CN101947233A - Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof - Google Patents
Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof Download PDFInfo
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- CN101947233A CN101947233A CN2010105092622A CN201010509262A CN101947233A CN 101947233 A CN101947233 A CN 101947233A CN 2010105092622 A CN2010105092622 A CN 2010105092622A CN 201010509262 A CN201010509262 A CN 201010509262A CN 101947233 A CN101947233 A CN 101947233A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention discloses a compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof. The compound medicinal composition for treating the livestock and poultry respiratory disease mainly comprises the following components in part by weight: 1 to 3 parts of tiamulin hydrogen fumarate, 5 to 15 parts of doxycycline hydrochloride, 1 to 15 parts of astragalus polysaccharide and 1 to 4 parts of antisepsis synergist. In the compound medicinal composition for treating the livestock and poultry respiratory disease, the tiamulin hydrogen fumarate and the doxycycline hydrochloride are adopted, and the antisepsis synergist is added, so the antiseptic effect of the medicament is improved on the basis of maintaining the medicinal effects of the tiamulin hydrogen fumarate and the doxycycline hydrochloride, and the aims of high efficiency and quick response are fulfilled; besides, the added traditional Chinese medicinal component astragalus polysaccharide adjusts the physiological function of the livestock and poultry, improves the immunity of the livestock and poultry, and improves the antiseptic capacity of organisms of the livestock and poultry.
Description
Technical field
The present invention relates to a kind of compound soluble powder that is used for the treatment of livestock and birds respiratory disease, belong to the veterinary drug technical field.
Background technology
Along with developing rapidly that scale, intensive culture are already produced, the generation of livestock and poultry and popularly many new characteristics also occurred, the disease that with animal body heating, cough and dyspnea is cardinal symptom is at many large-scale pig farm rapid spreads.Because cause of disease complexity, some experts are referred to as compound recipe cause of disease respiratory tract disease, these diseases are general names of the respiratory tract disease that caused by multiple factor interactions such as antibacterial, virus, mycoplasma, environmental stresses, and invasion or that normally carry often pathogen is with the environmental factors results of interaction.In a single day livestock and birds respiratory disease takes place, if only take the measure control of single medicine, effect is often not ideal.
Summary of the invention
The purpose of this invention is to provide one kind of multiple Chinese medicines, the bonded compound medicament composition of Western medicine, be used for the treatment of livestock and birds respiratory disease.
In order to realize above purpose, the present invention is used for the treatment of the compound medicament composition of livestock and birds respiratory disease, mainly is made up of the component of following weight portion: fumaric acid tiamulin 1-3 part, doxycycline hydrochloride 5-15 part, astragalus polysaccharides 1-15 part, Trimethoprim 1-4 part.
Also comprise Indomethacin sodium of 0.1-0.5 part and the ammonium chloride of 0.01-0.1 part in the described pharmaceutical composition.
Described Trimethoprim is trimethoprim, dimethoxy benzyl Aminometradine or trimethoprim.
The present invention also aims to provide a kind of compound soluble powder that is used for the treatment of livestock and birds respiratory disease.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of the present invention, component by following weight portion is formed: fumaric acid tiamulin 1-3 part, doxycycline hydrochloride 5-15 part, astragalus polysaccharides 1-15 part, Trimethoprim 1-4 part, Indomethacin sodium 0.1-0.5 part, ammonium chloride 0.01-0.1 part, anti-caking agent 0.5-1.5 part, adjuvant 60-91 part; Described Trimethoprim is trimethoprim, dimethoxy benzyl Aminometradine or trimethoprim.
Described anti-caking agent is a kind of or its mixture of silicon dioxide, Kaolin, kieselguhr, resin etc.
Described adjuvant is a kind of or its mixture of soluble starch, glucose, sucrose etc.
The compound medicament composition that is used for the treatment of livestock and birds respiratory disease of the present invention, adopt Western medicine fumaric acid tiamulin and doxycycline hydrochloride, add Trimethoprim, on the basis that keeps fumaric acid tiamulin and doxycycline hydrochloride drug effect, improved the antibacterial effect of medicine, realized efficient, quick-acting purposes, the Chinese medicine ingredients astragalus polysaccharides of Jia Ruing in addition, regulate the physiological function of poultry, improve the immunity of poultry, improve the antibacterial ability of poultry body.In addition, also added Indomethacin sodium with antipyretic effect and ammonium chloride in the pharmaceutical composition of the present invention, reduced physiological side effects to greatest extent, the Chinese medicine and western medicine drug combination the poultry body with tracheaectasy effect, improved antibacterial effect, evident in efficacy.In addition, pharmaceutical composition of the present invention is made soluble powder, and wherein anti-caking agent can effectively prevent powdered drug caking, the useful life who has prolonged pharmaceutical composition.
