CN102188494A - Medicament for treating high fever of pigs with pure Chinese medicine - Google Patents
Medicament for treating high fever of pigs with pure Chinese medicine Download PDFInfo
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Abstract
The invention discloses a medicament for treating high fever of pigs with pure Chinese medicine. The medicament is an injection prepared from traditional Chinese medicine materials through extraction, concentration and other processes in different parts by weight. The pharmaceutical for treating high fever of pigs with pure Chinese medicine is prepared from the following raw materials in parts by weight: 5-16 parts of scutellaria baicalensis, 5-14 parts of fructus forsythiae, 4-13 parts of cornu bubali and 4-13 parts of plaster. Through multiple times of experiments, the traditional Chinese prescription is determined, and the pharmaceutical has good synergistic effect, as well as strong effect on killing bacterium or virus causing the high fever of the pigs, can fast enhance the organism immunity of the pigs and prevent secondary infection and other diseases, with curative ratio of 90.03 percent, is safe and small in toxic and side effects, has no drug resistance, as well as effects of promoting recovery, clearing away heat and drying damp, purging intense heat and detonicating, cooling blood, relieving restlessness and quenching thirsty, removing swelling and dissipating binds through substituting similar medicines, thus being accurate in curative effect.
Description
Technical field
The present invention relates to the veterinary and use medicine, a kind of specifically medicine of pure treatment by Chinese herbs porcine hyperthermia.
Background technology
It is one of major industry of China's animal husbandry development that ecological pig produces, also be a main pillar of China livestock products foreign exchange earning, be aspect increasing national income and uplifting the people's living standard, accelerate the important goal of aspects such as farming and animal husbandry development, adjustment agriculture industrialization structure.Yet, since 2006 by the end of May, numerous pig farms from south to the north, pig is bred in growth and part sow, nursery pig have broken out unknown high fever of pigs, the pig sickness rate is suffered from more than 50% in most of morbidity pig farm, and mortality rate has caused serious economy loss for the pig farm and the family of raising pigs up to 50～90%, some pig farm even therefore go bankrupt, people are with one's hair standing on end once talking " heat ".
" porcine nameless high-fever " is high fever syndrome of pigs, it is the equal disease with high of a kind of M ﹠ M, mainly occur in finishing period pig and part sow, the clinical temperature of pig body of 1. falling ill that mainly shows as of sick pig is increased to 40～42.5 ℃, spirit is depressed, and feed intake descends or appetite is useless cuts off, and trouble Corii Sus domestica skin is rubescent, behind the ear in one's ear edge cyanosis, abdomen down and health many places skin such as extremity tip the speckle shape is arranged, be aubergine; 2. dyspnea, happiness is lain prostrate, and serious ventral breathing appears in the part pig, and asthma is rapid, and the performance that has is breathed or is irregular breathing; 3. part is suffered from pig rhinorrhea, sneeze, cough, discharge of eye and is increased, and most of pig has the tear speckle, the conjunctivitis symptom occurs; 4. part swinery constipation, feces is constipated, is spherical, yellowish urine and less, muddiness, color burn.The sick pig whole body that the course of disease is long slightly is pale, the anemia phenomenon occurs, and disorderly thick by hair, myasthenia of limbs behind the sick pig of part can not be stood indivedual sick pigs are dying before, and last whole body is twitched and extremely.Morbidity swinery mortality rate is very high, the pig farm that has even up to 50～90%.The part sow miscarriage occurs in later stage of pregnancy (100～110 days), produces stillborn fetus, weak son and mummy.
Its characteristics of incidence is: 1. occur in temperature higher season, the course of disease is long, generally about 5～20 days, and the case fatality rate height; 2. the pig farm to epidemic preventing working think little of, technical staff's idea that keeps healthy is poor, do not have strict sealing pig farm, swinery not to be carried out the pig farm morbidity of health care of system serious; 3. fall ill the body weight of pig generally at 20～80kg, sickness rate is the highest, and the piglet morbidity after the wean is also arranged; 4. medication effect is not ideal, and the pig farm mortality rate of abusing medicine is higher.
