CN107998264A - A kind of Chinese and Western medicine compound superfine powder for treating porcine respiratory disease and preparation method and application - Google Patents
A kind of Chinese and Western medicine compound superfine powder for treating porcine respiratory disease and preparation method and application Download PDFInfo
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- CN107998264A CN107998264A CN201810037500.0A CN201810037500A CN107998264A CN 107998264 A CN107998264 A CN 107998264A CN 201810037500 A CN201810037500 A CN 201810037500A CN 107998264 A CN107998264 A CN 107998264A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
Abstract
The present invention relates to a kind of Chinese and Western medicine compound superfine powder for treating porcine respiratory disease and preparation method and application, belong to field of veterinary.The preparation method of above-mentioned Chinese and Western medicine compound superfine powder comprises the following steps：Loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract, tilmicosin phosphate, menthol, essence, sucrose and auxiliary material are dissolved, then mixes, dry, pulverize with carrier.The preparation method is simple, and condition controllability is good, and production cost is low, and stability is good, has good application prospect.The bitter taste of common Tilmicosin medicine can be effectively covered by its obtained Chinese and Western medicine compound superfine powder, overcomes common Tilmicosin pharmaceutical preparation to cause the significant difficulty of pig feed intake degradation, and is avoided that the drug resistance of Tilmicosin medicine produces.Use it for preparing the medicine or feed for treating or preventing porcine respiratory disease, not only there is the effect of preferably treatment porcine respiratory disease, pig feed intake is influenced also smaller.
Description
Technical field
The present invention relates to field of veterinary, and more particularly to a kind of Chinese and Western medicine compound superfine powder for treating porcine respiratory disease
And preparation method and application.
Background technology
As livestock breeding industry develops rapidly and intensive culture, pig farm the more is built the more big, causes pig dense degree more
Concentrate, pig house air regime is deteriorated, and easily cross contamination, therefore the swinery breathing problem brought is in recent years in China
Pig farm occurrence frequency steeply rises, particularly the breathing problem syndrome (PRDC) and porcine reproductive and respiratory syndrome of pig
(PRRS, is commonly called as blue otopathy), the production to pig farm cause very big influence.
The choice drug for the treatment of porcine respiratory disease is Tilmicosin class medicine at present, and the approval of the Ministry of Agriculture of China is such
Medicine is mainly Tilmicosin pre-mixing agent and tilmicosin phosphate soluble powder.
There are the serious problems of palatability difference caused by Tilmicosin poorly water-soluble and bitter taste, clinic for Tilmicosin pre-mixing agent
Curative effect is poor.The application method of tilmicosin phosphate soluble powder is influenced to be dissolved in drinking water use by pig life habit
Waste very big.And tilmicosin phosphate soluble powder price is high, has further raised the use cost on pig farm.
Therefore, it is necessary to the medicine for treating porcine respiratory disease is improved.
The content of the invention
It is an object of the present invention to provide a kind of system for the Chinese and Western medicine compound superfine powder for treating porcine respiratory disease
Preparation Method, the preparation method is simple, and condition controllability is good, and production cost is low, and stability is good, has good application prospect.
The second object of the present invention is to provide a kind of Chinese and Western medicine compound superfine powder for treating porcine respiratory disease, its by
Above-mentioned preparation method is prepared, which can effectively cover the bitter taste of common Tilmicosin medicine,
Overcome common Tilmicosin pharmaceutical preparation to cause the significant difficulty of pig feed intake degradation, and be avoided that Tilmicosin medicine
Drug resistance produces.
The third object of the present invention is to provide a kind of Chinese and Western medicine compound superfine powder of above-mentioned treatment porcine respiratory disease
Application, use it for prepare treat or prevent porcine respiratory disease medicine or feed, not only have preferably treatment pig exhale
The effect of tract disease is inhaled, pig feed intake is influenced also smaller.
The present invention is solved its technical problem and is realized using following technical scheme：
The present invention proposes a kind of preparation method for the Chinese and Western medicine compound superfine powder for treating porcine respiratory disease, including following
Step：Loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract, tilmicosin phosphate, menthol, essence, sucrose and auxiliary material are dissolved, then
Mix, dry, pulverize with carrier.
Preferably, it is dry using spray drying.
Preferably, the particle diameter of the Chinese and Western medicine compound superfine powder after crushing is no more than 200 mesh.
The present invention also proposes a kind of Chinese and Western medicine compound superfine powder for treating porcine respiratory disease, it is by above-mentioned preparation method
It is prepared.