The specific embodiment
Embodiment 1
The compound medicament composition that is used for the treatment of livestock and birds respiratory disease of present embodiment is made up of the component of following weight portion: 1 part of fumaric acid tiamulin, 5 parts of doxycycline hydrochloride, 1 part of astragalus polysaccharides, 1.5 parts of trimethoprims, 0.1 part of Indomethacin sodium, 0.01 part of ammonium chloride.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment, component by following weight portion is formed: 1 part of fumaric acid tiamulin, 5 parts of doxycycline hydrochloride, 1 part of astragalus polysaccharides, 1.5 parts of trimethoprims, 0.1 part of Indomethacin sodium, 0.01 part of ammonium chloride, silica 1 part, 85 parts of glucoses.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment is to be made by following method:
1) earlier each raw material is pulverized respectively, pulverized the back and cross 60 mesh sieves;
2) get fumaric acid tiamulin 1g, doxycycline hydrochloride 5g and astragalus polysaccharides 1g after the pulverizing, with the glucose of equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 1;
3) get Indomethacin sodium 0.1g, ammonium chloride 0.01g, trimethoprim 1.5g and silica 1 g after the pulverizing, with the equivalent glucose with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 2;
4) with 2), 3) mixture 1 that obtains, mixture 2 mix, and crosses 60 order fine screens three times, obtains mixture 3;
5) with 4) mixture that obtains 3 and remaining glucose mix homogeneously, glucose is got 91g altogether, and mixture is crossed 80 order fine screens three times, obtains the about 100g of soluble powder.
Embodiment 2
The compound medicament composition that is used for the treatment of livestock and birds respiratory disease of present embodiment is made up of the component of following weight portion: 2 parts of fumaric acid tiamulins, 15 parts of doxycycline hydrochloride, 15 parts of astragalus polysaccharidess, 4 parts of trimethoprims, 0.5 part of Indomethacin sodium, 0.1 part of ammonium chloride.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment, component by following weight portion is formed: 2 parts of fumaric acid tiamulins, 15 parts of doxycycline hydrochloride, 15 parts of astragalus polysaccharidess, 4 parts of trimethoprims, 0.5 part of Indomethacin sodium, 0.1 part of ammonium chloride, 1.5 parts of Kaolin, 60 parts of sucrose.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment is to be made by following method:
1) earlier each raw material is pulverized respectively, pulverized the back and cross 60 mesh sieves;
2) get fumaric acid tiamulin 2g, doxycycline hydrochloride 15g and astragalus polysaccharides 15g after the pulverizing, with the sucrose of equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 1;
3) get Indomethacin sodium 0.5g, ammonium chloride 0.1g, trimethoprim 4g and Kaolin 1.5g after the pulverizing, with equivalent sucrose with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 2;
4) with 2), 3) mixture 1 that obtains, mixture 2 mix, and crosses 60 order fine screens three times, obtains mixture 3;
5) with 4) mixture that obtains 3 and remaining sucrose mix homogeneously, sucrose is got 60g altogether, and mixture is crossed 80 order fine screens three times, obtains the about 100g of soluble powder.
Embodiment 3
The compound medicament composition that is used for the treatment of livestock and birds respiratory disease of present embodiment is made up of the component of following weight portion: 1.5 parts of fumaric acid tiamulins, 10 parts of doxycycline hydrochloride, 10 parts of astragalus polysaccharidess, 2.5 parts of trimethoprims, 0.3 part of Indomethacin sodium, 0.05 part of ammonium chloride.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment, component by following weight portion is formed: 1.5 parts of fumaric acid tiamulins, 10 parts of doxycycline hydrochloride, 10 parts of astragalus polysaccharidess, 2.5 parts of trimethoprims, 0.3 part of Indomethacin sodium, 0.05 part of ammonium chloride, 0.5 part in kieselguhr, 75 parts of soluble starches.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment is to be made by following method:
1) earlier each raw material is pulverized respectively, pulverized the back and cross 60 mesh sieves;
2) get fumaric acid tiamulin 1.5g, doxycycline hydrochloride 10g and astragalus polysaccharides 10g after the pulverizing, with the soluble starch of equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 1;
3) get Indomethacin sodium 0.3g, ammonium chloride 0.05g, trimethoprim 2.5g and kieselguhr 0.5g after the pulverizing, with the equivalent soluble starch with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 2;
4) with 2), 3) mixture 1 that obtains, mixture 2 mix, and crosses 60 order fine screens three times, obtains mixture 3;
5) with 4) mixture that obtains 3 and remaining soluble starch mix homogeneously, soluble starch is got 75g altogether, and mixture is crossed 80 order fine screens three times, obtains the about 100g of soluble powder.
