CN116211964A - Livestock traditional Chinese veterinary medicine additive and preparation method thereof - Google Patents
Livestock traditional Chinese veterinary medicine additive and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a veterinary drug additive for livestock and a preparation method thereof, and relates to the technical field of veterinary drug additives, wherein the additive comprises the following components: fructus Terminaliae Billericae, herba Flat bud, herba Hyperici Japonici, herba Potentillae Discoloris, bulbus Iphigeniae Indicae, fructus Bruceae, rhizoma picrorhizae, and antiseptic composed of fructus Perillae, herba Salvia officinalis, and fructus Litseae. The traditional Chinese veterinary medicine additive provided by the invention firstly proposes that the Terminalia Billerica, the herba Hedyotidis Diffusae, the Indian iphigenia bulb, the fructus bruceae and the rhizoma picrorhizae are adopted as feed additives, so that the traditional Chinese veterinary medicine additive is used for preventing and treating production loss caused by the fowl cholera disease, the specific dosage of each component and the optimal addition amount of the feed additives in the feed are determined, and a new scheme and guiding support are provided for the fowl pasteurellosis prevention and treatment work.
Description
Technical Field
The invention relates to the technical field of veterinary drug additives, in particular to a veterinary drug additive for livestock and a preparation method thereof.
Background
The fowl cholera is caused by Pasteurella multocida, and is an acute infectious disease which can infect fowl such as chicken, duck, goose, etc., also called fowl Pasteurellosis and fowl outlet hemorrhagic septicemia. The main onset symptoms include: sinusitis, small amount of mucus flowing out of nostril, mucous secretion flowing out of oral cavity, severe diarrhea, fever, bearded edema, and death. In general, chicks have a certain immunity to the disease and are less infected. Chickens of 3 to 4 months of age and adult chickens in the early stages of laying are more susceptible to infection. Under the influence of adverse factors such as sudden weather change and improper feeding management, the disease is easy to happen, the death rate can reach 20%, in the prior art, the prevention measure of the fowl cholera is to immunize 30-day-old chicks by intramuscular injection of fowl cholera inactivated vaccine, and if the fowl cholera is treated, antibiotics, sulfonamides, olaquindox and other medicines are selected, but in the prior art, a livestock veterinary drug additive which has better effect and is used for preventing and treating the fowl cholera does not appear.
The Chinese herbal medicine feed additive is a pure natural compound feed additive which takes the traditional theory of the characteristics, the physical and the physical relations of Chinese herbal medicines as the main factor and is prepared by the subject theoretical techniques of the feeding industry, the feed industry and the like. At present, china puts forward the concept of developing green healthy cultivation on the current development situation of poultry cultivation industry, ensures the safety of animal foods, meets the quality standard of livestock and poultry products in domestic and foreign markets, and realizes the sustainable development of the cultivation industry. The Chinese veterinary medicine is an emerging industry in recent years, simply said Chinese medicine theory is applied to animals so as to replace chemical medicines with side effects, the research application of Chinese herbal medicine feed additives is the needs of win-win, cost reduction and benefit improvement of consumers and breeders, the Chinese herbal medicine feed additives can prevent and treat diseases, promote animal growth and generate no medicine residues harmful to human health, the traditional Chinese medicine of China is gradually valued by wide animal medicine production enterprises and livestock and poultry breeders, and the production and use proportion of the Chinese veterinary medicine is gradually increased year by year. Many large livestock and poultry raising enterprises have used traditional Chinese veterinary medicines as important application objects for preventing and treating diseases and promoting animal growth, and the traditional Chinese veterinary medicines of small and medium-sized farms (households) are increasingly widely used, so that the traditional Chinese veterinary medicines become the first choice for research and development of animal medicine production enterprises.
Disclosure of Invention
Aiming at the problems in the prior art, an object of the invention is to provide a veterinary drug additive for livestock, which comprises the following components in parts by weight: 7.6 to 8.8 parts of fructus terminaliae, 6.5 to 7.5 parts of herba platyphyllae, 5.4 to 6.8 parts of herba hyperici japonici, 5.0 to 6.2 parts of discolor cinquefoil herb, 4.3 to 5.4 parts of edible tulip, 2.7 to 3.9 parts of fructus brucea javanica, 2.2 to 3.5 parts of rhizoma picrorhizae and 1.0 to 2.4 parts of preservative.
Further, the livestock traditional Chinese veterinary medicine additive comprises the following components in parts by weight: 7.6 parts of fructus terminaliae, 6.5 parts of hyacinth bud, 5.4 parts of herba hyperici japonici, 5.0 parts of discolor cinquefoil herb, 4.3 parts of Indian iphigenia bulb, 2.7 parts of fructus bruceae, 2.2 parts of rhizoma picrorhizae and 1.0 part of preservative.
