CN104288718A

CN104288718A - Medicine for preventing and treating proventriculitis for chicken

Info

Publication number: CN104288718A
Application number: CN201410496112.0A
Authority: CN
Inventors: 纪瑞芳; 闫德伟; 孙振洲; 周保琨; 申玉军
Original assignee: QINGDAO LANYING POULTRY TECHNOLOGY Co Ltd
Current assignee: QINGDAO LANYING POULTRY TECHNOLOGY Co Ltd
Priority date: 2014-09-25
Filing date: 2014-09-25
Publication date: 2015-01-21

Abstract

The invention provides a medicine for preventing and treating proventriculitis for chicken. The medicine is prepared from the following components: 100-150g of cape jasmine, 100-150g of agastache rugosus, 100-150g of rheum officinale, 100-150g of coptis chinensis, 70-100g of shaved cinnamon bark, 70-100g of pericarpium citri reticulatae, 70-100g of pulsatilla chinensis regel, 70-100g of radix sophorae flavescentis, 70-100g of radix bupleuri, 70-100g of ginger, 70-100g of ginseng, 70-100g of myristica fragrans, 40-60g of radix aconite lateralis preparata, 40-60g of agilawood, 40-60g of paederia scandens, 40-60g of semen cassiae, 40-60g of herba cepbalanoplosis segeti, 40-60g of codonopsis pilosula, 40-60g of radix rehmanniae preparata, 40-60g of asparagus cochinchinensis, 20-30g of licorice root and 20-30g of Chinese date. The medicine is simple in method and convenient to use and can be used for preventing and treating infectious proventriculitis, and the morbidity probability can be remarkably reduced.

Description

A kind of chicken fowl medicine of control proventriculitis

technical field:

The present invention relates to technical field of pharmaceuticals, particularly relate to the medicine of a kind of chicken fowl with control proventriculitis.

background technology:

In the breeding process of chicken fowl, easily because various disease causes chicken fowl dead, for the infectious proventriculitis of chicken fowl, Infected regions sickness rate can reach 100%, is generally 7%-28%, and mortality rate is 3%-95%, is generally 30%-50%.Age in days of falling ill the earliest sees 7--8 age in days, and 15 age in days-50 ages in days are the multiple phase.This disease of the less generation of chicken about 80 ages in days, but the situation also having 100 age in days chicken morbidities.Report that laying hen also can fall ill.Course of disease 10-15 days, elder can reach 35 days, within 5-8 days, is peak mortality after morbidity.Infectious proventriculitis, without seasonality, all can occur throughout the year, but the most serious with autumn, winter, distributes more.Popular comparatively wide, spread speed is very fast.In 7 ~ 10 age in days each kind chickling susceptible, the chicken group more susceptible disease that room temperature of brooding is lower, mortality rate is low, the diseases such as morbidity rear its secondary escherichia coli, mycoplasma, newcastle, coccidiosis, enteritis, and cause mortality rate to rise, propagate by air droplet transmission or the feedstuff through polluting, drinking-water, apparatus and Excreta, and with the susceptible chicken given up, infected chicken occurs in 48 hours that this disease of symptom can be propagated between the laying hen of different cultivars and broiler usually, chicken of mixing also can occur meat.Generally in 21 age in days morbidities, laying hen there is the general course of disease of this disease at about 2 weeks, infects this sick peak mortality more than 1 week in broiler.This cause of disease is complicated, and the symptom of just recent pathogenic process and mixed sense and secondary is seen.Cause of disease may be vertical transmission, finds that the chicken of different cultivars occurs simultaneously at same chicken house with a collection of chicken.The swelling of sick chicken glandular stomach, gastric pH value 1 ~ 2, muscular stomach stratum corneal edge turns white, and horny layer easily strips off.Not material feeding or feed intake drop to below the half of normal feed intake, almost do not have death or seldom dead.Its factor of curing the disease comprises non-pathogenic factors and infectious agent two kinds, non-pathogenic factors: biogenic amine (histamine, cadaverine, histidine etc.) contained in daily ration; Day grain raw material is if the fish flour, Semen Maydis, bean cake, vitamin premix, fat, Fowl meat powder and meat meal tankage etc. piled up are containing high-caliber biogenic amine, and these biogenic amine all can to the toxic effect of body.Feedstuff condition inducement: feed nutrition imbalance (mainly feedstuff crude fibre class material content is high), albumen is low, vitamin deficiency etc. is all the inducement of primary disease morbidity.In feedstuff, mould mycomycin content is high, if citrinin is a kind of nephrotoxin, muscular stomach can be made to occur slight crack; The isthmus circumferentia that ovum spore toxin can make muscular stomach, glandular stomach is connected becomes large, downright bad, and mucosa is covered by pseudomembranosa exudate; Circular arc acid can cause glandular stomach, muscular stomach, liver and splenic injury, glandular stomach enlargement, mucosa hypertrophy, and ulcer is thickening, and muscular stomach mucosa occurs downright bad.Infectious agent: fowlpox: especially ocular form fowlpox (taking blind as feature) is the very important cause of disease of proventriculitis morbidity.Clinical discovery, the north in annual autumn, be fowlpox morbidity serious season, proventriculitis morbidity is also very serious, and a lot of chicken group first there occurs fowlpox, after secondary proventriculitis again, cause very high mortality rate, and Drug therapy is invalid.The ophthalmia of unknown cause: the ophthalmia caused as infectious bronchitis (IBV), infectious laryngotracheitis (ILTV), various antibacterial, vitamin A deficiency or improper ventilation, all can cause the morbidity of proventriculitis.The cause of disease of some vertical transmissions or pollute the Mareks disease vaccine of special cause of disease, is likely this pathogenetic main pathogen.As chicken reticuloendotheliosis (REV), chicken anemia factor (CAV) etc.

