CN107898861A - A kind of composition for preventing avian cholera and salmonella and preparation method thereof - Google Patents
A kind of composition for preventing avian cholera and salmonella and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines,Especially a kind of composition for preventing avian cholera and salmonella and preparation method thereof,Using 90~110 parts of Banlangen,40~60 parts of wrinkled giant hyssop,40~60 parts of the banksia rose,40~45 parts of Radix picrorrhizae,40~45 parts of dark plum,38~43 parts of Cortex Phellodendri,38~43 parts of rhizoma atractylodis,28~33 parts of Chinese lobelia,28~33 parts of rheum officinale,28~33 parts of the root of Dahurain angelica is raw material,Piece agent or pill are prepared by co-grinding,Being capable of effectively preventing avian cholera and salmonellosis,Prevention effect is notable,In conjunction with 5-methoxysulfadiazine,The addition of terramycin and trimethoprim,Further lift prevention effect,Reduce the death rate of diseased chicken,Reduce Poultry feeder economic loss,Especially for the fowl group for having infected cholera or salmonellosis,The propagation of disease can effectively be suppressed,Reduce infection rate；Present composition preparation method is simple, easy to use, is with a wide range of applications for poultry cultivation industry.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, especially a kind of composition and its preparation for preventing avian cholera and salmonella
Method.
Background technology
Since reform and opening-up, aquaculture is grown rapidly in China, especially the poultry such as aviculture, chicken, duck, goose livestock on hand
Total amount has leapt to the first in the world, and becomes qualified Yang Qin big countries；However, with aviculture popularization, flowing is frequent, fowl
An important factor for disease is also increasingly sophisticated, and poultry diease has become influence and restricted aviculture healthy and sustainable development；Such as avian cholera, also known as
Fowl pasteurellosis, fowl hemorrhagic sepsis infectious disease, it is the chicken as caused by pasteurella multocida, duck, goose, turkey and pigeon
A kind of acute sepsis infectious disease, relatively mostly occur in autumn, winter and spring, be one of chief threat of poultry-farm；For another example fowl sramana
Salmonella disease, is as the acute or chronic disease of the birds caused by a kind of salmonella of Salmonella kind, all over the world
Spread all over presence, be mainly shown as the symptoms such as white diarrhea, avian typhoid and avian paratyphoid, it is very big to the harmfulness of poultry.
At present, for treatment avian cholera and fowl salmonellosis use antibiotics, as terramycin, gentamicin,
The materials such as chloramphenicol, Ciprofloxacin, it be easy to cause the appearance of drug-fast bacteria and dissociant, and then causes the dosage of medicine more next
Higher, drug effect is more and more lower, the problem of additionally causing medicament residue, influences the meat of birds.
The content of the invention
In order to solve the above technical problems, the present invention provides a kind of method that cellulose is extracted from stalk.
It is achieved particular by following technical scheme：
A kind of composition for preventing avian cholera and salmonella, includes the raw material of following parts by weight：Banlangen 90~110
Part, 40~60 parts of wrinkled giant hyssop, 40~60 parts of the banksia rose, 40~45 parts of Radix picrorrhizae, 40~45 parts of dark plum, 38~43 parts of Cortex Phellodendri, rhizoma atractylodis 38
~43 parts, 28~33 parts of Chinese lobelia, 28~33 parts of rheum officinale, 28~33 parts of the root of Dahurain angelica.
The raw material is in parts by weight：100 parts of Banlangen, 50 parts of wrinkled giant hyssop, 50 parts of the banksia rose, 43 parts of Radix picrorrhizae, dark plum 43
Part, 40 parts of Cortex Phellodendri, 40 parts of rhizoma atractylodis, 30 parts of Chinese lobelia, 30 parts of rheum officinale, 30 parts of the root of Dahurain angelica.
Preferably, 28~33 parts of 5-methoxysulfadiazine is added in the raw material.
Preferably, 28~33 parts of terramycin is added in the raw material.
Preferably, 5~7 parts of trimethoprim is added in the raw material.
