CN102813909A - Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof - Google Patents
Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof Download PDFInfo
- Publication number
- CN102813909A CN102813909A CN2012102720065A CN201210272006A CN102813909A CN 102813909 A CN102813909 A CN 102813909A CN 2012102720065 A CN2012102720065 A CN 2012102720065A CN 201210272006 A CN201210272006 A CN 201210272006A CN 102813909 A CN102813909 A CN 102813909A
- Authority
- CN
- China
- Prior art keywords
- parts
- chronic respiratory
- doxycycline hydrochloride
- compositions
- poultry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as a preparation method of the compound doxycycline hydrochloride composition. The compound doxycycline hydrochloride composition is prepared by uniformly mixing the following components by weight: 10-15 parts of doxycycline hydrochloride, 10-20 parts of colistin sulfate, 5-15 parts of tylosin tartrate, 5-10 parts of trimethoprim lactate and 40-70 parts of anhydrous dextrose. The compound doxycycline hydrochloride composition has the beneficial effects of reasonable formula, easiness in preparation, remarkable treatment effect and clinically proven special effect for treating colibacillosis and chronic respiratory disease of the poultry.
Description
Technical field
The present invention relates to prevent and treat the compound doxycycline hyclate composition and method of making the same of poultry colibacillosis and chronic respiratory tract disease; Belong to the animal field of medicaments, particularly a kind of compound doxycycline hyclate composition and method of making the same of preventing and treating poultry colibacillosis and chronic respiratory tract disease.
Background technology
Poultry colibacillosis is a kind of common transmittable disease that is caused by escherichia coli; Various age in days poultry all can infect, and are characteristic with diarrhoea, row's yellow or white feces clinically, and pathological change mainly shows as perihepatitis, airsacculitis, septicemia etc.; Mortality rate is very high, very harmful to poultry.The poultry chronic respiratory tract disease is a kind of epidemic disease of the main infection 4-8 poultry in age in week that caused by the fowl virus mycoplasma, and to breathe hello sound, cough, stream nose liquid be characteristic to infect young fowl in clinical manifestation, and pathological change mainly shows as airsacculitis.These two kinds of diseases are one of vertical transmission disease, also can pass through the number of ways horizontal transmission.
Present medicine effect is outstanding inadequately, and therefore researching and developing a kind of specific medicament of treating poultry colibacillosis and chronic respiratory tract disease is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, effect obviously, is is effectively prevented and treated the compound doxycycline hyclate composition and method of making the same of poultry colibacillosis and chronic respiratory tract disease.
Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of compound doxycycline hyclate compositions of preventing and treating poultry colibacillosis and chronic respiratory tract disease; Process than uniform mixing by following components in weight portion number: 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 5～15 parts of tylosin tartrates, 5～10 parts of lactic acid trimethoprims, 40～70 parts of compositions of anhydrous glucose.
On the basis of such scheme, said various component optimum ratio amounts are: 12 parts of doxycycline hydrochloride, 15 parts of colistine sulfates, 10 parts of tylosin tartrates, 7.4 parts of lactic acid trimethoprims, 55.6 parts of compositions of anhydrous glucose.
A kind of compound doxycycline hyclate preparation of compositions method of preventing and treating poultry colibacillosis and chronic respiratory tract disease, carry out as follows:
(1) takes by weighing 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 20～30 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) take by weighing 5～15 parts of tylosin tartrates, 5～10 parts of lactic acid trimethoprims, 10～25 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mixed 10～15 minutes, mix homogeneously promptly gets.
The medicinal property of each component is following:
Doxycycline hydrochloride: faint yellow or yellow crystalline powder, odorless, bitter in the mouth.Belong to the Tetracyclines antimicrobial drug, be mainly used in responsive gram positive bacteria and respiratory tract infection due to the gram negative bacteria and colibacillosis etc.
Colistine sulfate: white powder, odorless, bitter in the mouth, soluble in water, gram negative bacteria such as bacillus pyocyaneus, escherichia coli, Salmonella etc. there are stronger antibacterial action, be mainly used in intestinal tract disease that the treatment gram negative bacteria causes etc.
