CN106491542A - Potentiation fumaric acid tiamulin pre-mixing agent and preparation method thereof - Google Patents
Potentiation fumaric acid tiamulin pre-mixing agent and preparation method thereof Download PDFInfo
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- CN106491542A CN106491542A CN201611010460.8A CN201611010460A CN106491542A CN 106491542 A CN106491542 A CN 106491542A CN 201611010460 A CN201611010460 A CN 201611010460A CN 106491542 A CN106491542 A CN 106491542A
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- fumaric acid
- acid tiamulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention discloses a kind of potentiation fumaric acid tiamulin pre-mixing agent, is mixed by following raw material, is pelletized, being dried and make：Fumaric acid tiamulin, α asarone, starch, maize cob meal.A kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent：The fumaric acid tiamulin, α asarone, maize cob meal are first weighed, the ground mesh sieve of difference, starch makes starch slurry using slurry processes are rushed, then by fumaric acid tiamulin, α asarone and maize cob meal mix homogeneously after, starch slurry is added to make soft material, and pelletize, dry, screen cloth granulate is crossed after drying.A kind of potentiation fumaric acid tiamulin pre-mixing agent of the present invention and preparation method thereof, cleverly fumaric acid tiamulin is combined with α asarone, and find through long-term test, α asarone can not only improve ventilatory function and dyspnea situation, distributed density of the taimulin in intrapulmonary can also be increased, strengthen its antibacterial curative effect, shorten the course of disease, reduce antibiotic dosage.
Description
Technical field
The invention belongs to animal pharmaceuticals technical field, specifically, is related to a kind of potentiation fumaric acid tiamulin premix
Agent and preparation method thereof.
Background technology
At present during large-scale cultivation, mycoplasma pneumonia is a kind of disease of solution of having a headache very much, be difficult to.The primary disease course of disease
Long, easy recurrent exerbation.Common method for the treatment of is using antibiotic such as tylosin tartrate, doxycycline hydrochloride, florfenicols
Preparation carries out spice or drinking-water.Single use antibiotic, does not carry out treating both the principal and secondary aspects of a disease, and treatment time is very long.Long-time uses antibiosis
Element, not only increases treatment cost, affects the growth of poultry, increases feedstuff-meat ratio, and it is a large amount of to the Nature discharge to pass through animal
Antibiotic, pollutes environment, causes substantial amounts of fastbacteria to produce.
Content of the invention
For solving above technical problem, it is an object of the invention to provide a kind of potentiation fumaric acid tiamulin pre-mixing agent
And preparation method thereof, it is dirty that the pre-mixing agent of preparation can be distributed in rapidly liver, kidney, bile and the heart, brain, lung, spleen etc. after poultry take
Device, Half-life in vivo about 4～6 hours can effectively improve antibacterial curative effect, shorten the course of disease, reduce antibiotic dosage.
The object of the invention is realized in：
First, a kind of potentiation fumaric acid tiamulin pre-mixing agent, which is it is critical only that by the raw material system of following percentage by weight
Into：Fumaric acid tiamulin 10～80%, alpha-ararin 0.5～4%, starch 2～10%, maize cob meal supply 100%.
Preferably, above-mentioned fumaric acid tiamulin 10～20%, alpha-ararin 1～3%, starch 2～10%, corn cob
Powder supplies 100%.
Preferably, above-mentioned fumaric acid tiamulin 10%, alpha-ararin 2%, starch 2～10%, maize cob meal are supplied
100%.
Preferably, above-mentioned fumaric acid tiamulin 10%, alpha-ararin 2%, starch 10%, maize cob meal 78%.
2nd, a kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent, which it is critical only that：First by weight percentage
The fumaric acid tiamulin, alpha-ararin, maize cob meal is weighed, ground 120 mesh sieve is distinguished, starch is using the slurry processes system of punching
Into starch slurry, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously after, add starch slurry to make soft
Material, and pelletized with 18 mesh nylon mesh, and dry, 12 eye mesh screen granulate are crossed after drying.
Preferably, the concentration of above-mentioned starch slurry is 10%.
Fumaric acid tiamulin has the antibacterials for efficiently suppressing and killing mycoplasma.
Alpha-ararin have relieving asthma, cough-relieving, eliminating the phlegm, calmness, spasmolytic, the effect such as convulsion.
Beneficial effect：
A kind of potentiation fumaric acid tiamulin pre-mixing agent of the present invention and preparation method thereof, cleverly will be wonderful for Fumaric acid Thailand
Rhzomorph is combined with alpha-ararin, and is found through long-term test, and alpha-ararin can not only improve ventilatory function and dyspnea
Situation, can also increase distributed density of the taimulin in intrapulmonary, strengthen its antibacterial curative effect, shorten the course of disease, reduce antibiotic dosage.
Specific embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1：
A kind of potentiation fumaric acid tiamulin pre-mixing agent, is made up of the raw material of following percentage by weight：Fumaric acid is safe
Wonderful rhzomorph 80%, alpha-ararin 0.5%, starch 10%, maize cob meal 9.5%.
A kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent：First the Rhizoma Corydalis are weighed by weight percentage
Sour taimulin, alpha-ararin, maize cob meal, ground 120 mesh sieve of difference, starch adopt and rush slurry processes and make concentration for 10%
Starch slurry, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously after, add starch slurry make soft
Material, is pelletized with 18 mesh nylon mesh, and is dried, and crosses 12 eye mesh screen granulate after drying.
Embodiment 2：
A kind of potentiation fumaric acid tiamulin pre-mixing agent, by following percentage by weight mixed raw material into：Rhizoma Corydalis
Sour taimulin 10%, alpha-ararin 4%, starch 2%, maize cob meal 84%.
A kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent：First the Rhizoma Corydalis are weighed by weight percentage
Sour taimulin, alpha-ararin, maize cob meal, ground 120 mesh sieve of difference, starch adopt and rush slurry processes and make concentration for 10%
Starch slurry, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously after, add starch slurry make soft
Material, and pelletized with 18 mesh nylon mesh, and dry, 12 eye mesh screen granulate are crossed after drying.
Embodiment 3：
A kind of potentiation fumaric acid tiamulin pre-mixing agent, is made up of the raw material of following percentage by weight：Fumaric acid is safe
Wonderful rhzomorph 45%, alpha-ararin 3%, starch 6%, maize cob meal 46%.
A kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent：First the Rhizoma Corydalis are weighed by weight percentage
Sour taimulin, alpha-ararin, maize cob meal, ground 120 mesh sieve of difference, starch adopt and rush slurry processes and make concentration for 10%
Starch slurry, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously after, add starch slurry make soft
Material, is pelletized with 18 mesh nylon mesh, and is dried, and crosses 12 eye mesh screen granulate after drying.
Embodiment 4：
A kind of potentiation fumaric acid tiamulin pre-mixing agent, is made up of the raw material of following percentage by weight：Fumaric acid is safe
Wonderful rhzomorph 10%, alpha-ararin 2%, starch 10%, maize cob meal supply 78%.
A kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent：First the Rhizoma Corydalis are weighed by weight percentage
Sour taimulin, alpha-ararin, maize cob meal, ground 120 mesh sieve of difference, starch adopt and rush slurry processes and make concentration for 10%
Starch slurry, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously after, add starch slurry make soft
Material, is pelletized with 18 mesh nylon mesh, and is dried, and crosses 12 eye mesh screen granulate after drying.
Embodiment 5：
A kind of potentiation fumaric acid tiamulin pre-mixing agent, is made up of the raw material of following percentage by weight：Fumaric acid is safe
Wonderful rhzomorph 70%, alpha-ararin 1%, starch 5%, maize cob meal 24%.
A kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent：First the Rhizoma Corydalis are weighed by weight percentage
Sour taimulin, alpha-ararin, maize cob meal, ground 120 mesh sieve of difference, starch adopt and rush slurry processes and make concentration for 10%
Starch slurry, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously after, add starch slurry make soft
Material, is pelletized with 18 mesh nylon mesh, and is dried, and crosses 12 eye mesh screen granulate after drying.
Embodiment 6：
A kind of potentiation fumaric acid tiamulin pre-mixing agent, is made up of the raw material of following percentage by weight：Fumaric acid is safe
Wonderful rhzomorph 80%, alpha-ararin 3%, starch 7%, maize cob meal 10%.
A kind of preparation method of potentiation fumaric acid tiamulin pre-mixing agent：First the Rhizoma Corydalis are weighed by weight percentage
Sour taimulin, alpha-ararin, maize cob meal, ground 120 mesh sieve of difference, starch adopt and rush slurry processes and make concentration for 10%
Starch slurry, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously after, add starch slurry make soft
Material, and pelletized with 18 mesh nylon mesh, and dry, 12 eye mesh screen granulate are crossed after drying.
Embodiment 7：
Potentiation fumaric acid tiamulin pre-mixing agent adopts commercially available back, (the temperature in the case where the actual holding conditions of medicine are close to
25 ± 2 DEG C, humidity 60 ± 10%), long term test is carried out, character is checked as shown in table 1, the safe wonderful bacterium of the Fumaric acid for wherein adding
Three criticize flats of element indicate content as shown in table 2, and it is as shown in table 3 that three criticize flats of alpha-ararin indicate content：
The character inspection of pre-mixing agent preserved under normal conditions by table 1
Three criticize flats of 2 fumaric acid tiamulin of table indicate content
Three criticize flats of 3 alpha-ararin of table indicate content
As can be seen that the present invention is compared with 0 month by the detection of 24 months from table 1, table 2 and table 3, character is stable, its
In principal agent fumaric acid tiamulin, alpha-ararin sign content in the range of 90%～110%, steady quality meets
《Chinese veterinary pharmacopoeia》The relevant regulations of version in 2010.