The present invention also proposes the application of the Chinese and Western medicine compound superfine powder of above-mentioned treatment porcine respiratory disease, such as is used
In the medicine or feed that prepare treatment or prevention porcine respiratory disease.
The Chinese and Western medicine compound superfine powder for the treatment porcine respiratory disease that present pre-ferred embodiments provide and its preparation side
Method and the beneficial effect of application are：
1) Chinese and Western medicine compound superfine powder provided by the invention combines the par height of Chinese medicine treatment breathing problem infection
Medicine fritillary-loquat liquid and treatment of respiratory diseases medicine tilmicosin phosphate for animals are imitated, treats the effect of the breathing problem of pig
It is more preferable than Tilmicosin medicine is used alone.
2) sweeteners such as menthol, essence are added in raw material, the bitter taste of common Tilmicosin medicine is effectively masked, overcomes
Common Tilmicosin pharmaceutical preparation causes this significant difficulty of pig feed intake degradation.
3) Chinese and Western medicine compound superfine powder provided by the invention reduces the content of Tilmicosin in medicine, has delayed to replace rice
The drug resistance for examining star medicine produces process.
4) for abusing and then causing the drug resistant selected swine farms of Tilmicosin, Chinese and Western medicine compound Ultramicro-powder provided by the invention
The traditional Chinese medicine ingredients of agent also can have therapeutic effect to the breathing problem for the pig that it occurs.
5) product form of the invention is superfine powder, adds the specific surface area of medicine, improves drug absorption efficiency.
6) product preparation method of the invention is simple, and condition controllability is good, and production cost is low, and stability is good, has fine
Application prospect.
7) use it for preparing the medicine or feed for treating or preventing porcine respiratory disease, not only there is preferably treatment pig
The effect of breathing problem, influences pig feed intake also smaller.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer, is the conventional production that can be obtained by commercially available purchase
Product.
Chinese and Western medicine compound superfine powder for the treatment of porcine respiratory disease to the embodiment of the present invention and preparation method thereof below
It is specifically described with application.
The raw material of the Chinese and Western medicine compound superfine powder for the treatment of porcine respiratory disease provided in an embodiment of the present invention includes 2-50
The loquat-leaf extract of parts by weight, the Bulbus Fritillariae Cirrhosae extract of 2-50 parts by weight, the tilmicosin phosphate of 2-50 parts by weight, 1-30 weights
Measure the menthol of part, the essence of 1-30 parts by weight, the sucrose of 1-30 parts by weight, the carrier of 20-90 parts by weight and 1-50 weight
The auxiliary material of part.
Further, loquat-leaf extract, the bulbus fritillariae cirrhosae of 20-30 parts by weight of the above-mentioned raw materials including 20-30 parts by weight carry
Take thing, the tilmicosin phosphate of 20-30 parts by weight, the menthol of 10-20 parts by weight, the essence of 10-20 parts by weight, 10-20 weights
Measure the sucrose, the carrier of 40-60 parts by weight and the auxiliary material of 20-30 parts by weight of part.
Further, the loquat-leaf extract of above-mentioned raw materials including 25 parts by weight, 25 parts by weight Bulbus Fritillariae Cirrhosae extract,
The tilmicosin phosphate of 25 parts by weight, the menthol of 15 parts by weight, the essence of 15 parts by weight, the sucrose of 15 parts by weight, 50 weight
The carrier of part and the auxiliary material of 25 parts by weight.
Wherein, loguat leaf has 14 kinds and subspecies in China, and distribution is very wide, mainly originates in Hubei, Jiangsu, Zhejiang, Fujian
Area is planted extensively Deng loquat fruit tree, it is cheap, it is Chinese traditional herbs.Loguat leaf is rich in triterpene acids, sesquiterpenoids, flavones
The resulting structures such as class, Polyphenols, its primary efficacy are removing heat from the lung to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI, lower gasification phlegm, and anti-inflammatory is antiviral etc..Usually
For treating cough with lung heat, circulation of vital energy in the wrong direction asthma is anxious, and stomach energy is vomitted inverse, and the symptom such as dysphoria and thirsty, is recorded in Chinese Pharmacopoeia.
Though in loquat-leaf extract containing nerolidol, fanesol, amphene, laurene, to a variety of work such as P-cymene
Property material, but the main work for alleviating respiratory disorder main by ursolic acid and nerolidol contained by it ing in the application at present
With.Loquat-leaf extract in the embodiment of the present invention mainly includes elemol and α-pilgerol, the rwo material is as function
Component with have the function that treat respiratory disorder.What deserves to be explained is by contrast, the chief active contained by loquat-leaf extract
The difference of the species and content of component, its effect risen to pig have marked difference, using elemol and α-pilgerol as
Main active ingredient can be improved relatively by the use of the positive effect that ursolic acid and nerolidol rise as main active.