Preferably, 28~33 parts of 5-methoxysulfadiazine, 28~33 parts of terramycin, emilium tosylate are added in the raw material
5~7 parts of pyrimidine.
The preparation method of the composition of above-mentioned prevention avian cholera and salmonella, comprises the following steps：Measured according to formula
Banlangen, wrinkled giant hyssop, the banksia rose, Radix picrorrhizae, dark plum, Cortex Phellodendri, rhizoma atractylodis, Chinese lobelia, rheum officinale and the root of Dahurain angelica, are crushed after being mixed,
Medically acceptable auxiliary material preparation piece agent or pill or not in addition.
After the pulverization process, 200~300 mesh sieves are crossed.
The auxiliary material is starch, microcrystalline cellulose, dextrin, lactose, sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone
In it is any.
Beneficial effect
The present invention is using 90~110 parts of Banlangen, 40~60 parts of wrinkled giant hyssop, 40~60 parts of the banksia rose, 40~45 parts of Radix picrorrhizae, crow
40~45 parts of plum, 38~43 parts of Cortex Phellodendri, 38~43 parts of rhizoma atractylodis, 28~33 parts of Chinese lobelia, 28~33 parts of rheum officinale, 28~33 parts of the root of Dahurain angelica
For raw material, piece agent or pill are prepared by co-grinding, can effectively preventing avian cholera and salmonellosis, prevention effect
Significantly, in conjunction with the addition of 5-methoxysulfadiazine, terramycin and trimethoprim, prevention effect is further lifted, is subtracted
The death rate of few diseased chicken, reduces Poultry feeder economic loss, especially for the fowl group for having infected cholera or salmonellosis,
The propagation of disease can effectively be suppressed, reduce infection rate；Present composition preparation method is simple, easy to use, for fowl
Class aquaculture is with a wide range of applications.
Embodiment
Tuberculosis specific embodiment is limited technical scheme is further below, but claimed
Scope is not only limited to made description.
Embodiment 1
A kind of composition for preventing avian cholera and salmonella, includes the raw material of following parts by weight：Banlangen 90g, wrinkled giant hyssop
40g, banksia rose 40g, Radix picrorrhizae 40g, dark plum 40g, Cortex Phellodendri 38g, rhizoma atractylodis 38g, Chinese lobelia 28g, rheum officinale 28g, root of Dahurain angelica 28g.
The preparation method of the composition of above-mentioned prevention avian cholera and salmonella, comprises the following steps：Measured according to formula
Banlangen, wrinkled giant hyssop, the banksia rose, Radix picrorrhizae, dark plum, Cortex Phellodendri, rhizoma atractylodis, Chinese lobelia, rheum officinale and the root of Dahurain angelica, are crushed after being mixed,
Tablet is made in addition starch.
After the pulverization process, 200 mesh sieves are crossed.
Embodiment 2, using the technical solution identical with embodiment 1, difference lies in add sulfanilamide (SN) to first in the tablet
28~33g of oxygen pyrimidine.
Embodiment 3, using the technical solution identical with embodiment 1, difference lies in add terramycin 28 in the tablet
~33g.
Embodiment 4, using the technical solution identical with embodiment 1, difference lies in add emilium tosylate in the tablet
5~7g of pyrimidine.
Embodiment 5, using the technical solution identical with embodiment 1, difference lies in add sulfanilamide (SN) to first in affiliated tablet
28~33g of oxygen pyrimidine, 28~33g of terramycin, 5~7g of trimethoprim.
Control group 1, according to daily 30mg 5-methoxysulfadiazines for oral administration；
Control group 2, according to daily 30mg terramycin for oral administration；
Control group 3, according to daily 30mg trimethoprims for oral administration；
Blank group, does not apply any medicine；
Cholera prevention effect：
Subjects：20~25 age in days chicken of Sinan County locality chicken house is selected in experiment, selects within weight difference 5g
Chicken 437, be fowl cholera diseased chicken by clinical diagnosis, then from health 20~25 age in days chickens in select 1350.
