CN110227109B - Composition for chronic eczema of pigs and preparation method thereof - Google Patents
Composition for chronic eczema of pigs and preparation method thereof Download PDFInfo
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- CN110227109B CN110227109B CN201910561537.8A CN201910561537A CN110227109B CN 110227109 B CN110227109 B CN 110227109B CN 201910561537 A CN201910561537 A CN 201910561537A CN 110227109 B CN110227109 B CN 110227109B
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- chronic eczema
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of animal medicines, and particularly relates to a composition for chronic eczema of pigs and a preparation method thereof. The composition comprises a topical composition and an oral composition, wherein the topical composition comprises folium Eucalypti Globueli, herba Patriniae, fresh Quanpi, Catechu, herba Pileae Scriptae, cortex Euonymi Fortunei, Cotinus coggygria root and Niuguifolia Nigri, and the oral composition comprises fructus Rosae Normalis, folium Platycladi, folium Mori, radix Cynanchi Atrati, herba Houttuyniae, folium Nelumbinis, Glycyrrhrizae radix, herba plantaginis, herba Sambuci Chiensis, ramulus et folium Adhatodae Vasicae and herba Inulae Cappae. The oral composition and the external composition are matched, and the effects of relieving itching, astringing, promoting granulation, clearing away heat and toxic materials, and harmonizing ying and wei and treating both exterior and interior can be achieved, so that the symptoms are quickly relieved, the infection is reduced and prevented, the relapse is prevented, the drug resistance is not generated, and the toxic and side effects are avoided.
Description
Technical Field
The invention relates to the technical field of animal medicines, and particularly relates to a composition for chronic eczema of pigs and a preparation method thereof.
Background
In pig raising production, due to factors such as poor pigsty sanitation, dark and damp, poor ventilation, parasitic infection, malnutrition, abnormal metabolism and the like, the skin diseases of pigs can be caused, wherein eczema is one of the common skin diseases of the pigs, is an allergic reaction of epidermis and dermal epithelium caused by sensitizers, and has very complex etiology and pathogenesis. Acute eczema is developed into flat papules under the jaw, under the abdomen and on the inner side of thighs, part of the papules can be developed into blisters, pustules and even ulcers can be formed after infection, although the papules are not infectious, the infected pigs are usually scratched on the wall and on the trees to relieve itching, so that the pigs are fallen off by hairs, locally infected or eroded to be suppurative, lack of appetite, retarded or stopped growth and development of the pigs and great harm to pig raising production. The acute eczema-suffering pig can be cured after treatment, but pustules formed by suppurative infection can be converted into chronic eczema if the treatment is not in time, so that the inflammation spreads deep, the disease course is long in duration and easy to recur, the suffering pig is extremely itchy and difficult to sleep and eat, lichenification and depilation occur, the skin is thickened, and the growth and development of the suffering pig are seriously influenced.
At present, the treatment methods of chronic eczema are mostly injection or oral antibiotics, skin medicine inunction and the like, and have long treatment course, poor treatment effect and easy relapse. The long-term use of antibiotics can cause the body to generate drug resistance to reduce the curative effect, and the risk of causing disability, teratogenesis and defect exists, and meanwhile, the residue of the antibiotics in the pig body can cause food safety hidden trouble.
Disclosure of Invention
Aiming at the technical problems of long treatment course and easy relapse of chronic eczema in the prior art, the invention provides a composition for chronic eczema of pigs.
In order to achieve the purpose of the invention, the embodiment of the invention adopts the following technical scheme:
the composition for the pig chronic eczema comprises an external composition and an oral composition, wherein the external composition comprises the following components in parts by weight: 5-10 parts of eucalyptus leaves, 5-10 parts of patrinia, 5-10 parts of fresh quanzhi bark, 5-9 parts of catechu, 4-8 parts of glabrous sarcandra herb, 4-8 parts of Zhuuguifeng, 3-7 parts of cotinus coggygria root and 3-7 parts of Japanese sumac; the oral composition comprises the following components in parts by weight: 6-12 parts of atriplex sinensis, 6-12 parts of cacumen biotae, 6-10 parts of folium mori, 6-10 parts of cynanchum atratum, 5-8 parts of houttuynia cordata, 4-8 parts of lotus leaves, 4-8 parts of liquorice, 4-8 parts of plantain, 3-7 parts of sambucus chinensis, 3-7 parts of daqu bone and 3-7 parts of inula cappa.
In the composition for external use:
the folium Eucalypti Globueli is cool, bitter and pungent in taste, and has effects of dispelling pathogenic wind, relieving exterior syndrome, clearing away heat and toxic materials, killing parasites, relieving itching, reducing and eliminating secretion of affected part, and promoting wound healing caused by eczema.
