weight, after carrying out micronizing, cross 300 mesh sieves, promptly make the Chinese medicine composition that the present invention treats fowl cholera after the mixing.
The clinical experiment report:
1.1 summary: product of the present invention has tangible antibacterial action to avian pasteurella multocida.Therapeutic dose to fowl pasteurellosis is prepared burden by every 1Kg feedstuff 1g.
1.2 test objective: the fowl cholera that is caused by pasteurella multocida is a kind of acute septic infectious disease, it is characterized in that sudden onset, and the mortality rate height is very harmful to aviculture.The medicine that can effectively prevent and treat fowl cholera is except that olaquindox before this, and other drug is all satisfactory inadequately to this sick prevention effect.Regrettably the toxicity of olaquindox is bigger, during clinical use intoxicating phenomenon is arranged, and its genetoxic does not cause the attention that people are enough.The fowl cholera pasteurellosis bacillus is very easy generation drug resistance in actual production, therefore selects a kind of safety, is difficult for producing chemical sproof medicine and just necessitates, product of the present invention is a pure Chinese medicinal preparation, in order to confirm its antibacterial action, for clinical application provides scientific basis, we have done test.
1.3 content of the test
1.3.1 experimental animal
1.3.1.1 kind: AA broiler
1.3.1.2 source: chicken farm, suburb, Shijiazhuang
1.3.1.3 body weight: average weight 0.816kg
1.3.1.4 age in days: 21 ages in days
1.3.1.5 physical examination: test chicken adopts online flat mode of supporting, manage by normal feeding and management, before test, do not add any antibacterials in the feedstuff for the examination chicken, and carry out the immunity inoculation of infectious bronchitis, infectious bursal disease and newcastle disease in advance.
1.3.1.6 every treated animal number: the chicken group is divided into A, B, C, D, E, F group at random, and 30 every group, the grouping situation sees Table 1.
Table 1
| Numbering | Group | Quantity/only | Average weight/kg | Usage and consumption | Drug treatment |
| A | Normal healthy controls (not infecting) | 30 | 0.821 | 0 | |
| B | Infect contrast | 30 | 0.814 | 0 | |
| C | Product high dose group of the present invention | 30 | 0.816 | The 2g/kg mixed feeding | 3 days |
| D | Dosage group in the product of the present invention | 30 | 0.810 | The 1g/kg mixed feeding | 3 days |
| E | Product low dose group of the present invention | 30 | 0.819 | 0.5g/kg mixed feeding | 3 days |
| F | Ciprofloxacin soluble powder matched group | 30 | 0.813 | 50ppm drinking-water | 3 days |
1.3.1.7 raising condition: test chicken adopts online flat mode of supporting, 25/meter of density
2, 25 ℃ of temperature, illumination 16 hours/day, daily ration is produced the complete granular material for Shijiazhuang Zhengda Group, main nutrient composition index: thick protein 〉=21.0%, methionine+cystine 〉=0.75%, crude fat 〉=3.2%, crude fibre≤5.0%, calcium 0.6-1.0%, total phosphorus 〉=0.6%, Sal 0.3-0.7%, coarse ash≤6.5%, moisture≤14.0%.Do not contain any antibacterials in the feedstuff.Adopt and freely drink water.
1.3.2 EXPERIMENTAL DESIGN: A group is the normal healthy controls group, and the B group is for infecting matched group, and the C group is product high dose group of the present invention, and the D group is product low dose group of the present invention for dosage group in the product of the present invention, E group, and the F group is ciprofloxacin soluble powder matched group.
1.3.3 be subjected to the reagent thing: the product of the embodiment of the invention 1
1.3.4 reference substance: ciprofloxacin soluble powder
1.3.4.1 specification: hydrochloric ciprofloxacin is 2%.
1.4 morbidity mode
1.4.1 artificial onset
1.4.1.1 fowl cholera strain: avian pasteurella multocida virulent strain C48-1, available from China Veterinary Drugs Supervisory Inst..
1.4.1.2 morbidity method:
1.4.1.2.1 bacterial strain rejuvenation: with C48-1 bacterial strain martin's bouillon 37 ℃ of 24 hours culture 1.0ml, one of 3 monthly age of intramuscular injection healthy chicken, dead separation of bacterial in 24 hours, inoculation blood agar inclined-plane, 37 ℃ cultivate 24 hours standby.
1.4.1.2.2 bacterium liquid preparation: with C48-1 blood agar inclined-plane seed, inoculate the interior 37 ℃ of water-bath shaken cultivation of the martin's bouillon that contains 0.1% cracking blood 24 hours, contain the bacterium number for every milliliter with cultivating counting method counting bacterium liquid, with bacterium liquid with martin's bouillon dilution for every milliliter of bacterium liquid that contains 5 viable bacterias as counteracting toxic substances usefulness, every chicken muscle injected dose is 5 bacterium/ml.
1.4.3 dosage
1.4.3.1 it is with reference to the usage in the Tianjin veterinary drug quality standard " Huang Malian looses " and consumption and fixed that dosage is selected according to above-mentioned dosage.