Sick chicken initial stage performance spirit is depressed, and drop-head vertical fin, wing is sagging, and feather is fluffy and disorderly not whole, searches for food and minimizing of drinking water.Chicken growth retardation or stagnation, weight gain stops or declining gradually, and some chicken body weight are only 50% or less of normal chicken.Chicken body is pale, skeletonize, and feed conversion rate reduces, and has indigested feedstuff in feces.Some chickens shed tears, swell eye and respiratory symptom, row's white or green loose stool.Chicken whole body of dying of illness is become thin or dysplasia, and polymyarian meat is pale soft, some eye swelling, forms the swelling district of sub-circular near the eyes, and there are mucus, purulence thing in canthus, and the hole under socket of the eye had has cheesy thing.Oral cavity, throat and tracheal mucosa have the caseous pseudomembrane of yellow-white, foul smelling, not easily strips off.The sick chicken also osteoporotic fracture had.Chicken characteristic of dying of illness pathological changes be glandular stomach enlargement as spherical, have translucent sense, be creamy white, examine visible canescence trellis outward appearance; Glandular stomach wall thickening, edema are shown in incision, and finger pressure can flow out serosity liquid; The swelling of glandular stomach mucosa is thickening; Nipple swelling is turned up, nipple base portion pinkiness, hemorrhage or hemorrhage not obvious, the ulcer of periphery.Some nipples merge, and boundary is unclear.Later stage nipple perforation or ulcer, depression, disappear; The flat contracting of muscular stomach, flesh muscle is easily peeled off, and edge is pale crack.Thymus, spleen, fabricius bursa atrophy are particularly outstanding; The sick Testis et penis Gallus domesticus enlargement of part, has urate deposition.Cloaca expands, and what have in various degree is hemorrhage, inside has yellow-white or green loose stool etc.Intestinal swelling in early stage, congested, in kermesinus, cut open inspection intestinal wall and turn up; Later stage mucosa departs from, frangible, thinning empty, and intestinal has hemorrhagic inflammation in various degree, and content is the chyme containing large water gaging.The cecal tonsil enlargement that the chicken that dies of illness individually has is hemorrhage, duodenum mild swelling, and it is hemorrhage that jejunum and rectum have in various degree.Pancreas enlargement has petechia, also has report atrophy of pancreas, lighten.But at other positions such as heart, liver, respiratory tracts without obvious naked eyes lesions visible.When there being bacterial disease secondary infection, liver enlargement, have downright bad point individually, uneven color, light and dark strip is alternate with bronze-colored.