Herba Patriniae is neutral in nature and light in taste, and has effects of clearing heat, removing toxic substance, killing parasite, removing necrotic tissue, cooling blood, removing blood stasis, relieving swelling, and expelling pus, and can be used for eliminating local inflammation, improving microcirculation of pathological change part, and promoting wound surface repair caused by eczema.
Fresh Quanpi is warm in nature, bitter and astringent in taste, and can promote blood circulation, remove blood stasis, astringe and promote granulation.
The catechu is cold in nature, bitter and astringent in taste, can promote blood circulation, relieve pain, promote granulation, astringe dampness and heal wound, has an inhibiting effect on pathogenic bacteria such as staphylococcus aureus and staphylococcus albus, viruses and partial fungi, and can effectively prevent and treat wound infection.
The glabrous sarcandra herb is slightly warm in nature, bitter and pungent in taste, and capable of promoting blood circulation to dissipate stagnation, dispelling wind and dredging collaterals, and resisting bacteria and diminishing inflammation.
Zhui Gu Feng is cool in nature and bitter in taste, and can clear heat, detoxify, activate blood and alleviate pain.
Cotinus coggygria root is cold in nature, pungent and bitter in taste, and can promote blood circulation, remove blood stasis and relieve itching.
The Japanese Saururus herb is cool in nature and bitter in taste, and has effects of removing toxic substance, cooling blood, relieving itching and detumescence.
The topical composition combines the above components, and can relieve itching of affected part through folium Eucalypti Globueli, Cotinus coggygria root and Nibeau albiflora, and reduce affected part damage caused by rubbing of sick pig due to itching; the eucalyptus, the catechu and the glabrous sarcandra herb play a good antibacterial role, and infection of an affected part is relieved and eliminated; the Chinese medicinal composition is supplemented with herba Patriniae, fresh Quanpi and Japanese maitake herb, and can promote the healing of the damaged part and restore the health of the skin. Meanwhile, the combination of the heat-clearing and detoxifying effects of the eucalyptus leaves, the patrinia, the lysimachia foenum-graecum hance and the Japanese spodophylla enables the components in the formula to have synergistic effects, and the effects of relieving itching, clearing heat, detoxifying, cooling blood, dredging collaterals, relieving pain, promoting healing and preventing and treating infection are achieved, so that the eczema symptom can be relieved more quickly. And the components of the external composition are nontoxic, so that even if the sick pigs bite the affected parts, the health of the sick pigs cannot be threatened.
The oral composition comprises:
chenopodium quinoa has mild nature and bland taste, and can promote blood circulation, dispel wind and relieve itching.
Folium Platycladi is cold in nature, bitter and astringent in taste, enters lung channel, liver channel and spleen channel, has effects of clearing heat, eliminating dampness, cooling blood, stopping bleeding, dredging collaterals, relieving pain, and resisting inflammation, and has inhibitory effect on Staphylococcus aureus and Cartacoccus. The composition can enhance antibacterial effect when used together with folium Mori, and has good prevention and treatment effect on infection caused by eczema.
The mulberry leaves are cold in nature, bitter and astringent in taste, enter lung channels, liver channels and spleen channels, can cool blood, stop bleeding and dry dampness, have good growth inhibition effect on most gram-positive bacteria and gram-negative bacteria, and have good prevention and treatment effect on infection caused by eczema.
Bai Wei is cold in nature, bitter and salty in taste, enters stomach channel, liver channel and kidney channel, can clear heat, cool blood, eliminate swelling, promote tissue regeneration and alleviate pain, is good at clearing and resolving, and can thoroughly eliminate all seasonal pathogenic factors and warm diseases to make the pathogenic factors come out from inside to outside.
The cordate houttuynia is slightly cold in nature and pungent in taste, enters lung channels, can clear away heat and toxic materials, eliminate carbuncles and discharge pus, and has an inhibiting effect on various gram positive bacteria and gram negative bacteria such as staphylococcus aureus and staphylococcus albus.
The lotus leaves are neutral in nature and bitter in taste, enter liver, spleen and stomach meridians, and can clear heat, resolve dampness, raise hair, clear yang, cool blood and stop bleeding.
The liquorice has mild nature and sweet taste, enters heart, lung, spleen and stomach channels, can tonify spleen and qi, clear away heat and toxic materials, relieve spasm and relieve pain, and can harmonize the medicines in the oral medicine composition.
Plantain herb is cold in nature and sweet in taste, enters liver channel, kidney channel, lung channel and small intestine channel, and can clear heat, promote urination, cool blood and remove toxicity.
Herba Sambuci Chiensis is neutral in nature, sweet in taste and slightly bitter in flavor, enters liver meridian, and has effects of dispelling pathogenic wind, activating collaterals, promoting diuresis, promoting blood circulation, removing blood stasis, dispersing stagnated liver qi, and invigorating spleen.
The Adhatoda has mild nature and pungent and bitter taste, enters liver and spleen meridians, can promote blood circulation, relieve pain, remove blood stasis, remove dampness, reduce swelling and remove toxicity, and has a certain antibacterial effect on pathogenic bacteria such as staphylococcus aureus.