Further, the livestock traditional Chinese veterinary medicine additive comprises the following components in parts by weight: 8 parts of fructus terminaliae, 6.8 parts of flat bud, 5.7 parts of herba hyperici japonici, 5.3 parts of discolor cinquefoil herb, 4.5 parts of Indian iphigenia bulb, 3 parts of brucea javanica, 2.5 parts of rhizoma picrorhizae and 1.2 parts of preservative.
Further, the livestock traditional Chinese veterinary medicine additive comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba hyperici japonici, 5.6 parts of discolor cinquefoil herb, 4.8 parts of Indian iphigenia bulb, 3.4 parts of brucea javanica, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative.
Further, the livestock traditional Chinese veterinary medicine additive comprises the following components in parts by weight: 8.5 parts of fructus terminaliae, 7.2 parts of hyacinth bud, 6.4 parts of herba hyperici japonici, 5.9 parts of discolor cinquefoil herb, 5.2 parts of Indian iphigenia bulb, 3.6 parts of fructus bruceae, 3.2 parts of rhizoma picrorhizae and 2 parts of preservative.
Further, the livestock traditional Chinese veterinary medicine additive comprises the following components in parts by weight: 8.8 parts of fructus terminaliae, 7.5 parts of hyacinth bud, 6.8 parts of herba hyperici japonici, 6.2 parts of discolor cinquefoil herb, 5.4 parts of Indian iphigenia bulb, 3.9 parts of fructus bruceae, 3.5 parts of rhizoma picrorhizae and 2.4 parts of preservative.
Preferably, the preservative consists of perilla fruit, sage herb and litsea cubeba according to the weight ratio of 0.5:1:1.
Another object of the present invention is to provide a method for preparing the veterinary drug additive for livestock, comprising the steps of: (1) taking materials and performing corresponding treatment for standby; (2) Mixing and chopping perilla fruit, sage and litsea cubeba according to the weight parts of the preservative and the weight ratio of the components of the preservative to the grain size of less than or equal to 0.5cm to obtain mixed slag, adding ethanol with the concentration of 95 percent relative to the mass of the mixed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the concentration of 95 percent relative to the mass of the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the two filtrate, removing the ethanol, and concentrating the filtrate after the impurity removal to 1/3 of the original volume to obtain the preservative; (3) Mixing and crushing the Billeaf terbula fruit, the flat bud, the herba Hyperici Japonici, the discolor cinquefoil herb, the edible tulip, the brucea javanica and the rhizoma picrorhizae according to parts by weight, sieving with a 20-mesh sieve, fully and uniformly mixing to obtain mixed powder, atomizing and spraying the prepared preservative into the mixed powder, and continuously stirring and stirring the mixed powder during spraying so that the preservative can be uniformly adhered to the mixed powder, thereby obtaining the traditional Chinese veterinary medicine additive after uniformly mixing.
The invention also aims to provide a using method of the livestock veterinary drug additive, wherein the feed additive accounts for 4.25% of the total weight of livestock feed, and the livestock veterinary drug additive is prepared by fully and uniformly mixing the feed additive and the feed when the livestock veterinary drug additive is used.
The invention has the following beneficial effects:
the traditional Chinese veterinary medicine additive provided by the invention firstly proposes that the Terminalia Billerica, the herba Hedyotidis Diffusae, the Indian iphigenia bulb, the fructus bruceae and the rhizoma picrorhizae are adopted as feed additives, so that the production loss caused by the diseases of the fowl cholera can be prevented and improved, the specific dosage of each component and the optimal addition amount of the feed additives in the feed can be determined, and a new scheme and guiding support are provided for the prevention and treatment of the fowl pasteurellosis;
the Chinese veterinary drug additive disclosed by the invention utilizes natural Chinese herbal medicines, carries out scientific and strict compatibility on the Billeaf tersweet herb, the flat bud, the herba Hyperici Japonici, the discolor cinquefoil herb, the Indian iphigenia bulb, the fructus bruceae and the rhizoma picrorhizae, has the effect of obviously improving and preventing and treating livestock and poultry cholera, does not generate drug resistance and side effects compared with chemical agents adopted in the prior art, can promote the growth and development of chickens, and improves the immunity and disease resistance of chickens, and is an environment-friendly pollution-free additive;
the preservative used in the veterinary drug additive can inhibit the decay of the additive and feed, and can prevent and treat chicken from being infected by avian pasteurellosis to a certain extent, the preservative is a natural material prepared by combining and matching three components of perilla fruit, sage and litsea cubeba, and has no side effect in use, and has positive effect on the growth and development of livestock;
the traditional Chinese veterinary medicine additive has small addition amount, can be directly added into livestock feed, and has the advantages of good economy, low cost, simple and convenient operation and implementation, safety, reliability, effectiveness and the like.