Traditional therapeutic scheme for this disease is: dry element drinking-water is disturbed in first aid, is used in conjunction two days; Or 1, cimetidine (people's medication) one jin of feedstuff or thunder rice are for fourth (people's medication) a slice 2 jin of feedstuffs, and spice is two kinds of optional one of medicine, continuous spice 4---6 days.Or, glandular stomach spirit (ampicillin, butylamine etc. are watered 150 kilograms by every bottle and calculate dosage)+ball prestige (Maduramicin is watered 200 kilograms by every bottle and calculates dosage) can be used, coordinate people's cod-liver oil emulsion, 500 milliliters every bottle are watered 200 ~ 250 kilograms of drinking-water.Serious symptom can with feeling clear (Radix Isatidis, the Radix Astragali, Herba Epimedii, hypericin, the Echinacea etc.) spice of poison, and 2000 chickens of the chicken after 30 ages in days 1 bag, then use glandular stomach spirit+ball prestige, coordinate people to drink water with cod-liver oil emulsion.Given this sick particularity and high mortality, so in breeding process, should to put prevention first, after morbidity, early treatment is secondary.The present invention on the basis of existing technology, aim to provide a kind of method simple, easy to use, the infectious proventriculitis of prevention and cure chicken fowl, obvious reduction incidence probability, obviously can reduce the medicine of chicken fowl with control proventriculitis of the loss that therefore disease is brought to raiser.

summary of the invention:

The object of the invention is to overcome the shortcoming existed in prior art, there is provided a kind of method simple, easy to use, the infectious proventriculitis of prevention and cure chicken fowl, obvious reduction incidence probability, obviously can reduce the medicine of chicken fowl with control proventriculitis of the loss that therefore disease is brought to raiser.

To achieve these goals, the invention provides the medicine of a kind of chicken fowl with control proventriculitis, wherein, operate in accordance with the following steps:

A, broiler 1-2 week the length of time in, in feedstuff, crude fibre class material content is not more than 2% of feeding quality;

B, broiler are within 3-8 length of time in week, and in feedstuff, crude fibre class material content starts from 2% of the feeding quality of the 3rd week, increases progressively 1% weekly, only reaches 7% of feeding quality, maintain the crude fibre class material content of 7% of feeding quality until deliver for sale to the 8th week;

C, broiler 1-2 week the length of time in, in feedstuff, the content of bone meal or fish flour is not higher than 3% of feeding quality;

D, broiler 3-8 week the length of time in, in feedstuff, the content of bone meal or fish flour is not higher than 5% of feeding quality;

Described feedstuff all adds mildew removing agent, and addition is the 0.05-0.4% of feeding quality;

Add control adjuvant in described feedstuff, addition is the 1-2% of feeding quality.

Described mildew removing agent is any one in sodium diacetate, rich bar dimethyl phthalate, potassium sorbate.

Described crude fibre class raw material is any one in furfur, hay powder, bran coat, powder of straw, Pericarppium arachidis hypogaeae powder, rice chaff, rice chaff.

Described control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 100-150g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 70-100g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 40-60g of Radix Asparagi, Radix Glycyrrhizae, each 20-30g of Fructus Jujubae.

Or, described control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 100-120g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 70-90g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 40-50g of Radix Asparagi, Radix Glycyrrhizae, each 20-25g of Fructus Jujubae.

Or, described control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 120-150g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 90-100g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 50-60g of Radix Asparagi, Radix Glycyrrhizae, each 25-30g of Fructus Jujubae.

