CN113952399A

CN113952399A - Traditional Chinese medicine composition, preparation method and application thereof in preparation of medicine for treating exudative dermatitis of piglets

Info

Publication number: CN113952399A
Application number: CN202111509779.6A
Authority: CN
Inventors: 王孝武; 张鑫義
Original assignee: Sichuan Province Qiang Mountain Animal Husbandry Polytron Technologies Inc
Current assignee: Sichuan Province Qiang Mountain Animal Husbandry Polytron Technologies Inc
Priority date: 2021-12-10
Filing date: 2021-12-10
Publication date: 2022-01-21

Abstract

The invention provides a traditional Chinese medicine composition, a preparation method and application thereof in preparing a medicine for treating exudative dermatitis of piglets, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises, by weight, 90-110 parts of Chinese artichoke, 54-66 parts of Japanese pagodatree fruit, 54-66 parts of green bristlegrass herb, 54-66 parts of fructus chaenomelis, 54-66 parts of cortex cicadae, 36-44 parts of callicarpa bodinieri, 36-44 parts of nidus vespae, 36-44 parts of climbing entada and 36-44 parts of liquorice. The traditional Chinese medicine composition solves the problems that the treatment method in the prior art treats both symptoms and root causes, the curative effect is easy to rebound, the side effect is large and the like. By reasonably matching the medicinal components in a specific proportion, the piglet can be quickly cured after taking the composition, can treat both symptoms and root causes, has no side effect, and is beneficial to treatment of exudative dermatitis of the piglet and growth of the piglet after treatment; the composition is simple to prepare, convenient to use, low in raw material cost, free of toxic reaction after use, high in cure rate, free of residue and remarkable in curative effect on exudative dermatitis of piglets.

Description

Traditional Chinese medicine composition, preparation method and application thereof in preparation of medicine for treating exudative dermatitis of piglets

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition, a preparation method and application thereof in preparation of a medicine for treating exudative dermatitis of piglets.

Background

The exudative dermatitis of piglets, also known as exudative epidermatitis, commonly known as "pig oil skin disease" or "soot disease", is an acute contact infectious disease caused by staphylococcus infection, which is frequently generated in the pig raising industry and mainly infects newborn suckling piglets and weaned piglets, the staphylococcus is gram-positive and conditional pathogenic bacteria and often inhabits on the skin and mucous membrane of the pigs, and when the resistance of organisms is reduced or the skin and mucous membrane are damaged, the pathogenic bacteria enter by deficiency to cause the diseases. Generally, the disease occurs in piglets, but the sudden onset of the disease is that the petechial process of piglets and eyelids appear punctate erythema, then the petechial process turns into black, then oily sticky synovial fluid exudes from the whole body, the odor is foul, then the mucus, dander and dirt are dried, agglomerated and stuck on the skin to form black crusts, the appearance of the black crusts is like that the whole body is coated with soot, and the skin feels like touching grease by hands, so the disease is called as the greasy skin disease. The disease condition is more serious later, some piglets cannot suck milk, some piglets have swollen joints of limbs, can not stand and have tremor of the whole body, and some piglets have the phenomena of skin thickening, dryness, cracking, dyspnea, weakness, dehydration, septicemia and death and the like. Affected pigs often develop systemic dermatitis and can cause dehydration and death. The autopsy sick pig has the defects of exudation of mucilage in the whole body, stink, black crusts formed on the whole body, pachynsis and rhagadia, peach-red dermal tissue exposed after the crusts are stripped, body surface lymphadenectasis, ureteral dilatation, renal pelvis and ureter accumulation of mucus-like urine.

The skin disease occurs in spring, summer and autumn, rarely occurs in winter, although the death rate is not high, the occurrence and infection speed is high, the diseased piglet grows and develops slowly, the constitution is reduced, the piglet gradually becomes thin, the body is dehydrated and dry, the immunologic function is low, and the secondary pneumonia, diarrhea or enteritis and the like are easy to occur. Although the secondary disease occurs to the piglets after being treated by multiple times of medication, most of the piglets die due to exhaustion of multiple organ functions, which directly affects the survival rate of the piglets, brings obstacles to the propagation and the crowd expansion of the live pigs and also causes certain economic loss. Therefore, the harm of exudative dermatitis of piglets to the pig industry is huge. Therefore, the effective control of the exudative dermatitis of the piglets has extremely important significance for improving the pig raising productivity and reducing the economic loss.