Description of the embodiments
The following examples are provided to illustrate the technical aspects of the present invention more clearly, but are not intended to limit the scope of the present invention.
Examples
The embodiment 1 discloses a veterinary drug additive for livestock, which comprises the following components in parts by weight:
7.6 parts of fructus terminaliae, 6.5 parts of hyacinth bud, 5.4 parts of herba hyperici japonici, 5.0 parts of discolor cinquefoil herb, 4.3 parts of Indian iphigenia bulb, 2.7 parts of fructus bruceae, 2.2 parts of rhizoma picrorhizae and 1.0 part of preservative.
Examples
The embodiment 2 discloses a veterinary drug additive for livestock, which comprises the following components in parts by weight:
8 parts of fructus terminaliae, 6.8 parts of flat bud, 5.7 parts of herba hyperici japonici, 5.3 parts of discolor cinquefoil herb, 4.5 parts of Indian iphigenia bulb, 3 parts of brucea javanica, 2.5 parts of rhizoma picrorhizae and 1.2 parts of preservative.
Examples
The embodiment 3 discloses a veterinary drug additive for livestock, which comprises the following components in parts by weight:
8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba hyperici japonici, 5.6 parts of discolor cinquefoil herb, 4.8 parts of Indian iphigenia bulb, 3.4 parts of brucea javanica, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative.
Examples
The embodiment 1 discloses a veterinary drug additive for livestock, which comprises the following components in parts by weight:
8.5 parts of fructus terminaliae, 7.2 parts of hyacinth bud, 6.4 parts of herba hyperici japonici, 5.9 parts of discolor cinquefoil herb, 5.2 parts of Indian iphigenia bulb, 3.6 parts of fructus bruceae, 3.2 parts of rhizoma picrorhizae and 2 parts of preservative.
Examples
The embodiment 1 discloses a veterinary drug additive for livestock, which comprises the following components in parts by weight:
8.8 parts of fructus terminaliae, 7.5 parts of hyacinth bud, 6.8 parts of herba hyperici japonici, 6.2 parts of discolor cinquefoil herb, 5.4 parts of Indian iphigenia bulb, 3.9 parts of fructus bruceae, 3.5 parts of rhizoma picrorhizae and 2.4 parts of preservative.
Examples
Based on examples 1-5, the present example 6 discloses a preservative which can inhibit the spoilage of feed and additives and has the effect of prolonging the shelf life of the feed and additives, wherein the preservative is prepared by mixing perilla fruit, sage and litsea cubeba according to the weight ratio of 0.5:1:1.
Examples
Based on examples 1-5, this example 7 discloses a preparation method of veterinary drug additive for livestock, which specifically comprises the following steps:
drawing materials: taking a sufficient amount of mature fruit of Terminalia bellerica, cleaning, removing impurities and air-drying for later use; taking a sufficient amount of whole annual flat buds, cleaning and air-drying for later use; taking a sufficient amount of whole annual or at least annual herb of the herba hyperici japonici, cleaning and air-drying for later use; taking a sufficient amount of whole perennial discolor cinquefoil herb, cleaning and air-drying for later use; cleaning and air-drying enough edible tulip for standby; taking enough mature fruit brucea javanica, cleaning, removing impurities and air-drying for later use; taking a sufficient amount of whole plant of the picrorhiza rhizome for cleaning and air-drying for later use; taking enough mature fruit perilla seeds, cleaning, removing impurities and air-drying for later use; taking enough annual sage whole plants, cleaning and air-drying for later use; taking enough ripe fruit litsea cubeba, cleaning, removing impurities and air-drying for later use;
mixing and chopping the perilla fruit, the sage herb and the litsea cubeba which are used for later use according to the weight parts of the preservative and the weight ratio of the components thereof until the particle size is less than or equal to 0.5cm to obtain mixed slag, adding ethanol with the concentration of 95 percent relative to 3 times of the mass of the mixed slag, heating and refluxing for 85min, filtering to obtain filter residues, then adding ethanol with the concentration of 95 percent relative to 3 times of the mass of the filter residues into the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining filtrate for two times, removing the ethanol, and concentrating the filtrate after the impurity removal to 1/3 of the original volume to obtain the preservative required by the embodiment of the invention;
mixing and crushing the ready-to-use fructus terminaliae, the flat bud, the hypericum japonicum, the discolor cinquefoil herb, the edible tulip, the brucea javanica and the rhizoma picrorhizae to a 20-mesh sieve according to parts by weight, fully and uniformly mixing to obtain mixed powder, atomizing and spraying the prepared preservative into the mixed powder, and continuously stirring and stirring the mixed powder during spraying so that the preservative can be uniformly adhered to the mixed powder, thereby obtaining the veterinary drug additive in livestock.