Or, described control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 110-140g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 75-85g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 45-55g of Radix Asparagi, Radix Glycyrrhizae, each 22-28g of Fructus Jujubae.

The preparation method of control adjuvant: by Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, Radix Asparagi, Radix Glycyrrhizae, Fructus Jujubae use water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting, to thick, adds modified starch and hydroxy methocel, correctives; The mass ratio of modified starch and hydroxy methocel, correctives is 2:1:1, the quality of modified starch, hydroxy methocel and correctives and for prevent and treat adjuvant raw material (Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, Radix Asparagi, Radix Glycyrrhizae, Fructus Jujubae) the 3-4% of quality.Also cross 80 mesh sieves in powder after dry, the powder after sieving, after ultra-vioket radiation is sterilized 10 seconds, adds ampicillin, and the quality of the ampicillin added is the 1-2% of powder quality, the control adjuvant that after mix homogeneously, obtained the present invention is used.

The manufacture method of feedstuff:

1-2 week age:

Semen Maydis 54-63%, bean cake 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone powder 1-1.2%, edible oil 2-3%, fish flour 1-3%, furfur 1-2%, mildew removing agent 0.05-0.2%, multivitamin 0.2-0.5%, control adjuvant 1-1.5%.

Be preferably:

Semen Maydis 59.5%, bean cake 30.45%, carbonic acid fine particle calcium carbonate 1.25%, stone powder 1.1%, edible oil 2.5%, fish flour 1.8%, furfur 1.8%, mildew removing agent 0.1%, multivitamin 0.3%, control adjuvant 1.2%.

3-8 week age:

Semen Maydis 54-61%, bean cake 27-32%, carbonic acid fine particle calcium carbonate 1-1.5%, stone powder 1-1.2%, edible oil 2-3%, fish flour 3-5%, bran coat 2-7%, mildew removing agent 0.2-0.4%, multivitamin 0.2-0.5%, control adjuvant 1.5-2%.

Within 3 weeks, be preferably:

Semen Maydis 58.65%, bean cake 28%, carbonic acid fine particle calcium carbonate 1.5%, stone powder 1.2%, edible oil 3%, fish flour 3%, bran coat 2%, mildew removing agent 0.35%, multivitamin 0.5%, control adjuvant 1.8%.

In follow-up 4-8 week, raise bran coat 1 percentage point weekly, and reduce the content of Semen Maydis or bean cake, keep formula always than being 100%.

Be preferably when 8 weeks

Semen Maydis 54%, bean cake 27%, carbonic acid fine particle calcium carbonate 1%, stone powder 1.1%, edible oil 2%, fish flour 5%, bran coat 7%, mildew removing agent 0.4%, multivitamin 0.5%, control adjuvant 2%.

Each component in the preparation, is fully mixed rear feeding by described feedstuff,

Also, after each component fully can being mixed, add water after being adjusted to water content 34-38% and carry out pelletize operation.

Advantage of the present invention is: method is simple, and easy to use, the infectious proventriculitis of prevention and cure chicken fowl, obviously reduces incidence probability, can obviously reduce therefore disease to raiser.Be specially;

1. limit the reasonable volume of crude fibre raw material, although crude fibre digestive utilization ratio and being of low nutritive value, be indispensable composition in feedstuff.Because its volume is large, can filling effect be played, have certain expansion effect to gastrointestinal volume, have full sense after food, save feedstuff.Crude fibre has the mechanism of stimulation gastrointestinal peristalsis, is conducive to digestion and arranges drying excrement normally, but too much can cause dyspepsia, easily brings out this disease.The advantageous effect of crude fibre in chicken body: because coarse-fibred water absorption is large, after entering the water suction of chicken gastrointestinal tract, its volumetric expansion increases, and plays filling effect, chicken is unlikely and feels hungry.Meanwhile, crude fibre is harder, produces stimulation, can promote that gastrointestinal is wriggled, be convenient to digesting and assimilating of other nutrient substance chicken intestinal.In crude fibre, cellulose and hemicellulose also can be decomposed by the cellulase that intestinal bacteria produces at the latter half of chicken intestinal, but the nutrient substance after decomposing seldom can be absorbed by chicken, and major part excretes with feces.