Embodiment 4
The compound medicament composition that is used for the treatment of livestock and birds respiratory disease of present embodiment is made up of the component of following weight portion: 3 parts of fumaric acid tiamulins, 10 parts of doxycycline hydrochloride, 8 parts of astragalus polysaccharidess, 2 parts of trimethoprims, 0.1 part of Indomethacin sodium, 0.01 part of ammonium chloride.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment, component by following weight portion is formed: 3 parts of fumaric acid tiamulins, 10 parts of doxycycline hydrochloride, 8 parts of astragalus polysaccharidess, 2 parts of trimethoprims, 0.1 part of Indomethacin sodium, 0.01 part of ammonium chloride, 1 part of resin, 75 parts of glucoses.
The compound soluble powder that is used for the treatment of livestock and birds respiratory disease of present embodiment is to be made by following method:
1) earlier each raw material is pulverized respectively, pulverized the back and cross 60 mesh sieves;
2) get fumaric acid tiamulin 3g, doxycycline hydrochloride 10g and astragalus polysaccharides 8g after the pulverizing, with the glucose of equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 1;
3) get Indomethacin sodium 0.1g, ammonium chloride 0.01g, trimethoprim 2g and resin 1g after the pulverizing, with the equivalent glucose with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture 2;
4) with 2), 3) mixture 1 that obtains, mixture 2 mix, and crosses 60 order fine screens three times, obtains mixture 3;
5) with 4) mixture that obtains 3 and remaining glucose mix homogeneously, glucose is got 75g altogether, and mixture is crossed 80 order fine screens three times, obtains the about 100g of soluble powder.
Clinical trial
Occur pathological symptoms such as asthma, dyspnea, loss of appetite when pig, be diagnosed as respiratory tract disease.Select the pig that is diagnosed as respiratory tract disease of some to carry out following test
Divide two groups of tests:
50 of experimental grouies, the medicinal soluble powder of the embodiment of the invention 1 is stirred according to the mixed that accounts for pig feed 3%, feed, one day three times to pig, first day, sx, symptom took a turn for the better in second day, and spirit is better, the 3rd day, the basic healing fed continuously and all cured to the 5th day, do not have dead.
50 of matched groups, the tilmicosin injection, intramuscular injection, one to three day, sx was not obvious, indivedual sxs, four to five days, most sxs six to eight days, were clearly better dead 3.
Adopting identical method to the pharmaceutical composition of embodiment 1 and pharmaceutical composition and the soluble powder of embodiment 2-4, all obtained and the close result of embodiment 1 soluble powder, is all to cure after five days not have death equally.
Show that by clinical trial this product is compared with the medicine matched group, this product cure rate height, rapid-action, curative effect is strong.
Claims (6)
1. compound medicament composition that is used for the treatment of livestock and birds respiratory disease, it is characterized in that: mainly form: fumaric acid tiamulin 1-3 part by the component of following weight portion, doxycycline hydrochloride 5-15 part, astragalus polysaccharides 1-15 part, Trimethoprim 1-4 part.
2. the compound medicament composition that is used for the treatment of livestock and birds respiratory disease according to claim 1 is characterized in that: also comprise Indomethacin sodium of 0.1-0.5 part and the ammonium chloride of 0.01-0.1 part in the described pharmaceutical composition.
3. the compound medicament composition that is used for the treatment of livestock and birds respiratory disease according to claim 1 and 2 is characterized in that: described Trimethoprim is trimethoprim, dimethoxy benzyl Aminometradine or trimethoprim.