Examples
Based on the livestock veterinary drug additive prepared in the embodiment 7, the application method of the feed additive is disclosed in the embodiment 8, wherein the additive accounts for 4.25% of the total weight of the livestock feed, and the feed additive and the feed are fully and uniformly mixed when the feed additive is used.
In order to facilitate verification of the effect of the feed additives of comparative examples 1 to 5 in the following test examples, the following comparative examples were also recorded during the development of the additives.
The veterinary drug additive composition of the livestock of comparative example 1 only comprises: fructus Terminaliae Billericae.
The preparation method of the additive comprises the following steps: weighing mature fruit fructus Terminaliae Billericae, cleaning, removing impurities, air drying, and pulverizing to 20 mesh sieve according to the additive amount of the additive in the feed.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 2 comprises the following components in parts by weight: 8.2 parts of Terminalia chebula and 7 parts of herba chebulae.
The preparation method of the additive comprises the following steps: weighing mature fruit fructus Terminaliae Billericae and at least annual whole plant of herba Billericae, cleaning, removing impurities, air drying, pulverizing to 20 mesh sieve, and mixing thoroughly.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 3 comprises the following components in parts by weight: 8.2 parts of Terminalia chebula, 7 parts of herba chebulae, and 6 parts of herba Hyperici Japonici.
The preparation method of the additive comprises the following steps: weighing mature fruit fructus Terminaliae Billericae, at least annual whole plant of herba Hedyotidis Diffusae, cleaning, removing impurities, air drying, pulverizing to 20 mesh sieve, and mixing thoroughly.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 4 comprises the following components in parts by weight: 8.2 parts of Terminalia chebula, 7 parts of herba Hedyotidis Diffusae, 6 parts of herba Hyperici Japonici and 5.6 parts of herba Potentillae Discoloris.
The preparation method of the additive comprises the following steps: weighing mature fruit Terminalia chebula, at least annual whole plant of herba Hyperici Japonici, and perennial whole plant of herba Potentillae Discoloris, cleaning, removing impurities, air drying, pulverizing to 20 mesh sieve, and mixing thoroughly.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 5 comprises the following components in parts by weight: 8.2 parts of Terminalia chebula, 7 parts of flat bud, 6 parts of herba Hyperici Japonici, 5.6 parts of herba Potentillae Discoloris and 4.8 parts of Pseudobulbus Cremastrae seu pleiones.
The preparation method of the additive comprises the following steps: weighing mature fruit fructus Terminaliae Billericae, at least annual whole plant of herba Hyperici Japonici, perennial whole plant of herba Potentillae Discoloris, and Bulbus Iphigeniae Indicae, cleaning, removing impurities, air drying, pulverizing to 20 mesh sieve, and mixing.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 6 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba hyperici japonici, 5.6 parts of discolor cinquefoil herb, 4.8 parts of Indian iphigenia bulb and 3.4 parts of brucea javanica.
The preparation method of the additive comprises the following steps: weighing mature fruit fructus Terminaliae Billericae and fructus Bruceae, at least annual whole bud and whole herba Hyperici Japonici, perennial whole herba Potentillae Discoloris and Bulbus Iphigeniae Indicae, respectively cleaning, removing impurities, air drying, pulverizing to 20 mesh sieve, and mixing thoroughly.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 7 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba hyperici japonici, 5.6 parts of discolor cinquefoil herb, 4.8 parts of Indian iphigenia bulb, 3.4 parts of brucea javanica and 2.8 parts of rhizoma picrorhizae.
The preparation method of the additive comprises the following steps: weighing mature fruit fructus Terminaliae Billericae and fructus Bruceae, at least annual whole bud and whole herba Hyperici Japonici, perennial whole herba Potentillae Discoloris and whole rhizoma picrorhizae, and Bulbus Iphigeniae Indicae, respectively cleaning, removing impurities, air drying, pulverizing to 20 mesh sieve, and mixing thoroughly.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 8 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba Hyperici Japonici, 5.6 parts of herba Potentillae Discoloris, 4.8 parts of Pseudobulbus Cremastrae seu pleiones, 3.4 parts of fructus Bruceae, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative; wherein the preservative comprises only one component of perilla.
