CN108743923A - A kind of compound preparation and preparation method thereof for the antiviral raising immunity of livestock and poultry - Google Patents

A kind of compound preparation and preparation method thereof for the antiviral raising immunity of livestock and poultry Download PDF

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Publication number
CN108743923A
CN108743923A CN201810684652.XA CN201810684652A CN108743923A CN 108743923 A CN108743923 A CN 108743923A CN 201810684652 A CN201810684652 A CN 201810684652A CN 108743923 A CN108743923 A CN 108743923A
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parts
extract
livestock
poultry
preparation
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李启程
丁大明
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HENAN DEFANG BIOLOGICAL PHARMACEUTICAL Co Ltd
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HENAN DEFANG BIOLOGICAL PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/808—Scrophularia (figwort)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

The invention belongs to feed additive fields, disclose a kind of for the antiviral compound preparation and preparation method thereof for improving immunity of livestock and poultry.It is to be grouped as by following groups in terms of 100 parts by the sum of parts by weight：5-10 parts of peptide rhzomorph, 1-3 parts of chitosan oligosaccharide, 3-5 parts of Swine spleen transfer factor, 10-25 parts of shikimic acid, 5-10 parts of Echinacea Purpurea Herb P.E, 5-10 parts of Flos Chrysanthemi Indici extract, 10-20 parts of Hypericum Perforatum P.E, 2-5 parts of calculus bovis factitius, 5-10 parts of yam extract, extract 5-10 parts antipyretic and detoxicated, DEXTROSE ANHYDROUS complement to 100 parts.The use in conjunction of the above drug, the interference and duplication of virus can not only be resisted, have to virosis and treats and prevents effect well, the immunity of body can be also improved simultaneously, reduce the Probability of life cycle inner virus disease, it is raw materials used be safely, effectively, the green product of noresidue, therefore be good anti-virus product for raiser.