At present, no ideal treatment method and no specific medicine exist in western medicine for treating exudative dermatitis of piglets, and common medicines are broad-spectrum antibiotics and hormones. Although broad-spectrum antibiotics and hormones have the advantages of quick response, strong action and the like, the defects of large toxic and side effects of the antibiotics, enhanced bacterial drug resistance, residual veterinary drugs of meat products, high medication cost and the like still exist in the use process, the effects of the antibiotics and hormones are temporary inhibition effects when the antibiotics and hormones are used for controlling and treating exudative dermatitis of piglets, the symptoms of the antibiotics and hormones can appear in swinery after the antibiotics are stopped, the blindly used antibiotics can inhibit or kill a plurality of nonpathogenic flora and destroy the composition structure of the nonpathogenic flora, the digestion function of the organism is seriously influenced to aggravate the disease, and the antibiotics are easy to generate drug resistance after being used for a long time in large quantity. Chemical drugs, antibiotics and monomer drugs are abused greatly, so that various drug-induced diseases such as multi-drug resistance, receptor hypersensitivity and the like are generated, and the pollution of livestock and poultry products is caused, thereby endangering the health and safety of human food.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition, a preparation method and application thereof in preparing a medicine for treating exudative dermatitis of piglets, and the traditional Chinese medicine composition has a remarkable curative effect on exudative dermatitis of piglets.

In order to achieve the above object, the present invention provides the following technical solutions:

the invention provides a traditional Chinese medicine composition which is prepared from the following raw materials in parts by mass:

90-110 parts of fresh goat grass, 54-66 parts of Japanese pagodatree fruit, 54-66 parts of green bristlegrass herb, 54-66 parts of fructus lycii, 54-66 parts of cortex lycii, 36-44 parts of callicarpa bodinieri, 36-44 parts of nidus vespae, 36-44 parts of climbing entada herb and 36-44 parts of liquorice.

Preferably, 95-105 parts of fresh sheep grass, 56-64 parts of Japanese pagodatree fruit, 55-62 parts of green bristlegrass herb, 57-60 parts of fructus arctii, 56-65 parts of Japanese privet root bark, 38-40 parts of callicarpa bodinieri, 37-42 parts of nidus vespae, 39-43 parts of climbing entada and 37-40 parts of liquorice.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:

(1) mixing all the raw materials, and performing first water extraction treatment to obtain a first extracting solution and first decoction dregs;

(2) performing second water extraction treatment on the obtained first decoction dregs to obtain a second extracting solution and second decoction dregs;

(3) mixing the first extractive solution and the second extractive solution, filtering, and concentrating to obtain concentrated solution;

(4) mixing the concentrated solution with ethanol, and filtering to obtain the Chinese medicinal composition.

Preferably, the first water extraction treatment is carried out by decocting 8-12 times of the weight of the raw materials for 1.5-3 hours.

Preferably, the second water extraction treatment is carried out by decocting 8-12 times of the weight of the raw materials for 1-2.5 hours.

Preferably, the relative density of the concentrated solution in the step (3) is 1.10-1.20.

Preferably, the volume ratio of the concentrated solution to the ethanol in the step (4) is 1: 4.5-6.5.

Preferably, the concentrated solution is mixed with ethanol and then stands for 12-36 h.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating exudative dermatitis of piglets.

The invention has the technical effects and advantages that:

the traditional Chinese medicine composition provided by the invention adopts the fresh Chinese artichoke to clear away heat and toxic materials, purge fire and remove dampness, dispel wind and relieve itching, and the Japanese pagodatree fruit to clear away heat and remove dampness and relieve itching, and the two medicines are monarch medicines; herba Geranii has effects of clearing heat and promoting diuresis; detoxifying and detumescence, fructus toruli disperses wind and heat, clears away heat and toxic material, promotes eruption, knows that the skin dispels wind and removes heat, promotes eruption, and the callicarpa bodinieri astringes to stop bleeding, clears away heat and toxic material, and combines the four medicines as ministerial medicines; nidus Vespae has effects of dispelling pathogenic wind, removing toxic substance, killing parasite, relieving pain, and radix Linderae has effects of removing toxic substance and eliminating dampness as adjuvant drugs; licorice root, radix Glycyrrhizae is used as an adjuvant for clearing away heat and toxic materials, and also for harmonizing the effects of the other drugs in the recipe. The traditional Chinese medicine composition adopts a Chinese veterinary therapy, adopts pure traditional Chinese medicine components, is taken orally, can quickly cure piglets after being taken, treats both symptoms and root causes, has no side effect, and is beneficial to treatment of exudative dermatitis of the piglets and growth of the piglets after treatment; the traditional Chinese medicine compound of the invention has the advantages of simple preparation, convenient use, low raw material cost, no toxic reaction after use, high cure rate and no residue, and is an ideal medicine for treating exudative dermatitis of piglets.