The above additive preparation method is essentially the same as in example 7, with the only two differences:
no material-taking operation is performed on sage and litsea cubeba;
the preparation method of the preservative comprises the following steps: cutting the perilla seeds to be used according to the weight parts of the preservative until the particle size is less than or equal to 0.5cm to obtain crushed slag, adding ethanol with the alcohol concentration of 95% which is 3 times of the mass of the crushed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the alcohol concentration of 95% which is 3 times of the mass of the filter residues into the filter residues again, heating and refluxing for 120min, filtering and removing impurities, combining the two filtered liquids, removing the ethanol, and concentrating the filtered liquid after removing the impurities to 1/3 of the original volume to obtain the preservative required by the comparative example 8.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 9 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba Hyperici Japonici, 5.6 parts of herba Potentillae Discoloris, 4.8 parts of Pseudobulbus Cremastrae seu pleiones, 3.4 parts of fructus Bruceae, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative; wherein the preservative comprises only one component of sage.
The above additive preparation method is essentially the same as in example 7, with the only two differences:
the material taking operation of perilla fruit and litsea cubeba is not performed;
the preparation method of the preservative comprises the following steps: and (3) taking the sage for standby according to the weight parts of the preservative, cutting the sage into pieces with the particle size of less than or equal to 0.5cm to obtain crushed slag, adding ethanol with the alcohol concentration of 95% which is 3 times of the mass of the crushed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the alcohol concentration of 95% which is 3 times of the mass of the filter residues into the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the two filtered solutions, removing the ethanol, and concentrating the filtered solution after the impurity removal to 1/3 of the original volume to obtain the preservative required by the comparative example 9.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 10 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba Hyperici Japonici, 5.6 parts of herba Potentillae Discoloris, 4.8 parts of Pseudobulbus Cremastrae seu pleiones, 3.4 parts of fructus Bruceae, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative; wherein the preservative comprises only one component of litsea cubeba.
The above additive preparation method is essentially the same as in example 7, with the only two differences:
the material taking operation of perilla fruit and sage herb is not performed;
the preparation method of the preservative comprises the following steps: taking the litsea cubeba for later use according to the weight parts of the preservative, cutting the litsea cubeba to the grain diameter of less than or equal to 0.5cm to obtain crushed slag, adding ethanol with the alcohol concentration of 95% which is 3 times of the mass of the crushed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the alcohol concentration of 95% which is 3 times of the mass of the filter residues into the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the two filtrate, removing the ethanol, and concentrating the filtrate after removing the impurities to 1/3 of the original volume to obtain the preservative required by the comparative example 10.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 11 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba Hyperici Japonici, 5.6 parts of herba Potentillae Discoloris, 4.8 parts of Pseudobulbus Cremastrae seu pleiones, 3.4 parts of fructus Bruceae, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative; wherein the preservative is prepared by mixing perilla fruit and sage according to the weight ratio of 0.5:1.
The above additive preparation method is essentially the same as in example 7, with the only two differences:
no litsea cubeba material taking operation is performed;
the preparation method of the preservative comprises the following steps: mixing and chopping the perilla fruit and the sage herb which are used for later use according to the weight parts of the preservative and the weight ratio of the components of the preservative until the particle size is less than or equal to 0.5cm to obtain mixed slag, adding ethanol with the concentration of 95 percent relative to the mass of the mixed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the concentration of 95 percent relative to the mass of the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the two filtrate, removing the ethanol, and concentrating the filtrate after the impurity removal to 1/3 of the original volume to obtain the preservative required by the comparative example 11.
And (3) adding ethanol with the concentration of 95% relative to the mass of the crushed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the concentration of 95% relative to the mass of the filter residues into the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the filtrate obtained in the two steps, removing the ethanol, and concentrating the filtrate obtained in the two steps to 1/3 of the original volume to obtain the preservative required by the comparative example 10.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 12 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba Hyperici Japonici, 5.6 parts of herba Potentillae Discoloris, 4.8 parts of Pseudobulbus Cremastrae seu pleiones, 3.4 parts of fructus Bruceae, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative; wherein the preservative is prepared by mixing perilla fruit and litsea cubeba according to the weight ratio of 0.5:1.
The above additive preparation method is essentially the same as in example 7, with the only two differences:
no material drawing operation is performed on sage;
the preparation method of the preservative comprises the following steps: mixing and chopping the perilla fruit and the litsea cubeba which are used for later use according to the weight parts of the preservative and the weight ratio of the components, obtaining mixed slag, adding ethanol with the concentration of 95 percent relative to the mass of the mixed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the concentration of 95 percent relative to the mass of the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the two filtering liquids, removing the ethanol, and concentrating the filtered liquid after the impurity removal to 1/3 of the original volume, thus obtaining the preservative required by the comparative example 12.