Description

A kind of compound preparation and preparation method thereof for the antiviral raising immunity of livestock and poultry
Technical field
The invention belongs to feed additive fields, and in particular to a kind of for the antiviral compound system for improving immunity of livestock and poultry Agent and preparation method thereof.
Background technology
In current livestock breeding industry, most allow raiser's headache be no more than various diseases.The livestock and poultry of cultivation are due to length Phase in enclosed environment, the feed that edible function is single and constitution is weaker, to the lower for the resistance of various diseases.Especially exist In winter, viral disease is serious, and the farm caused is annihilated, and raiser is made to have suffered great economic loss.
Viral disease is always to perplex the problem of farm, and the disabling of people's antiviral drugs makes the prevention face of virosis Face new challenge, how to make it is a kind of not only can be antiviral well, but also the immunity of body can be improved, reduce entire life The generation of virosis in the process, while the health of the mankind can not be endangered again, it is the problem of we pay close attention to always.
Invention content
In view of the above-mentioned defects in the prior art with deficiency, the purpose of the present invention is to provide one kind to carry for livestock and poultry to be antiviral The compound preparation and preparation method thereof of high immunity.
To achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of compound preparation for the antiviral raising immunity of livestock and poultry is in terms of 100 parts, by following components by the sum of parts by weight Composition：5-10 parts of peptide rhzomorph, 1-3 parts of chitosan oligosaccharide, 3-5 parts of Swine spleen transfer factor, 10-25 parts of shikimic acid, Echinacea Purpurea Herb P.E 5- 10 parts, 5-10 parts of Flos Chrysanthemi Indici extract, 10-20 parts of Hypericum Perforatum P.E, 2-5 parts of calculus bovis factitius, 5-10 parts of yam extract, Antipyretic and detoxicated extract 5-10 parts, DEXTROSE ANHYDROUS complement to 100 parts.
In the present invention, the peptide rhzomorph, Swine spleen transfer factor, Echinacea Purpurea Herb P.E, Flos Chrysanthemi Indici extract, hypericum perforatum carry Take object, yam extract, antipyretic and detoxicated extract（Prescription：Glutinous rehmannia, cape jasmine, radix scutellariae, Fructus Forsythiae, radix scrophulariae, Radix Isatidis）It is existing Product can pass through acquisition purchased in market.
Peptide rhzomorph, 1, can directly be combined with virion, to prevent the integration of virion and host cell from reaching anti- Virus effectiveness；2, peptide rhzomorph inhibits the proliferation of virus by the expression of repressor gene；3, peptide rhzomorph can imitate infecting for virus Process, the assembling of viral interference and inhibit or kill virus.
Chitosan oligosaccharide, chitosan oligosaccharide is to improving poultry, fowl, aquatic livestock（Fish, shrimp, shellfish, ginseng）Immunity, premunition and growth promotion And other effects very significantly, chitosan oligosaccharide also have the function of hinder growth of pathogenic bacteria breeding, can promote protein synthesis, cell work Change, to improve livestock and poultry production performance.
Swine spleen transfer factor, the immune function for enhancing pig, chicken.
Shikimic acid, the new antiviral drug extracted from plant have various DNA and RNA virus disease relatively strong Inhibiting effect has good control effect to various viral diseases, directly virion is inhibited to be discharged from cell, to It prevents it from further infecting normal cell, plays the role of controlling the state of an illness rapidly.
Echinacea Purpurea Herb P.E, Echinacea have stronger immunocompetence, have stronger anti-inflammatory activity and antiviral, anti-thin Bacterium, antimycotic effect have prevention effect to the actinic damage of skin.
Flos Chrysanthemi Indici extract, clearing heat and detoxicating, swelling and pain relieving, for viral diseases such as influenza, epidemic meningitis, sore carbuncle, pneumonia.
Hypericum Perforatum P.E, (1) vaccine protective effect：Active ingredient hypericin in Hypericum Perforatum P.E can pierce Swash processing of the phagocyte to antigen, promote the contact between lymphocyte, enhance the effect of T helper cell, stimulation sensitization is drenched The division of bar cell and thick liquid cell generate antibody, are used cooperatively with vaccine, can enhance protective effect of the vaccine to domestic animal；（2）By force Inhibiting effect, can be used for porcine hyperthermia, pig breeding with respiratory system syndrome, pig circular ring virus, pseudoabies, swine fever, biography The prevention and treatment of the diseases such as metachromia gastroenteritis, porcine parvovirus simplex infection or mixed infection；（3）Antibacterial action：It is right A variety of gram-positive bacterias, negative bacterium have bacteriostasis, can be used for colibacillosis of pigs, salmonellosis, Staphylococcus aureus The prevention of the bacterial infection diseases such as disease.
Calculus bovis factitius, clearing heat and detoxicating, resolving sputum arresting convulsion, for phlegm heat rave mad, coma in silence, pediatric acute convulsion, abscess of throat, Aphthae, carbuncle swells furunculosis.
Yam extract, tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying, breath with cough for spleen eating less, endless diarrhea, the deficiency syndrome of the lung, Under emission due to the kidney deficiency, band, frequent micturition, abnormal heat quench one's thirst.
Antipyretic and detoxicated extract, it is clearing heat and detoxicating, it is used for fever caused by exogenous pathogens.
The use in conjunction of the above drug, can not only resist virus interference and duplication, to virosis have well treatment and Preventive effect, while the immunity of body can be also improved, the Probability of life cycle inner virus disease is reduced, it is raw materials used to be Safely, effectively, the green product of noresidue, therefore be good anti-virus product for raiser.
Preparation method：Proportionally take peptide rhzomorph, chitosan oligosaccharide, Swine spleen transfer factor, shikimic acid, Echinacea Purpurea Herb P.E, open country Chrysanthemum extract, Hypericum Perforatum P.E, calculus bovis factitius, yam extract, antipyretic and detoxicated extract, DEXTROSE ANHYDROUS, mixing Uniformly to get for the antiviral compound preparation for improving immunity of livestock and poultry.
The application method of compound preparation of the present invention：Mixed drink is watered 100kg per 100g, is used in conjunction 5-7 days, severe is multiplicable.
The present invention has the advantage that and advantageous effect：（1）The method can significantly improve the immunity of organisms of livestock and poultry, enhancing is anti- Sick ability；（2）The present invention has good inhibiting effect to viral disease, significantly reduces mortality of livestock；（3）The present invention mixes Object is abundant with raw material sources, and production technology is easy；（4）Inventive mixture is ultra-micro powder, and fineness enters up to 200 mesh It is easy to be absorbed after body, and Clinical practice is convenient, is suitble to group to use, uses manpower and material resources sparingly；（5）Instant component content is bright Really, quality controllable.
Specific implementation mode
Explanation, but the protection model of the present invention are further explained to technical scheme of the present invention with reference to specific embodiment It encloses and is not limited thereto.
