CN102772478B - Traditional Chinese medicine granule for enhancing immunity of livestock and poultry - Google Patents
Traditional Chinese medicine granule for enhancing immunity of livestock and poultry Download PDFInfo
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Abstract
The invention discloses Chinese medicinal granule for enhancing immunity of livestock and poultry. The Chinese medicinal granule is prepared from the following materials by weight: 10-80 parts of Radix Isatidis, 10-80 parts of Radix Astragali and 10-40 parts of Herba Epimedii by soaking, decocting twice, concentrating decoction, adding water-soluble adjuvants 20-120 and binder 2-40, granulating, and drying. Through dosage form improvement, the inventive granule can be stored with stable medicinal effect without adding any preservative. Unnecessary impurities are removed to improve absorption rate of effective medicinal ingredients by animals. Meanwhile, application range to target animals is widened, such as pig, chicken, duck, etc.
Description
Technical field
The present invention relates to medicine for animals, be specifically related to a kind of Chinese medicine granules that strengthens poultry immunity of organisms.
Background technology
Along with the fast development of intensive, the scale of China's aquaculture, livestock and poultry pestilence is more and more.Serious infectious diseases, as swine fever, foot and mouth disease, bird flu, pig blue-ear disease happen occasionally, cause huge economic loss to aquaculture, also cause the worry of people to animal foodstuff safety simultaneously.There is different types and hypotype in many livestock and poultry sexually transmitted disease (STD) poison that cause, and in continuous variation, its variant toxicity is stronger.
Vaccine immunity is one of measure of prevention livestock and poultry, and during vaccine immunity, vaccine used must comprise that all Virus Types and hypotype that this area is popular just can play good preventive effect.Due to bacterial strain, serotype difference and immunogenic impact, add Lou and exempt from, operate the artificial origins such as lack of standardization, immune effect of vaccine is greatly affected.
In breeding production process, the medicines such as antibiotic are long-term to be added and a large amount of use, antiviral drugs abuse phenomenon is more common, though disease is necessarily controlled, new problem has occurred: growth of animals or poultry is suppressed, medicine is residual in body destroys feeding environment, ecological environment simultaneously.Some lawless person, in order to pursue economic benefit, uses forbidden drug, as: clenbuterol hydrochlorides etc. improve growth of animal performance, to animal husbandry, bring serious crisis, to social stability, cause and have a strong impact on.These problems not only hinder the development of animal husbandry, final health that also can be insulting.In addition, due to many countries and regions, all to antibiotic, the application on food animal is limited, European Union just completely forbade and beverage, adds antibiotic from 2006, and international " Green Trade Barrier " is more and more obvious, and Zhe Dui China animal husbandry aquaculture proposes institute's stern challenge.Therefore, the efficient green bio veterinary drug of research and development new type of safe is not only the needs of animal husbandry self-growth, is more related to social harmonious development.
Chinese herbal medicine can carry out omnibearing adjusting to the nerve of body, body fluid and cellular and molecular level.The healthy energy that traditional Chinese veterinary medicine refers to, actual is exactly the immunologic function of body.Because much Chinese medicine and prescription all contain glycoside, alkaloid, polysaccharide, organic sugar, volatilization wet goods immunologic active material, therefore can activate cell and the immunity system of body, improve the resistance against diseases of body, reach the object of disease preventing and treating.It is the rule for the treatment of that herbal control virus generally be take heat-clearing and toxin-vanquishing, strengthening vital QI to eliminate pathogenic factors.Application number is that 200910068740.8 Chinese invention patent application discloses a kind of oral liquid for strengthening healthy energy and relieving internal heat containing Radix Isatidis, the Radix Astragali, Herba Epimedii, it has obvious curative effect at treatment chicken bursal disease, but because the volume of oral liquid is large, quality heavily makes transportation inconvenience.Not perishable for making in transportation, in storage and transportation, added antiseptic, the pH value of oral liquid is changed, and redox reaction so that effective ingredient easily occur in liquid environment produce decomposition or sedimentation and lost efficacy, even cause the poisoning potential hazard that waits of animal.
Summary of the invention
The object of the invention is to overcome the defect of above-mentioned prior art, provide a kind of Chinese medicine granules that strengthens poultry immunity of organisms, the immunity that its storage does not need to add any antiseptic, convenient transportation, efficacy stability, animal absorbance is high and can effectively improves poultry body.