It is preferred that above-mentioned loquat-leaf extract is in terms of its dry product, the quality of elemol and α-pilgerol contained by it
Fraction amounts to and is more than or equal to 90wt%.Preferably, the mass ratio of elemol and α-pilgerol is 1-3：5.Under the proportioning, loquat
Leaf extract to the therapeutic effect of pig breathing problem more preferably.
Bulbus fritillariae cirrhosae is Liliaceae herbaceos perennial crow flower fritillaria, Fritillaria unibracteata, Roche fritillaria, Fritillaria Cirrhosa D. Don, rib sand
The underground bulb of the fritillarias such as fritillaria, because main product is gained the name in Sichuan.Bulbus fritillariae cirrhosae bitter but sweet flavor cold in nature, can clearing lung-heat expel the heat-evil resolving sputum, moistening lung
Cough-relieving, swallows dry, cough up phlegm yellow thick for treating phlegm heat cough, exogenous cough, cough due to yin deficiency, phlegm, is suitable for internal injury chronic cough especially less, dry
Phlegm, the card of hot phlegm, is a kind of conventional Chinese medicine, and medicinal history is very long, is recorded in Chinese Pharmacopoeia.
Though answered at present containing various active materials such as fritimine, chinpeimine and chuanbeinones in Bulbus Fritillariae Cirrhosae extract
Mainly play main alleviation respiratory disorder by the fritimine contained by it and chuanbeinone in.River in the embodiment of the present invention
Fritillaria extract mainly includes loose shellfish alkali and fritiminine, the rwo material treats the work of respiratory disorder as functional component to reach
With.What deserves to be explained is by contrasting, the difference of the species and content of the main active contained by Bulbus Fritillariae Cirrhosae extract, its
The effect risen to pig has marked difference, and relatively fritimine and river can be used as main active ingredient using loose shellfish alkali and fritiminine
Shellfish ketone is improved as the positive effect that main active rises.
It is preferred that above-mentioned Bulbus Fritillariae Cirrhosae extract is in terms of its dry product, the mass fraction of loose shellfish alkali and fritiminine contained by it
It is more than or equal to 95wt% altogether.Preferably, the mass ratio of loose shellfish alkali and fritiminine is 1-2：3-8.Under the proportioning, bulbus fritillariae cirrhosae extraction
Thing to the therapeutic effect of pig breathing problem more preferably.
Tilmicosin is by a kind of semi-synthetic special antibiotic of macrolides livestock and poultry of hydrolysate of tylosin.Its
There is inhibitory action to gram-positive bacteria, some Gram-negative bacterias, mycoplasma and conveyor screw etc., and to pleuropneumonia unwrapping wire
Bacterium and Pasteurella have antibacterial activity more stronger than tylosin.At present, which has gone through to be clinically used for ox, goat, silk floss
The prevention of the animal infectious diseases such as sheep, milk cow, pig and chicken, particularly livestock and birds respiratory disease, such as domestic animal Actinobacillus property chest
The treatment of membrane lung inflammation, pasteurellosis and gallisepticum chicken disease etc. and lactating mammal mammitis.
But since Tilmicosin is insoluble in water, seriously limit clinical application effect.Because in inventive embodiments with water solubility
Substitute of the tilmicosin phosphate as common Tilmicosin.
Since tilmicosin phosphate bitter taste is heavier, the feed intake of pig is seriously affected.And when it stops in the stomach of pig
Stay the time too long, its time of contact and area with gastric mucosa can be increased, increase the stimulation to gastric mucosa, cause gastric ulcer.
By adding the sweeteners such as menthol, essence and sucrose in the feed in the present embodiment, on the one hand can effectively cover
The bitter taste of common Tilmicosin class medicine is covered, overcoming common Tilmicosin pharmaceutical preparation to cause pig feed intake degradation, this is heavy
Disaster, on the other hand since sweetener is easily decomposed under the action of digestive ferment under one's belt, can aid in improving it is mixed after
Tilmicosin phosphate absorption and digestion rate, strengthen drug effect, and avoid causing stomach unnecessary burden.
