CN108042690B - Traditional Chinese medicine composition for treating swine mycoplasmal pneumonia and application thereof - Google Patents
Traditional Chinese medicine composition for treating swine mycoplasmal pneumonia and application thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating swine mycoplasmal pneumonia and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: wild buckwheat rhizome: 20-30 parts of cantharis: 5-10 parts, evergreen: 15-20 parts of dragon tongue leaves: 10-20 parts of aristolochia: 10-20 parts of earthworm: 10-20 parts of borneol: 2-8 parts. The cataplasm takes the traditional Chinese medicine composition as the only active ingredient. The using method comprises the following steps: the cataplasma is applied to Tianmen acupoint, Suqi acupoint and Feishu acupoint on two sides of affected pig. The effective rate and the cure rate of the invention are both high and respectively reach 95 percent and 80 percent.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating swine mycoplasma pneumonia and application thereof.
Background
Mycoplasma hyopneumoniae is also called mycoplasmal pneumonia of swine, and is a chronic and contact respiratory infectious disease caused by mycoplasma hyopneumoniae. The main clinical symptoms are cough and asthma, and the anatomical changes are the symmetrical deterioration of the tip, heart and diaphragm of the lung. According to different disease conditions, the clinical treatment is divided into three types, acute type, chronic type and recessive type. Acute types are commonly found in newly-built pig farms and newly-infected swineries, and are commonly found in piglets, pregnant sows and lactating sows. Sudden pig attack, severe cough and asthma, depression, much loss of appetite, slightly high body temperature, obvious abdominal respiration, a dog sitting posture and few and low cough times. The chronic type is mostly transformed from the acute type, and is mostly seen in setting pigs, fattening pigs and replacement gilts in the old epidemic areas. The clinical symptoms are long-term cough, asthma and spasmodic cough, obvious air temperature sudden change, morning and evening and after sports eating, and abdominal respiration. When the resistance of the organism is reduced under the conditions of poor feeding and management conditions, poor feed quality, cold and damp pig house, poor ventilation, crowding and sudden change of environmental conditions, the mycoplasma pneumonia of the pig is caused to occur or symptoms are aggravated. The disease is widely prevalent in the world, has high incidence rate and is difficult to eradicate, the growth of the sick pigs is slow, the utilization rate of feed is low, and the fattening feeding period is prolonged.
At present, although the mycoplasma hyopneumoniae attenuated vaccine exists clinically, mycoplasma can change surface antigens to cause immune escape, so that the immunity is weak. In addition, the immunization route using thoracic injection requires a very high professional manipulation technique, and thus is limited in its popularization and application. Therefore, mycoplasma prevention and treatment in pig farms are mainly drug therapy, but drug resistance is easily generated by antibiotic therapy, drug residue time is long, growth of swinery is seriously affected, and economic loss is caused. Most of the traditional Chinese veterinary medicine preparations are powder preparations which are required to be taken by mixing materials. Because the taste sense of the pigs is sensitive, the taste of the traditional Chinese medicine often influences the palatability of the feed and the ingestion of the pigs, and the enough dosage is difficult to ensure.
Disclosure of Invention
Aiming at the problems of poor effect, inconvenient use and the like in the prior art, the invention provides a traditional Chinese medicine composition for treating swine mycoplasma pneumonia.
The invention also provides a cataplasm for treating the mycoplasma pneumonia of swine.
The invention also provides a preparation method of the cataplasm for treating the mycoplasma pneumonia of the swine.
The invention also provides a use method of the cataplasm for treating the mycoplasma pneumonia of the swine.
In order to achieve the purpose of the invention, the embodiment of the invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating mycoplasma pneumonia of swine comprises the following components in parts by weight: wild buckwheat rhizome: 20-30 parts of cantharis: 5-10 parts, evergreen: 15-20 parts of dragon tongue leaves: 10-20 parts of aristolochia: 10-20 parts of earthworm: 10-20 parts of borneol: 2-8 parts.