For achieving the above object, the present invention adopts following technical scheme:
Strengthen a Chinese medicine granules for poultry immunity of organisms, it is characterized in that making according to the following steps in turn:
1) soak: get by weight 10～40 parts of 10～80 parts of Radix Isatidis, 10～80 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, the extraction fluid extract that to be concentrated into 65 ℃ of relative densities be 1.15～1.40;
5) add 20～120 parts of water soluble adjuvants and 2～40 parts of binding agents, granulation, dry.
Preferably, 60 parts of Radix Isatidis by weight in step 1), 60 parts of the Radixs Astragali, 30 parts of Herba Epimedii.
Preferably, described water soluble adjuvant is one or more mixing in sucrose, glucose, lactose.
Preferably, described binding agent is that one or both in polyvidone, dextrin, Polyethylene Glycol, soluble starch are through upper mixing.
Preferably, extract after fluid extract is first spray dried to extract powder and add water soluble adjuvant again in step 5), after granulating, first coating is dry again.
Preferably, in step 5), the addition of water soluble adjuvant is 120 parts, and the addition of binding agent is 2 parts.
Preferably, in step 5), adopt oscillating granulation or fluidized bed granulation.
Compared with prior art, the invention has the beneficial effects as follows:
1, by after the improvement of dosage form, efficacy stability, and removed unnecessary impurity, and increased the absorbance of animal to active drug composition, expanded the range of application of target animals, as being applied to pig, chicken, duck etc. simultaneously;
2, Chinese medicine granules of the present invention is easily preserved, and does not need to add any antiseptic;
3, Chinese medicine granules of the present invention is different from Chinese medicine oral liquid or injection and need to repeatedly extracts or add like that ethanol and make its precipitation or cold preservation precipitation in leaching process, can better preserve the effective ingredient of former Chinese crude drug and save energy consumption and resource, being adapted at applying in veterinary drug manufacturing enterprise.
The specific embodiment
Below by specific embodiment, a kind of Chinese medicine granules that strengthens poultry immunity of organisms of the present invention is described in further detail.
Embodiment 1
A Chinese medicine granules that increases poultry immunity of organisms, it makes in turn according to the following steps:
1) soak: get by weight 30 parts of 60 parts of Radix Isatidis, 60 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak half an hour;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, the extraction fluid extract that to be concentrated into 65 ℃ of relative densities be 1.35;
5) add 120 parts of sucrose and 2 parts of mix homogeneously of dextrin, make soft material, then granulate, be drying to obtain product by oscillating granulator.
Embodiment 2
A Chinese medicine granules that increases poultry immunity of organisms, it makes in turn according to the following steps:
1) soak: get by weight 10 parts of 10 parts of Radix Isatidis, 10 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak half an hour;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, the extraction fluid extract that to be concentrated into 65 ℃ of relative densities be 1.40;
5) add 20 parts of lactose and 5 parts of mix homogeneously of polyvidone, make soft material, then granulate, be drying to obtain product by fluidised bed granulator.
Embodiment 3
A Chinese medicine granules that increases poultry immunity of organisms, it makes in turn according to the following steps:
1) soak: get by weight 40 parts of 80 parts of Radix Isatidis, 80 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak half an hour;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, be concentrated into the extraction fluid extract that relative density is 1.15 in the time of 65 ℃;
5) the dry extract powder that obtains of spraying; in extract powder, add again 40 parts of (being equivalent to 20 parts of polyvidones) mix homogeneously of polyvidone liquid that 35 parts of lactose and 20 parts, dextrin and mass percent are 5%; make soft material, then granulate, be drying to obtain product by oscillating granulator.
Embodiment 4
A Chinese medicine granules that increases poultry immunity of organisms, it makes in turn according to the following steps:
1) soak: get by weight 10 parts of 30 parts of Radix Isatidis, 30 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak half an hour;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, be concentrated into the extraction fluid extract that relative density is 1.40 in the time of 65 ℃;
5) spraying is dried to obtain extract powder; in extract powder, add again 20 parts of (being equivalent to 10 parts of polyvidones) mix homogeneously of polyvidone liquid that 20 parts of lactose, 5 parts of polyvidones, 7 parts of Polyethylene Glycol, mass fraction are 5%; make soft material; by oscillating granulator granulation, employing shot-blasting machine ball blast, recycling bed spray polyglycol solution carries out being drying to obtain product after coating again.