Optionally, auxiliary material can for example include at least one of calcium carbonate, silica and talcum powder, above-mentioned auxiliary
On the one hand material can increase the mobility of material powder, prevent superfine powder from making moist, on the other hand by being mixed with tilmicosin phosphate
Close and use, the time that tilmicosin phosphate is entered small intestine by stomach can be shortened, cooperate with enhancing phosphoric acid to be examined for rice with above-mentioned sweetener
The using effect of star, while reduce damage of the tilmicosin phosphate to gastric mucosa.
Optionally, carrier can for example include any in starch, maize cob meal, powdered glucose, wheat bran and rice bran
One kind, to carry little particle medicine.
Hold, the embodiment of the present invention is by the way that loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract and tilmicosin phosphate are made jointly
For the material composition of Chinese and Western medicine compound superfine powder, can the medicine of the more existing class containing Tilmicosin substantially reduce Tilmicosin
Dosage, delays the drug resistance of Tilmicosin medicine to produce process, secondly, above two material each can exhale pig respectively
Inhaling tract disease has certain therapeutic effect.Also, the main active in the embodiment of the present invention contained by loquat-leaf extract
Elemol and α-pilgerol can effectively improve the targeting of tilmicosin phosphate, strengthen the combination of itself and ribosomes 50s subunits
Degree.Contained loose shellfish alkali and fritiminine can aid in the defence work(of tilmicosin phosphate adjusting pig body in Bulbus Fritillariae Cirrhosae extract
Can, collaboration macrophage produces bactericidal effect.By loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract and tilmicosin phosphate triplicity
Afterwards, Tilmicosin medicine can relatively be used alone to alleviating the positive effect of pig breathing problem more preferably.Sweetener and auxiliary material master
It is used to reduce influence of the tilmicosin phosphate to pig stomach, improves taste, improves feed intake.
In addition, the embodiment of the present invention additionally provides a kind of Chinese and Western medicine compound superfine powder of above-mentioned treatment porcine respiratory disease
Preparation method, such as may include following steps：Examined by proportioning dissolving loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract, phosphoric acid for rice
Star, menthol, essence, sucrose and auxiliary material, then mix with carrier, dry, pulverize.
Preferably, it is dry largely to maintain the active ingredient of raw material to be had using spray drying, this drying mode
Activity.
Crushing uses superfine grinding method, superfine powder is made, so as to increase the specific surface area of medicine, improve medicine
Absorption efficiency.It is preferred that the particle diameter of the Chinese and Western medicine compound superfine powder after crushing is no more than 200 mesh, allow it to effectively
Absorption is easy to use on the medicine or feed granules of various forms, wastes less.
Further, above-mentioned each raw material can refer in the following manner mixing：Loquat-leaf extract, river are dissolved under heating condition
Fritillaria extract, menthol, essence, sucrose and auxiliary material, obtain the first mixed liquor, are then mixed with dissolved tilmicosin phosphate
Close, obtain the second mixed liquor, then mixed with carrier, be dry, pulverize.
Heating is carried out under conditions of 50-60 DEG C, so that loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract, menthol, perfume (or spice)
Essence, sucrose and auxiliary material are fully dissolved.
By that by raw material batch mixed, on the one hand can ensure that tilmicosin phosphate can fully be dissolved, on the other hand
Each raw material and mixing uniformity can be improved.
In addition, the embodiment of the present invention additionally provides a kind of Chinese and Western medicine compound superfine powder of above-mentioned treatment porcine respiratory disease
Application, including use it for preparing the medicine or feed for treating or preventing porcine respiratory disease, when being used to prepare treatment or pre-
During the feed of anti-porcine respiratory disease, it can be added in the feed of pig in 1kg/ tons of ratio.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
By the loquat-leaf extract of 2 parts by weight, the Bulbus Fritillariae Cirrhosae extract of 2 parts by weight, the menthol of 1 parts by weight, 1 parts by weight
Essence, the sucrose of 1 parts by weight and the auxiliary material of 1 parts by weight and water dissolved under conditions of 50 DEG C, obtain the first mixed liquor.Then
First mixed liquor is mixed with the dissolved tilmicosin phosphate of 2 parts by weight, obtains the second mixed liquor.Again by the second mixed liquor with
The starch mixing of 90 parts by weight, spray drying, pelletizes after being crushed in micronizer, crosses sieve, it is 200 purposes to obtain particle diameter
Treat the Chinese and Western medicine compound superfine powder of porcine respiratory disease.
Wherein, in terms of its dry product, the mass fraction of elemol and α-pilgerol amounts to be equal to loquat-leaf extract
90wt%.The mass ratio of elemol and α-pilgerol is 1：5.Bulbus Fritillariae Cirrhosae extract is in terms of its dry product, loose shellfish alkali and lubei
The mass fraction of alkali amounts to and is equal to 95wt%.The mass ratio of loose shellfish alkali and fritiminine is 1：3.Auxiliary material contains calcium carbonate.