2. the reasonable volume of biogenic amine in limiting feed.Biogenic amine is the general name that a class has the nitrogenous low molecular weight organic compound of biological activity.Can be regarded as in amino molecule the material generated after 1 ~ 3 hydrogen atom is replaced by alkyl or aryl, is the low-molecular-weight organic base of aliphatic, Zhi Huan race or heterocycle race, is often formed in the bodies of aminal and plant and in food.Biogenic amine can be divided three classes according to its structure: aliphatic, and comprise putrescine, cadaverine, spermine, spermidine etc., they are the requisite ingredients of biological activity cell, is regulating synthesis and the biomembrane stability important role of nucleic acid and protein; Aromatic series, comprises tyramine, phenethylamine etc.; Heterocyclic amine, comprises histamine, tryptamines etc.Constituent according to biogenic amine can be divided into two classes again: monoamine and polyamines.Monoamine mainly contains tyramine, histamine, putrescine, cadaverine, phenethylamine, tryptamines etc., and a certain amount of monoamines compound on vascular and muscle have obvious diastole and contraction, have important regulating action to ergasia and cerebral cortex; Polyamines mainly comprises spermine and spermidine, and it can promote the synthesis of DNA, RNA and protein in the growth course of organism, accelerates the growth promoter of organism.Trace biogenic amine is the normal activity composition in organism (comprising human body), has important physiological function in biological cell; But when biogenic amine (the taking in multiple biogenic amine) of organism excess intake especially simultaneously, can cause such as have a headache, feel sick, the anaphylaxis such as cardiopalmus, blood pressure, disordered breathing, serious goes back entail dangers to life.Fish flour and meat/bone meal are widely used as the animal protein feed raw material of high-quality.It is inadequate that the quality of their quality is only evaluated with crude protein content, except detecting amino acid content, use fish flour or the meat meal tankage product of stale, that corruption is gone mouldy fish or meat products making, its Content of Biogenic Amines is necessarily high, so, the present invention, while the use amount of restriction fish flour, bone meal, must ensure that the fish flour, the bone meal that use are fresh.

3, feedstuff carries out de-mould, prevents and treats mould mycomycin and brings out this disease.Sodium diacetate, the anti-mold effect of sodium diacetate is obviously better than propionate compound product.The general palatability of current traditional antifungus agent is all poor, and sodium diacetate sweet and sour, can cover the foreign odor of various synthetic drug and multiple additives in feedstuff, mouthfeel is good, can strengthen animal appetite, improves feed intake.Sodium diacetate is added in feedstuff, and can show increases its nutritive value.It can be used as buffer agent, can regulate the pH value in animal intestinal, infiltration and destroy fungal cell wall, to kill, the harmful fungoid suppressed in animal intestinal, thus plays defending and fighting against diseases effect.Rich bar dimethyl phthalate is a kind of novel anticorrosion antifungus agent, has that virus killing is efficient, broad-spectrum antiseptic, safety, chemical stability are good, the feature of long action time.Sorbic acid (potassium) sorbic acid (potassium) can the activity of effectively mould fungus inhibition, yeast and aerobic bacteria, can also prevent the harmful microbe Growth and reproductions such as bacillus botulinus, staphylococcus, Salmonella.

4, increase control adjuvant, to put prevention first, also can be used for treatment.