In following embodiment and reference examples, peptide rhzomorph 727C carrys out the biological limited public affairs of Engineering Unit part purchased from Shandong Bora profit Department, specification：Viable count is 10,000,000,000 CFU/g, and antibacterial peptide CEC-38 contents are 100000 international units/g；Swine spleen transfer factor can Dissolubility powder is purchased from Hangzhou Shan Mu bioengineering Co., Ltd, trade name：It is kind to herd TOEFL TF, specification：Transfer factor content 10%；Clearly Pest removing toxic substances extract, reaches bio tech ltd, specification purchased from Sichuan perseverance Easthome：20:1（Every gram of extract is equivalent to primary Medicine 20g）, prescription：Glutinous rehmannia, cape jasmine, radix scutellariae, Fructus Forsythiae, radix scrophulariae, Radix Isatidis mixed extract；Echinacea Purpurea Herb P.E, it is permanent purchased from Sichuan Easthome reaches bio tech ltd, specification：20:1；Flos Chrysanthemi Indici extract reaches the limited public affairs of biotechnology purchased from Sichuan perseverance Easthome Department, specification：20:1；Hypericum Perforatum P.E reaches bio tech ltd, specification purchased from Sichuan perseverance Easthome：20: 1, Hypericum Chinense Element >=0.3%；Yam extract reaches bio tech ltd, specification purchased from Sichuan perseverance Easthome：25:1.
Embodiment 1-3 and reference examples 1
A kind of compound preparation for the antiviral raising immunity of livestock and poultry, composition（In parts by weight）It is shown in Table 1.
The preparation method of 1 product of embodiment 1-3 and reference examples：Proportionally take each component（Use preceding ultramicro grinding respectively To 200 mesh）, it is placed in mixing machine, stirs 30 minutes to get product.
The effect of compound preparation of the present invention is to pig epidemic diarrhea contrast test
1, trial drug
Test group 1,2,3：Product prepared by embodiment 1,2,3；
Control group 1：Product prepared by reference examples 1；
Control group 2：Chinese bulbul（According to version in 2015《Chinese veterinary pharmacopoeia》Self-control）.
2, test method
The morbid pig for choosing 30-60 ages in days, is randomly divided into 5 groups, every group 20, wherein 3 test groups, 2 control groups.
The cardinal symptom of sick pig is watery diarrhea, or has vomiting during diarrhea, after vomiting mostly occurs in food, sick pig Body temperature is normal or slightly higher, and spirit is depressed, and anorexia or useless exhausted, is after diagnosing epidemic diarrhea.
Adding method is as follows：
Test group 1：Mixed drink is watered 100kg per 1 product of 100g embodiments, freely drinks, be used in conjunction 7 days；
Test group 2：Mixed drink is watered 100kg per 2 product of 100g embodiments, freely drinks, be used in conjunction 7 days；
Test group 3：Mixed drink is watered 100kg per 3 product of 100g embodiments, freely drinks, be used in conjunction 7 days；
Control group 1：Mixed drink is watered 100kg per 1 product of 100g reference examples, freely drinks, be used in conjunction 7 days；
Control group 2：With the dosage oral medication of every pig 25g Chinese bulbul, 1 time a day, it is used in conjunction 7 days.
Take free choice feeding, epidemic prevention, management measure with it is daily consistent, with 7 days for a test period.
3, efficacy determination and performance assessment criteria
As medication continues or resistance to mistake, what clinical symptoms all disappeared, it is judged to curing；It is clinical as medication continues or resistance to mistake Symptom mitigates until restoring, and dead judgement is not effective.
After the test, every group of death pig number accounts for the percentage of experiment pig sum, the as death rate；Every group of healing pig Number of elements accounts for the percentage of experiment pig sum, as cure rate；Every group of survival pig sum accounts for the percentage of experiment pig sum, It is as efficient.
4, test result
Clinical observation result：Pig clinical manifestation is clearly better after 1,2,3 medication of test group, and the sick pig death rate obtains on the day of medication Effectively control, to medication the 3rd day without pig death, the 4th day swinery symptom of medication is improved well, and medication the 6th day is It is almost recovered, searches for food, normal, spirit improvement of drinking water, excrement is normal.
The pig clinical manifestation after medication of control group 1 is improved, and the 3rd day swinery spirit improves after medication, and appetite increases, Sick pig death is reduced, and the 5th day swinery spirit improves after medication, and appetite increases, and the 6th day symptom of diarrhea of medication mitigates.
The pig clinical manifestation after medication of control group 2 is mitigated, and the 4th day swinery spirit improves after medication, and appetite increases, Sick pig death in the 5th day is reduced after medication, and the 7th day swinery spirit improves after medication, and symptom of diarrhea mitigates.
Curative effect statistical result is shown in Table 2.
As shown in Table 2：1,2,3 death rate of test group is substantially less than control group 1,2, and cure rate is then significantly higher than control Group.Illustrate that compound preparation of the present invention has a better effect pig epidemic diarrhea, compound preparation of the present invention can enhance animal body Immunity can effectively reduce dead caused by human body immune function is low caused by virosis.
The contrast test of compound preparation enhancing pig immunity of the present invention
It carries out as follows：
（One）Drug and reagent
Trial drug：Product prepared by embodiment 1,2,3；
Control drug：Product prepared by reference examples 1；
Control drug：Tonifying middle-Jiao and Qi dissipates（According to version in 2015《Chinese veterinary pharmacopoeia》Self-control）.
（Two）Test method
（1）Experimental design：Select that parity, weight are close, the identical 10 age in days piglet of blood relationship 150 is as experimental animal, by with Machine block design is divided into 5 groups, every group 30, wherein 3 test groups, 2 control groups.
Adding method is as follows：
Test group 1：Mixed drink is watered 100kg per 1 product of 100g embodiments, freely drinks；
Test group 2：Mixed drink is watered 100kg per 2 product of 100g embodiments, freely drinks；
Test group 3：Mixed drink is watered 100kg per 3 product of 100g embodiments, freely drinks；
Control group 1：Mixed drink is watered 100kg per 1 product of 100g reference examples, freely drinks；
Control group 2：The dosage oral medication dissipated with every pig 10g tonifying middle-Jiao and Qi, 1 time a day.
Take free choice feeding, epidemic prevention, management measure with it is daily consistent.Each group according to conventional immune programme vaccine inoculation, I.e. 20 age in days hog cholera lapinised virus seedling head exempt from, 50 age in days booster immunizations 1 time.
Start within 5 days before pig immunity inoculation to be administered by above-mentioned requirements dosage, successive administration 5 days is a cycle.Reinforcing Immune first 5 days, then continuous use 5 days.
Hog cholera antibody level is measured using indirect hemagglutination (IHA) method, respectively in 15 age in days of piglet（Before first immunisation）, 30 days Age（After first immunisation）, 70 ages in days（After booster immunization）Blood sampling carries out hog cholera antibody level detection.
Hemagglutinative titer is up to 1:16 or more be immuno-competent, 1:16 or less be immune unqualified.The high head number of hemagglutinative titer value It is more, illustrate that antibody level is higher.
（2）As a result with analysis
As can be seen from Table 3：5 groups of maternal antibody level is 1:8~1:It is relatively more steady between 64, it is examined for the first time after being immunized It surveys, antibody level is in rising trend, and test group 1,2,3 is obviously improved, and antibody level is also higher, reaches 1:256 or more.Second Detection, antibody level have different degrees of raising again.Illustrate that compound preparation of the present invention puies forward hog cholera antibody, immune disease-resistance ability Height has apparent facilitation.