The traditional veterinary medicine considers that the mycoplasma pneumonia of swine belongs to the syndrome of lung heat caused by the invasion of pathogenic heat toxin (i.e. mycoplasma). Pathogenic heat accumulates in the lung and affects the dispersing function of the lung, resulting in failure of lung qi to disperse and cough and asthma; the lung's dispersing and hair weakening, food essence is difficult to nourish the skin and hair, and there appears thin hair and scorched hair. Lung heat accumulation can lead to up-flaming of lung fire, swollen and sore throat, lung swelling, necrosis and excess change.
Compared with the prior art, the traditional Chinese medicine composition for treating swine mycoplasmal pneumonia provided by the invention has the effects of clearing away heat and toxic materials, promoting blood circulation and removing carbuncles, and the wild buckwheat rhizome, the cantharis and the rohdea japonica are adopted. The composition can clear lung heat, eliminate lung and respiratory tract inflammation, slow down blood stasis and carbuncle swelling caused by inflammation and achieve the effect of detumescence, and is used as a main drug in the composition; ma Dou Ling can clear lung heat and descend qi, Long Li Ye can clear heat and moisten lung, resolve phlegm and stop cough. The two ingredients assist the wild buckwheat rhizome to clear away lung heat, play roles of relieving cough, relieving asthma, eliminating phlegm and resisting inflammation, and are used as auxiliary medicines together in the composition; pheretima aspergillum has effects of clearing heat, calming endogenous wind, relieving asthma, and promoting urination, and can be used as adjuvant drug in the composition for further relieving cough and asthma; borneol can clear heat and relieve pain, and more importantly, can penetrate skin, can guide other medicines to penetrate into acupuncture points and guide the medicines to enter meridians, and can be used as a messenger medicine in the composition.
Furthermore, the invention also provides a cataplasm for treating swine mycoplasmal pneumonia, wherein the traditional Chinese medicine composition of the cataplasm serves as the only active ingredient.
The cataplasm for treating the mycoplasma pneumonia of the swine, which is provided by the invention, adopts the water-soluble high polymer as the external patch of the matrix framework material, has the advantages of large drug-loading rate, strong moisture retention, good compatibility with the skin and aging resistance; the patch can be repeatedly torn off and the administration can be stopped at any time; the dosage is accurate, the blood concentration is balanced without peak-valley phenomenon, and the toxic and side effects can be reduced; no organic solvent pollution in industrial production, and meets the requirement of environmental protection.
Further, the invention also provides a preparation method of the cataplasm for treating swine mycoplasmal pneumonia, which at least comprises the following steps:
(1) weighing the components according to the raw material ratio of the traditional Chinese medicine composition for treating swine mycoplasmal pneumonia;
(2) dissolving the borneol into a blank matrix of the cataplasm;
(3) pulverizing rhizoma Fagopyri Dibotryis, Mylabris, Rohdea Japonica, folium et cacumen Draconis, fructus Aristolochiae, and Lumbricus, and adding into the cataplasma blank matrix to obtain cataplasma for treating mycoplasma hyopneumoniae.
Compared with the prior art, the cataplasm for treating the swine mycoplasmal pneumonia provided by the invention takes the cataplasm as a carrier to treat the swine mycoplasmal pneumonia, does not influence the ingestion of pigs, and has little residue.
Accordingly, the invention provides a use method of the cataplasm for treating swine mycoplasmal pneumonia, which comprises the following steps: the cataplasma is applied to Tianmen acupoint, Suqi acupoint and Feishu acupoint on both sides of affected pig.
Compared with the prior art, the application method is simple, the surface antigen is not changed to cause immune escape, the immunity is weak, a high professional operation technology is not needed, the ingestion of the pig is not influenced, and the application method is suitable for industrial production and large-scale popularization and application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The embodiment of the invention provides a traditional Chinese medicine composition for treating swine mycoplasmal pneumonia, which comprises the following components in parts by weight: wild buckwheat rhizome: 20-30 parts of cantharis: 5-10 parts, evergreen: 15-20 parts of dragon tongue leaves: 10-20 parts of aristolochia: 10-20 parts of earthworm: 10-20 parts of borneol: 2-8 parts.