Embodiment 2
By the loquat-leaf extract of 50 parts by weight, the Bulbus Fritillariae Cirrhosae extract of 50 parts by weight, the menthol of 30 parts by weight, 30 weights
Essence, the sucrose of 30 parts by weight and the auxiliary material of 50 parts by weight and water for measuring part dissolve under conditions of 60 DEG C, obtain the first mixing
Liquid.Then the first mixed liquor is mixed with the dissolved tilmicosin phosphate of 50 parts by weight, obtains the second mixed liquor.Again by second
Mixed liquor is mixed with the maize cob meal of 90 parts by weight, spray drying, is pelletized after being crushed in micronizer, is crossed sieve, obtain
Particle diameter is the Chinese and Western medicine compound superfine powder of 200 therapeutic interest porcine respiratory diseases.
Wherein, in terms of its dry product, the mass fraction of elemol and α-pilgerol amounts to be equal to loquat-leaf extract
95wt%.The mass ratio of elemol and α-pilgerol is 3：5.Bulbus Fritillariae Cirrhosae extract is in terms of its dry product, loose shellfish alkali and lubei
The mass fraction of alkali amounts to and is equal to 98wt%.The mass ratio of loose shellfish alkali and fritiminine is 2：8.Auxiliary material contains silica.
Embodiment 3
By the loquat-leaf extract of 20 parts by weight, the Bulbus Fritillariae Cirrhosae extract of 30 parts by weight, the menthol of 10 parts by weight, 10 weights
Essence, the sucrose of 10 parts by weight and the auxiliary material of 20 parts by weight and water for measuring part dissolve under conditions of 55 DEG C, obtain the first mixing
Liquid.Then the first mixed liquor is mixed with the dissolved tilmicosin phosphate of 20 parts by weight, obtains the second mixed liquor.Again by second
Mixed liquor is mixed with the powdered glucose of 40 parts by weight, spray drying, is pelletized after being crushed in micronizer, is crossed sieve, obtain
Particle diameter is the Chinese and Western medicine compound superfine powder of 200 therapeutic interest porcine respiratory diseases.
Wherein, in terms of its dry product, the mass fraction of elemol and α-pilgerol amounts to be equal to loquat-leaf extract
98wt%.The mass ratio of elemol and α-pilgerol is 1.5：5.Bulbus Fritillariae Cirrhosae extract is in terms of its dry product, loose shellfish alkali and stove
The mass fraction of shellfish alkali amounts to and is equal to 100wt%.The mass ratio of loose shellfish alkali and fritiminine is 1：8.Auxiliary material contains talcum powder.
Embodiment 4
By the loquat-leaf extract of 30 parts by weight, the Bulbus Fritillariae Cirrhosae extract of 20 parts by weight, the menthol of 20 parts by weight, 20 weights
Essence, the sucrose of 20 parts by weight and the auxiliary material of 30 parts by weight and water for measuring part dissolve under conditions of 55 DEG C, obtain the first mixing
Liquid.Then the first mixed liquor is mixed with the dissolved tilmicosin phosphate of 30 parts by weight, obtains the second mixed liquor.Again by second
Mixed liquor is mixed with the wheat bran of 60 parts by weight, spray drying, is pelletized after being crushed in micronizer, is crossed sieve, obtain particle diameter
For the Chinese and Western medicine compound superfine powder of 200 therapeutic interest porcine respiratory diseases.
Wherein, in terms of its dry product, the mass fraction of elemol and α-pilgerol amounts to be equal to loquat-leaf extract
100wt%.The mass ratio of elemol and α-pilgerol is 2.5：5.Bulbus Fritillariae Cirrhosae extract is in terms of its dry product, loose shellfish alkali and stove
The mass fraction of shellfish alkali amounts to and is equal to 100wt%.The mass ratio of loose shellfish alkali and fritiminine is 2：3.Auxiliary material contains calcium carbonate and two
Silica.
Embodiment 5
By the loquat-leaf extract of 25 parts by weight, the Bulbus Fritillariae Cirrhosae extract of 25 parts by weight, the menthol of 15 parts by weight, 15 weights
Essence, the sucrose of 15 parts by weight and the auxiliary material of 25 parts by weight and water for measuring part dissolve under conditions of 55 DEG C, obtain the first mixing
Liquid.Then the first mixed liquor is mixed with the dissolved tilmicosin phosphate of 25 parts by weight, obtains the second mixed liquor.Again by second
Mixed liquor is mixed with the rice bran of 50 parts by weight, spray drying, is pelletized after being crushed in micronizer, is crossed sieve, obtain particle diameter
For the Chinese and Western medicine compound superfine powder of 200 therapeutic interest porcine respiratory diseases.