The inula cappa has warm property, pungent, sweet and slightly bitter taste, can detoxify, detumescence and remove dampness, has good inhibiting effect on staphylococcus albus, and has certain antibacterial effect on pathogenic bacteria such as staphylococcus aureus, catacoccus catarrhalis, escherichia coli, pseudomonas aeruginosa and the like.
The oral composition contains fructus Chenopodii for dispelling pathogenic wind and relieving itching, and can be used for relieving eczema and skin dryness and itching by cooperating with the synergistic blood cooling effect of folium Mori, folium Nelumbinis, radix Cynanchi Atrati, folium Platycladi and herba plantaginis; the lotus leaf, the cynanchum atratum, the cacumen biotae, the plantain herb, the houttuynia cordata and the liquorice can clear heat, the plantain herb, the houttuynia cordata, the argyleaf gloryvine stem, the inula cappa and the liquorice can detoxify in a synergistic way, and the heat clearing and detoxifying effects of all the components are enhanced through the cynanchum atratum; the mulberry leaves, the lotus leaves, the cacumen biotae, the sambucus chinensis, the gendarussa japonica and the inula cappa can promote diuresis, the sambucus chinensis and the liquorice can invigorate spleen and tonify spleen, and the combination of the ingredients in the formula can invigorate spleen and dispel dampness, so that the health of sick pigs is enhanced; the mulberry leaf, the Chinese arborvitae twig, the houttuynia cordata, the asket fern and the inula cappa cooperate with each other to achieve good antibacterial action, and drug resistance cannot be generated. The oral composition is matched with the external composition, can better play the effects of relieving itching, astringing, promoting tissue regeneration, clearing away heat and toxic materials and harmonizing exterior and interior of yingfen and weifen, thereby quickly relieving symptoms, reducing and preventing infection and relapse, generating no drug resistance and having no toxic or side effect.
Preferably, the external composition comprises the following components in parts by weight: 6-9 parts of eucalyptus leaves, 6-8 parts of patrinia, 6-8 parts of fresh quanpiak bark, 6-8 parts of catechu, 5-7 parts of glabrous sarcandra herb, 5-7 parts of Zhuuguifeng, 4-6 parts of cotinus coggygria root and 4-6 parts of Japanese sumac; the oral composition comprises the following components in parts by weight: 7-11 parts of atriplex sinensis, 7-11 parts of cacumen biotae, 7-9 parts of folium mori, 7-9 parts of cynanchum atratum, 6-8 parts of houttuynia cordata, 5-7 parts of lotus leaves, 5-7 parts of liquorice, 5-7 parts of plantain, 4-6 parts of sambucus chinensis, 4-6 parts of daqu bone and 4-6 parts of inula cappa.
Preferably, the external composition comprises the following components in parts by weight: 8 parts of eucalyptus leaves, 7 parts of patrinia, 7 parts of fresh quanbian bark, 7 parts of catechu, 6 parts of glabrous sarcandra herb, 6 parts of lysimachia foenum-graecum hance, 5 parts of cotinus coggygria roots and 5 parts of Japanese sumac; the oral composition comprises the following components in parts by weight: 9 parts of atriplex sinensis, 9 parts of cacumen biotae, 8 parts of mulberry leaves, 8 parts of cynanchum atratum, 7 parts of houttuynia cordata, 6 parts of lotus leaves, 6 parts of liquorice, 6 parts of plantain, 5 parts of sambucus chinensis, 5 parts of argyleaf gloryvine stems and 5 parts of inula cappa.
Preferably, the preparation method of the composition for external use specifically includes the following operations:
weighing the raw materials according to the raw material ratio of the external composition, decocting the eucalyptus leaves, the patrinia, the catechu, the glabrous sarcandra herb and the lysimachia foenum-graecum with water for 1.5-3 h, adding the cotinus coggygria root, decocting for 15-20 min, and drying the obtained extracting solution to obtain a mixed extract;
squeezing and extracting the fresh quanbia and the Japanese maitake to obtain squeezed liquid;
and adding water into the mixed extract to prepare a solution with the mass percentage concentration of 15-25%, adding the squeezed solution, and mixing to obtain the composition.
The preparation method adopts different extraction methods to extract different components, so that the obtained extract has better effects of relieving itching, clearing heat, removing toxic substances, cooling blood, dredging collaterals, relieving pain, promoting granulation and resisting bacteria.
Preferably, the method for extracting the eucalyptus leaves, the patrinia, the catechu, the glabrous sarcandra herb and the lysimachia foenum-graecum by decocting with water comprises the following steps: decocting the eucalyptus leaves, the patrinia, the catechu, the glabrous sarcandra herb and the lysimachia foenum-graecum hance with 6-10 times of water for 2-3 times, and each time for 0.5-1.5 hours.