The veterinary drug additive component of the livestock traditional Chinese medicine of the comparative example 13 comprises the following components in parts by weight: 8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba Hyperici Japonici, 5.6 parts of herba Potentillae Discoloris, 4.8 parts of Pseudobulbus Cremastrae seu pleiones, 3.4 parts of fructus Bruceae, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative; wherein the preservative is prepared by mixing sage and litsea cubeba according to the weight ratio of 0.5:1.
The above additive preparation method is essentially the same as in example 7, with the only two differences:
the perilla seed is not obtained;
the preparation method of the preservative comprises the following steps: mixing and chopping the sage and the litsea cubeba which are used for later use according to the weight parts of the preservative and the weight ratio of the components, obtaining mixed slag, adding ethanol with the concentration of 95 percent relative to the mass of the mixed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the concentration of 95 percent relative to the mass of the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the two filtrate, removing the ethanol, and concentrating the filtrate after the impurity removal to 1/3 of the original volume, thus obtaining the preservative required by comparative example 13.
Additive and feed-additive preservative test
Additive preservative test method: preparing 18 containers with the same size, shape and material for later use, respectively placing 1kg of the additive prepared in the examples 1-5 and the comparative examples 1-13 into each container, sealing at normal temperature (16-32 ℃) and standing for 45 days, opening the container after the test period is over, and observing and recording whether the additive in each container has bad smell, mildewing, living insects and other deterioration and rot phenomena;
feed-additive preservative test method: preparing 18 container tanks with the same size, shape and material, 180kg of corn feed, dividing the corn feed into 18 parts, respectively adding the 18 parts into each tank, wherein the weight of the feed in each tank is 10kg, respectively taking 425g of the additive prepared in examples 1-5 and comparative examples 1-13, putting the additive into each tank, fully and uniformly mixing the additive with the feed (according to example 8, the additive accounts for 4.25% of the total weight of livestock and poultry feed), sealing at normal temperature (16-32 ℃) and standing for 45 days, and after the test period is finished, opening the tank to observe and record whether deterioration and rot phenomena such as peculiar smell, mildewing, living insects and the like occur in the feed-additive in each tank; the corn feed used in the above test specifically comprises 65.4% of corn, 25.2% of peanut meal, 1.9% of fish meal, 2% of soybean oil, 1.3% of stone dust, 1.45% of calcium hydrophosphate, 0.57% of L-lysine hydrochloride, 0.19% of DL-methionine, 0.16% of isoleucine, 0.14% of valine, 0.075% of threonine, 0.365% of zeolite powder, 1% of premix and 0.25% of sodium chloride.
The results of the above test recordings are shown in table 1 below:
table 1: additive preservative test results
From the records and statistical results of the above table 1, the animal drug additives of examples 1 to 5 and the animal feed after mixing with the animal feed were all free from the problems of off-flavor, rotting and mold, while the control group (comparative examples 1 to 13) which was set in the reverse view was tested for the preservative property of the modified animal drug additives by changing the formulation components of the animal drug additives of examples to a different extent, and it is apparent from table 1 that the additives of comparative examples 1 to 10 and the mixed feed thereof all had the occurrence of off-flavor and mold during the test period, wherein the additives of comparative examples 1 to 7 were not added with the preservative described in example 6, and the preservative of comparative examples 8 to 10 contained only any one of the components of example 6, but it was demonstrated that the preservative effect was not apparently achieved by using only one of the above components as the preservative; in the following test process, whether the dual-component preservative can achieve the expected effect is verified by setting the comparative examples 11-13, but the final test result shows that the dual-component preservative still cannot achieve the anti-corrosion effect of the embodiment, and serious rotting conditions exist, so that the veterinary drug additive prepared in the embodiments 1-5 has excellent anti-corrosion performance, and the adopted preservative prepared by mixing perilla, sage and litsea cubeba according to the weight ratio of 0.5:1:1 has unexpected technical effects.
2. Test for preventing and treating fowl cholera
(2.1) test poultry: 380 healthy SPF chickens of 30 days old are not epidemic-prevented by the inactivated vaccine of fowl cholera.
(2.2) test packets: the random number is divided into 19 groups of 20, and each group is respectively:
challenge control group: after detoxification, no medicine is fed, and the corn feed (the feed formula is the same as that used in the preservative test) is fed for isolated feeding.
