CN107737106A - Safe ten thousand rhzomorph sol particles of a kind of tartaric acid and preparation method thereof - Google Patents
Safe ten thousand rhzomorph sol particles of a kind of tartaric acid and preparation method thereof Download PDFInfo
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- CN107737106A CN107737106A CN201711112720.7A CN201711112720A CN107737106A CN 107737106 A CN107737106 A CN 107737106A CN 201711112720 A CN201711112720 A CN 201711112720A CN 107737106 A CN107737106 A CN 107737106A
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- tartaric acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses safe ten thousand rhzomorph sol particles of a kind of tartaric acid and preparation method thereof, the sol particle composition is made up of medicinal ingredient and adjunct ingredient, wherein, medicinal ingredient is safe ten thousand rhzomorphs of tartaric acid；Adjunct ingredient is made up of binder and filler.The present invention have developed the new type of preparation of safe ten thousand rhzomorphs of tartaric acid, the sol particle can with drinking water administration, also can spice administration, it is easy to use, meet the demand of large-scale cultivation industry, while can effectively control the Eaton agent pneumonia of livestock and poultry, significant effect.
Description
Technical field
The invention belongs to field of veterinary, and in particular to a kind of safe ten thousand rhzomorph sol particles of tartaric acid and its preparation technology.
Background technology
Livestock and birds respiratory disease is with obstinate famous, characterized by " three are not ", i.e., not dead, be not cured, do not grow, add cultivation into
This, and the respiratory tract infection caused by mycoplasma is especially common, and pig can be caused to cough and pant, and is commonly called as asthma, can also cause chicken cough
Cough, flow nose liquid, respiratory tract rale, mouth breathing.Once infection mycoplasma in plant, can long-term existence, it is quite obstinate, have
Investigation shows that epidemic swine pneumonia (asthma) causes daily gain averagely to decline 17%, and efficiency of feed utilization averagely declines
14%.Respiratory disease (especially chronic respiratory disease) is to hinder pig to play the important of maximum growth heredity potential
One of factor, and the maximum disease of cost in swine disease at present.
Ten thousand rhzomorphs of tartaric acid Thailand are to be applied in recent years on veterinary clinic, can effectively prevent and treat livestock and poultry mycoplasma disease.Japan certain grind
The person of studying carefully to 10 age in days piglets carry out artificial challenge's mycoplasma hyopneumoniae, after attacking malicious 3d, respectively with every kg body weight 0.625,1.25,
2.5th, safe ten thousand rhzomorphs of 5mg mixed feedings administration tartaric acid, successive administration 7d, compared with control group, it is administered by every kg body weight 5mg mixed feedings
The pulmonary lesion of group have dropped 86%, have obvious therapeutic effect.
Ten thousand rhzomorphs of tartaric acid Thailand are the macrolide antibiotics for applying to veterinary clinic in recent years, and ten thousand rhzomorphs of tartaric acid Thailand face
Bed is evident in efficacy, but only has the safe ten thousand rhzomorph soluble powders of tartaric acid and tartaric acid on veterinary drug related quality criterion at home at present
Two preparations of safe ten thousand rhzomorph pre-mixing agent, to the preparation limited amount of antibiotic exploitation.Ten thousand rhzomorph soluble powders of tartaric acid Thailand are pressed
Standard is merely provided to chicken drinking water administration, and only 25g specification, therefore said preparation can not meet the medication demand of domestic animal
And the demand of colony's administration of large-scale cultivation.Ten thousand rhzomorph pre-mixing agents of tartaric acid Thailand are only capable of mixed feeding administration in Clinical practice,
Therefore plant also needs to be equipped with mixer, if larger plant, feeding amount is larger every time daily, mixes also not side
Just；Also, due to pre-mixing agent and feed granules granule size, the difference of proportion size, it is likely that cause incomplete mixing, Yi Zhijia
Fowl Livestock poisoned.
And abroad, a kind of ratio of raw material and preparation type is about 1：6, therefore, it is contemplated that exploitation tartaric acid is safe
The novel formulation of ten thousand rhzomorphs, enrich the preparation variety of safe ten thousand rhzomorphs of tartaric acid.
The content of the invention：
For above-mentioned problem, it is an object of the invention to provide a kind of industrialized producing technology is simple, strong operability,
Quality stability is good, curative effect is excellent, and use, adapts to the safe ten thousand rhzomorph sol particles of tartaric acid of large-scale cultivation industry.
It is a further object of the present invention to provide a kind of safe ten thousand rhzomorphs solubility of tartaric acid for preventing and treating livestock and poultry mycoplasma pneumonia
The preparation technology of grain.