Wherein, in terms of its dry product, the mass fraction of elemol and α-pilgerol amounts to be equal to loquat-leaf extract
100wt%.The mass ratio of elemol and α-pilgerol is 2：5.Bulbus Fritillariae Cirrhosae extract is in terms of its dry product, loose shellfish alkali and lubei
The mass fraction of alkali amounts to and is equal to 100wt%.The mass ratio of loose shellfish alkali and fritiminine is 1.5：5.5.Auxiliary material contain calcium carbonate and
Talcum powder.
Embodiment 6
By the loquat-leaf extract of 5 parts by weight, the Bulbus Fritillariae Cirrhosae extract of 5 parts by weight, the menthol of 2 parts by weight, 2 parts by weight
Essence, the sucrose of 5 parts by weight and the auxiliary material of 6 parts by weight and water dissolved under conditions of 55 DEG C, obtain the first mixed liquor.Then
First mixed liquor is mixed with the dissolved tilmicosin phosphate of 5 parts by weight, obtains the second mixed liquor.Again by the second mixed liquor with
The rice bran mixing of 50 parts by weight, spray drying, pelletizes after being crushed in micronizer, crosses sieve, it is 200 purposes to obtain particle diameter
Treat the Chinese and Western medicine compound superfine powder of porcine respiratory disease.
Wherein, in terms of its dry product, the mass fraction of elemol and α-pilgerol amounts to be equal to loquat-leaf extract
100wt%.The mass ratio of elemol and α-pilgerol is 2：5.Bulbus Fritillariae Cirrhosae extract is in terms of its dry product, loose shellfish alkali and lubei
The mass fraction of alkali amounts to and is equal to 100wt%.The mass ratio of loose shellfish alkali and fritiminine is 1.5：5.5.Auxiliary material contains calcium carbonate, two
Silica and talcum powder.
Embodiment 7
The present embodiment and embodiment 6 difference lies in：By loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract, menthol, essence,
Sucrose, auxiliary material, tilmicosin phosphate and rice bran mix at the same time, spray drying, pelletize after being crushed in micronizer, sieve
Net, obtains the Chinese and Western medicine compound superfine powder that particle diameter is 100 therapeutic interest porcine respiratory diseases.
Embodiment 8
The present embodiment provides a kind of application of the Chinese and Western medicine compound superfine powder of upper treatment porcine respiratory disease, that is, used
In the medicine for preparing treatment or prevention porcine respiratory disease.
Embodiment 9
The present embodiment provides a kind of application of the Chinese and Western medicine compound superfine powder of upper treatment porcine respiratory disease, that is, used
In the feed for preparing treatment or prevention porcine respiratory disease.Specifically, added in 1 kg/tonne of ratio in the feed of pig.
Test example 1
Repeat to implement above-described embodiment 1-7, obtain the Chinese and Western medicine compound Ultramicro-powder of enough treatment porcine respiratory diseases
Agent.Tests below is carried out by taking the Chinese and Western medicine compound superfine powder of the treatment porcine respiratory disease obtained by embodiment 1-7 as an example.
This experiment is designed using single-factor, certain that blue otopathy selection health status in pig farm occurred frequently, weight are close in Fujian
The morbidity child care pig 120 of age in days kind 15kg or so initial weight, is randomly divided into 8 groups, is divided into certain brand Tilmicosin pre-mixing agent
Control group and test group 1-7 (corresponding embodiment 1-7), every group 15,21 days experimental periods.Two groups use identical forage feed,
Administering mode is spice administration, i.e., Chinese and Western medicine compound superfine powder or certain brand Tilmicosin pre-mixing agent is pressed 1 kg/tonne
Ratio add pig feed in.Occur cough, asthma, feed intake less than sodium selenite of the same age less than half etc. symptom i.e. be judged as disease
Pig, counts sick pig quantity after 21 days.Result of the test is as shown in table 1.
1 result of the test of table
As can be seen from Table 1,21 days cure rates of control group are 53.33%, and 21 days counterpoises are 20.28kg.Test group 1-7
21 days cure rates be that and 21 days counterpoises illustrate that 1-7 of the embodiment of the present invention is corresponding and control in more than 22kg more than 80%
Treat porcine respiratory disease Chinese and Western medicine compound superfine powder compared with control group Tilmicosin pre-mixing agent to treat porcine respiratory disease
With it is more preferable the effect of, while also smaller is influenced on the feed intake of pig.
