CN102813909B - Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof - Google Patents
Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof Download PDFInfo
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- CN102813909B CN102813909B CN201210272006.5A CN201210272006A CN102813909B CN 102813909 B CN102813909 B CN 102813909B CN 201210272006 A CN201210272006 A CN 201210272006A CN 102813909 B CN102813909 B CN 102813909B
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Abstract
The invention relates to a compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as a preparation method of the compound doxycycline hydrochloride composition. The compound doxycycline hydrochloride composition is prepared by uniformly mixing the following components by weight: 10-15 parts of doxycycline hydrochloride, 10-20 parts of colistin sulfate, 5-15 parts of tylosin tartrate, 5-10 parts of trimethoprim lactate and 40-70 parts of anhydrous dextrose. The compound doxycycline hydrochloride composition has the beneficial effects of reasonable formula, easiness in preparation, remarkable treatment effect and clinically proven special effect for treating colibacillosis and chronic respiratory disease of the poultry.
Description
Technical field
The present invention relates to prevent and treat the compound doxycycline hyclate composition and method of making the same of poultry colibacillosis and chronic respiratory tract disease, belong to animal field of medicaments, particularly a kind of compound doxycycline hyclate composition and method of making the same of preventing and treating poultry colibacillosis and chronic respiratory tract disease.
Background technology
Poultry colibacillosis is that a kind of common transmittable being caused by escherichia coli is sick, various age in days poultry all can infect, take clinically diarrhoea, row is yellow or white feces is feature, pathological change main manifestations is perihepatitis, airsacculitis, septicemia etc., mortality rate is very high, very harmful to poultry.Poultry chronic respiratory tract disease be by fowl virus mycoplasma, caused age in main infection 4-8 week poultry a kind of epidemic disease, clinical manifestation be take and infected young fowl to breathe rale, cough, stream nose liquid be feature, pathological change main manifestations is airsacculitis.These two kinds of diseases are one of vertical transmission disease, also can pass through number of ways horizontal transmission.
Current medicine effect is outstanding not, and therefore researching and developing a kind of specific medicament for the treatment of poultry colibacillosis and chronic respiratory tract disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, effectively prevent and treat the compound doxycycline hyclate composition and method of making the same of poultry colibacillosis and chronic respiratory tract disease.
Implementation of the present invention is as follows for achieving the above object: a kind of compound doxycycline hyclate compositions of preventing and treating poultry colibacillosis and chronic respiratory tract disease, by following components in weight portion number than being evenly mixed: 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 5～15 parts of tylosin tartrates, 5～10 parts of lactic acid trimethoprims, 40～70 parts of compositions of anhydrous glucose.
On the basis of such scheme, described various component optimum ratio amounts are: 12 parts of doxycycline hydrochloride, 15 parts of colistine sulfates, 10 parts of tylosin tartrates, 7.4 parts of lactic acid trimethoprims, 55.6 parts of compositions of anhydrous glucose.
Prevent and treat a preparation method for the compound doxycycline hyclate compositions of poultry colibacillosis and chronic respiratory tract disease, carry out as follows:
(1) take by weight 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 20～30 parts of anhydrous glucose, mix 5～10 minutes;
(2) take 5～15 parts of tylosin tartrates, 5～10 parts of lactic acid trimethoprims, 10～25 parts of anhydrous glucose, mix 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mix 10～15 minutes, mix homogeneously and get final product.
The medicinal property of each component is as follows:
Doxycycline hydrochloride: faint yellow or yellow crystalline powder, odorless, bitter in the mouth.Belong to Tetracyclines antimicrobial drug, be mainly used in responsive gram positive bacteria and the respiratory tract infection due to gram negative bacteria and colibacillosis etc.
Colistine sulfate: white powder, odorless, bitter in the mouth, soluble in water, gram negative bacteria, as bacillus pyocyaneus, escherichia coli, Salmonella etc. have stronger antibacterial action, is mainly used in treating intestinal tract disease that gram negative bacteria causes etc.
Tylosin tartrate: white to pale yellow powder, macrolide antibiotics.This product is very easily absorbed in vivo, and rapidly, noresidue in tissue, has specially good effect to gram positive bacteria, mycoplasma in excretion.It is the choice drug of the poultry chronic respiratory tract disease that causes for the treatment of mycoplasma.
Lactic acid trimethoprim: white or off-white color crystalloid powder, soluble in water.During with couplings such as sulfonamides, Tetracyclines, penicillins, Macrolide, colistine sulfate, aminoglycosides, there is notable synergistic effect, can increase by ten times to the effect of decades of times.Do not use separately, generally in the ratio of 1: 5, use, can treat fowl poultry colibacillosis, cholera, respiratory tract disease etc.Also can be used for the control of coccidiosis.
Above-mentioned four antibacterials that belong to a different category, action principle is different, but has the effect of the colibacillosis of preventing and treating and respiratory tract disease, and has other antibacterial actions concurrently, lactic acid trimethoprim is three's Trimethoprim, can make antibacterial action significantly strengthen.By the present invention, limiting proportioning, to prepare effect better, can effectively prevent and treat poultry colibacillosis and chronic respiratory tract disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even, curative effect highly significant.The present invention is compound preparation, adopt pharmacological experiment method, optimize these three kinds of medicine-doxycycline hydrochloride, colistine sulfate, tylosin tartrate, and make them according to best proportioning, form compound preparation, lactic acid trimethoprim, as Trimethoprim, significantly strengthens antibacterial action in addition again.Clinical practice proves that control poultry colibacillosis and chronic respiratory tract disease are had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
Prevent and treat a preparation method for the compound doxycycline hyclate compositions of poultry colibacillosis and chronic respiratory tract disease, carry out as follows: (every part by 10g)
(1) take by weight 100 parts of doxycycline hydrochloride, 100 parts of colistine sulfates, 200 parts of anhydrous glucose, mix 5～10 minutes;
(2) take 50 parts of tylosin tartrates, 50 parts of lactic acid trimethoprims, 100 parts of anhydrous glucose, mix 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mix 10～15 minutes, mix homogeneously and get final product.