The present invention concrete technical scheme be：
A kind of safe ten thousand rhzomorph sol particles of tartaric acid, the sol particle composition is by medicinal ingredient and adjunct ingredient group
Into, wherein, medicinal ingredient is safe ten thousand rhzomorphs of tartaric acid；Adjunct ingredient is made up of binder and filler, and wherein binder is by can
Soluble starch, PVP K30 composition, filler are made up of one or more in lactose, glucose, sucrose.
The percentage by weight of each component is in the sol particle：Ten thousand rhzomorphs of tartaric acid Thailand：5~50%, soluble starch：
0.5~5%, PVP K30：0.5~5%, filler：Surplus.
One or more of the filler of ten thousand rhzomorph sol particles of tartaric acid Thailand in lactose, glucose, sucrose, when
During several mixing, it can be mixed with arbitrary proportion.
The preparation method of the safe ten thousand rhzomorph sol particles of above-mentioned tartaric acid, comprises the following steps：
1) safe ten thousand rhzomorphs of medicinal ingredient tartaric acid, filler are crushed, crosses 60-100 mesh sieves；
2) it is soluble starch and PVP K30 is soluble in water successively, the soluble starches of 2-4% containing mass percent are made
With the binder of PVP K30；
3) safe ten thousand rhzomorphs of tartaric acid, filler suction fluid bed granulator after pulverizing and sieving, are mixed 5~10 minutes, and
Material is heated to 40~50 DEG C；
4) binder prepared by step (2) is sprayed onto in above-mentioned material and pelletized, the control material temperature during spraying granulation
40~50 DEG C of degree, set 150~180r/min of jet velocity, fogging degree：20~30m of compressed air consumption3/h；
5) after binder has sprayed, slowly heating drying particle, but must not exceed 70 DEG C, dry 5~20 minutes, with moisture drying
Weight-loss ratio only 5% is standard, stops drying, takes out packaging.
The positive effect of the present invention is embodied in：
The present invention disclose a kind of ten thousand rhzomorph sol particles of tartaric acid Thailand, and the sol particle composition is by medicinal ingredient and auxiliary
Expect composition composition, wherein, medicinal ingredient is safe ten thousand rhzomorphs of tartaric acid；Adjunct ingredient is made up of binder and filler, wherein glutinous
Mixture is made up of soluble starch, PVP K30, and filler is made up of one or more in lactose, glucose, sucrose.Formula
Middle soluble starch and PVP K30 are altogether mixed adhesive, the two is learnt from other's strong points to offset one's weaknesses, and strengthen stickiness, make particle good into graininess,
And water is fully soluble in, meet the requirement of sol particle；Filler glucose, sucrose, lactose dilution raw material, and animal machine
The basic substance of physical efficiency amount synthesis, animal body is got well, and it is positive beneficial to have the function that, and can be dissolved in that water meets can
The requirement of soluble particles.
The present invention have developed the new type of preparation of safe ten thousand rhzomorphs of tartaric acid, while the safe ten thousand rhzomorph sol particles of tartaric acid
Can with drinking water administration, also can spice administration, that is, ensure that the uniform of medicine, and time saving and energy saving, it is very convenient, meet scale and support
Grow the demand of industry.Ten thousand rhzomorph sol particles of tartaric acid Thailand dissolve in water, are not in blocking drinking water pipeline during drinking water administration
Phenomenon, and the particle preventing and treating livestock and poultry mycoplasma pneumonia significant effect.
Embodiment
With reference to embodiment, the present invention is further described, but does not limit the scope of the invention.
Embodiment 1：
A kind of safe ten thousand rhzomorph sol particles of tartaric acid, the sol particle composition include medicinal ingredient and adjunct ingredient,
Wherein, medicinal ingredient is made up of safe ten thousand rhzomorphs of tartaric acid；Auxiliary material is made up of binder and filler, and wherein adhesive is by solubility
Starch, PVP K30 composition, filler are made up of one or more in lactose, glucose, sucrose.
The percentage by weight of each component is in the sol particle：Ten thousand rhzomorphs of tartaric acid Thailand are 5%, and soluble starch is
1%th, PVP K30 0.5%, lactose 93.5%.
Embodiment 2：
A kind of safe ten thousand rhzomorph sol particles of tartaric acid, the sol particle composition include medicinal ingredient and adjunct ingredient,
Wherein, medicinal ingredient is made up of safe ten thousand rhzomorphs of tartaric acid；Auxiliary material is made up of binder and filler, and wherein adhesive is by solubility
Starch, PVP K30 composition, filler are made up of one or more in lactose, glucose, sucrose.