This control adjuvant, with clear spleen damp eliminating to medicine Fructus Gardeniae, Herba Pogostemonis, eliminating stomach-fire removing toxic substances be monarch drug to medicine Radix Et Rhizoma Rhei, Rhizoma Coptidis; With warming stomach for dispelling cold to medicine Cortex Cinnamomi, Pericarpium Citri Reticulatae, bowel relieving antidiarrheal to the medicine Radix Pulsatillae, Radix Sophorae Flavescentis, clearing gallbladder stomach function regulating to medicine Radix Bupleuri, Rhizoma Zingiberis Recens, QI invigorating astringing intestine to stop diarrhea be ministerial drug to medicine Radix Ginseng, Semen Myristicae, the Radix Rehmanniae Preparata of the Herba Cirsii of the Herba Paederiae of the Radix Aconiti Lateralis Preparata of recuperating depleted YANG and rescuing the patient from collapse, the Lignum Aquilariae Resinatum of promoting the circulation of QI to relieve pain, consumer product dredge stasis, the Semen Cassiae of liver heat removing and eyesight improving, eliminating stasis to stop pain, the Radix Codonopsis of tonifying Qi and lifting yang, nourishing blood for regulating menstruation, the Radix Asparagi relieved inflammation or internal heat are adjuvant drug, make medicine with Radix Glycyrrhizae and Fructus Jujubae.After restricted-access media effective ingredient, add ampicillin, strengthen prevention effect.

Run into the sick chicken situation having morbidity infectious proventriculitis, control adjuvant can be washed by water separately, the solution being adjusted to mass percent 8-12% gavages, and often only gavages 3-5ml, and every day twice, therapeutic effect is remarkable.Usually fit in material by control adjuvant, protection effect is good, reduces incidence probability.

To sum up cultural method, greatly reduces incidence probability, decreases the loss of raiser.

detailed description of the invention:

The manufacture method of feedstuff:

1-2 week age:

Be preferably:

3-8 week age:

Within 3 weeks, be preferably:

Be preferably when 8 weeks

Object lesson 1

1-2 feeding in age in week:

Be preferably:

Mildew removing agent is sodium diacetate.

Control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 100g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 70g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 40g of Radix Asparagi, Radix Glycyrrhizae, each 20g of Fructus Jujubae.

3-8 feeding in age in week:

Mildew removing agent is potassium sorbate.

Control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 150g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 100g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 60g of Radix Asparagi, Radix Glycyrrhizae, each 30g of Fructus Jujubae.

Within 3 weeks, be preferably:

Be preferably when 8 weeks

Said method uses cultivation laying hen at Liu Jia, delivering for sale, cultivate 4000 laying hens from baby chick to becoming chicken, and infectious proventriculitis number of elements of falling ill is 354, and sickness rate is only 8.8%, and 354 merely hit healing 307, effective percentage 86.7%.

Example 2

1-2 feeding in age in week:

Be preferably:

Mildew removing agent is sodium diacetate.

Control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 110g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 80g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 50g of Radix Asparagi, Radix Glycyrrhizae, each 25g of Fructus Jujubae.

3-8 feeding in age in week:

Mildew removing agent is potassium sorbate.

Control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 145g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 90g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 55g of Radix Asparagi, Radix Glycyrrhizae, each 25g of Fructus Jujubae.

Within 3 weeks, be preferably:

Be preferably when 8 weeks

Said method uses cultivation laying hen in Yan Jia plant, delivering for sale, cultivate 4500 chickens from baby chick to becoming chicken, and infectious proventriculitis number of elements of falling ill is 392, and sickness rate is only 8.7%, and 392 merely hit healing 351, effective percentage 89.5%.

Example 3

1-2 feeding in age in week:

Be preferably:

Mildew removing agent is sodium diacetate.

Control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 120g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 85g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 55g of Radix Asparagi, Radix Glycyrrhizae, each 25g of Fructus Jujubae.

3-8 feeding in age in week:

Mildew removing agent is potassium sorbate.

Control adjuvant component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 140g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 85g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 50g of Radix Asparagi, Radix Glycyrrhizae, each 25g of Fructus Jujubae.

Within 3 weeks, be preferably:

Be preferably when 8 weeks

Said method uses cultivation laying hen in Zhang Jia plant, delivering for sale, cultivate 7000 chickens from baby chick to becoming chicken, and infectious proventriculitis number of elements of falling ill is 618, and sickness rate is only 8.8%, and 618 merely hit healing 552, effective percentage 89.3%.