1.4.3.2 high, medium and low dosage: high dose is by every 2g/kg mixed feeding, and middle dosage is by every 1g/kg mixed feeding, and low dosage is by every 0.5g/kg mixed feeding.
1.4.4 route of administration product spice of the present invention, ciprofloxacin soluble powder are freely drunk water, administration in 4 hours behind counteracting toxic substances is organized in each treatment, and successive administration 3 days is changed new medicinal liquid every day, clinical observation 7 days, record morbidity and death condition.Experimental result is represented with mortality rate.
1.4.5 observation index
1.4.5.1 symptom: the artificial challenge is after 24 hours, and the chicken clinical manifestation of medicine matched group and positive controls is lethargy, anorexia, useless food.
1.4.6 result of the test and analysis: test clinical experiment efficacy result sees Table 2.
1.4.6.1.1 cure rate: all at duration of test, mental status and diet desire recover normal after administration, row's yellow-white watery stools no longer occurs and all belong to healing.Calculate cure rate according to curing the chicken number.
1.4.6.1.2 mortality rate: all at duration of test, the classical symptom and the death of fowl cholera appears in chicken, cuts open the pathological change that all dead chickens of inspection present fowl cholera.The mortality rate of product high dose group of the present invention and middle dosage group all is lower than 5%, statistical analysis shows that the mortality rate of dosage group significantly is lower than product low dose group of the present invention and ciprofloxacin soluble powder matched group in product high dose group of the present invention and the product of the present invention.
1.4.6.3 untoward reaction: pressed every 5g/kg mixed feeding 5 days.Test chicken is not observed any untoward reaction.
1.5 conclusion
This result of the test shows that product of the present invention is used for the treatment of fowl cholera obvious effects.Dosage in the product of the present invention is used in clinical recommendation, promptly presses the 1g/kg mixed feeding.
Table 2
| Numbering | Group | The chicken number | Counteracting toxic substances dosage CFU | Observed 3 days | ||
| Death toll (plumage) | Mortality rate (%) | Protective rate (%) | ||||
| A | Normal healthy controls (not infecting) | 30 | - | 0 | - | - |
| B | Infect contrast | 30 | 5 | 30 | 100 | 0 |
| C | Product high dose group of the present invention | 30 | 5 | 0 | 0 | 100 |
| D | Dosage group in the product of the present invention | 30 | 5 | 1 | 3.3 | 96.7 |
| E | Product low dose group of the present invention | 30 | 5 | 4 | 13.3 | 86.7 |
| F | Ciprofloxacin soluble powder matched group | 30 | 5 | 2 | 6.6 | 93.4 |
Claims (3)
1, a kind of Chinese medicine composition for the treatment of fowl cholera is characterized in that the Chinese herbal medicine by the following portions by weight proportioning is that preparation of raw material forms: Radix Scutellariae 5-15 part, Herba Portulacae 5-15 part, Herba Andrographis 18-22 part, Fructus Crataegi 4-6 part, Radix Sanguisorbae 9-13 part, Herba Taraxaci 9-13 part, Radix Glycyrrhizae 4-6 part, Herba Houttuyniae 18-22 part.
2, a kind of preparation method for the treatment of the Chinese medicine composition of fowl cholera, it is characterized in that, take by weighing Radix Scutellariae 5-15 part, Herba Portulacae 5-15 part, Herba Andrographis 18-22 part, Fructus Crataegi 4-6 part, Radix Sanguisorbae 9-13 part, Herba Taraxaci 9-13 part, Radix Glycyrrhizae 4-6 part, Herba Houttuyniae 18-22 part by weight, carry out micronizing, sieve, mix homogeneously gets final product.
3, the preparation method of the Chinese medicine composition of treatment fowl cholera according to claim 2 is characterized in that, the granularity after sieving is the 200-300 order.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100567981A CN101015619A (en) | 2007-02-13 | 2007-02-13 | Chinese medicine composition for treating avian cholera and preparing method thereof |
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| CNA2007100567981A CN101015619A (en) | 2007-02-13 | 2007-02-13 | Chinese medicine composition for treating avian cholera and preparing method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115607614A (en) * | 2022-10-21 | 2023-01-17 | 河南省现代中兽医研究院 | Traditional Chinese medicine composition for treating livestock and poultry colibacillosis and preparation method thereof |
| CN116211964A (en) * | 2023-04-06 | 2023-06-06 | 临沂金翠兽药有限公司 | Livestock traditional Chinese veterinary medicine additive and preparation method thereof |
-
2007
- 2007-02-13 CN CNA2007100567981A patent/CN101015619A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115607614A (en) * | 2022-10-21 | 2023-01-17 | 河南省现代中兽医研究院 | Traditional Chinese medicine composition for treating livestock and poultry colibacillosis and preparation method thereof |
| CN115607614B (en) * | 2022-10-21 | 2023-09-26 | 河南省现代中兽医研究院 | Traditional Chinese medicine composition for treating colibacillosis of livestock and poultry and preparation method thereof |
| CN116211964A (en) * | 2023-04-06 | 2023-06-06 | 临沂金翠兽药有限公司 | Livestock traditional Chinese veterinary medicine additive and preparation method thereof |
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Open date: 20070815 |