In test group 1-7,21 days cure rates of test group 5 and 21 days more other test groups of counterpoise are more excellent, illustrate this
The proportioning of the corresponding each raw material of test group rises better.Contrast test group 6 and test group 7, test group 6 is compared with test group 7
Therapeutic effect more preferably, illustrate that each raw material mixes the drug effect relatively while mixed more preferably step by step.
Test example 2
Using the test method in test example 1, by taking test group 5 as an example, control group 1-5 is set.Control group and test group 5
Difference lies in：Main active in the loquat-leaf extract of control group 1 is ursolic acid, the loquat-leaf extract of control group 2
In main active be nerolidol, the main active in the loquat-leaf extract of control group 3 is ursolic acid and orange
The flower tertiary alcohol, the main active in the loquat-leaf extract of control group 4 are elemol, in the loquat-leaf extract of control group 5
Main active be α-pilgerol, the results are shown in Table 2 for it.
2 result of the test of table
As can be seen from Table 2,21 days cure rates of control group 1-5 and 21 days counterpoises are worse compared with test example 5.Wherein,
Control group 1-3 is worse compared with the effect of control group 4-5 and test group 5, illustrates for pig, contains in loquat-leaf extract
Elemol and/or α-pilgerol containing ursolic acid and/or nerolidol compared with having the function that more obviously to treat respiratory disorder.
Contrast control group 4-5 and test group 5 are as can be seen that α-pilgerol in loquat-leaf extract exhales treatment pig compared with elemol
The influence bigger and drug effect of suction disease more preferably, and will can obtain both it with the use of the effect that any of which is relatively used only
To being obviously improved, and there is synergy after the two cooperation.
Test example 3
Using the test method in test example 1, by taking test group 5 as an example, control group 6-10 is set.Control group and test group 5
Difference lies in：Main active in the Bulbus Fritillariae Cirrhosae extract of control group 6 is fritimine, and the bulbus fritillariae cirrhosae of control group 7 extracts
Main active in thing is chuanbeinone, and the main active in the Bulbus Fritillariae Cirrhosae extract of control group 8 is fritimine and river
Shellfish ketone, the main active in the Bulbus Fritillariae Cirrhosae extract of control group 9 are loose shellfish alkali, in the Bulbus Fritillariae Cirrhosae extract of control group 5
Main active is fritiminine, and the results are shown in Table 3 for it.
3 result of the test of table
As can be seen from Table 3,21 days cure rates of control group 6-10 and 21 days counterpoises are worse compared with test example 5.Wherein,
Control group 6-8 is worse compared with the effect of control group 9-10 and test group 5, illustrates for pig, contains in Bulbus Fritillariae Cirrhosae extract
Play the role of loose shellfish alkali and/or fritiminine has more obviously treatment respiratory disorder compared with containing fritimine and/or chuanbeinone.Contrast
Control group 9-10 and test group 5 can be seen that respiratory disorder of the more loose shellfish alkali of fritiminine in Bulbus Fritillariae Cirrhosae extract to treatment pig
Influence bigger and drug effect more preferably, and will both it be used cooperatively relatively be used only any of which effect can obtain substantially
Lifting, and there is synergy after the two cooperation.
Test example 4
Using the test method in test example 1, by taking test group 5 as an example, control group 11-14 is set.Control group and test group 5
Difference lies in：Menthol is free of in the raw material of control group 11, essence, the raw material of control group 13 are free of in the raw material of control group 12
In be free of sweetener, menthol, essence and sweetener are free of in the raw material of control group 14, its results show control group 11-14's
21 days counterpoises are worse compared with test example 5, and the counterpoise of control group 14 differs obvious compared with control group 11-13 and test example 5, explanation
Whether the food-intake of pig can be significantly affected containing sweetener in raw material, so as to influence the medicine of Chinese and Western medicine compound superfine powder
Effect.
In conclusion the Chinese and Western medicine compound superfine powder for the treatment of porcine respiratory disease provided by the invention can be covered effectively
The bitter taste of common Tilmicosin medicine, overcomes common Tilmicosin pharmaceutical preparation to cause the great difficulty of pig feed intake degradation
Point, and it is avoided that the drug resistance of Tilmicosin medicine produces.Its preparation method is simple, and condition controllability is good, and production cost is low, surely
It is qualitative good, there is good application prospect.Use it for preparing the medicine or feed for treating or preventing porcine respiratory disease, not only
Effect with preferable treatment porcine respiratory disease, influences pig feed intake also smaller.