Preferably, the method for extracting the fresh quanpiazumi and the Japanese sumac herb by pressing is a wet pressing method.
Preferably, the preparation method further comprises mixing the solution with the squeezed solution, and adding excipient to prepare an external preparation.
Preferably, the external preparation comprises a water-soluble paste, a water-soluble ointment, a spray or a powder.
Preferably, the preparation method of the oral composition specifically comprises the following operations:
weighing the raw materials according to the raw material proportion of the oral composition, decocting the chenopodium album linn, the mulberry leaf, the cynanchum atratum, the liquorice, the plantain, the sambucus chinensis and the Adhatoda japonica with water for extraction, ultrasonically extracting the houttuynia cordata with water, decocting the cacumen biotae with ethanol for extraction, and drying the obtained extracting solution to obtain a mixture a; drying the lotus leaves and the inula cappa and then crushing to obtain a mixture b; and (3) mixing the mixture a and the mixture b to obtain the composite material.
Preferably, the method for extracting the chenopodium album linn, the mulberry leaf, the cynanchum atratum, the liquorice, the plantain herb, the sambucus chinensis and the asket fern by decocting with water comprises the following steps: decocting and extracting the chenopodium album linn, the mulberry leaves, the cynanchum atratum, the liquorice, the plantain, the sambucus chinensis and the argyleaf euphorbia herb with 5-8 times of water for 1-3 times, and each time for 0.5-1 h.
Preferably, the volume percentage concentration of the ethanol is 65-85%.
Preferably, the lotus leaves and the inula cappa are dried and then crushed to a particle size of less than 2 mm.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The embodiment of the invention provides a composition for chronic eczema of pigs, which comprises an external composition and an oral composition, wherein the external composition comprises the following components in parts by weight: 5g of eucalyptus leaves, 5g of patrinia, 5g of fresh Quanpi, 5g of catechu, 4g of glabrous sarcandra herb, 4g of Zhushegu rheumatism, 3g of cotinus coggygria roots and 3g of Japanese maitake; the oral composition comprises the following components in parts by weight: 6g of atriplex sinensis, 6g of cacumen biotae, 6g of mulberry leaf, 6g of cynanchum atratum, 5g of houttuynia cordata, 4g of lotus leaf, 4g of liquorice, 4g of plantain herb, 3g of sambucus chinensis, 3g of argyleaf gloryvine stem and 3g of inula cappa.
The preparation method of the external composition comprises the following steps:
weighing the raw materials according to the raw material proportion of the external composition, decocting folium eucalypti globueli, herba patriniae, catechu, glabrous sarcandra herb and chastetree fruit with 6 times of water for 3 times, each time for 0.5h, adding cotinus coggygria root, decocting for 15min, and drying the obtained extracting solution at 40 ℃ under reduced pressure to obtain a mixed extract;
squeezing fresh quanliu peel and Chinese sumac herb, adding water with the same mass as the herb residue into the squeezed residue, squeezing again, and repeating for 2 times to obtain squeezed liquid;
③ adding water into the mixed extract to prepare a solution with the mass percentage concentration of 15 percent, adding the squeezed solution, and mixing to obtain the composition.
The preparation method of the oral composition comprises the following steps:
weighing the raw materials according to the proportion of the oral composition, decocting and extracting the chenopodium album linn, the mulberry leaf, the cynanchum atratum, the liquorice, the plantain, the sambucus chinensis and the Adhatoda japonica by 5 times of water for 2 times, 0.5h each time, ultrasonically extracting the houttuynia cordata for 30min by using water, decocting and extracting the cacumen biotae by using 65% (v/v) ethanol for 2 times, 0.5h each time, and drying the obtained extracting solution to obtain a mixture a;
② drying the lotus leaves and the inula cappa and then crushing the dried lotus leaves and the inula cappa to obtain a mixture b, wherein the particle size of the mixture b is less than 2 mm;
and mixing the mixture a and the mixture b to obtain the composite material.
Example 2
The embodiment of the invention provides a composition for chronic eczema of pigs, which comprises an external composition and an oral composition, wherein the external composition comprises the following components in parts by weight: 6g of eucalyptus leaves, 6g of patrinia, 6g of fresh quanhan bark, 6g of catechu, 5g of glabrous sarcandra herb, 5g of Zhushegu, 4g of cotinus coggygria roots and 4g of Japanese sumac; the oral composition comprises the following components in parts by weight: 7g of atriplex sinensis, 7g of cacumen biotae, 7g of mulberry leaves, 7g of cynanchum atratum, 6g of houttuynia cordata, 5g of lotus leaves, 5g of liquorice, 5g of plantain, 4g of sambucus chinensis, 4g of argyleaf gloryvine stems and 4g of inula cappa.