Compared with the prior art, the traditional Chinese medicine composition for treating swine mycoplasmal pneumonia provided by the invention has the effects of clearing away heat and toxic materials, promoting blood circulation and removing carbuncles, and the wild buckwheat rhizome, the cantharis and the rohdea japonica are adopted. The composition can clear lung heat, eliminate lung and respiratory tract inflammation, slow down blood stasis and carbuncle swelling caused by inflammation and achieve the effect of detumescence, and is used as a main drug in the composition; ma Dou Ling can clear lung heat and descend qi, Long Li Ye can clear heat and moisten lung, resolve phlegm and stop cough. The two ingredients assist the wild buckwheat rhizome to clear away lung heat, play roles of relieving cough, relieving asthma, eliminating phlegm and resisting inflammation, and are used as auxiliary medicines together in the composition; pheretima aspergillum has effects of clearing heat, calming endogenous wind, relieving asthma, and promoting urination, and can be used as adjuvant drug in the composition for further relieving cough and asthma; borneol can clear heat and relieve pain, and more importantly, can penetrate skin, can guide other medicines to penetrate into acupuncture points and guide the medicines to enter meridians, and can be used as a messenger medicine in the composition.
Particularly preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: wild buckwheat rhizome: 20-25 parts of cantharis: 7-9 parts, rohdea japonica: 16-18 parts of dragon tongue leaves: 12-17 parts of aristolochia debilis: 12-17 parts of earthworm: 12-17 parts, borneol: 3-7 parts.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: wild buckwheat rhizome: 25 parts of cantharis: 8 parts, evergreen: 17 parts, dragon tongue leaves: 15 parts, aristolochia debilis: 15 parts, earthworm: 15 parts, borneol: 5 parts of the raw materials.
The invention also provides a cataplasm for treating swine mycoplasmal pneumonia, wherein the traditional Chinese medicine composition is used as the only active ingredient.
The cataplasm for treating the mycoplasma pneumonia of the swine, which is provided by the invention, adopts the water-soluble high polymer as the external patch of the matrix framework material, has the advantages of large drug-loading rate, strong moisture retention, good compatibility with the skin and aging resistance; the patch can be repeatedly torn off and the administration can be stopped at any time; the dosage is accurate, the blood concentration is balanced without peak-valley phenomenon, and the toxic and side effects can be reduced; no organic solvent pollution in industrial production, and meets the requirement of environmental protection.
The invention also provides a preparation method of the cataplasm for treating swine mycoplasmal pneumonia, which at least comprises the following steps:
(1) weighing the components according to the raw material ratio of the traditional Chinese medicine composition for treating swine mycoplasmal pneumonia;
(2) dissolving the borneol into a blank matrix of the cataplasm;
(3) pulverizing rhizoma Fagopyri Dibotryis, Mylabris, Rohdea Japonica, folium et cacumen Draconis, fructus Aristolochiae, and Lumbricus, and adding into the cataplasma blank matrix to obtain cataplasma for treating mycoplasma hyopneumoniae.
Compared with the prior art, the cataplasm for treating the swine mycoplasmal pneumonia provided by the invention takes the cataplasm as a carrier to treat the swine mycoplasmal pneumonia, does not influence the ingestion of pigs, and has little residue.
Preferably, the conditions of the pulverization treatment in the step (3) are: crushing to 450-mesh and 550-mesh.
The invention also provides a use method of the cataplasm for treating swine mycoplasmal pneumonia, which comprises the following steps: the cataplasma is applied to Tianmen acupoint, Suqi acupoint and Feishu acupoint on both sides of affected pig.
Compared with the prior art, the application method is simple, the surface antigen is not changed to cause immune escape, the immunity is weak, a high professional operation technology is not needed, the ingestion of the pig is not influenced, and the application method is suitable for industrial production and large-scale popularization and application.
Preferably, the Tianmen acupoint, Suqi acupoint and Feishu acupoint on both sides of the affected pig are cut, the acupoint is cleaned with 75% alcohol, the cataplasm is applied to the above 4 acupoints simultaneously, and the application is carried out once every 22-24h for 3-5 times.
The following examples are provided to better illustrate the embodiments of the present invention.
Example 1
The embodiment provides a cataplasm for treating swine mycoplasmal pneumonia, which is prepared from the following traditional Chinese medicine compositions serving as raw materials, wherein the traditional Chinese medicine compositions comprise the following components in parts by weight: wild buckwheat rhizome: 25 parts of cantharis: 8 parts, evergreen: 17 parts, dragon tongue leaves: 15 parts, aristolochia debilis: 15 parts, earthworm: 15 parts, borneol: 5 parts of the raw materials.