Detailed Description

The preparation raw materials of the traditional Chinese medicine composition comprise 90-110 parts of fresh sheep grass, preferably 95-105 parts of fresh sheep grass, and further preferably 98-102 parts of fresh sheep grass.

The preparation raw materials of the traditional Chinese medicine composition comprise 54-66 parts of sophora japonica, preferably 56-62 parts, and more preferably 58-60 parts.

The traditional Chinese medicine composition provided by the invention comprises 54-66 parts of herba cibotii, preferably 55-64 parts, and more preferably 57-59 parts.

The preparation raw materials of the traditional Chinese medicine composition comprise 54-66 parts of fructus momordicae, preferably 58-65 parts of fructus momordicae, and further preferably 59-64 parts of fructus momordicae.

The preparation raw materials of the traditional Chinese medicine composition comprise 54-66 parts of cortex cicadae, preferably 55-65 parts of cortex cicadae, and further preferably 57-61 parts of cortex cicadae.

The preparation raw materials of the traditional Chinese medicine composition comprise 36-44 parts of callicarpa bodinieri, preferably 37-43 parts of callicarpa bodinieri, and more preferably 39-41 parts of callicarpa bodinieri.

The preparation raw materials of the traditional Chinese medicine composition comprise 36-44 parts of nidus vespae, preferably 38-42 parts of nidus vespae, and further preferably 39-40 parts of nidus vespae.

The traditional Chinese medicine composition provided by the invention comprises 36-44 parts of the climbing entada, preferably 39-43 parts of the climbing entada, and more preferably 40-41 parts of the climbing entada.

The traditional Chinese medicine composition provided by the invention comprises 36-44 parts of liquorice, preferably 37-42 parts of liquorice, and more preferably 38-40 parts of liquorice.

In the invention, the processing method for preparing the raw materials has no special requirements and can be realized by adopting a conventional processing mode.

In the present invention, the mixing in step (1) preferably further comprises rinsing the raw materials with drinking water; the first water extraction treatment is preferably carried out by water decoction, the amount of the water is preferably 8-12 times, more preferably 9-11 times of the weight of the raw materials, the decoction time is preferably 1.5-3 hours, more preferably 1.8-2.5 hours, and more preferably 2.0-2.4 hours; in the invention, the duration of the decoction is not required, and the duration of the decoction is only required by adopting the duration of the conventional decoction.

In the invention, the second water extraction treatment is preferably carried out by decocting with water, the dosage of the water is preferably 8-12 times, more preferably 9-11 times, and the decocting time is preferably 1-2.5 hours, more preferably 1.8-2.2 hours.

In the invention, in the step (3), the filtration is preferably 200-400 mesh filtration, the filtration is preferably performed by using a duplex filter, the filtration preferably comprises standing for 12-20 hours, and further preferably 15-18 hours, the concentration preferably is performed by concentrating supernatant obtained by standing, the relative density of the concentrated solution is preferably 1.10-1.20, further preferably 1.12-1.18, and further preferably 1.14-1.16, and the concentration mode is not required, and a conventional concentration mode can be adopted.

In the invention, the volume ratio of the concentrated solution to the ethanol in the step (4) is preferably 1: 4.5-6.5, more preferably 1: 5.2-6.0, and still more preferably 1: 5.5-5.8, in the invention, the ethanol is preferably an ethanol aqueous solution with a volume concentration of 80-99%, and the volume concentration of the ethanol aqueous solution is more preferably 85-95%; in the invention, the mixing of the concentrated solution and ethanol preferably comprises standing, wherein the standing time is preferably 12-36 h, and more preferably 15-30 h; the method further comprises the step of adding water to adjust the relative density of the traditional Chinese medicine composition after filtering in the step (4), wherein the relative density of the traditional Chinese medicine composition after being adjusted by adding water is preferably 1.00-1.10, and is further preferably 1.02-1.08; the preservative is preferably added into the traditional Chinese medicine composition, the preservative is preferably potassium sorbate, the potassium sorbate is preferably 1-3 parts by weight, the traditional Chinese medicine composition after the preservative is added is preferably cooled and filtered, and the cooling time is preferably 10-14 hours; the quality control mode of the traditional Chinese medicine composition in the specific production process is not particularly limited, any mode can be adopted, and in a specific implementation process of the traditional Chinese medicine composition, the traditional Chinese medicine composition is preferably subpackaged and sealed by brown sterile polyester bottles, and circulating steam at the temperature of 80-120 ℃ is adopted for 20-40 min.