The preparation method of the external composition comprises the following steps:
weighing the raw materials according to the raw material proportion of the external composition, decocting folium eucalypti globueli, herba patriniae, catechu, glabrous sarcandra herb and chastetree fruit with 7 times of water for 3 times, each time for 0.5h, adding cotinus coggygria root, decocting for 15min, and drying the obtained extracting solution at 45 ℃ under reduced pressure to obtain a mixed extract;
squeezing fresh quanliu peel and Chinese sumac herb, adding water with the same mass as the herb residue into the squeezed residue, squeezing again, and repeating for 2 times to obtain squeezed liquid;
③ adding water into the mixed extract to prepare a solution with the mass percentage concentration of 15 percent, adding the squeezed solution, and mixing to obtain the composition.
The preparation method of the oral composition comprises the following steps:
weighing the raw materials according to the proportion of the oral composition, decocting and extracting the chenopodium album linn, the mulberry leaf, the cynanchum atratum, the liquorice, the plantain, the sambucus chinensis and the Adhatoda japonica by 6 times of water for 1 time and 1 hour, ultrasonically extracting the houttuynia cordata by water for 30min, decocting and extracting the cacumen biotae by 70 percent (v/v) ethanol for 1 time and 1.5 hours, and drying the obtained extracting solution to obtain a mixture a;
② drying the lotus leaves and the inula cappa and then crushing the dried lotus leaves and the inula cappa to obtain a mixture b, wherein the particle size of the mixture b is less than 2 mm;
and mixing the mixture a and the mixture b to obtain the composite material.
Example 3
The embodiment of the invention provides a composition for chronic eczema of pigs, which comprises an external composition and an oral composition, wherein the external composition comprises the following components in parts by weight: 8g of eucalyptus leaves, 7g of patrinia, 7g of fresh quanhan bark, 7g of catechu, 6g of glabrous sarcandra herb, 6g of Zhushegu rheumatism, 5g of cotinus coggygria roots and 5g of Japanese sumac; the oral composition comprises the following components in parts by weight: 9g of atriplex sinensis, 9g of cacumen biotae, 8g of mulberry leaves, 8g of cynanchum atratum, 7g of houttuynia cordata, 6g of lotus leaves, 6g of liquorice, 6g of plantain, 5g of sambucus chinensis, 5g of argyleaf gloryvine stems and 5g of inula cappa.
The preparation method of the external composition comprises the following steps:
weighing the raw materials according to the raw material proportion of the external composition, decocting folium eucalypti, herba patriniae, catechu, glabrous sarcandra herb and lysimachia foenum-graecum with water of which the weight is 8 times that of the raw materials for 2 times, decocting for 1 hour each time, adding cotinus coggygria root, decocting for 20min, and drying the obtained extracting solution at 50 ℃ under reduced pressure to obtain a mixed extract;
squeezing fresh quanliu peel and Chinese sumac herb, adding water with the same mass as the herb residue into the squeezed residue, squeezing again, and repeating for 2 times to obtain squeezed liquid;
③ adding water into the mixed extract to prepare a solution with the mass percentage concentration of 20 percent, adding the squeezed solution, and mixing to obtain the composition.
The preparation method of the oral composition comprises the following steps:
weighing the raw materials according to the proportion of the oral composition, decocting and extracting the chenopodium album linn, the mulberry leaf, the cynanchum atratum, the liquorice, the plantain, the sambucus chinensis and the Adhatoda japonica by 7 times of water for 2 times, 0.5h each time, ultrasonically extracting the houttuynia cordata for 30min by using water, decocting and extracting the cacumen biotae by using 75% (v/v) ethanol for 2 times, 0.5h each time, and drying the obtained extracting solution to obtain a mixture a;
② drying the lotus leaves and the inula cappa and then crushing the dried lotus leaves and the inula cappa to obtain a mixture b, wherein the particle size of the mixture b is less than 2 mm;
and mixing the mixture a and the mixture b to obtain the composite material.
Example 4
The embodiment of the invention provides a composition for chronic eczema of pigs, which comprises an external composition and an oral composition, wherein the external composition comprises the following components in parts by weight: 9g of eucalyptus leaves, 8g of patrinia, 8g of fresh quanhan bark, 8g of catechu, 7g of glabrous sarcandra herb, 7g of Zhushegu rheumatism, 6g of cotinus coggygria roots and 6g of Japanese sumac; the oral composition comprises the following components in parts by weight: 11g of atriplex sinensis, 11g of cacumen biotae, 9g of mulberry leaves, 9g of cynanchum atratum, 8g of houttuynia cordata, 7g of lotus leaves, 7g of liquorice, 7g of plantain, 6g of sambucus chinensis, 6g of argyleaf gloryvine stems and 6g of inula cappa.