Tylosin tartrate: white to pale yellow powder, macrolide antibiotics.These article very easily are absorbed in vivo, drain rapidly, and noresidue in tissue has specially good effect to gram positive bacteria, mycoplasma.It is the choice drug of the poultry chronic respiratory tract disease that causes of treatment mycoplasma.
The lactic acid trimethoprim: white or off-white color crystalloid powder, soluble in water.Have the notable synergistic effect during with couplings such as sulfonamides, Tetracyclines, PCs, Macrolide, colistine sulfate, aminoglycosides, can increase by ten times to tens of times effect.Do not use separately, generally use, can treat fowl poultry colibacillosis, cholera, respiratory tract disease etc. in 1: 5 ratio.Also can be used for the control of coccidiosis.
Above-mentioned four antibacterials that belong to a different category; Action principle is different, but the effect of colibacillosis of preventing and treating and respiratory tract disease is all arranged, and has other antibacterial actions concurrently; The lactic acid trimethoprim is three's a Trimethoprim, and antibacterial action is significantly strengthened.Limiting proportioning by the present invention, to prepare effect better, can effectively prevent and treat poultry colibacillosis and chronic respiratory tract disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even, the curative effect highly significant.The present invention is a compound preparation; Adopt the pharmacological experiment method; Optimize these three kinds of medicine-doxycycline hydrochloride, colistine sulfate, tylosin tartrate; And make them form compound preparation according to best proportioning, in addition the lactic acid trimethoprim significantly strengthens antibacterial action as Trimethoprim again.Clinical practice proves that control poultry colibacillosis and chronic respiratory tract disease are had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound doxycycline hyclate preparation of compositions method of preventing and treating poultry colibacillosis and chronic respiratory tract disease is carried out: (every part by 10g) as follows
(1) takes by weighing 100 parts of doxycycline hydrochloride, 100 parts of colistine sulfates, 200 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) take by weighing 50 parts of tylosin tartrates, 50 parts of lactic acid trimethoprims, 100 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mixed 10～15 minutes, mix homogeneously promptly gets.
Embodiment 2
A kind of compound doxycycline hyclate preparation of compositions method of preventing and treating poultry colibacillosis and chronic respiratory tract disease is carried out: (every part by 10g) as follows
(1) takes by weighing 120 parts of doxycycline hydrochloride, 150 parts of colistine sulfates, 250 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) take by weighing 100 parts of tylosin tartrates, 75 parts of lactic acid trimethoprims, 150 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mixed 10～15 minutes, mix homogeneously promptly gets.
Embodiment 3
A kind of compound doxycycline hyclate preparation of compositions method of preventing and treating poultry colibacillosis and chronic respiratory tract disease is carried out: (every part by 10g) as follows
(1) takes by weighing 150 parts of doxycycline hydrochloride, 200 parts of colistine sulfates, 300 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) take by weighing 150 parts of tylosin tartrates, 100 parts of lactic acid trimethoprims, 250 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mixed 10～15 minutes, mix homogeneously promptly gets.
Clinical trial:
The clinical experiment animal selects for use 15 ages in days, body weight at 0.6kg-0.7kg, and laboratory is diagnosed as the ill broiler of chicken colibacillosis.Ill chicken is isolated raising separately, the complete feed of feeding, and be divided into 3 groups at random, and 100 every group, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with institute's control drug by its description; Present composition group can be with product of the present invention (embodiment of the invention 1 prepared compositions) the ill poultry of feeding, and usage and dosage is: these article are by every 100g drinking-water 220kg, every day 2～3 times, logotype 3～5 days.Oral back reaches the purpose of treatment disease through gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table 1 is the situation contrast of the present composition and other medicines control chicken colibacillosis:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 10.0 | 60.0 | 30.0 |
| II | The ciprofloxacin group | 6.0 | 79.0 | 15.0 |
| III | Present composition group | 3.0 | 89.0 | 8.0 |
This result of the test is through statistical analysis, and present composition group is being compared difference extremely significantly (P＜0.01) with the ciprofloxacin group aspect the cure rate.