Strain：Avian pasteurella multocida C48-1Bacterial strain is provided by China Veterinary Drugs Supervisory Inst.；
Attack cytotoxic drug：By C before experiment48-1When Pasteurella velogen strain immigration brain heart soup nutrient solution culture 24 is small, through health
Suitable culture medium is inoculated in after chicken passage rejuvenation, 37 DEG C of water-baths 18 harvest bacterium solution when small, count viable bacteria；With the sterilizing of PH7.0
Physiological saline incrementally dilutes bacterium solution with 10 times, and it is 4 viable bacterias to measure to the minimum lethal dose of chicken, is prepared into every ml and contains 4 viable bacterias
Attack toadstool liquid.
Experimental design：
Experiment on therapy：Diseased chicken with cholera is randomly divided into 9 groups, is prepared using 1~embodiment of above-described embodiment, 5 scheme
Medicine, daily 30~40g, is dissolved in the solution that 1g/ml is prepared into distilled water, at twice gastric infusion, control group and blank
Group is administered in the manner described above, test period 5d, each group feeding common wheat feed during treatment；Therapeutic effect such as following table
1：
1 each group medication effect of table
| Group | Diseased chicken number (only) | Cure number (only) | Cure rate (%) | The death rate (%) |
| Embodiment 1 | 45 | 37 | 82 | 18 |
| Embodiment 2 | 51 | 45 | 88 | 12 |
| Embodiment 3 | 48 | 41 | 88 | 12 |
| Embodiment 4 | 46 | 39 | 85 | 15 |
| Embodiment 5 | 47 | 46 | 98 | 2 |
| Control group 1 | 53 | 42 | 79 | 11 |
| Control group 2 | 49 | 39 | 80 | 20 |
| Control group 3 | 46 | 37 | 80 | 20 |
| Blank group | 52 | 5 | 10 | 90 |
By result of the test, medication effect prepared by 5 scheme of embodiment is optimal, and cure rate reaches 98%, and the death rate is
2%；And the cure rate of 1 group of embodiment is (mould only with soil higher than control group 1 (only with 5-methoxysulfadiazine), control group 2
Element), control group 3 (only with trimethoprim)；And the cure rate of 1 group of embodiment less than embodiment 2, embodiment 3 and is implemented
Example 4, due to the addition of 5-methoxysulfadiazine, terramycin, trimethoprim respectively in formula, and then improves controlling for medicine
Therapeutic effect, wherein the most notable to add the effect of 5-methoxysulfadiazine, terramycin and trimethoprim at the same time.
Prophylactic tria：Above-mentioned 450 healthy chickens are randomly divided into 9 groups, are administered according to the method described above, after feeding 4 weeks,
Every group of chicken attacks poison with the C48-1 avian cholera living bacterial liquids of 1 minimum lethal dose, observes 1 week, as a result such as table 2 below：
2 each group preventive effect of table
| Group | Test chicken (only) | Morbidity number (only) | Incidence (%) |
| Embodiment 1 | 150 | 11 | 7.3 |
| Embodiment 2 | 150 | 8 | 5.3 |
| Embodiment 3 | 150 | 8 | 6 |
| Embodiment 4 | 150 | 7 | 5.3 |
| Embodiment 5 | 150 | 3 | 2 |
| Control group 1 | 150 | 12 | 8 |
| Control group 2 | 150 | 14 | 9.3 |
| Control group 3 | 150 | 11 | 7.3 |
| Blank group | 150 | 29 | 19.3 |
As seen from the experiment, 9 groups of experiments have different degrees of fowl cholera, wherein being prepared with 5 scheme of embodiment
Chemoprophylaxis fowl cholera effect it is best, incidence is only 2%.