The preparation method of the external composition comprises the following steps:
weighing the raw materials according to the raw material proportion of the external composition, decocting folium eucalypti globueli, herba patriniae, catechu, glabrous sarcandra herb and chastetree fruit with 9 times of water for 2 times, each time for 1.5h, adding cotinus coggygria root, decocting for 20min, and drying the obtained extracting solution at 50 ℃ under reduced pressure to obtain a mixed extract;
squeezing fresh quanliu peel and Chinese sumac herb, adding water with the same mass as the herb residue into the squeezed residue, squeezing again, and repeating for 2 times to obtain squeezed liquid;
③ adding water into the mixed extract to prepare a solution with the mass percentage concentration of 25 percent, adding the squeezed solution, and mixing to obtain the composition.
The preparation method of the oral composition comprises the following steps:
weighing the raw materials according to the proportion of the oral composition, decocting and extracting the chenopodium album linn, the mulberry leaf, the cynanchum atratum, the liquorice, the plantain, the sambucus chinensis and the Adhatoda japonica by 7 times of water for 3 times, 0.5h each time, ultrasonically extracting the houttuynia cordata for 30min by using water, decocting and extracting the cacumen biotae by using 80% (v/v) ethanol for 2 times, 1h each time, and drying the obtained extracting solution to obtain a mixture a;
② drying the lotus leaves and the inula cappa and then crushing the dried lotus leaves and the inula cappa to obtain a mixture b, wherein the particle size of the mixture b is less than 2 mm;
and mixing the mixture a and the mixture b to obtain the composite material.
Example 5
The embodiment of the invention provides a composition for chronic eczema of pigs, which comprises an external composition and an oral composition, wherein the external composition comprises the following components in parts by weight: 10g of eucalyptus leaves, 10g of patrinia, 10g of fresh quanhan bark, 9g of catechu, 8g of glabrous sarcandra herb, 8g of Zhushegu rheumatism, 7g of cotinus coggygria roots and 7g of Japanese sumac; the oral composition comprises the following components in parts by weight: 12g of atriplex sinensis, 12g of cacumen biotae, 10g of mulberry leaves, 10g of cynanchum atratum, 8g of houttuynia cordata, 8g of lotus leaves, 8g of liquorice, 8g of plantain, 7g of sambucus chinensis, 7g of argyleaf gloryvine stems and 7g of inula cappa.
The preparation method of the external composition comprises the following steps:
weighing the raw materials according to the raw material proportion of the external composition, decocting folium eucalypti globueli, herba patriniae, catechu, glabrous sarcandra herb and chastetree fruit with 10 times of water for 2 times, each time for 1.5h, adding cotinus coggygria root, decocting for 20min, and spray drying the obtained extracting solution at 55 ℃ to obtain a mixed extract;
squeezing fresh quanliu peel and Chinese sumac herb, adding water with the same mass as the herb residue into the squeezed residue, squeezing again, and repeating for 2 times to obtain squeezed liquid;
③ adding water into the mixed extract to prepare a solution with the mass percentage concentration of 25 percent, adding the squeezed solution, and mixing to obtain the composition.
The preparation method of the oral composition comprises the following steps:
weighing the raw materials according to the proportion of the oral composition, decocting and extracting the chenopodium album linn, the mulberry leaf, the cynanchum atratum, the liquorice, the plantain, the sambucus chinensis and the Adhatoda japonica by using water with the weight being 8 times of that of the composition for 3 times, each time for 0.5h, ultrasonically extracting the houttuynia cordata for 30min by using water, decocting and extracting the cacumen biotae by using 85% (v/v) ethanol for 3 times, each time for 0.5h, and drying the obtained extracting solution to obtain a mixture a;
② drying the lotus leaves and the inula cappa and then crushing the dried lotus leaves and the inula cappa to obtain a mixture b, wherein the particle size of the mixture b is less than 2 mm;
and mixing the mixture a and the mixture b to obtain the composite material.
Example 6
The embodiment of the invention provides a composition for treating pig chronic eczema, which comprises an external composition and an oral composition, and the components of the composition are the same as those in the embodiment 3.
The preparation method of the external composition comprises the following steps:
(iii) same as example 3;
fourthly, drying the mixture obtained in the third step and then preparing the mixture and the water-soluble gel matrix into paste.
The oral composition was prepared in the same manner as in example 3.
Example 7
The embodiment of the invention provides a composition for treating pig chronic eczema, which comprises an external composition and an oral composition, and the components of the composition are the same as those in the embodiment 3.
The preparation method of the external composition comprises the following steps:
(iii) same as example 3;
fourthly, the mixture obtained in the third step and water-soluble ointment base are made into water-soluble ointment.
The oral composition was prepared in the same manner as in example 3.
Example 8
The embodiment of the invention provides a composition for treating pig chronic eczema, which comprises an external composition and an oral composition, and the components of the composition are the same as those in the embodiment 3.
The preparation method of the external composition comprises the following steps:
(iii) same as example 3;
fourthly, the mixture obtained in the third step is filtered and then is subpackaged into a spray bottle to prepare the spray.
The oral composition was prepared in the same manner as in example 3.