The percentage by weight of each component is in the sol particle：Ten thousand rhzomorphs of tartaric acid Thailand are 10%, and soluble starch is
1%th, PVP K30 0.5%, glucose 88.5%.
Embodiment 3：
A kind of safe ten thousand rhzomorph sol particles of tartaric acid, the sol particle composition include medicinal ingredient and adjunct ingredient,
Wherein, medicinal ingredient is made up of safe ten thousand rhzomorphs of tartaric acid；Auxiliary material is made up of binder and filler, and wherein adhesive is by solubility
Starch, PVP K30 composition, filler are made up of one or more in lactose, glucose, sucrose.
The percentage by weight of each component is in the sol particle：Ten thousand rhzomorphs of tartaric acid Thailand are 20%, and soluble starch is
1%th, PVP K30 0.5%, sucrose 78.5%.
Embodiment 4：
A kind of safe ten thousand rhzomorph sol particles of tartaric acid, the sol particle composition include medicinal ingredient and adjunct ingredient,
Wherein, medicinal ingredient is made up of safe ten thousand rhzomorphs of tartaric acid；Auxiliary material is made up of binder and filler, and wherein adhesive is by solubility
Starch, PVP K30 composition, filler are made up of one or more in lactose, glucose, sucrose.
The percentage by weight of each component is in the sol particle：Ten thousand rhzomorphs of tartaric acid Thailand are 30%, and soluble starch is
2%th, PVP K30 1%, sucrose 20%, glucose 20%, lactose 27%.
Embodiment 5：
A kind of safe ten thousand rhzomorph sol particles of tartaric acid, the sol particle composition include medicinal ingredient and adjunct ingredient,
Wherein, medicinal ingredient is made up of safe ten thousand rhzomorphs of tartaric acid；Auxiliary material is made up of binder and filler, and wherein adhesive is by solubility
Starch, PVP K30 composition, filler are made up of one or more in lactose, glucose, sucrose.
The percentage by weight of each component is in the sol particle：Ten thousand rhzomorphs of tartaric acid Thailand are 40%, and soluble starch is
2%th, PVP K30 1%, sucrose 15%, glucose 20%, lactose 22%.
Embodiment 6：
A kind of safe ten thousand rhzomorph sol particles of tartaric acid, the sol particle composition include medicinal ingredient and adjunct ingredient,
Wherein, medicinal ingredient is made up of safe ten thousand rhzomorphs of tartaric acid；Auxiliary material is made up of binder and filler, and wherein adhesive is by solubility
Starch, PVP K30 composition, filler are made up of one or more in lactose, glucose, sucrose.
The percentage by weight of each component is in the sol particle：Ten thousand rhzomorphs of tartaric acid Thailand are 50%, and soluble starch is
2%th, PVP K30 1%, sucrose 47%.
The preparation method of the safe ten thousand rhzomorph sol particles of above-mentioned tartaric acid is：
1) safe ten thousand rhzomorphs of medicinal ingredient tartaric acid, filler are crushed, crosses 60-100 mesh sieves；
2) it is soluble starch and PVP K30 is soluble in water successively, the soluble starches of 2-4% containing mass percent are made
With the binder of PVP K30；
3) safe ten thousand rhzomorphs of tartaric acid, filler suction fluid bed granulator after pulverizing and sieving, are mixed 5~10 minutes, and
Material is heated to 40~50 DEG C；
4) binder prepared by step (2) is sprayed onto in above-mentioned material and pelletized, the control material temperature during spraying granulation
40~50 DEG C of degree, set 150~180r/min of jet velocity, fogging degree：20~30m of compressed air consumption3/h；
5) after binder has sprayed, slowly heating drying particle, but must not exceed 70 DEG C, dry 5~20 minutes, with moisture drying
Weight-loss ratio only 5% is standard, stops drying, takes out packaging.
The safe ten thousand rhzomorph sol particles of tartaric acid in embodiment 1- embodiments 6 can be prepared using the above method, only
Feed change, auxiliary material proportion relation.
Embodiment 7：The controlling experiment to porcine mycoplasmal pneumonia of ten thousand rhzomorph sol particles of tartaric acid Thailand is studied
1. material
1.1 test drug
Table 1：Test drug
1.2 experimental animal
The piglet 77 that mycoplasma infection is diagnosed as through Laboratory X-ray of natural occurrence is chosen, is grouped after random number
For experiment.