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of preparation method for the Chinese and Western medicine compound superfine powder for treating porcine respiratory disease, it is characterised in that including following
Step：Loquat-leaf extract, Bulbus Fritillariae Cirrhosae extract, tilmicosin phosphate, menthol, essence, sucrose and auxiliary material are dissolved, then
Mix, dry, pulverize with carrier；
Preferably, it is dry using spray drying；
Preferably, the particle diameter of the Chinese and Western medicine compound superfine powder after crushing is no more than 200 mesh.
2. preparation method according to claim 1, it is characterised in that the loguat leaf extraction is dissolved under heating condition
Thing, the Bulbus Fritillariae Cirrhosae extract, the menthol, the essence, the sucrose and the auxiliary material, obtain the first mixed liquor, so
Mixed afterwards with the dissolved tilmicosin phosphate, obtain the second mixed liquor, then mixed with the carrier, dry, pulverize.
A kind of 3. Chinese and Western medicine compound superfine powder for treating porcine respiratory disease, it is characterised in that the Chinese and Western medicine compound ultra micro
Pulvis is prepared by preparation method as claimed in claim 1 or 2.
4. Chinese and Western medicine compound superfine powder according to claim 3, it is characterised in that the Chinese and Western medicine compound superfine powder
Raw material include the loquat-leaf extract of 2-50 parts by weight, the Bulbus Fritillariae Cirrhosae extract of 2-50 parts by weight, the phosphoric acid of 2-50 parts by weight
Tilmicosin, the menthol of 1-30 parts by weight, the essence of 1-30 parts by weight, the sucrose of 1-30 parts by weight, the load of 20-90 parts by weight
The auxiliary material of body and 1-50 parts by weight；
The auxiliary material includes at least one of calcium carbonate, silica and talcum powder.
5. Chinese and Western medicine compound superfine powder according to claim 4, it is characterised in that the raw material includes 20-30 weight
The loquat-leaf extract, the Bulbus Fritillariae Cirrhosae extract of 20-30 parts by weight, the phosphoric acid of 20-30 parts by weight of part replace rice
Examine star, the menthol of 10-20 parts by weight, the essence of 10-20 parts by weight, the sucrose, the 40- of 10-20 parts by weight
The auxiliary material of carrier and the 20-30 parts by weight of 60 parts by weight.
6. Chinese and Western medicine compound superfine powder according to claim 5, it is characterised in that the raw material includes 25 parts by weight
The loquat-leaf extract, the Bulbus Fritillariae Cirrhosae extract of 25 parts by weight, the tilmicosin phosphate of 25 parts by weight, 15 weight
The menthol, the essence of 15 parts by weight, the sucrose of 15 parts by weight, the carrier and 25 of 50 parts by weight of part
The auxiliary material of parts by weight.
7. Chinese and Western medicine compound superfine powder according to claim 3, it is characterised in that the carrier includes starch, corn
Any one in core powder, powdered glucose, wheat bran and rice bran.
8. Chinese and Western medicine compound superfine powder according to claim 3, it is characterised in that with the dry of the loquat-leaf extract
Dry product meter, the mass fraction of elemol and α-pilgerol amounts to and is more than or equal to 90wt% in the loquat-leaf extract；
Preferably, the mass ratio of the elemol and the α-pilgerol is 1-3：5.
9. Chinese and Western medicine compound superfine powder according to claim 3, it is characterised in that with the dry of the Bulbus Fritillariae Cirrhosae extract
Dry product meter, the mass fraction of loose shellfish alkali and fritiminine, which amounts to, in the Bulbus Fritillariae Cirrhosae extract is more than or equal to 95wt%；
Preferably, the mass ratio of the loose shellfish alkali and the fritiminine is 1-2：3-8.
10. as claim 3-9 any one of them Chinese and Western medicine compound superfine powder is preparing treatment or prevention porcine respiratory disease
Application in the medicine or feed of disease.
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| CN115316539A (en) * | 2022-09-02 | 2022-11-11 | 山东和美集团有限公司 | Nutritional feed for transition period of suckling pigs and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115316539A (en) * | 2022-09-02 | 2022-11-11 | 山东和美集团有限公司 | Nutritional feed for transition period of suckling pigs and preparation method thereof |
| CN115316539B (en) * | 2022-09-02 | 2023-10-10 | 山东和美集团有限公司 | Nutritional feed for suckling pigs in transitional period and preparation method thereof |
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Application publication date: 20180508 |