Embodiment 5
A Chinese medicine granules that increases poultry immunity of organisms, it makes in turn according to the following steps:
1) soak: get by weight 20 parts of 50 parts of Radix Isatidis, 50 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak half an hour;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, be concentrated into the extraction fluid extract that relative density is 1.20 in the time of 65 ℃;
5) in fluid bed, add 25 parts, 50 parts of glucoses and dextrin mix homogeneously, utilize fluid bed to spray into and extract fluid extract granulation, be drying to obtain product.
Embodiment 6
A Chinese medicine granules that increases poultry immunity of organisms, it makes in turn according to the following steps:
1) soak: get by weight 15 parts of 40 parts of Radix Isatidis, 40 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak half an hour;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, be concentrated into the extraction fluid extract that relative density is 1.20 in the time of 65 ℃;
5) spraying is dried to obtain extract powder; in extract powder, add again the polyvidone liquid 30 parts (being equivalent to 15 parts of polyvidones) that 45 parts of lactose, 5 parts of polyvidones, 5 parts of Polyethylene Glycol, mass fraction are 5% to close evenly; make soft material; by oscillating granulator granulation, employing shot-blasting machine ball blast, recycling bed spray polyglycol solution carries out being drying to obtain product after coating again.
Below by a kind of clinical efficacy that strengthens the Chinese medicine granules of poultry immunity of organisms of zoopery explanation the present invention.
Embodiment 7
1. experimental technique
Choose the morbidity chicken group at certain cultivation chicken family, 100 of Sanhuang chicken that therefrom select and do not used any Drug therapy, are diagnosed as infectious bursal disease through clinical observation, laboratory diagnosis, are divided into 2 groups at random, i.e. experimental group and matched group, 50 every group.Experimental group adds the Chinese medicine granules of the enhancing poultry immunity of organisms that embodiment 1 makes in drinking-water, gives mixed drink in the quantity set of 1g by every chicken; Matched group gives 1g Fuzheng Jiedu powder (prepare voluntarily by the Fuzheng Jiedu powder requirement of Chinese veterinary pharmacopoeia, its formula is Radix Isatidis 60g, Radix Astragali 60g, Herba Epimedii 30g) by every chicken; Two groups of feedings and managements are identical, and continuous use is 3 days separately, stop observation post administration 1 week.
2. curative effect judgement
Cure: at duration of test, test chicken after administration, lassitude, diarrhoea, row is faint yellow or the clinical symptoms such as linen not sample loose stool, dehydration all disappears and spirit, appetite, feces, breathing etc. to recover normal be healing.According to healing chicken number, account for the percentage calculation cure rate of every group of test chicken number of elements.
Effective: all at experimental session, after chicken medication, the spirit of test chicken, appetite, breathing are clearly better as effectively.
Invalid: duration of test, there is classical symptom the death of infectious bursal disease in test chicken, after necropsy, visible chest muscle, lower limb flesh, glandular stomach, kidney and bursal disease etc. have the change of typical feature disease, all can be judged to be infection death or symptom and do not alleviate or continue deterioration for invalid.
3. experimental result: show through clinical observation on the therapeutic effect statistics: the cure rate of experimental group is 82.0%(41/50), effective percentage is 97.0%(47/50), inefficiency 6.%(3/50), matched group be respectively 70.0%(35/50), 86%(43/50), 14%(7/50).
4. experiment conclusion: the cure rate of experimental group is higher by 12.0% than matched group, difference is (p<0.01) extremely significantly, and the Chinese medicine granules of enhancing fowl poultry immunity of organisms of the present invention is having better clinical effectiveness than existing powder aspect treatment chicken bursal disease as can be seen here.