Embodiment 2
Prevent and treat a preparation method for the compound doxycycline hyclate compositions of poultry colibacillosis and chronic respiratory tract disease, carry out as follows: (every part by 10g)
(1) take by weight 120 parts of doxycycline hydrochloride, 150 parts of colistine sulfates, 250 parts of anhydrous glucose, mix 5～10 minutes;
(2) take 100 parts of tylosin tartrates, 75 parts of lactic acid trimethoprims, 150 parts of anhydrous glucose, mix 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mix 10～15 minutes, mix homogeneously and get final product.
Embodiment 3
Prevent and treat a preparation method for the compound doxycycline hyclate compositions of poultry colibacillosis and chronic respiratory tract disease, carry out as follows: (every part by 10g)
(1) take by weight 150 parts of doxycycline hydrochloride, 200 parts of colistine sulfates, 300 parts of anhydrous glucose, mix 5～10 minutes;
(2) take 150 parts of tylosin tartrates, 100 parts of lactic acid trimethoprims, 250 parts of anhydrous glucose, mix 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mix 10～15 minutes, mix homogeneously and get final product.
Clinical trial:
Clinical experiment animal selects 15 ages in days, body weight at 0.6kg-0.7kg, the ill broiler that Laboratory Diagnosed is chicken colibacillosis.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Present composition group can be by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill poultry of feeding, and usage and dosage is: this product, by every 100g drinking-water 220kg, every day 2～3 times, is used in conjunction 3～5 days.After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 5th day) when following table is experiment end.
Table 1 is the situation contrast of the present composition and other medicines control chicken colibacillosis:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 10.0 | 60.0 | 30.0 |
| II | Ciprofloxacin group | 6.0 | 79.0 | 15.0 |
| III | Present composition group | 3.0 | 89.0 | 8.0 |
This result of the test statistical analysis, present composition group is being compared difference extremely significantly (P < 0.01) with ciprofloxacin group aspect cure rate.
Clinical experiment animal selects 20 ages in days, body weight at 1.0kg-1.1kg, the ill broiler that Laboratory Diagnosed is chronic respiratory disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Present composition group is by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill broiler of feeding, and usage and dosage is: 250 kilograms of every 100 grams of present compositions drinking-water, every day 2～3 times, are used in conjunction 3～5 days.After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 5th day) when following table is experiment end.
Table 2 is situation contrasts of the present invention and other medicines treatment chronic respiratory disease:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 8.0 | 62.0 | 30.0 |
| II | Erythromycin thiocyanate group | 5.0 | 80.0 | 15.0 |
| III | Present composition group | 3.0 | 89.0 | 8.0 |
This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P < 0.01) with erythromycin thiocyanate group aspect cure rate.
Safety testing:
Choose 60 of the healthy broiler of 15 ages in days, according to 5 times of the made compositions recommended dose of the embodiment of the present invention 1 drinking-water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of the compound doxycycline hyclate composition and method of making the same of this control poultry colibacillosis and chronic respiratory tract disease being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (2)
1. a compound doxycycline hyclate compositions of preventing and treating poultry colibacillosis and chronic respiratory tract disease, it is characterized in that by following components in weight portion number than being evenly mixed: 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 5～15 parts of tylosin tartrates, 5～10 parts of lactic acid trimethoprims, 40～70 parts of compositions of anhydrous glucose;
Concrete preparation method is as follows:
(1) take by weight 10～15 parts of doxycycline hydrochloride, 10～20 parts of colistine sulfates, 20～30 parts of anhydrous glucose, mix 5～10 minutes;
(2) take 5～15 parts of tartaric acid Qin Le rhzomorphs, 5～10 parts of lactic acid trimethoprims, 10～25 parts of anhydrous glucose, mix 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, mix 10～15 minutes, mix homogeneously and get final product.
2. the compound doxycycline hyclate compositions of control poultry colibacillosis according to claim 1 and chronic respiratory tract disease, it is characterized in that by following components in weight portion number than being evenly mixed: 12 parts of doxycycline hydrochloride, 15 parts of colistine sulfates, 10 parts of tylosin tartrates, 7.4 parts of lactic acid trimethoprims, 55.6 parts of compositions of anhydrous glucose.
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| CN102813909B true CN102813909B (en) | 2014-10-22 |
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| CN103933543B (en) * | 2014-04-25 | 2015-12-02 | 广西大学 | Utilize the method for Herba Andrographis and colistin treatment poultry coli-infection disease |
| CN103933544B (en) * | 2014-04-25 | 2015-11-25 | 广西大学 | A kind of poultry compound medicine containing Herba Andrographis and colistin |
| CN106236758B (en) * | 2016-07-29 | 2020-07-28 | 山东金瑞生物科技有限公司 | Compound preparation for treating chicken respiratory tract bacterial and virus mixed infection and preparation method thereof |
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| CN101947233A (en) * | 2010-10-15 | 2011-01-19 | 郑州后羿制药有限公司 | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof |
| CN101972226A (en) * | 2010-10-13 | 2011-02-16 | 郑州后羿制药有限公司 | Veterinary doxycycline hydrochloride injection and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972226A (en) * | 2010-10-13 | 2011-02-16 | 郑州后羿制药有限公司 | Veterinary doxycycline hydrochloride injection and preparation method thereof |
| CN101947233A (en) * | 2010-10-15 | 2011-01-19 | 郑州后羿制药有限公司 | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof |
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