The invention also provides an application of the traditional Chinese medicine composition in preparing a medicine for treating exudative dermatitis of piglets, and the medicine preferably takes the traditional Chinese medicine composition as the only active component; the medicine preferably also comprises auxiliary materials, the type of the auxiliary materials is not specially limited, and the medicine can be prepared by adopting conventional medicine auxiliary materials in the field; the medicament dosage form of the invention is preferably powder, tablet, granule, capsule, solution, emulsion, suspension, injection, spray, aerosol or powder spray and the like. In the present invention, the medicament comprises a carrier, and the carrier is preferably a binder, a lubricant, a disintegrating agent, a cosolvent, a diluent, a stabilizing agent, a suspending agent, a pigment-free agent, a flavoring agent and the like for oral preparation; preservatives, solubilizers, stabilizers and the like for injectable preparations; bases for topical formulations, diluents, lubricants, preservatives, and the like.

The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.

Example 1

100 parts of fresh goat grass, 60 parts of Japanese pagodatree fruit, 60 parts of Japanese cinia herb, 60 parts of fructus chaulmi, 60 parts of Japanese ardisia root bark, 40 parts of callicarpa bodinieri, 40 parts of nidus vespae, 40 parts of climbing entada herb and 40 parts of liquorice are taken, the mixture is washed by drinking water and then mixed, purified water with the weight being 10 times that of the mixed medicinal materials is added, the decoction is carried out for 2 times, the first decoction time is 2 hours, and the second decoction time is 1.5 hours. Respectively collecting decoctions, mixing the decoctions, filtering, standing the filtrate for 18 hours, concentrating the supernatant until the relative density is 1.15, adding 98% ethanol until the alcohol content is 85%, standing for 24 hours, filtering, recovering the filtrate, adding water until the relative density is 1.05, adding 2 parts of potassium sorbate, mixing uniformly, cooling for 12 hours, filtering, subpackaging with brown sterile polyester bottles, sealing, and allowing steam to flow at 100 ℃ for 30 minutes to obtain the final product.

Example 2

Taking 105 parts of fresh leymus chinensis, 58 parts of sophora japonica, 60 parts of herba cibotii, 61 parts of fructus chaulmi, 59 parts of cortex dictamni, 36 parts of callicarpa bodinieri, 37 parts of nidus vespae, 43 parts of caulis perllae and 42 parts of liquorice, washing and mixing the materials with drinking water, adding purified water 11 times of the mixed materials, and decocting for 2 times, wherein the first decocting time is 1.8 hours, and the second decocting time is 1.4 hours. Respectively collecting decoctions, mixing decoctions, filtering, standing the filtrate for 15 hr, concentrating the supernatant to relative density of 1.20, adding 96% ethanol until the ethanol content is 84%, standing for 24 hr, filtering, recovering the filtrate, and adding water to relative density of 1.10.

Example 3

98 parts of fresh goat grass, 62 parts of Japanese pagodatree fruit, 58 parts of Japanese cinquefoil herb, 60 parts of fructus chaenomelis, 57 parts of Japanese ardisia root, 38 parts of callicarpa bodinieri, 39 parts of nidus vespae, 40 parts of climbing entada herb and 40 parts of liquorice are taken, the mixture is washed and mixed by drinking water, purified water with the weight 9 times that of the mixed medicinal materials is added, the decoction is carried out for 2 times, the first decoction time is 1.9 hours, and the second decoction time is 1.6 hours. Respectively collecting decoctions, mixing the decoctions, filtering, standing the filtrate for 17 hr, concentrating the supernatant to relative density of 1.15, adding 95% ethanol until the ethanol content is 83%, standing for 24 hr, filtering, recovering the filtrate, adding water until the relative density is 1.10, adding 2 parts of potassium sorbate, mixing, cooling for 12 hr, filtering, packaging with brown sterile polyester bottle, sealing, and allowing steam to flow at 100 deg.C for 30 min.