The characteristics of porcine hyperthermia " three-hypers one is low " are that fever, sickness rate height, mortality rate height, cure rate are low.This disease is a kind of height contagious disease, ill pig and be the important source of infection of primary disease with malicious pig, and main route of transmission is that contact infection, air borne and seminal fluid are propagated, and also can pass through the Placenta Hominis vertical transmission.But number of ways such as susceptible pig per os, nasal cavity, muscle, abdominal cavity, vein and intrauterine inoculation and infective virus, 2-14 week all can be given other susceptible pig with virus disseminating by contact behind the pig infective virus.Flowing of infected pigs also is important circulation way.
Country adopts antibiosis prevention and control usually at present, to the swinery of pig hyperpyrexia is taken place, adds Florfenicol+sulfamonomethoxine 300 gram/tons in feedstuff per ton; Feedstuff reduces because ill swinery searches for food, and can not absorb the medicine of enough therapeutic doses, and dosing in drinking-water is simultaneously used the effective antibiotics of antibacterial and virus, allows swinery freely drink 5～7 days.Or a pig isolated rearing to having fallen ill, use sulfamethoxyplridazine class injection to carry out injection for curing, or with 80% Tiamulin, 125 gram/tons+chlortetracycline 300 gram/tons+ampicillin 200 gram/tons, or injection florfenicol, doxycycline, ampicillin etc., or cut off the horizontal transmission of disease between piglet and piglet.This cause of disease is responsive to above used chemical drugs, but toxic and side effects is big, and carcinogenic teratogenesis is in various degree arranged.To state of an illness especially severe and the not good sick pig of therapeutic effect, electricity can only resolutely be eliminated.
The Ministry of Agriculture makes the industry standard (NY5029-2001) of " pollution-free food-Carnis Sus domestica ", has stipulated organoleptic indicator, physical and chemical index, microbiological indicator of nuisanceless Carnis Sus domestica etc.It is more and more higher to the appealing of nuisanceless Carnis Sus domestica that " clenbuterol hydrochloride " incident of in March, 2011 exposure just can embody people, so the equal toxic side effect of chemical drugs has very big harm to people's health.The present invention is a pure Chinese medicinal preparation, does not contain any antibiotic, and chemical hormone etc., have no side effect at noresidue, and are safe, are the environmental type preparation.
Summary of the invention
Purpose of the present invention just provides a kind of good effect, short treating period, consumption is few, cost is low, the pure Chinese medicinal preparation medicine of residual few treatment porcine hyperthermia.Is the epoch at center now with back to nature with life sciences, and directional steerings that some developed countries propose from synthetics are sought the medicine for the treatment of in natural Chinese medicinal herb.So we take active action, again through clinical trial for many years, prescription with pure Chinese medicine extraction effective ingredient, repeatedly small quantities of demonstration test shows according to available data: evident in efficacy, treating both the principal and secondary aspects of a disease, safely, have no side effect noresidue, meat does not have the melancholy of commodity inspection, favored by numerous raisers, help improving the physique of the nation people, for vast breeding enterprise escorts.
The present invention is characteristic and the Chinese veterinarian's theory according to the antibacterial of physiological property of pig and sufferer pig, virus, from the Chinese prescription worked out, single medicinal material or pharmaceutically active ingredient, carry out in the body, external control test, the best prescription that filters out.
The Chinese medicine preparation of treatment porcine hyperthermia of the present invention, by the raw material of following parts by weight through extracting technological procedure preparation such as embedding: Radix Scutellariae 5-16 part, Fructus Forsythiae 5-14 part, Cornu Bubali 4-13 part, Gypsum Fibrosum 4-13 part.
The side that the present invention treats porcine hyperthermia separates as follows:
Radix Scutellariae: hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The fire of the kind eliminating the pathogens from the lung part of the body cavity above the diaphragm housing the heart and lungs of Radix Scutellariae, the fire of the descending large intestine part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is used for calentura hyperpyrexia excessive thirst, and cough due to lung-heat or intenseness of heat forcing blood are excessive, and disease such as pathopyretic ulcer.Effective ingredient: flavone compound is mainly baicalin (C
21H
18O
11).According to pharmacological research, it has antibacterial action, antifungic action, antivirus action.