Claims (2)

1. a kind of for the antiviral compound preparation for improving immunity of livestock and poultry, which is characterized in that with the sum of parts by weight for 100 parts Meter, is grouped as by following groups：5-10 parts of peptide rhzomorph, 1-3 parts of chitosan oligosaccharide, 3-5 parts of Swine spleen transfer factor, 10-25 parts of shikimic acid, 5-10 parts of Echinacea Purpurea Herb P.E, 5-10 parts of Flos Chrysanthemi Indici extract, 10-20 parts of Hypericum Perforatum P.E, 2-5 parts of calculus bovis factitius, mountain 5-10 parts of medicament extract, extract 5-10 parts antipyretic and detoxicated, DEXTROSE ANHYDROUS complement to 100 parts.
2. a kind of preparing the method as claimed in claim 1 or 2 for the antiviral compound preparation for improving immunity of livestock and poultry, It is characterized in that：Proportionally take peptide rhzomorph, chitosan oligosaccharide, Swine spleen transfer factor, shikimic acid, Echinacea Purpurea Herb P.E, wild chrysanthemum extraction Object, Hypericum Perforatum P.E, calculus bovis factitius, yam extract, antipyretic and detoxicated extract, DEXTROSE ANHYDROUS, be uniformly mixed to get For the antiviral compound preparation for improving immunity of livestock and poultry.
CN201810684652.XA 2018-06-28 2018-06-28 A kind of compound preparation and preparation method thereof for the antiviral raising immunity of livestock and poultry Pending CN108743923A (en)

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Application publication date: 20181106