Experimental example 1

In the experimental example, clinical treatment tests with different dosages (high, medium and low) are carried out on the sick piglets with confirmed diagnosis of the exudative dermatitis of the piglets, and the florfenicol is selected as a positive drug control group to observe the treatment effect of the traditional Chinese medicine composition on the exudative dermatitis of the piglets:

clinical treatment control tests were conducted in four farms, a farming and animal husbandry limited, Mianyang, Sichuan, at 03-2021, 09 months. The pigs with exudative dermatitis of piglets are suckling piglets and weaning piglets with the age of 5-35 days, and have the main symptoms: sudden onset of disease, reddening of the skin around the mouth, eyes, ears and abdomen, reddening of the skin color with red or copper, erythema, increased skin discharge, and clear exudates, peeling off the skin on the abdomen with light scraping to give thin, grayish brown flaky exudates under the armpits and ribs, spreading to the whole body in 3-5 days, and rapidly darkening the color and richness of lipids; then, as soil and feces stick to the infected skin, the affected part is covered with a thick, brown, greasy and odorous crust; thickening, drying and cracking of partial pig skin, increasing the temperature of the skin of a pig suffering from touch, thickening and disorderly hair, directly connecting exudate to eyelashes, and generating oral ulcer and cutin of a hoof bulb falling off; loss of appetite.

128 sick pigs with natural onset confirmed by clinical diagnosis were randomly divided into 4 groups of 32 pigs each. Groups 1-3 are groups treated with the drug of the present invention (three groups of low, medium and high doses, respectively); the 4 th group is a florfenicol positive drug control group; the pigs are separately kept in isolation, the skin lesions, general symptoms, healing and other conditions of the sick pigs are recorded in detail, and the grouping mode is shown in the following table 1.

TABLE 1 piglet exudative dermatitis treatment experimental group

In the experimental groups 1-4, the tested drugs are administered by drenching for 1 time every day and continuously administered for 5 days, and the observation is continued for 3 days after the drug is stopped. After administration, the tested piglets are allowed to freely take food and drink water.

During the clinical trial (pre-dose, during dose and within 3d post-dose discontinuation), clinical symptoms of the experimental piglets were recorded with daily observations and included: the behavior of piglets (mental, motor/muscle tissue, appetite and stool), skin (including itching, erythema, edema, heat, pain, exudate and other symptoms), activity, appetite decrease or increase, body temperature increase, general symptoms such as mental status, death and other conditions were observed visually.

The observation index evaluation is carried out according to a 4-grade scoring method:

0 is no symptom;

1 is mild, and symptoms are: the skin around the mouth, eyes, ears and abdomen turns red, the complexion is red or bronze, erythema occurs, the skin discharge is increased, and clear exudates appear. The appetite is reduced, the body temperature is unchanged, and the spirit is not obviously changed;

2, the score is moderate, and the symptoms are: erythema appears everywhere throughout the body, and the color becomes dark quickly and is rich in lipid; the affected area is then covered with a thick, brown, greasy and odorous crust due to the soil and feces sticking to the infected skin. Poor appetite, elevated body temperature, poor spirit and reluctance to move;

3, severe, with symptoms: thickening, drying and cracking of the pig skin, increasing the temperature of the pig skin with touch diseases, coarse and disordered hair, directly connecting exudate to eyelashes, causing oral ulcer and cutin of hoof bulbs to fall off; loss of appetite, swollen joints of the limbs, inability to stand, and tremor of the whole body.