Fructus Forsythiae: hardship, be slightly cold, go into the heart, gallbladder meridian.Function: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.The modern pharmacology effect studies show that Fructus Forsythiae has significant inhibitory effect external to multiple pathogen, and antiinflammatory is analgesic, protect the liver the town effect such as tells significantly.
Cornu Bubali: Kucheng, cold.Go into the heart, liver, spleen, stomach four warps.Effect: control epidemic febrile disease intenseness of heat heated, high fever does not move back, unconsciousness and delirium, and the typhoid fever pestilence pathogenic heat attacking blood system in febrile diseases, the clear excess-heat of removing heat from blood, mania and irritation, agitation, delirium, macule, epistaxis, hematochezia, swollen ulcer drug are spitted blood in jaundice.Effective ingredient: cholesterol, aminoacid such as alanine, arginine, aspartic acid, cystine, leucine, tyrosine, serine, valine.
Gypsum Fibrosum: Xin Gan, cold.Effect: clearing heat in QI system divides excess-heat, the epidemic febrile disease hyperpyrexia, and the enhancing human body immunity function, expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst, heat-clearing and toxic substances removing.Effective ingredient: calcium sulphate dihydrate (CaSO
42H
2O).
Fang Yi: we are monarch drug with the Radix Scutellariae heat of losing heart clearly, the bitter gas that stagnates that looses of Radix Scutellariae, and diarrhea due to cold pathogen lung-fire and the cough-relieving of detoxifying, forcing blood is capable and end epistaxis, " property of medicine opinion ": " can control pyretic toxicity "; " book on Chinese herbal medicine just ": " separating pestilence ", " expectorant promoting the circulation of QI ".Fructus Forsythiae is a ministerial drug, is usually used in epidemic febrile disease heating, hyperpyrexia disease, and agitation, thirsty or send out disease such as macule, clearing heat in QI system, blood system heat.Cornu Bubali, Gypsum Fibrosum are adjuvant among the we.Cornu Bubali, heat-clearing and toxic substances removing, antiviral, antibacterium, enhancing human body immunity function.Control to porcine hyperthermia is better than most antibiotics and antiviral drugs.
Take this medicine, experimental results show that this curable substance porcine hyperthermia through batch, and the cure rate height, side effect is little, and alternative similar chemical medicine can be prevented and treated porcine hyperthermia, and the meat nonhazardous.
The present invention treats the pure Chinese medicinal preparation of porcine hyperthermia, and commodity are called " pyretic toxicity loses injection ".Use this invention medicine cure rate 90.03%, effect is obvious.
Toxicity test, the present invention is treated the medicine of porcine hyperthermia and give 40 white mice, injection 2ml medicinal liquid 1kg, quite 20 times of the pig consumption, the viewing duration animal diet followed is normal, do not see animal dead, after the injection, activity reduces to some extent, but animal survival is in good condition, recover normal behind the 8h, illustrate with this medicine it is safe.
The specific embodiment:
[prescription] prescription of the present invention is to clean weighing by following materials of weight proportions: Radix Scutellariae 5-16 part, Fructus Forsythiae 5-14 part, Cornu Bubali 4-13 part, Gypsum Fibrosum 4-13 part.Take by weighing gross weight and be the medical material after proportioning cleans according to the above ratio of 1200g, make the 1000ml injection.