The clinical experiment animal selects for use 20 ages in days, body weight at 1.0kg-1.1kg, and laboratory is diagnosed as the ill broiler of chronic respiratory disease.Ill chicken is isolated raising separately, the complete feed of feeding, and be divided into 3 groups at random, and 100 every group, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with institute's control drug by its description; Present composition group is with product of the present invention (embodiment of the invention 1 prepared compositions) the ill broiler of feeding, and usage and dosage is: 250 kilograms of per 100 gram present composition drinking-water, every day 2～3 times, logotype 3～5 days.Oral back reaches the purpose of treatment disease through gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table 2 is situation contrasts of the present invention and other medicines treatment chronic respiratory disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 8.0 | 62.0 | 30.0 |
| II | The erythromycin thiocyanate group | 5.0 | 80.0 | 15.0 |
| III | Present composition group | 3.0 | 89.0 | 8.0 |
This clinical effectiveness is through statistical analysis, and present composition group is being compared difference extremely significantly (P＜0.01) with the erythromycin thiocyanate group aspect the cure rate.
Safety testing:
Choose 60 of the healthy broiler of 15 ages in days; Accordinging to 5 times of the embodiment of the invention 1 made compositions RD drank water 5 days; During the medication; Healthy broiler has no bad or the Deviant Behavior performance, and the drinking-water of searching for food is normal, and it is not remarkable that weight increase and blank group (being not administration of health group) are compared difference.
Above-mentioned detailed description of the compound doxycycline hyclate composition and method of making the same of this control poultry colibacillosis and chronic respiratory tract disease being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound doxycycline hyclate compositions of preventing and treating poultry colibacillosis and chronic respiratory tract disease; It is characterized in that processing than uniform mixing: 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 5～15 parts of tylosin tartrates, 5～10 parts of lactic acid trimethoprims, 40～70 parts of compositions of anhydrous glucose by following components in weight portion number.
2. the compound doxycycline hyclate compositions of control poultry colibacillosis according to claim 1 and chronic respiratory tract disease; It is characterized in that processing than uniform mixing: 12 parts of doxycycline hydrochloride, 15 parts of colistine sulfates, 10 parts of tylosin tartrates, 7.4 parts of lactic acid trimethoprims, 55.6 parts of compositions of anhydrous glucose by following components in weight portion number.
3. the compound doxycycline hyclate preparation of compositions method of control poultry colibacillosis according to claim 1 and 2 and chronic respiratory tract disease is characterized in that carrying out as follows:
(1) takes by weighing 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 20～30 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) take by weighing 5～15 parts of tylosin tartrates, 5～10 parts of lactic acid trimethoprims, 10～25 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mixed 10～15 minutes, mix homogeneously promptly gets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210272006.5A CN102813909B (en) | 2012-08-02 | 2012-08-02 | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210272006.5A CN102813909B (en) | 2012-08-02 | 2012-08-02 | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102813909A true CN102813909A (en) | 2012-12-12 |
| CN102813909B CN102813909B (en) | 2014-10-22 |
Family
ID=47298591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210272006.5A Expired - Fee Related CN102813909B (en) | 2012-08-02 | 2012-08-02 | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102813909B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933544A (en) * | 2014-04-25 | 2014-07-23 | 广西大学 | Creat/colimycin-containing compound medicine for livestock and fowl |
| CN103933543B (en) * | 2014-04-25 | 2015-12-02 | 广西大学 | Utilize the method for Herba Andrographis and colistin treatment poultry coli-infection disease |
| CN106236758A (en) * | 2016-07-29 | 2016-12-21 | 山东金瑞生物科技有限公司 | A kind of compound preparation treating chicken respiratory antibacterial and virus mixed type infection and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947233A (en) * | 2010-10-15 | 2011-01-19 | 郑州后羿制药有限公司 | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof |
| CN101972226A (en) * | 2010-10-13 | 2011-02-16 | 郑州后羿制药有限公司 | Veterinary doxycycline hydrochloride injection and preparation method thereof |
-
2012
- 2012-08-02 CN CN201210272006.5A patent/CN102813909B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972226A (en) * | 2010-10-13 | 2011-02-16 | 郑州后羿制药有限公司 | Veterinary doxycycline hydrochloride injection and preparation method thereof |
| CN101947233A (en) * | 2010-10-15 | 2011-01-19 | 郑州后羿制药有限公司 | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof |
Non-Patent Citations (2)
| Title |
|---|
| 周春炎等: "肉鸡大肠杆菌病的发生情况和诊治", 《当代畜牧》 * |
| 李中兴: "当前猪呼吸道疾病的特点与防制", 《今日畜牧兽医》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933544A (en) * | 2014-04-25 | 2014-07-23 | 广西大学 | Creat/colimycin-containing compound medicine for livestock and fowl |
| CN103933544B (en) * | 2014-04-25 | 2015-11-25 | 广西大学 | A kind of poultry compound medicine containing Herba Andrographis and colistin |
| CN103933543B (en) * | 2014-04-25 | 2015-12-02 | 广西大学 | Utilize the method for Herba Andrographis and colistin treatment poultry coli-infection disease |
| CN106236758A (en) * | 2016-07-29 | 2016-12-21 | 山东金瑞生物科技有限公司 | A kind of compound preparation treating chicken respiratory antibacterial and virus mixed type infection and preparation method thereof |
| CN106236758B (en) * | 2016-07-29 | 2020-07-28 | 山东金瑞生物科技有限公司 | Compound preparation for treating chicken respiratory tract bacterial and virus mixed infection and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102813909B (en) | 2014-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101468032A (en) | Soluble powder for treating respiratory illness of livestock and poultry | |
| CN102813909B (en) | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof | |
| CN105943629A (en) | Traditional Chinese medicine compound preparation for treating piglet diarrhea and preparation method thereof | |
| CN105616485A (en) | Doxycycline hydrochloride and origanum oil composition | |
| CN103432150B (en) | The compound medicine of potentiation tylosin tartrate soluble powder | |
| CN101780270A (en) | Compound soluble powder for treating respiratory diseases of birds | |
| CN103169652B (en) | Veterinary alkaline lincomycin injection as well as preparation method and use thereof | |
| CN101468057A (en) | Compound Chinese medicine preparation for treating yellow-white dysentery of piglet | |
| CN102000092B (en) | New application of sulfadiazine sodium in preparing medicine for preventing or treating Bombyx mori septicemia | |
| CN104161768A (en) | Veterinary compound tilmicosin injection and preparation method thereof | |
| CN102973583B (en) | Compound gentamicin sulphate composition for treating poultry diarrhea and preparation method thereof | |
| CN101966201A (en) | Compound norfloxacin nicotinic soluble powder and preparation method thereof | |
| CN102973584B (en) | Composition for treating nematodosis in dogs and cats, and preparation method thereof | |
| CN102847160B (en) | Compound quinolone injection for livestock, and preparation method thereof | |
| CN101829129B (en) | Veterinary compound gentamycin sulfate injection and preparation method thereof | |
| CN101966200A (en) | Composition for treating poultry digestive tract bacterial infection and preparation method thereof | |
| CN103054891A (en) | Compound erythromycin thiocyanate composition for controlling poultry bacterial and mycoplasma infection and preparation method thereof | |
| CN102973577B (en) | Compound sodium sulfaquinoxaline composition for treating coccidiosis in young rabbits, and preparation method thereof | |
| CN103405463A (en) | Preparation method of synergistic tylosin tartrate soluble powder compound medicine | |
| CN103405466B (en) | Compound synergistic tylosin tartrate | |
| CN103830254A (en) | Soluble powder for treating respiratory diseases of livestock and poultry | |
| CN103405465A (en) | Preparation method of medicine for treating respiratory system infection of livestock and poultry | |
| CN104784182B (en) | It is a kind of to treat composition of livestock and poultry diarrhea and preparation method thereof | |
| CN102784158B (en) | Preparation method of compound synergy tylosin tartrate for veterinary injection | |
| CN103405464B (en) | Medicine for treating respiratory system infection of livestock and poultry |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141022 Termination date: 20150802 |
|
| EXPY | Termination of patent right or utility model |