The preparation method of the cataplasm comprises the following steps:
(1) weighing the components according to the raw material ratio;
(2) dissolving the borneol into a blank matrix of the cataplasm;
(3) pulverizing rhizoma Fagopyri Dibotryis, Mylabris, Rohdea Japonica, folium et cacumen Draconis, fructus Aristolochiae, and Lumbricus, pulverizing to 500 mesh, and adding the cataplasma blank matrix to obtain cataplasma for treating mycoplasma pneumonia of swine.
Example 2
The embodiment provides a cataplasm for treating swine mycoplasmal pneumonia, which is prepared from the following traditional Chinese medicine compositions serving as raw materials, wherein the traditional Chinese medicine compositions comprise the following components in parts by weight: wild buckwheat rhizome: 30 parts, cantharis: 5 parts, evergreen: 15 parts of dragon tongue leaves: 20 parts, aristolochia debilis: 10 parts, earthworm: 12 parts, borneol: 8 parts.
The preparation method of the cataplasm comprises the following steps:
(1) weighing the components according to the raw material ratio;
(2) dissolving the borneol into a blank matrix of the cataplasm;
(3) pulverizing rhizoma Fagopyri Dibotryis, Mylabris, Rohdea Japonica, folium et cacumen Draconis, fructus Aristolochiae, and Lumbricus, pulverizing to 550 mesh, and adding the cataplasma blank matrix to obtain cataplasma for treating mycoplasma pneumonia of swine.
Example 3
The embodiment provides a cataplasm for treating swine mycoplasmal pneumonia, which is prepared from the following traditional Chinese medicine compositions serving as raw materials, wherein the traditional Chinese medicine compositions comprise the following components in parts by weight: wild buckwheat rhizome: 20 parts of cantharis: 5 parts, evergreen: 20 parts, dragon tongue leaves: 10 parts, aristolochia: 20 parts, earthworm: 10 parts, borneol: 5 parts of the raw materials.
The preparation method of the cataplasm comprises the following steps:
(1) weighing the components according to the raw material ratio;
(2) dissolving the borneol into a blank matrix of the cataplasm;
(3) pulverizing rhizoma Fagopyri Dibotryis, Mylabris, Rohdea Japonica, folium et cacumen Draconis, fructus Aristolochiae, and Lumbricus, pulverizing to 450 mesh, and adding the cataplasma blank matrix to obtain cataplasma for treating mycoplasma pneumonia of swine.
To better illustrate the properties of the cataplasma for treating mycoplasma hyopneumoniae provided in the examples of the present invention, the following drug efficacy tests were performed on the cataplasma prepared in examples 1, 2 and 3.
Sick pig for experiment: the fattening pig with acute natural morbidity in a certain pig farm in a baoding full city is selected as a test animal. Sick pigs are marked by lassitude, laziness in movement, rough and lusterless fur. Rapid respiration, dyspnea with mouth opening, abdominal respiration or dog sitting posture, no obvious change in body temperature. The pigs with serious diseases are selected for the autopsy, the lesion part of the lung of the sick pigs has obvious boundary, and the front ventral side leaves are in the solid appearance from purple red to gray. The section and alveoli were indistinct and became tender. The mycoplasma infection is confirmed by laboratory diagnosis of collected disease material.
The tested drugs are: cataplasma for the treatment of mycoplasma hyopneumoniae prepared in examples 1-3; the reference medicine is Maxingshigan powder produced by Dahua nong biotechnology, Inc., West, Guangdong.
Test grouping and treatment: from the sick pigs confirmed to be mycoplasma pneumonia, 100 sick pigs with basically consistent disease course are selected and randomly divided into 5 groups, and each group has 20 pigs. Wherein, 1 group, 2 groups and 3 groups are treatment groups of the invention, the Tianmen acupoint, Suqi acupoint and Feishu acupoint (the intersection of the penultimate intercostal and the iliocostal groove, the left and right 1 acupoints) of each sick pig are sheared, 75% alcohol cotton is used for cleaning the acupoints, the prepared cataplasm is simultaneously applied to the 4 acupoints, and the treatment groups are replaced once in 24 hours and are used for 5 times continuously; the 4 groups are Maxingshigan powder control groups, and are fed in a mixed manner at a dose of 2g/kg body weight per head per day for 5 days; group 5 is a no-drug control group. The sick pigs are independently raised, and are managed by a specially-assigned person to eat and drink water freely. The therapeutic effect of the sick pigs of each group according to the therapeutic effect judgment criteria is shown in the following table 1.