Salmonella prevention effect：
Subjects：20~25 age in days chicken of Sinan County locality chicken house is selected in experiment, selects within weight difference 5g
Chicken 357, by clinical diagnosis for Salmonella pullorum disease；
Experiment on therapy：9 groups will be randomly divided into Salmonella pullorum diseased chicken, using 1~embodiment of above-described embodiment, 5 side
Case prepares medicine, and daily 30~40g, is dissolved in the solution that 1g/ml is prepared into distilled water, at twice gastric infusion, control group
It is administered in the manner described above with blank group, test period 5d, each group feeding common wheat feed during treatment；Therapeutic effect
Such as table 3 below：
3 each group medication effect of table
| Group | Diseased chicken number (only) | Cure number (only) | Cure rate (%) | The death rate (%) |
| Embodiment 1 | 39 | 33 | 85 | 15 |
| Embodiment 2 | 43 | 39 | 91 | 9 |
| Embodiment 3 | 37 | 34 | 92 | 8 |
| Embodiment 4 | 36 | 33 | 89 | 11 |
| Embodiment 5 | 43 | 43 | 100 | 0 |
| Control group 1 | 38 | 32 | 84 | 16 |
| Control group 2 | 40 | 34 | 85 | 15 |
| Control group 3 | 39 | 33 | 85 | 15 |
| Blank group | 42 | 5 | 12 | 88 |
By result of the test, medication effect prepared by 5 scheme of embodiment is optimal, and cure rate reaches 100%, and the death rate is
0；And the cure rate of 1 group of embodiment higher than control group 1 (only with 5-methoxysulfadiazine), control group 2 (only with terramycin),
Control group 3 (only with trimethoprim)；And the cure rate of 1 group of embodiment is less than embodiment 2, embodiment 3 and embodiment 4,
Due to the addition of 5-methoxysulfadiazine, terramycin, trimethoprim respectively in formula, and then improve the treatment effect of medicine
Fruit, therefore 5-methoxysulfadiazine, terramycin and trimethoprim are added in formula, it is husky can effectively to improve treatment chicken
The effect of door Salmonella disease.
Embodiment 2
A kind of composition for preventing avian cholera and salmonella, includes the raw material of following parts by weight：110 parts of Banlangen, the leaves of pulse plants
Fragrant 60 parts, it is 60 parts of the banksia rose, 45 parts of Radix picrorrhizae, 45 parts of dark plum, 43 parts of Cortex Phellodendri, 43 parts of rhizoma atractylodis, 33 parts of Chinese lobelia, 33 parts of rheum officinale, white
33 parts of the root of Dahurian angelica.
The preparation method of the composition of above-mentioned prevention avian cholera and salmonella, comprises the following steps：Measured according to formula
Banlangen, wrinkled giant hyssop, the banksia rose, Radix picrorrhizae, dark plum, Cortex Phellodendri, rhizoma atractylodis, Chinese lobelia, rheum officinale and the root of Dahurain angelica, are crushed after being mixed,
Pill is made in addition starch.
After the pulverization process, 300 mesh sieves are crossed.
The prevention effect of this medicine is verified according to above-mentioned test method, Experiment on therapy cure rate reaches 85%, in advance
Anti- experiment incidence is 5%.
Embodiment 3
A kind of composition for preventing avian cholera and salmonella, includes the raw material of following parts by weight：Banlangen 100g, wrinkled giant hyssop
50g, banksia rose 50g, Radix picrorrhizae 43g, dark plum 43g, Cortex Phellodendri 40g, rhizoma atractylodis 40g, Chinese lobelia 30g, rheum officinale 30g, root of Dahurain angelica 30g.
The preparation method of the composition of above-mentioned prevention avian cholera and salmonella, comprises the following steps：Measured according to formula
Banlangen, wrinkled giant hyssop, the banksia rose, Radix picrorrhizae, dark plum, Cortex Phellodendri, rhizoma atractylodis, Chinese lobelia, rheum officinale and the root of Dahurain angelica, are crushed after being mixed,
Tablet or pill is made.
After the pulverization process, 250 mesh sieves are crossed.
The prevention effect of this medicine is verified according to above-mentioned test method, Experiment on therapy cure rate reaches 87%, in advance
Anti- experiment incidence is 3%.
Embodiment 4
A kind of composition for preventing avian cholera and salmonella, includes the raw material of following parts by weight：Banlangen 90g, wrinkled giant hyssop
60g, banksia rose 40g, Radix picrorrhizae 40g, dark plum 45g, Cortex Phellodendri 38g, rhizoma atractylodis 43g, Chinese lobelia 33g, rheum officinale 33g, root of Dahurain angelica 33g.