Test 1 group: the feed additive prepared in example 1 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 2 group: the feed additive prepared in example 2 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 3 group: the feed additive prepared in example 3 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 4 groups: the feed additive prepared in example 4 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 5 group: the feed additive prepared in example 5 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 6 groups: the feed additive prepared in comparative example 1 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 7 groups: the feed additive prepared in comparative example 2 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test group 8: the feed additive prepared in comparative example 3 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 9 groups: the feed additive prepared in comparative example 4 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 10 groups: the feed additive prepared in comparative example 5 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 11 group: the feed additive prepared in comparative example 6 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 12 groups: the feed additive prepared in comparative example 7 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 13 group: the feed additive prepared in comparative example 8 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 14 group: the feed additive prepared in comparative example 9 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 15 groups: the feed additive prepared in comparative example 10 (the addition amount is 4.25% of the weight of the feed) is added into the feed 3 days before the challenge, and the feeding environment and the feed are the same as those of the challenge control group.
Test 16 groups: the feed additive prepared in comparative example 11 (the addition amount is 4.25% of the weight of the feed) was added to the feed 3 days before the challenge, and the feeding environment and the feed were the same as those of the challenge control group.
Test 17 group: the feed additive prepared in comparative example 12 (the addition amount is 4.25% of the weight of the feed) was added to the feed 3 days before the challenge, and the feeding environment and the feed were the same as those of the challenge control group.
Test group 18: the feed additive prepared in comparative example 13 (the addition amount is 4.25% of the weight of the feed) was added to the feed 3 days before the challenge, and the feeding environment and the feed were the same as those of the challenge control group.
(2.3) test method: the virulent strain (C48-1) of the avian Pasteurella multocida is adopted for the virus attack, and is provided by Chinese veterinary drug supervision, 0.2 ml/chicken is inoculated by dripping into the nose through the trachea after the virus is diluted by 1:10 when in use, when a control group to be attacked and a plurality of chickens in the test group are ill, the chickens in each group are recorded, the test period is 3 months old, whether the chickens in each group only are ill and die is observed, and the symptoms of the chicken only include: mental depression, feather disorder, cockscomb, pale-bearded, sinusitis, small amount of mucus flowing out of nostrils, mucous secretions flowing out of oral cavity, severe diarrhea, fever, bearded edema and death, and the data recorded in the final groups are shown in table 2 below:
table 2: test data for preventing fowl cholera
From the records and statistical data of table 2, the morbidity and mortality of chickens in the toxicity attack control group are the most serious, the morbidity is 100%, the mortality is 20%, the morbidity and mortality in the test 1 group to the test 18 group are better than those in the toxicity attack control group to different degrees, wherein the morbidity interval is [5%,10% ], and the mortality is zero of the traditional Chinese veterinary medicine additives in the embodiments 1-5 used in the test 1 group to the test 5 group respectively; the additives described in comparative examples 1 to 13 used in each of the test 6 to the test 18 had a prevalence interval of [10%,100% ], and a mortality interval of [0%,25% ].
According to the data analysis of the combination statistics, the prevalence rate of the chickens in the test 1 group to the test 5 group is reduced by 90-95% compared with that of the chickens in the toxicity attack control group, and the mortality rate is reduced by 20%; compared with the test 6 to the test 18, the prevalence rate of the chickens in the test 1 to the test 5 is reduced by 0 to 95 percent, and the mortality rate is reduced by 0 to 25 percent; therefore, the composite feed additive for poultry, which is used in the embodiment of the invention, has the effect of obviously improving the effect of preventing and curing the pasteurellosis of chickens;
specifically, by further observing and analyzing the disease and death conditions of the chickens in the test 6 group to the test 18 group, when the formula components of the veterinary drug additive in the embodiment of the invention are changed, the disease and death conditions of the chickens in the test 6 group to the test 9 group are not obviously improved, and compared with the disease rate of the virus attack control group, the disease rate is maximally reduced by 15%; the test 10 groups are used as the first turning points, the feed additive formula used by the test 10 groups can greatly improve the illness and death conditions of chickens, and compared with an attack control group, the illness rate of the test 10 groups is reduced by 25%, and the death rate is reduced by 10%; the test 11 group is used as a second turning point, and the feed additive formula adopted by the test 11 group can obviously improve the illness and death conditions of chickens, and compared with an attack control group, the morbidity is reduced by 45 percent, and the death rate is reduced by 10 percent; the test group 12 is used as a third turning point, and the feed additive formula can radically improve the illness and death conditions of chickens, and compared with an attack control group, the morbidity is reduced by 75%, and the death rate is reduced by 15%.
It is worth pointing out that the researchers also find that in the test process, the arrangement of the test 13 group to the test 18 group verifies that the preservative adopted in the embodiment of the invention not only has excellent preservative effect on the additive and the feed, but also can further improve the disease and death conditions of chickens in the test 12 group, and in conclusion, the formula components of the veterinary drug additive in the embodiment of the invention have rigor in compatibility, and the preservative not only can inhibit the decay of the additive and the feed, but also can prevent and treat the chicken from being infected with the fowl pasteurellosis to a certain extent.