Embodiment 8：The contrast test of therapeutic effect：
1st, the therapeutic effect test of artificial challenge's mycoplasma, as a result as shown in table 4：
The therapeutic effect test of 4 artificial challenge's mycoplasma of table
2nd, the therapeutic effect test of artificial challenge's actinobacillus pleuropneumoniae, as a result as shown in table 5：
The therapeutic effect test of 5 artificial challenge's actinobacillus pleuropneumoniae of table
Consolidated statement 4 and 5 result of table can be seen that potentiation fumaric acid tiamulin pre-mixing agent cure rate obtained in the present invention
High (present invention can improve 10% or so), administration time short (other medicines administration time at 7-15 days, the present invention about 3-4
My god), hence it is evident that reduce antibiotic usage amount and reduce the mortality rate of animal, reduce the treatment cost of animal.Shortening for the course of disease is same
When reduce feedstuff-meat ratio, pig can be allowed to deliver for sale in advance.
Finally it should be noted that foregoing description is only the preferred embodiments of the present invention, the ordinary skill people of this area
Member without prejudice to present inventive concept and claim on the premise of, can make table as multiple types under the enlightenment of the present invention
Show, such conversion is each fallen within protection scope of the present invention.
Claims (6)
1. a kind of potentiation fumaric acid tiamulin pre-mixing agent, it is characterised in that be made up of the raw material of following percentage by weight：Prolong
Fumarate taimulin 10～80%, alpha-ararin 0.5～4%, starch 2～10%, maize cob meal supply 100%.
2. potentiation fumaric acid tiamulin pre-mixing agent according to claim 1, it is characterised in that by following weight percent
The raw material of ratio is made：The fumaric acid tiamulin 10～20%, alpha-ararin 1～3%, starch 2～10%, maize cob meal
Supply 100%.
3. potentiation fumaric acid tiamulin pre-mixing agent according to claim 1 and 2, it is characterised in that by following weight hundred
The raw material of ratio is divided to make：The fumaric acid tiamulin 10%, alpha-ararin 2%, starch 2～10%, maize cob meal are supplied
100%.
4. potentiation fumaric acid tiamulin pre-mixing agent according to claim 3, it is characterised in that by following weight percent
The raw material of ratio is made：The fumaric acid tiamulin 10%, alpha-ararin 2%, starch 10%, maize cob meal 78%.
5. the preparation method of the potentiation fumaric acid tiamulin pre-mixing agent described in a kind of any one of Claims 1 to 4, its feature
It is：The fumaric acid tiamulin, alpha-ararin, maize cob meal, difference ground 120 mesh are first weighed by weight percentage
Sieve, starch makes starch slurry using slurry processes are rushed, then by fumaric acid tiamulin, alpha-ararin and maize cob meal mix homogeneously
Afterwards, add starch slurry to make soft material, and pelletized with 18 mesh nylon mesh, and dry, after drying, cross 12 eye mesh screen granulate.
6. the preparation method of potentiation fumaric acid tiamulin pre-mixing agent according to claim 5, it is characterised in that：Described
The concentration of starch slurry is 10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611010460.8A CN106491542A (en) | 2016-11-17 | 2016-11-17 | Potentiation fumaric acid tiamulin pre-mixing agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611010460.8A CN106491542A (en) | 2016-11-17 | 2016-11-17 | Potentiation fumaric acid tiamulin pre-mixing agent and preparation method thereof |
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| CN106491542A true CN106491542A (en) | 2017-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611010460.8A Pending CN106491542A (en) | 2016-11-17 | 2016-11-17 | Potentiation fumaric acid tiamulin pre-mixing agent and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693495A (en) * | 2017-10-31 | 2018-02-16 | 成都乾坤动物药业股份有限公司 | A kind of new Tiamulin pre-mixing agent and its preparation technology and application |
| CN114796128A (en) * | 2022-06-30 | 2022-07-29 | 山东国邦药业有限公司 | Tiamulin fumarate premix and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450067A (en) * | 2007-11-29 | 2009-06-10 | 天津瑞普生物技术集团有限公司 | Premixing agent for treating and preventing livestock and poultry respiratory disease |
| CN102441014A (en) * | 2010-10-15 | 2012-05-09 | 天津瑞普生物技术股份有限公司 | Compound Chinese medicine injection for treating porcine respiratory disease |
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2016
- 2016-11-17 CN CN201611010460.8A patent/CN106491542A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450067A (en) * | 2007-11-29 | 2009-06-10 | 天津瑞普生物技术集团有限公司 | Premixing agent for treating and preventing livestock and poultry respiratory disease |
| CN102441014A (en) * | 2010-10-15 | 2012-05-09 | 天津瑞普生物技术股份有限公司 | Compound Chinese medicine injection for treating porcine respiratory disease |
Non-Patent Citations (1)
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|---|
| 姚德胜等: "α-细辛脑对哮喘豚鼠气道炎症的影响", 《新乡医学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693495A (en) * | 2017-10-31 | 2018-02-16 | 成都乾坤动物药业股份有限公司 | A kind of new Tiamulin pre-mixing agent and its preparation technology and application |
| CN114796128A (en) * | 2022-06-30 | 2022-07-29 | 山东国邦药业有限公司 | Tiamulin fumarate premix and preparation method and application thereof |
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Application publication date: 20170315 |