Pathological experiment:

1, model is set up

Select 300 1 week age chickling, bodyweight difference is less than 5g, is divided into 6 groups at random, often organize 50,1-5 group is experimental group, and 6 groups is Normal group.

Experimental group modeling:

Be placed in small space by 1-5 group, add the fish flour slightly gone mouldy or bone meal in the feedstuff of feeding, addition is the 12-15% of feeding quality, and interpolation rice chaff and powder of straw are as crude fibre material, and the amount of interpolation is 13-16%.Feeding, after one week, uses the sick chicken infecting fowlpox to raise together with, infects, and after 3 days, sick chicken performance spirit is depressed, and drop-head vertical fin, wing is sagging, and feather is fluffy and disorderly not whole, searches for food and minimizing of drinking water.Chicken body is pale, skeletonize, and feed conversion rate reduces, and has indigested feedstuff in feces.Chicken sheds tears, swell eye and respiratory symptom, row's white or green loose stool.The chicken that dies of illness dissect pathological changes be glandular stomach enlargement as spherical, have translucent sense, be creamy white, examine visible canescence trellis outward appearance; Glandular stomach wall thickening, edema are shown in incision, and finger pressure can flow out serosity liquid; The swelling of glandular stomach mucosa is thickening; Nipple swelling is turned up, nipple base portion pinkiness, hemorrhage or hemorrhage not obvious, the ulcer of periphery.Intestinal swelling, congested, in kermesinus, cut open inspection intestinal wall and turn up.Model is set up.1-5 group model chicken is the 60-62% of the body weight of 6 groups of Normal group chickens.

2, contrast test

1 group of feeding example 2 of the present invention, every feeding 50g feedstuff.Every day three times.Feeding 4 days

Control adjuvant in 2 groups of feeding examples 1 of the present invention, the bath of control adjuvant is made into the solution of mass percent 10%.Often only gavage 5ml, every day 2 times, gavage in three feeding gaps.Gavage 4 days

Clear (Radix Isatidis, the Radix Astragali, Herba Epimedii, hypericin, Echinacea etc.) spice of sense poison in 3 groups of feeding background technologies of the present invention, 2000 chickens of the chicken after 30 ages in days 1 bag, then use glandular stomach spirit+ball prestige, coordinate people to drink water with cod-liver oil emulsion.Take 4 days

4 groups use the spirit of the glandular stomach in background technology--and ampicillin is watered 150 kilograms by every bottle and calculates dosage, and feedwater is fed.Take 4 days

5 groups, use the medicine of traditional treatment fowlpox, golden toadpoison loses+moroxydine, carries out drug treatment.Treat 4 days.

6 groups is Normal group.

Above-mentioned 1-5 respectively organized treatment after 4 days, and continue diet one week, comparative effectiveness is as follows:

By above-mentioned contrast, can find, the present invention obviously can reduce mortality rate, and reduce raiser's loss, the present invention comparatively prior art compares, and after treatment, body weight speedup is fast, and control effective percentage is high.

Preventive effect is tested

Select 300 1 week age chickling, bodyweight difference is less than 5g, is divided into 3 groups at random, often organize 100,1-2 group is experimental group, and the 3rd group is Normal group.

1st group of feeding example 3 of the present invention, in feeding process, uses the sick chicken 5 suffering from fowlpox only to carry out infecting raising together with,

2nd group of feeding conventional feed, the Chinese medicinal formulae simultaneously in spice background technology, uses the sick chicken 5 suffering from fowlpox only to carry out infecting raising together with.

3rd group is Normal group.

Find after one week,

1st group 100 to merely hit, only has 8 to catch an illness, remaining 92 consistent with Normal group sign.Ill probability 8%

2nd group 100 to merely hit, has 36 to catch an illness, remaining 76 consistent with Normal group sign, ill probability 36%

Can find, use control adjuvant of the present invention, significantly can reduce incidence probability.