Experimental example 8
1. experimental technique
Choose the morbidity duck group of certain cultivation duck field, 200 of Muscovy duck that therefrom select and do not used any Drug therapy, are diagnosed as oromeningitis through clinical observation, laboratory diagnosis, are divided into 2 groups at random, i.e. experimental group and matched group, 100 every group.Experimental group adds the Chinese medicine granules of the enhancing poultry immunity of organisms that embodiment 1 makes in drinking-water, gives mixed drink in the quantity set of 1g by every duck; Matched group gives 1g Fuzheng Jiedu powder (preparing voluntarily by the Fuzheng Jiedu powder requirement of Chinese veterinary pharmacopoeia, i.e. Radix Isatidis 60g, Radix Astragali 60g, Herba Epimedii 30g) by every duck; Two groups of feedings and managements are identical, and continuous use is 3 days separately, stop observation post administration 1 week.
2. curative effect judgement
Cure: at duration of test, test Muscovy duck after administration, clinical symptoms all disappears and spirit, appetite, feces, breathing etc. to recover normal be healing.According to curing Muscovy duck number of elements, account for every group of percentage calculation cure rate of testing Muscovy duck number.
Effective: all at experimental session, after Muscovy duck medication, spirit, appetite, the breathing of test Muscovy duck are clearly better as effectively.
Invalid: duration of test, oromeningitis classical symptom dead appears in test Muscovy duck, has typical feature pathological changes after necropsy, all can be judged to be infection death or symptom and does not alleviate or continue deterioration for invalid.
3. experimental result
Through clinical observation on the therapeutic effect statistics, show: the cure rate of experimental group is 87.0% (87/100), effective percentage is 98.0%(98/100), inefficiency 2.0% (2/100), matched group be respectively 77.0%(77/100), 89%(89/100), 11%(11/100).
4. experiment conclusion
The cure rate of experimental group is higher by 10.0% than matched group, and difference is (p < 0.01) extremely significantly, and Fuzheng Jiedu granule sample is embodying the clinical effectiveness better than powder aspect treatment Muscovy duck oromeningitis as can be seen here.
Embodiment 9
1. experimental technique
Choose that certain large-scale pig farm is basic identical from numerous autotrophy, feeding and management condition, birth age in days is close, infect 100 of the growing and fattening pigs of respiratory tract disease, be divided at random 2 groups, be i.e. experimental group and matched group, 50 every group.Experimental group adds by feedstuff per ton the Chinese medicine granules that 2500g10% tilmicosin pre-mixing agent+500g makes by embodiment 1; Matched group adds 2500g 10% tilmicosin pre-mixing agent by feedstuff per ton; Each is organized medicine and uses 5 days continuously, and feeding and management is identical.
Cure: at duration of test, piglet, after administration, coughs, breathes, ventral breathing, mouth and nose flow out foam sample liquid, and lassitude, is reluctant to walk about, and the clinical symptoms such as loss of appetite all disappear.According to every group, cure the ratio calculating cure rate that pig's head number accounts for total group test pig's head number.
Invalid: at duration of test, test pig occurs that death or clinical symptoms do not disappear.The ratio that accounts for total group test pig's head number according to every group of pig's head number that does not have to cure calculates inefficiency.
Effective: symptom alleviates, after drug withdrawal, there is recurrence.
Experimental result: show through clinical observation on the therapeutic effect statistics: the cure rate of experimental group is 92.0% (46/50), effective percentage is 98.0%(49/50), inefficiency 2.0% (1/50), matched group be respectively 78.0%(39/50), 82%(41/50), 18%(9/50).
Experiment conclusion: the cure rate of experimental group is higher by 14.0% than matched group, difference is (p < 0.01) extremely significantly, and the Chinese medicine granules of enhancing poultry immunity of organisms of the present invention is embodying the clinical effectiveness better than powder aspect treatment porcine respiratory disease thus.
Above-described embodiment is only the preferred embodiment of the present invention, can not limit protection scope of the present invention with this, and the variation of any unsubstantiality that those skilled in the art does on basis of the present invention and replacement all belong to protection scope of the present invention.