Integral reduction index (total of symptom and sign integral on initial diagnosis day-total of symptom and sign integral after medication)/total of symptom and sign integral on initial diagnosis day x 100%

And (3) evaluating the curative effect: the recovery is that the integral is reduced by more than 85 percent, the improvement is that the integral is reduced by more than 30 to 60 percent, the ineffectiveness is that the integral is reduced by less than 30 percent, and the statistical results are shown in the following table 2:

TABLE 2 piglet exudative dermatitis treatment test results

As can be seen from Table 2, 29 pigs of 32 sick pigs treated by the medicament with high dose are cured, 3 pigs are obviously relieved, and the cure rate is 90.6%; in 32 sick pigs in the medium-dose treatment group, 28 pigs are cured, 4 pigs are obviously lightened, and the cure rate is 87.5 percent; in 32 sick pigs in the low-dose treatment group, 24 pigs are healed, 4 pigs are obviously relieved, 4 pigs have no change of symptoms, and the cure rate is 75.0%; in 32 pigs in the florfenicol group (control group), 29 pigs are cured, 1 pig is improved, and 3 pigs are ineffective, and the cure rate is 90.6%. The results prove that the high, medium and low doses of the invention have treatment effect on exudative dermatitis of piglets, can relieve symptoms, and the cure rate of the high and medium doses has no significant difference with that of florfenicol groups, namely the treatment effect of the invention on exudative dermatitis of piglets can reach the same curative effect as that of florfenicol, but simultaneously can overcome the defects of temporary treatment, non-permanent treatment, easy rebound curative effect, great side effect and the like in the treatment of florfenicol.

The observation results after 3 days of medicine feeding of the medicine treatment groups show that the spirits of the sick pigs of the medicine groups are better than those before the treatment, the symptoms of red, swollen, hot and pain skin are relieved, the macula is reduced, the exudates are obviously reduced, and the observation after 5 days shows that the symptoms of skin itch, erythema, edema, heat and pain around the mouth, eyes and ears and the abdomen of the sick pigs of each treatment group disappear, the macula disappears, the exudates do not exist or are obviously reduced, the spirits and the appetite are improved (seen from the increase of the feeding amount), and the feces are normal.

From the test results, the traditional Chinese medicine compound disclosed by the invention can realize the effects of clearing away heat and toxic materials, purging fire and removing dampness, and dispelling wind and arresting itching, and no adverse reaction is found in the clinical test process. The high, medium and low doses have better treatment effect on exudative dermatitis of piglets, and the cure rate of the high and medium doses in the florfenicol group has no significant difference. The low-dose group has lower treatment effect than the high-dose group and the medium-dose group, and the medium-dose group and the high-dose group have no significant difference in cure rate and total effective rate. According to the severity of the disease and the cost of treatment, 2ml/kg BW was suggested for clinical application as the medium dose, 1 time daily for 5 consecutive days.

The above embodiments show that the traditional Chinese medicine composition provided by the invention realizes effective treatment of exudative dermatitis of piglets by adopting pure traditional Chinese medicine components, has obvious inhibition effect on growth and reproduction of a plurality of bacterial pathogens due to the advantages of high overall curative effect, difficulty in generation of drug resistance, low residue, small toxic and side effects and the like, and is composed of a plurality of traditional Chinese medicines, so that the traditional Chinese medicine composition has strong antibacterial, anti-inflammatory and antiviral effects, strong mucosa repairing effect and capability of enhancing immunity. Has no residue, drug resistance and toxic and side effects, and is a specific medicine for treating exudative dermatitis of piglets.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by mass:

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by mass:

95-105 parts of fresh goat grass, 56-64 parts of Japanese pagodatree fruit, 55-62 parts of green bristlegrass herb, 57-60 parts of fructus lycii, 56-65 parts of Japanese privet root bark, 38-40 parts of callicarpa bodinieri, 37-42 parts of nidus vespae, 39-43 parts of climbing entada and 37-40 parts of liquorice.

3. The method for preparing the traditional Chinese medicine composition of claim 1 or 2, which is characterized by comprising the following steps:

4. The preparation method of the traditional Chinese medicine composition according to claim 3, wherein the first water extraction treatment is carried out by decocting 8-12 times of the weight of the raw materials for 1.5-3 h.

5. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the second water extraction treatment is carried out by decocting with water 8-12 times of the weight of the raw materials for 1-2.5 h.

6. The method for preparing a Chinese medicinal composition according to claim 5, wherein the relative density of the concentrated solution in the step (3) is 1.10-1.20.

7. The preparation method of the traditional Chinese medicine composition according to claim 6, wherein the volume ratio of the concentrated solution to the ethanol in the step (4) is 1: 4.5-6.5.

8. The preparation method of the traditional Chinese medicine composition according to claim 7, wherein the concentrated solution is mixed with ethanol and then is kept still for 12-36 hours.

9. The use of the Chinese medicinal composition of claim 1 or 2 in the preparation of a medicament for the treatment of exudative dermatitis of piglets.