[preparation method] carries out the strictness screening to each raw material, cleans, and takes by weighing, and by regular pharmaceutical technology rules such as extraction, embedding, sterilizations, produces " pyretic toxicity loses " injection then.Method for making: above four flavors, baikal skullcap root decoction pieces decocts with water secondary, each 1 hour, gradation filtered, merging filtrate, filtrate transfers pH value to 1.0-2.0 with hydrochloric acid (2mol/L), 80 ℃ of insulations 30 minutes, leaves standstill 24 hours, filter, precipitation adds 8 times of water gagings, stirs, transfer PH to 7.0 with 40% sodium hydroxide solution, and add equivalent ethanol, stirring makes molten, filter, filtrate is transferred PH to 2.0 with hydrochloric acid (2mol/L), and 60 ℃ are incubated 30 minutes, left standstill 12 hours, and filtered, precipitation is washed till PH to 4.0 with ethanol, add 10 times of water gagings, stir, transfer PH to 6.0 with 40% sodium hydroxide solution, add 0.5% active carbon, fully stir, 50 ℃ are incubated 30 minutes, add 1 times of amount ethanol and stir, filter immediately, filtrate is transferred PH to 2.0 with hydrochloric acid (2mol/L), and 60 ℃ are incubated 30 minutes, left standstill 12 hours, filter, after precipitation is washed with small amount of ethanol, in dry, standby below 60 ℃.Cornu Bubali pound sheet is cleaned, and adds 10 times of amounts of water together with rubble cream and decocts secondary, each 7-10 hour, replenish the moisture that boils off, collecting decoction in the decoction process at any time, add Fructus Forsythiae, decoct with water three times, each 1 hour, collecting decoction, filter, be concentrated into relative density and be 1.10-1.15 (70-80 ℃ of survey) and put and be chilled to 40 ℃, add 4% gelatin solution and be stirred to and do not have precipitation and produce cold preservation 24 hours, filter, filtrate is used ethanol precipitation three times, and content is respectively 60%, 75%, 85%, cold preservation filtered more than 48 hours, filtrate recycling ethanol is to there not being the alcohol flavor, filter, filtrate is regulated pH value to 7.0 with 40% sodium hydroxide, and is standby.Get Radix Scutellariae extract, it is an amount of to add water, heating also transfers pH value to 7.0 to make dissolving with 40% sodium hydroxide, and adding Cornu Bubali, Gypsum Fibrosum, Fructus Forsythiae extracting solution add water to full dose, add 0.5% active carbon, keep pH value 7.0, heat little boiling 15 minutes, cooling filters, supply water for injection to full dose, differentiate baicalin (C
21H
18O
11), phillyrin (C
29H
36O
15) and the qualified back embedding of assay, pH value, sterilization, promptly.
[character] this product is pale brown color clear liquid.
This product 10ml is got in [discriminating] (1), puts in the water-bath evaporate to dryness residue and adds 85% ethanol 5ml and make dissolving, as need testing solution.Other gets the baicalin reference substance, adds 85% ethanol and makes the solution that every 1ml contains 0.1mg, in contrast product solution.According to the thin layer chromatography test, draw above-mentioned solution 1 μ l, put on same polyamide film, be developing solvent with 36% acetic acid, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color.
(2) get this product 4ml, put evaporate to dryness in the water-bath, residue adds methanol 5ml makes dissolving, as need testing solution.Other gets Fructus Forsythiae control medicinal material 0.5g, adds methanol 10ml, and hot dipping 1h filters, and filtrate is medical material solution in contrast.Test according to thin layer chromatography (appendix VIB), draw above-mentioned two kinds of solution 2-5 μ l, put respectively in same be on the silica gel g thin-layer plate of binding agent with the sodium carboxymethyl cellulose, be developing solvent with chloroform-methanol (8: 1), launch, take out, spray is with acetic anhydride-sulphuric acid (20: 1) solution, in 105 ℃ of bakings several minutes, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
[inspection] pH value should be 6.0-7.5.
[assay] (1) baicalin precision is measured this product 1.5ml and is put in the centrifuge tube, drip 2 of 6mol/L hydrochloric acid solutions, stir, promptly separate out precipitation, centrifugal, abandoning supernatant (being sure not to make the precipitation loss), precipitation adds the about 5ml of 70% ethanol with 5 washings of 0.2mol/L hydrochloric acid solution 1 time, and slight fever makes dissolving, quantitatively change in the 50ml measuring bottle,, shake up to scale with 70% ethanol dilution, precision is measured 1ml, put in the 25ml measuring bottle, add the 0.2mol/L hydrochloric acid solution to scale, shake up, according to spectrophotography, measure trap at 276nm wavelength place, press baicalin (C
21H
18O
11) absorptance (
) be 631 calculating, promptly.