2. method
2.1 packets and therapeutic scheme
Experiment point 4 groups are administered, and ten thousand rhzomorph sol particles of tartaric acid Thailand have 3 dosage groups, i.e., high dose group, in
Dosage group, low dose group are recommended in amount ranges in the Ministry of Agriculture；Blank control group separately is set, the group does not give any medicine.
Table 2：Packet and administrations situation table
Note：Above dosage is with reference to Ministry of Agriculture's relevant criterion setting.
2.2 efficacy assessment standard
2.2.1 cure：After one course for the treatment of of continuous use, the various symptoms such as cough, asthma disappear, and every physical signs is recovered
Normally, spiritual appetite is good.
2.2.2 effectively：After one course for the treatment of of continuous use, cough, asthma various symptoms are alleviated, and every physical signs is substantially extensive
Multiple normal, spiritual appetite takes a turn for the better.
It is 2.2.3 invalid：After two courses for the treatment of of continuous use, without being clearly better, some even aggravates, is dead various symptoms.
3. result of the test
Effective case load and healing case load after medication treatment, see the table below：
Table 3：Various medicines are to piglet Eaton agent pneumonia therapeutic effect
4. interpretation of result
After medication whether in terms of effective situation, the effective percentage of senior middle school's low dose group of ten thousand rhzomorph sol particles of tartaric acid Thailand
Reach 100%, and the cure rate of low dose group illustrates that safe ten thousand rhzomorphs of tartaric acid are soluble also close to 90% on cure rate
Particle can effectively prevent and treat the Eaton agent pneumonia of piglet.
Embodiment 8：The controlling experiment to chronic respiratory disease of ten thousand rhzomorph sol particles of tartaric acid Thailand is studied
1. material
1.1 test drug
Table 4：Test drug
1.2 experimental animal
The chicken 157 through laboratory etiological diagnosis for mycoplasma infection of natural occurrence is chosen, is grouped after random number
For experiment.
2. method
2.1 packets and therapeutic scheme
Experiment point 4 groups are administered, and ten thousand rhzomorph sol particles of tartaric acid Thailand have 3 dosage groups, i.e., high dose group, in
Dosage group, low dose group are recommended in amount ranges in the Ministry of Agriculture；Blank control group separately is set, the group does not give any medicine.
Table 5：Packet and administrations situation table
Note：Above dosage is with reference to Ministry of Agriculture's relevant criterion setting.
2.2 efficacy assessment standard
2.2.1 cure：After one course for the treatment of of continuous use, the various diseases such as cough, stream nose liquid, respiratory tract rale, mouth breathing
Shape disappears, and every physical signs recovers normal, and spiritual appetite is good.
2.2.2 effectively：After one course for the treatment of of continuous use, cough, stream nose liquid, respiratory tract rale, mouth breathing various symptoms
Alleviate, every physical signs returns to normal, and spiritual appetite takes a turn for the better.
It is 2.2.3 invalid：After two courses for the treatment of of continuous use, without being clearly better, some even aggravates, is dead various symptoms.
3. result of the test
Effective case load and healing case load after medication treatment, see the table below：
Table 6：Various medicines are to piglet Eaton agent pneumonia therapeutic effect
4. interpretation of result
After medication whether in terms of effective situation, the effective percentage of senior middle school's low dose group of ten thousand rhzomorph sol particles of tartaric acid Thailand
Reach and be higher than 95%, and the cure rate of low dose group has also reached 90% on cure rate, illustrates that safe ten thousand rhzomorphs of tartaric acid are solvable
Property particle can effectively prevent and treat the young chronic respiratory disease for causing chicken by mycoplasma infection.
Claims (4)
- A kind of 1. safe ten thousand rhzomorph sol particles of tartaric acid, it is characterised in that：The sol particle composition is by medicinal ingredient and auxiliary Expect composition composition, wherein, medicinal ingredient is safe ten thousand rhzomorphs of tartaric acid；Adjunct ingredient is made up of binder and filler, wherein glutinous Mixture is made up of soluble starch, PVP K30, and filler is made up of one or more in lactose, glucose, sucrose.
- A kind of 2. safe ten thousand rhzomorph sol particles of tartaric acid according to claim 1, it is characterised in that：The sol particle The percentage by weight of middle each component is：Ten thousand rhzomorphs of tartaric acid Thailand are 5~50%, and soluble starch is 0.5~5%, PVP K30 For 0.5~5%, filler：Surplus.
- A kind of 3. safe ten thousand rhzomorph sol particles of tartaric acid according to claim 1 or 2, it is characterised in that：Described fills out One or more of the agent in lactose, glucose, sucrose are filled, when several mixing, can be mixed with arbitrary proportion.