The criteria for therapeutic effect are as follows:
and (3) curing: after administration, the clinical symptoms of asthma, cough, abdominal respiration and the like of the sick pigs completely disappear, the spirit, the appetite and the like are recovered to be normal, and relapse is not found within 7 days after the administration is stopped.
The method has the following advantages: after administration, the clinical symptoms of asthma, cough, abdominal respiration and the like of the sick pigs are relieved or temporarily disappeared, but relapse occurs within 7 days after the administration is stopped.
And (4) invalidation: after administration, clinical symptoms of the sick pigs have no obvious change, even have serious symptoms or death.
TABLE 1 therapeutic Effect of the groups of sick pigs
The test results show that the traditional Chinese medicine of the invention and the traditional Chinese medicine of the ephedra, almond and licorice powder have good treatment effect on the mycoplasma pneumonia of swine, and the effective rate and the cure rate are both remarkably higher than those of a control group without medicines (P is less than 0.01). The effective rate and the cure rate of the traditional Chinese medicine of the invention are respectively 95% and 80%, and the cure rate is obviously higher than that of the traditional Chinese medicine of Maxingshigan powder (P is less than 0.05).
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (7)
1. A traditional Chinese medicine composition for treating swine mycoplasmal pneumonia is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by weight: wild buckwheat rhizome: 20-30 parts of cantharis: 5-10 parts, evergreen: 15-20 parts of dragon tongue leaves: 10-20 parts of aristolochia: 10-20 parts of earthworm: 10-20 parts of borneol: 2-8 parts.
2. The traditional Chinese medicine composition for treating swine mycoplasmal pneumonia of claim 1, wherein the traditional Chinese medicine composition comprises: the traditional Chinese medicine composition comprises the following components in parts by weight: wild buckwheat rhizome: 20-25 parts of cantharis: 7-9 parts, rohdea japonica: 16-18 parts of dragon tongue leaves: 12-17 parts of aristolochia debilis: 12-17 parts of earthworm: 12-17 parts, borneol: 3-7 parts.
3. The traditional Chinese medicine composition for treating swine mycoplasmal pneumonia of claim 1, wherein the traditional Chinese medicine composition comprises: the traditional Chinese medicine composition comprises the following components in parts by weight: wild buckwheat rhizome: 25 parts of cantharis: 8 parts, evergreen: 17 parts, dragon tongue leaves: 15 parts, aristolochia debilis: 15 parts, earthworm: 15 parts, borneol: 5 parts of the raw materials.
4. A cataplasm for treating swine mycoplasmal pneumonia, which is characterized by comprising the following components in percentage by weight: the cataplasm uses the traditional Chinese medicine composition as the only active ingredient in any one of claims 1 to 3.
5. A preparation method of a cataplasm for treating swine mycoplasma pneumonia is characterized by comprising the following steps: at least comprises the following steps:
(1) weighing the components according to the raw material proportion of the traditional Chinese medicine composition for treating swine mycoplasmal pneumonia according to any one of claims 1 to 3;
(2) dissolving the borneol into a blank matrix of the cataplasm;
(3) pulverizing rhizoma Fagopyri Dibotryis, Mylabris, Rohdea Japonica, folium et cacumen Draconis, fructus Aristolochiae, and Lumbricus, and adding into the cataplasma blank matrix to obtain cataplasma for treating mycoplasma hyopneumoniae.
6. The method of preparing a cataplasm of claim 5 for use in the treatment of mycoplasma hyopneumoniae, wherein: the conditions of the crushing treatment in the step (3) are as follows: crushing to 450-mesh and 550-mesh.
7. The cataplasm of claim 4 for use in the treatment of mycoplasma hyopneumoniae: the cataplasma is applied to Tianmen acupoint, Suqi acupoint and Feishu acupoint on two sides of affected pig.
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