This product contains baicalin (C
21H
18O
11) every ml must not be lower than 5.0mg
(2) test of phillyrin chromatographic condition and system suitability is a filler with the octadecylsilane chemically bonded silica; With acetonitrile-water (25: 75) is mobile phase; The detection wavelength is 277nm.Number of theoretical plate calculates by the phillyrin peak should be not less than 3000.It is an amount of that the preparation precision of reference substance solution takes by weighing the phillyrin reference substance, adds methanol and make the solution that every 1ml contains 0.2mg, promptly.
The about 1g of this product powder is got in the preparation of need testing solution, and accurate the title decides, and puts in the tool plug conical flask, the accurate methanol 15ml that adds claims to decide weight, and dipping spends the night, supersound process 25 minutes is put coldly, claims to decide weight again, supply the weight that subtracts mistake with methanol, shake up, filter, precision is measured subsequent filtrate 5ml, steams near and does, and adds neutral alumina 0.5g and mixes thoroughly, add and put on the neutral alumina post (100-120 order, 1g, internal diameter 1-1.5cm), with 70% ethanol 80ml eluting, collect eluent, be concentrated into dried, residue 50% dissolve with methanol is transferred in the 5ml measuring bottle, and is diluted to scale, shake up, filter, get subsequent filtrate, promptly.
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, promptly.This product contains phillyrin (C
29H
36O
15) every 1ml must not be lower than 0.3mg.
" pyretic toxicity loses injection " and other antibiotic therapy test with the treatment porcine hyperthermia: " pyretic toxicity loses injection " is by every kg body weight 0.05-0.1ml, intramuscular injection logotype 3 days; The every kg body weight of florfenicol is used 20-30mg, and intramuscular injection is 5 days continuously; The every kg body weight of doxycycline is used 10-20mg, and intramuscular injection is 5 days continuously; The every kg body weight of ampicillin is used 25-40mg, and intramuscular injection is 5 days continuously.
Duration of test: test is unified feeding and management with positive pig.
Criterion: clinical symptom disappearance, diet recover normal.
Result of the test
Therapeutic effect compares:
| Grouping | The test number | Cure number | The produce effects number | Invalid death | Cure rate |
| Pyretic toxicity loses the injection group | 3250 | 2926 | 324 | 0 | 90.03％ |
| The florfenicol group | 19 | 15 | 2 | 2 | 78.95％ |
| The doxycycline group | 22 | 17 | 2 | 3 | 77.27％ |
| The ampicillin group | 24 | 18 | 3 | 3 | 75％ |
| Matched group | 6 | 1 | 1 | 4 | 17％ |
Clinical experiment disease is bright: experiment effect obviously is better than other medicines, can substitute other similar drugs, and toxic and side effects is few, and meat does not have the melancholy of commodity inspection, helps improving the overall quality of the population, and helps animal husbandry and develops in a healthy way.
Innovative point:
1, according to motherland's Chinese medicine theory, in conjunction with knowledge such as modern Chinese medicine, reasonable compatibility cooperation potentiation is set up prescription and is determined most preferred dosage form.
2, according to infective pathogen, directly select medicine, from natural goods, extract active anti-porcine hyperthermia material, with strong points.
3, according to clinical symptoms, from the dynamic change of molecular biology horizontal adjustment body related immune competent cell and cytokine, careful to the basic mechanism of this treatment of diseases, effect is remarkable.
4, by research to pharmacokinetics, selected the dosage form that the most suitable body absorbs, be optimal treatment approach and Therapeutic Method at type.
5, this product is a pure Chinese medicinal preparation, does not contain any antibiotic, chemical hormone etc., and noresidue has no side effect, and is safe, is the environmental type preparation.
Claims (1)
1. the medicine of a pure treatment by Chinese herbs porcine hyperthermia, it is characterized in that: the component of its raw material is: Radix Scutellariae, Fructus Forsythiae, Cornu Bubali, Gypsum Fibrosum, and its described composition weight proportioning is Radix Scutellariae 5-16 part, Fructus Forsythiae 5-14 part, Cornu Bubali 4-13 part, Gypsum Fibrosum 4-13 part, through extracting the injection that technology such as concentrated is made.