The preparation method of the composition of above-mentioned prevention avian cholera and salmonella, comprises the following steps：Measured according to formula
Banlangen, wrinkled giant hyssop, the banksia rose, Radix picrorrhizae, dark plum, Cortex Phellodendri, rhizoma atractylodis, Chinese lobelia, rheum officinale and the root of Dahurain angelica, are crushed after being mixed,
Add medically acceptable auxiliary material and prepare piece agent or pill.
After the pulverization process, 250 mesh sieves are crossed.
The auxiliary material is any in microcrystalline cellulose, dextrin, lactose, sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone
Kind.
The prevention effect of this medicine is verified according to above-mentioned test method, Experiment on therapy cure rate reaches 83%, in advance
Anti- experiment incidence is 4.3%.
It is important to point out that, above example and test example are only limitted to do further technical scheme herein
Elaboration and understanding, it is impossible to be interpreted as further to technical scheme and limited, what those skilled in the art made
Non-protruding essential characteristics and the innovation and creation of marked improvement, still fall within the protection category of the present invention.
Claims (9)
1. a kind of composition for preventing avian cholera and salmonella, it is characterised in that include the raw material of following parts by weight：Banlangen
90~110 parts, 40~60 parts of wrinkled giant hyssop, 40~60 parts of the banksia rose, 40~45 parts of Radix picrorrhizae, 40~45 parts of dark plum, 38~43 parts of Cortex Phellodendri,
38~43 parts of rhizoma atractylodis, 28~33 parts of Chinese lobelia, 28~33 parts of rheum officinale, 28~33 parts of the root of Dahurain angelica.
2. the composition of prevention avian cholera and salmonella as claimed in claim 1, it is characterised in that the raw material is with parts by weight
It is calculated as：100 parts of Banlangen, 50 parts of wrinkled giant hyssop, 50 parts of the banksia rose, 43 parts of Radix picrorrhizae, 43 parts of dark plum, 40 parts of Cortex Phellodendri, 40 parts of rhizoma atractylodis, one side of something
30 parts of lotus, 30 parts of rheum officinale, 30 parts of the root of Dahurain angelica.
3. the composition of prevention avian cholera and salmonella as claimed in claim 1 or 2, it is characterised in that contain in the raw material
There is 28~33 parts of 5-methoxysulfadiazine.
4. the composition of prevention avian cholera and salmonella as claimed in claim 1 or 2, it is characterised in that contain in the raw material
There is 28~33 parts of terramycin.
5. the composition of prevention avian cholera and salmonella as claimed in claim 1 or 2, it is characterised in that contain in the raw material
There is 5~7 parts of trimethoprim.
6. the composition of prevention avian cholera and salmonella as claimed in claim 1 or 2, it is characterised in that contain in the raw material
There are 28~33 parts of 5-methoxysulfadiazine, 28~33 parts of terramycin, 5~7 parts of trimethoprim.
7. the preparation method of the composition of prevention avian cholera and salmonella as claimed in claim 1 or 2, it is characterised in that bag
Include following steps：Banlangen, wrinkled giant hyssop, the banksia rose, Radix picrorrhizae, dark plum, Cortex Phellodendri, rhizoma atractylodis, Chinese lobelia, rheum officinale and white are measured according to formula
The root of Dahurian angelica, is crushed after being mixed, and adds or do not add medically acceptable auxiliary material preparing piece agent or pill.
8. the preparation method of the composition of prevention avian cholera and salmonella as claimed in claim 7, it is characterised in that the powder
After broken processing, 200~300 mesh sieves are crossed.
9. the preparation method of the composition of prevention avian cholera and salmonella as claimed in claim 7, it is characterised in that described auxiliary
Expect to be any in starch, microcrystalline cellulose, dextrin, lactose, sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone.
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| CN116211964A (en) * | 2023-04-06 | 2023-06-06 | 临沂金翠兽药有限公司 | Livestock traditional Chinese veterinary medicine additive and preparation method thereof |
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