4. compound soluble powder that is used for the treatment of livestock and birds respiratory disease, it is characterized in that: the component by following weight portion is formed: fumaric acid tiamulin 1-3 part, doxycycline hydrochloride 5-15 part, astragalus polysaccharides 1-15 part, Trimethoprim 1-4 part, Indomethacin sodium 0.1-0.5 part, ammonium chloride 0.01-0.1 part, anti-caking agent 0.5-1.5 part, adjuvant 60-91 part; Described Trimethoprim is trimethoprim, dimethoxy benzyl Aminometradine or trimethoprim.
5. the compound soluble powder that is used for the treatment of livestock and birds respiratory disease according to claim 4 is characterized in that: described anti-caking agent is a kind of or its mixture of silicon dioxide, Kaolin, kieselguhr, resin etc.
6. the compound soluble powder that is used for the treatment of livestock and birds respiratory disease according to claim 4 is characterized in that: described adjuvant is a kind of or its mixture of soluble starch, glucose, sucrose etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105092622A CN101947233A (en) | 2010-10-15 | 2010-10-15 | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105092622A CN101947233A (en) | 2010-10-15 | 2010-10-15 | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof |
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| CN101947233A true CN101947233A (en) | 2011-01-19 |
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| CN2010105092622A Pending CN101947233A (en) | 2010-10-15 | 2010-10-15 | Compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813909A (en) * | 2012-08-02 | 2012-12-12 | 青岛绿曼生物工程有限公司 | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof |
| CN102895377A (en) * | 2012-11-09 | 2013-01-30 | 挑战（天津）动物药业有限公司 | Pharmaceutical composition for treating livestock respiratory diseases and method for preparing pharmaceutical composition for treating livestock respiratory diseases |
| CN105770138A (en) * | 2014-12-16 | 2016-07-20 | 洛阳惠中兽药有限公司 | Composition, preparation method and application thereof |
| CN105878228A (en) * | 2016-06-27 | 2016-08-24 | 河北天元药业有限公司 | Soluble powder with tiamulin hydrogen famarate and method for preparing soluble powder |
| CN111603448A (en) * | 2020-06-22 | 2020-09-01 | 南京大方生物工程有限公司 | Compound doxycycline hydrochloride soluble powder and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804062A (en) * | 2010-04-23 | 2010-08-18 | 镇江威特药业有限责任公司 | Long-acting veterinary compound doxycycline injection and preparation method thereof |
-
2010
- 2010-10-15 CN CN2010105092622A patent/CN101947233A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804062A (en) * | 2010-04-23 | 2010-08-18 | 镇江威特药业有限责任公司 | Long-acting veterinary compound doxycycline injection and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《中国兽医杂志》 20090930 吴玉臣等 3种药物对猪支原体肺炎的疗效观察 参见第42页表1、表2，3.3段 1-6 第45卷, 第9期 2 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813909A (en) * | 2012-08-02 | 2012-12-12 | 青岛绿曼生物工程有限公司 | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof |
| CN102813909B (en) * | 2012-08-02 | 2014-10-22 | 青岛绿曼生物工程有限公司 | Compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as preparation method thereof |
| CN102895377A (en) * | 2012-11-09 | 2013-01-30 | 挑战（天津）动物药业有限公司 | Pharmaceutical composition for treating livestock respiratory diseases and method for preparing pharmaceutical composition for treating livestock respiratory diseases |
| CN102895377B (en) * | 2012-11-09 | 2015-03-11 | 挑战（天津）动物药业有限公司 | Pharmaceutical composition for treating livestock respiratory diseases and method for preparing pharmaceutical composition for treating livestock respiratory diseases |
| CN105770138A (en) * | 2014-12-16 | 2016-07-20 | 洛阳惠中兽药有限公司 | Composition, preparation method and application thereof |
| CN105878228A (en) * | 2016-06-27 | 2016-08-24 | 河北天元药业有限公司 | Soluble powder with tiamulin hydrogen famarate and method for preparing soluble powder |
| CN105878228B (en) * | 2016-06-27 | 2018-05-18 | 河北天元药业有限公司 | A kind of fumaric acid tiamulin soluble powder and preparation method thereof |
| CN111603448A (en) * | 2020-06-22 | 2020-09-01 | 南京大方生物工程有限公司 | Compound doxycycline hydrochloride soluble powder and preparation method thereof |
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Application publication date: 20110119 |