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| CN2011101123698A CN102188494B (en) | 2011-05-03 | 2011-05-03 | Medicament for treating high fever of pigs with pure Chinese medicine |
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| CN2011101123698A CN102188494B (en) | 2011-05-03 | 2011-05-03 | Medicament for treating high fever of pigs with pure Chinese medicine |
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| CN102188494B CN102188494B (en) | 2012-08-22 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103168957A (en) * | 2012-06-12 | 2013-06-26 | 北京伟嘉人生物技术有限公司 | Animal health feed for preventing hyperthermia of dairy cow |
| CN107551151A (en) * | 2017-09-18 | 2018-01-09 | 颍上庆丰农牧发展有限公司 | It is a kind of to be used to treat parenteral solution of high fever syndrome of pigs and preparation method thereof |
| CN109432287A (en) * | 2018-12-21 | 2019-03-08 | 济南亿民动物药业有限公司 | A kind of traditional Chinese medicine oral liquid and preparation method thereof of prevention and treatment poultry excessive heat in the system card |
| CN110613054A (en) * | 2019-09-17 | 2019-12-27 | 中国农业大学 | Chinese herbal medicine additive for lactating sows and application thereof |
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|---|---|---|---|---|
| CN101156916A (en) * | 2007-09-30 | 2008-04-09 | 中国农业大学 | A medicine for treating hyperpyrexia disease of pig |
| CN101317884A (en) * | 2008-07-08 | 2008-12-10 | 赵志敏 | Medicament for treating interference with respiration diseases of pig |
| CN101721602A (en) * | 2008-10-16 | 2010-06-09 | 岳道友 | Animal remedy for treating porcine nameless high-fever syndrome |
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2011
- 2011-05-03 CN CN2011101123698A patent/CN102188494B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101156916A (en) * | 2007-09-30 | 2008-04-09 | 中国农业大学 | A medicine for treating hyperpyrexia disease of pig |
| CN101317884A (en) * | 2008-07-08 | 2008-12-10 | 赵志敏 | Medicament for treating interference with respiration diseases of pig |
| CN101721602A (en) * | 2008-10-16 | 2010-06-09 | 岳道友 | Animal remedy for treating porcine nameless high-fever syndrome |
Non-Patent Citations (2)
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| 《中国畜牧兽医》 20081231 邹春生 中西医结合辨证治疗猪无名高热综合征 122-123页 1 第35卷, 第5期 * |
| 《中国畜禽种业》 20071231 周望平 等 猪高热综合征的防治 54页 1 , 第5期 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103168957A (en) * | 2012-06-12 | 2013-06-26 | 北京伟嘉人生物技术有限公司 | Animal health feed for preventing hyperthermia of dairy cow |
| CN107551151A (en) * | 2017-09-18 | 2018-01-09 | 颍上庆丰农牧发展有限公司 | It is a kind of to be used to treat parenteral solution of high fever syndrome of pigs and preparation method thereof |
| CN109432287A (en) * | 2018-12-21 | 2019-03-08 | 济南亿民动物药业有限公司 | A kind of traditional Chinese medicine oral liquid and preparation method thereof of prevention and treatment poultry excessive heat in the system card |
| CN109432287B (en) * | 2018-12-21 | 2021-06-04 | 济南亿民动物药业有限公司 | Traditional Chinese medicine oral liquid for preventing and treating excessive heat syndrome of poultry qi system and preparation method thereof |
| CN110613054A (en) * | 2019-09-17 | 2019-12-27 | 中国农业大学 | Chinese herbal medicine additive for lactating sows and application thereof |
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| Publication number | Publication date |
|---|---|
| CN102188494B (en) | 2012-08-22 |
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Inventor after: Zhao Zhimin Inventor after: Su Yali Inventor after: Wu Hao Inventor after: Wang Lihui Inventor before: Zhao Zhimin Inventor before: Su Yali Inventor before: Wang Hao Inventor before: Wang Lihui |
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