Experimental data: the various pathogens of the present invention to the morbidity of chicken fowl height has inhibitory action as Salmonella, pasteurellosis bacillus, chicken source property escherichia coli etc.These pathogenic bacterium easily excite infectious proventriculitis after infecting chicken group.

For the inhibition test of Salmonella.

Get 3 parts of each 50g of powder, be respectively charged into 500ml small beaker, add the organic solvent methanol of powder 5 times of weight.Chloroform, petroleum ether.Soak 3 days under room temperature, filtering and concentrating, to paste, takes a certain amount of extract and adds Tween 80 and make emulsifying agent, 4 degrees Celsius of preservations,

Adopt growth rate method, the vigorous strain of 6mm colony edge is got with card punch, the PDA flat board being placed on dosing is cultivated, the sterilized water adding equivalent with culture medium contrasts, each repetition 3 times, is placed in 25 degrees Celsius of cultivations, surveys each colony diameter by decussation method, represent the diameter of bacterium colony with meansigma methods, obtain rate of growth=(contrast colony diameter-process colony diameter)/(contrast colony diameter-0.6) × 100% of anti-bacteria.

The extract of 3 kinds of organic solvents is made the PEA culture medium that final concentration is the extracting solution of 1mg/ml, get the suspension 10ul prepared in advance, be inoculated into the culture dish central authorities that diameter is 9cm, logical spreader is smeared evenly, cultivate 48 hours in 25 degrees Celsius of incubators, calculate the rate of growth of anti-bacteria.

Can find out that protective agents of the present invention has good inhibitory action to Salmonella by above-mentioned data.Suppress various pathogenic bacterium, the incidence probability of infectious proventriculitis can be reduced.

The present invention prevents and treats the powder of adjuvant, and toxicity is to the experiment of rat:

Acute oral (LD50) > 500mg/kg,

Acute percutaneous (LD 50) > 2000mg/kg,

Belong to low toxicity.

The present invention's advantage of the present invention is: method is simple, and easy to use, the infectious proventriculitis of prevention and cure chicken fowl, obviously reduces incidence probability, can obviously reduce therefore disease to raiser.Be specially; The reasonable volume of restriction crude fibre raw material, the reasonable volume of biogenic amine in limiting feed.Feedstuff carries out de-mould, increases control adjuvant, to put prevention first, also can be used for treatment.To sum up cultural method, greatly reduces incidence probability, decreases the loss of raiser.

Claims

1. the chicken fowl medicine preventing and treating proventriculitis, it is characterized in that, component is: Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 100-150g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 70-100g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 40-60g of Radix Asparagi, Radix Glycyrrhizae, each 20-30g of Fructus Jujubae.

2. chicken fowl use prevents and treats the medicine of proventriculitis according to claim 1, it is characterized in that, component is, Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 100-120g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 70-90g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 40-50g of Radix Asparagi, Radix Glycyrrhizae, each 20-25g of Fructus Jujubae.

3. chicken fowl use prevents and treats the medicine of proventriculitis according to claim 1, it is characterized in that, component is, Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 120-150g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 90-100g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 50-60g of Radix Asparagi, Radix Glycyrrhizae, each 25-30g of Fructus Jujubae.

4. chicken fowl use prevents and treats the medicine of proventriculitis according to claim 1, it is characterized in that, component is, Fructus Gardeniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, each 110-140g of Rhizoma Coptidis, Cortex Cinnamomi, Pericarpium Citri Reticulatae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Bupleuri, Rhizoma Zingiberis Recens, Radix Ginseng, each 75-85g of Semen Myristicae, Radix Aconiti Lateralis Preparata, Lignum Aquilariae Resinatum, Herba Paederiae, Semen Cassiae, Herba Cirsii, Radix Codonopsis, Radix Rehmanniae Preparata, each 45-55g of Radix Asparagi, Radix Glycyrrhizae, each 22-28g of Fructus Jujubae.