- A kind of 4. preparation method of the safe ten thousand rhzomorph sol particles of tartaric acid according to claim 1, it is characterised in that：Bag Include following steps：1) safe ten thousand rhzomorphs of medicinal ingredient tartaric acid, filler are crushed, crosses 60-100 mesh sieves；2) it is soluble starch and PVP K30 is soluble in water successively, the soluble starches of 2-4% containing mass percent are made and gather Tie up ketone K30 binder；3) safe ten thousand rhzomorphs of tartaric acid after pulverizing and sieving, filler suction fluid bed granulator, are mixed 5~10 minutes, and by thing Material is heated to 40~50 DEG C；4) binder prepared by step (2) is sprayed onto in above-mentioned material and pelletized, the control material temperature 40 during spraying granulation ~50 DEG C, set 150~180r/min of jet velocity, fogging degree：20~30m of compressed air consumption3/h；5) after binder has sprayed, slowly heating drying particle, but must not exceed 70 DEG C, dry 5~20 minutes, it is weightless with moisture drying Rate only 5% is standard, stops drying, takes out packaging.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711112720.7A CN107737106A (en) | 2017-11-10 | 2017-11-10 | Safe ten thousand rhzomorph sol particles of a kind of tartaric acid and preparation method thereof |
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| CN201711112720.7A CN107737106A (en) | 2017-11-10 | 2017-11-10 | Safe ten thousand rhzomorph sol particles of a kind of tartaric acid and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272757A (en) * | 2018-04-23 | 2018-07-13 | 大连民族大学 | A kind of application of granule for animals in pig blue-ear disease prevention and control |
| CN108354908A (en) * | 2018-04-23 | 2018-08-03 | 大连民族大学 | Safe ten thousand rhzomorph granules and preparation method thereof |
| CN110604725A (en) * | 2019-11-06 | 2019-12-24 | 山东胜利生物工程有限公司 | Tylosin tartrate preparation and preparation method thereof |
| CN113750049A (en) * | 2021-10-08 | 2021-12-07 | 山东惠民德赛克生物科技有限公司 | Soluble powder of antibacterial composition and preparation method thereof |
| CN114404372A (en) * | 2022-03-16 | 2022-04-29 | 重庆威鹏药业有限公司 | Dichroa febrifuga ketone granules and preparation method thereof |
| CN114699376A (en) * | 2022-03-24 | 2022-07-05 | 浙江大飞龙动物保健品股份有限公司 | Tylosin tartrate effervescent granules for livestock and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285374A (en) * | 2013-05-20 | 2013-09-11 | 广东大华农动物保健品股份有限公司 | Amoxicillin colistin sulphate granule and preparation method thereof |
| CN107308119A (en) * | 2017-07-10 | 2017-11-03 | 浙江万方生物科技有限公司 | Safe ten thousand rhzomorph particles of a kind of highly-water-soluble tartaric acid and preparation method thereof |
-
2017
- 2017-11-10 CN CN201711112720.7A patent/CN107737106A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285374A (en) * | 2013-05-20 | 2013-09-11 | 广东大华农动物保健品股份有限公司 | Amoxicillin colistin sulphate granule and preparation method thereof |
| CN107308119A (en) * | 2017-07-10 | 2017-11-03 | 浙江万方生物科技有限公司 | Safe ten thousand rhzomorph particles of a kind of highly-water-soluble tartaric acid and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272757A (en) * | 2018-04-23 | 2018-07-13 | 大连民族大学 | A kind of application of granule for animals in pig blue-ear disease prevention and control |
| CN108354908A (en) * | 2018-04-23 | 2018-08-03 | 大连民族大学 | Safe ten thousand rhzomorph granules and preparation method thereof |
| CN110604725A (en) * | 2019-11-06 | 2019-12-24 | 山东胜利生物工程有限公司 | Tylosin tartrate preparation and preparation method thereof |
| CN113750049A (en) * | 2021-10-08 | 2021-12-07 | 山东惠民德赛克生物科技有限公司 | Soluble powder of antibacterial composition and preparation method thereof |
| CN114404372A (en) * | 2022-03-16 | 2022-04-29 | 重庆威鹏药业有限公司 | Dichroa febrifuga ketone granules and preparation method thereof |
| CN114699376A (en) * | 2022-03-24 | 2022-07-05 | 浙江大飞龙动物保健品股份有限公司 | Tylosin tartrate effervescent granules for livestock and preparation method thereof |
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Application publication date: 20180227 |