Claims (1)
1. strengthen a Chinese medicine granules for poultry immunity of organisms, it is characterized in that making according to the following steps in turn:
1) soak: get by weight 10～40 parts of 10～80 parts of Radix Isatidis, 10～80 parts of the Radixs Astragali, Herba Epimedii and add water and do not have medical material to soak;
2) do not decoct person for the first time: boil that rear maintenance is micro-boils 1.5 hours;
3) decoct for the second time: filter, add water and do not have filtering residue to boil that rear maintenance is micro-boils 1 hour;
4) merge the filtrate of first and second decoction, be concentrated into the extraction fluid extract that relative density is 1.15～1.40 in the time of 65 ℃;
5) add water soluble adjuvant 20-120 part and binding agent 2-40 part, granulation, dry;
Described water soluble adjuvant is one or more mixing in sucrose, glucose, lactose;
Described binding agent is that one or both in polyvidone, dextrin, Polyethylene Glycol, soluble starch are through upper mixing;
In step 5), extract after fluid extract is first spray dried to extract powder and add water soluble adjuvant again, after granulating, first coating is dry again.
2. the Chinese medicine granules of enhancing as claimed in claim 1 poultry immunity of organisms, is characterized in that: 60 parts of Radix Isatidis by weight in step 1), 60 parts of the Radixs Astragali, 30 parts of Herba Epimedii.
3. the Chinese medicine granules of enhancing poultry immunity of organisms as claimed in claim 1, is characterized in that: in step 5), the addition of water soluble adjuvant is 120 parts, and the addition of binding agent is 2 parts.
4. the Chinese medicine granules of enhancing poultry immunity of organisms as claimed in claim 1, is characterized in that: in step 5), adopt oscillating granulation or fluidized bed granulation.
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102895295A (en) * | 2012-11-09 | 2013-01-30 | 河南牧翔动物药业有限公司 | Preparation method of compound traditional Chinese medicine extract for veterinary use |
| CN103393738B (en) * | 2013-07-29 | 2015-07-22 | 河南中医学院 | Traditional Chinese medicine composition for preventing influenza A viruses H1N1 |
| CN103494038B (en) * | 2013-09-30 | 2015-08-05 | 江苏省淡水水产研究所 | Anti-white spot syndrome virus Chinese medicine immunity enhancer of a kind of Procambius clarkii and its preparation method and application |
| CN103720779B (en) * | 2014-01-06 | 2016-04-20 | 四川德润通生物科技有限公司 | The Fuzheng Jiedu superfine powder of high stable |
| CN104642256A (en) * | 2015-02-10 | 2015-05-27 | 河南普尼尔生物制药有限公司 | Fifty-fifty pig-raising method |
| CN104887761A (en) * | 2015-06-07 | 2015-09-09 | 胡凡兴 | Herba siegesbeckiae active juice livestock and poultry nutritional type traditional Chinese medicine |
| CN106265869A (en) * | 2015-06-12 | 2017-01-04 | 北京大北农动物保健科技有限责任公司 | A kind of Fuzheng Jiedu granule, containing its feedstuff and purposes |
| CN106176900A (en) * | 2016-08-11 | 2016-12-07 | 扬中牧乐药业有限公司 | The preparation method of granule is exempted from excessive yellow increasing |
| CN106943514A (en) * | 2017-04-06 | 2017-07-14 | 安徽天安生物科技股份有限公司 | Treat Chinese medicine of avian nephropathogenic infectious bronchitis and preparation method thereof |
| CN110604757A (en) * | 2018-06-15 | 2019-12-24 | 北京中农劲腾生物技术股份有限公司 | Compound preparation for strengthening body resistance and detoxifying, and preparation method and application thereof |
| CN111920844A (en) * | 2020-08-04 | 2020-11-13 | 安徽天安生物科技股份有限公司 | Production process of body resistance strengthening and detoxifying powder |
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| CN101879209A (en) * | 2009-05-05 | 2010-11-10 | 天津市天合力药物研发有限公司 | Oral liquid for strengthening healthy energy and relieving internal heat or fever for animals |
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Effective date of registration: 20160623 Address after: 527400 Yunfu City, Xinxing County Province, the new town of North East embankment road, No. 6 Patentee after: GUANGDONG WENS DAHUANONG BIOTECHNOLOGY CO., LTD. Address before: 527400, No. 2, Wen Science Park, east north embankment road, Xinxing County new town, Guangdong, Yunfu, three Patentee before: Guangdong Dahuanong Animal Health Products Co., Ltd. Patentee before: Zhaoqing Dahuanong Biological Pharmaceutical Co., Ltd. |