Example 9
The embodiment of the invention provides a composition for treating pig chronic eczema, which comprises an external composition and an oral composition, and the components of the composition are the same as those in the embodiment 3.
The preparation method of the external composition comprises the following steps:
(iii) same as example 3;
fourthly, the mixture obtained in the third step is dried and then crushed to the particle size of less than 150 mu m to prepare powder.
The oral composition was prepared in the same manner as in example 3.
Comparative example 1
The comparative example provides a composition for chronic eczema in pigs, which comprises an external composition and an oral composition. In the comparative example, the eucalyptus leaf, the patrinia herb, the chenopodium album and the cynanchum atratum in the composition are respectively replaced by the shrubalthea bark, the Japanese thistle herb, the dittany bark and the radix rehmanniae with similar medicine properties and effects, and the specific steps are as follows:
the external composition comprises the following components in parts by weight: 8g of shrubalthea bark, 7g of Japanese thistle herb, 7g of fresh Quanpi bark, 7g of catechu, 6g of glabrous sarcandra herb, 6g of Zhushegu rheumatism, 5g of cotinus coggygria root and 5g of Japanese sumac; the oral composition comprises the following components in parts by weight: 9g of dittany bark, 9g of Chinese arborvitae twig, 8g of mulberry leaf, 8g of radix rehmanniae recen, 7g of houttuynia cordata, 6g of lotus leaf, 6g of liquorice, 6g of plantain herb, 5g of sambucus chinensis, 5g of argyleaf glorybower rhizome and 5g of inula cappa.
The preparation method is the same as example 8.
Comparative example 2
The comparative example provides a composition for chronic eczema in pigs, which comprises an external composition and an oral composition. In the comparative example, part of the components (catechu, japanese sumac and cordate houttuynia) in the composition of the invention are removed, and the contents of other components are adjusted correspondingly, specifically:
the external composition comprises the following components in parts by weight: 10g of eucalyptus leaves, 9g of herba patriniae, 9g of fresh quanhan bark, 8g of glabrous sarcandra herb, 8g of lysimachia foenum-graecum and 7g of cotinus coggygria root; the oral composition comprises the following components in parts by weight: 11g of atriplex sinensis, 11g of cacumen biotae, 10g of cynanchum atratum, 8g of lotus leaf, 8g of liquorice, 8g of plantain herb, 6g of sambucus chinensis, 6g of argyleaf glorybower rhizome and 6g of inula cappa.
The preparation method is the same as example 8.
Examples of effects
This effect example provides the above examples and comparative experiments for chronic swine eczema:
1. experimental animals: 79 chronic eczema pigs in a pig farm in Hebei province have the weight of 30-64 kg, relapse for more than 3 times, and have the same disease degree before experiment, and are marked by large-area papules with pustules, erosion and scabs more than half of the papules. The sick pigs are randomly divided into a blank group, an experimental group, a control 1 group and a control 2 group, and are separately fed among the sick pigs.
2. Test drugs:
the experimental group, the control 1 group and the control 2 group used the compositions obtained in example 8, the control 1 and the control 2, respectively, according to the present invention.
3. Test method
The topical composition is sprayed onto affected part 3 times per day, and the oral composition is mixed with feed at a dose of 0.25g/kg per time and fed twice per day. The blank group did not use any drug.
4. Results of the experiment
The recovery of the sick pigs was observed daily during the dosing period. After recovery, observation is carried out for 3 months, and the recurrence rate of each group is counted. The results are shown in table 1:
TABLE 1
The experimental results show that compared with the control groups 1 and 2, the experimental group has faster effect, higher cure rate within the same administration time, the cure rate after being taken for 3 days can reach 96%, and no relapse occurs within 3 months. The composition provided by the invention has a remarkable effect on the chronic eczema of the pigs.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (9)
1. The composition for the chronic eczema of the pigs is characterized by comprising an external composition and an oral composition, wherein the external composition comprises the following components in parts by weight: 5-10 parts of eucalyptus leaves, 5-10 parts of patrinia, 5-10 parts of fresh quanzhi bark, 5-9 parts of catechu, 4-8 parts of glabrous sarcandra herb, 4-8 parts of Zhuuguifeng, 3-7 parts of cotinus coggygria root and 3-7 parts of Japanese sumac; the oral composition comprises the following components in parts by weight: 6-12 parts of atriplex sinensis, 6-12 parts of cacumen biotae, 6-10 parts of folium mori, 6-10 parts of cynanchum atratum, 5-8 parts of houttuynia cordata, 4-8 parts of lotus leaves, 4-8 parts of liquorice, 4-8 parts of plantain, 3-7 parts of sambucus chinensis, 3-7 parts of daqu bone and 3-7 parts of inula cappa.