The foregoing description is only a preferred embodiment of the present invention, and the present invention is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present invention has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The veterinary drug additive for livestock is characterized by comprising the following components in parts by weight:
7.6 to 8.8 parts of fructus terminaliae, 6.5 to 7.5 parts of herba platycladi, 5.4 to 6.8 parts of herba hyperici japonici, 5.0 to 6.2 parts of discolor cinquefoil herb, 4.3 to 5.4 parts of edible tulip, 2.7 to 3.9 parts of fructus brucea javanica and 2.2 to 3.5 parts of rhizoma picrorhizae.
2. The veterinary drug additive as claimed in claim 1, further comprising 1.0 to 2.4 parts of a preservative.
3. The veterinary drug additive as claimed in claim 2, comprising the following components in parts by weight:
7.6 parts of fructus terminaliae, 6.5 parts of hyacinth bud, 5.4 parts of herba hyperici japonici, 5.0 parts of discolor cinquefoil herb, 4.3 parts of Indian iphigenia bulb, 2.7 parts of fructus bruceae, 2.2 parts of rhizoma picrorhizae and 1.0 part of preservative.
4. The veterinary drug additive as claimed in claim 2, comprising the following components in parts by weight:
8 parts of fructus terminaliae, 6.8 parts of flat bud, 5.7 parts of herba hyperici japonici, 5.3 parts of discolor cinquefoil herb, 4.5 parts of Indian iphigenia bulb, 3 parts of brucea javanica, 2.5 parts of rhizoma picrorhizae and 1.2 parts of preservative.
5. The veterinary drug additive as claimed in claim 2, comprising the following components in parts by weight:
8.2 parts of fructus terminaliae, 7 parts of hyacinth bud, 6 parts of herba hyperici japonici, 5.6 parts of discolor cinquefoil herb, 4.8 parts of Indian iphigenia bulb, 3.4 parts of brucea javanica, 2.8 parts of rhizoma picrorhizae and 1.6 parts of preservative.
6. The veterinary drug additive as claimed in claim 2, comprising the following components in parts by weight:
8.5 parts of fructus terminaliae, 7.2 parts of hyacinth bud, 6.4 parts of herba hyperici japonici, 5.9 parts of discolor cinquefoil herb, 5.2 parts of Indian iphigenia bulb, 3.6 parts of fructus bruceae, 3.2 parts of rhizoma picrorhizae and 2 parts of preservative.
7. The veterinary drug additive as claimed in claim 2, comprising the following components in parts by weight:
8.8 parts of fructus terminaliae, 7.5 parts of hyacinth bud, 6.8 parts of herba hyperici japonici, 6.2 parts of discolor cinquefoil herb, 5.4 parts of Indian iphigenia bulb, 3.9 parts of fructus bruceae, 3.5 parts of rhizoma picrorhizae and 2.4 parts of preservative.
8. The veterinary drug additive as claimed in claim 2, wherein the preservative is composed of perilla fruit, sage and litsea cubeba in a weight ratio of 0.5:1:1.
9. A method of preparing a veterinary drug additive according to any one of claims 2 to 8, comprising the steps of:
drawing materials;
mixing and chopping perilla fruit, sage and litsea cubeba according to the weight parts of the preservative and the weight ratio of the components of the preservative to the grain size of less than or equal to 0.5cm to obtain mixed slag, adding ethanol with the concentration of 95 percent relative to the mass of the mixed slag, heating and refluxing for 85min, filtering to obtain filter residues, adding ethanol with the concentration of 95 percent relative to the mass of the filter residues again, heating and refluxing for 120min, filtering to remove impurities, combining the two filtrate, removing the ethanol, and concentrating the filtrate after the impurity removal to 1/3 of the original volume to obtain the preservative;
mixing and crushing the Billeaf terbula fruit, the flat bud, the herba Hyperici Japonici, the discolor cinquefoil herb, the edible tulip, the brucea javanica and the rhizoma picrorhizae according to parts by weight, sieving with a 20-mesh sieve, fully and uniformly mixing to obtain mixed powder, atomizing and spraying the prepared preservative into the mixed powder, and continuously stirring and stirring the mixed powder during spraying so that the preservative can be uniformly adhered to the mixed powder, thereby obtaining the traditional Chinese veterinary medicine additive after uniformly mixing.
10. A method of using a veterinary drug additive according to any one of claims 2 to 8, wherein the additive comprises 4.25% of the total weight of the livestock feed, and the additive is mixed with the feed thoroughly when used.
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