2. The composition for the chronic eczema of pigs according to claim 1, wherein the composition for external use comprises the following components in parts by weight: 6-9 parts of eucalyptus leaves, 6-8 parts of patrinia, 6-8 parts of fresh quanpiak bark, 6-8 parts of catechu, 5-7 parts of glabrous sarcandra herb, 5-7 parts of Zhuuguifeng, 4-6 parts of cotinus coggygria root and 4-6 parts of Japanese sumac;
the oral composition comprises the following components in parts by weight: 7-11 parts of atriplex sinensis, 7-11 parts of cacumen biotae, 7-9 parts of folium mori, 7-9 parts of cynanchum atratum, 6-8 parts of houttuynia cordata, 5-7 parts of lotus leaves, 5-7 parts of liquorice, 5-7 parts of plantain, 4-6 parts of sambucus chinensis, 4-6 parts of daqu bone and 4-6 parts of inula cappa.
3. The composition for the chronic eczema of pigs according to claim 2, wherein the composition for external use comprises the following components in parts by weight: 8 parts of eucalyptus leaves, 7 parts of patrinia, 7 parts of fresh quanbian bark, 7 parts of catechu, 6 parts of glabrous sarcandra herb, 6 parts of lysimachia foenum-graecum hance, 5 parts of cotinus coggygria roots and 5 parts of Japanese sumac;
the oral composition comprises the following components in parts by weight: 9 parts of atriplex sinensis, 9 parts of cacumen biotae, 8 parts of mulberry leaves, 8 parts of cynanchum atratum, 7 parts of houttuynia cordata, 6 parts of lotus leaves, 6 parts of liquorice, 6 parts of plantain, 5 parts of sambucus chinensis, 5 parts of argyleaf gloryvine stems and 5 parts of inula cappa.
4. The composition for chronic eczema in pigs according to any one of claims 1 to 3, wherein the preparation method of the external composition specifically comprises the following operations:
weighing the raw materials according to the raw material proportion of the external composition, decocting folium eucalypti globueli, herba patriniae, catechu, glabrous sarcandra herb and rheumatalgia by using water with the weight of 8 times of the raw materials for 2 times, adding cotinus coggygria root each time for decocting for 20min, and drying the obtained extracting solution to obtain a mixed extract;
squeezing fresh Quanpi and Japanese sumac to obtain squeezed liquid;
and adding water into the mixed extract to prepare a solution with the mass percentage concentration of 20%, adding the squeezed solution, and mixing to obtain the composition.
5. The composition for swine chronic eczema according to claim 4, wherein the squeezing extraction method is a wet squeezing method.
6. The composition for swine chronic eczema according to claim 4, wherein the preparation method further comprises mixing the solution with the obtained squeezed solution, and adding an excipient to prepare an external preparation.
7. The composition for swine chronic eczema according to claim 6, wherein the external preparation comprises a paste, an ointment, a spray or a powder.
8. The composition for chronic eczema in pigs according to any one of claims 1 to 3, wherein the preparation method of the oral composition specifically comprises the following operations:
weighing the raw materials according to the raw material proportion of the oral composition, decocting and extracting the chenopodium album linn, the mulberry leaf, the cynanchum atratum bunge, the liquorice, the plantain, the sambucus chinensis and the Adhatoda japonica with 7 times of water for 2 times, each time for 0.5h, ultrasonically extracting the houttuynia cordata for 30min, decocting and extracting the cacumen biotae with 75% (v/v) ethanol for 2 times, each time for 0.5h, and drying the obtained extracting solution to obtain a mixture a; drying and crushing lotus leaves and inula cappa to obtain a mixture b; and (3) mixing the mixture a and the mixture b to obtain the composite material.
9. The composition for swine chronic eczema according to claim 8, wherein the lotus leaves and inula cappa are dried and then pulverized to a particle size of less than 2 mm.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283899A (en) * | 2011-08-18 | 2011-12-21 | 湖南省普天春生物科技有限公司 | Traditional Chinese medicine external preparation and application thereof |
| CN103432289A (en) * | 2013-08-01 | 2013-12-11 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine oral liquid for treating eczema in pig and preparation method of traditional Chinese medicine oral liquid |
| CN108403500A (en) * | 2018-04-20 | 2018-08-17 | 佛山汇沐化学科技有限公司 | A kind of refrigerant anti-pruritic compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283899A (en) * | 2011-08-18 | 2011-12-21 | 湖南省普天春生物科技有限公司 | Traditional Chinese medicine external preparation and application thereof |
| CN103432289A (en) * | 2013-08-01 | 2013-12-11 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine oral liquid for treating eczema in pig and preparation method of traditional Chinese medicine oral liquid |
| CN108403500A (en) * | 2018-04-20 | 2018-08-17 | 佛山汇沐化学科技有限公司 | A kind of refrigerant anti-pruritic compositions |
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| Title |
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| 五叶煎剂治疗家畜皮肤病;牛永新;《中兽医学杂志》;20010825(第03期);第29页 * |
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