CN104645311A - Drinking agent for treating intestinal infection of livestock and poultry and preparation method of drinking agent - Google Patents

Drinking agent for treating intestinal infection of livestock and poultry and preparation method of drinking agent Download PDF

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Publication number
CN104645311A
CN104645311A CN201510098755.4A CN201510098755A CN104645311A CN 104645311 A CN104645311 A CN 104645311A CN 201510098755 A CN201510098755 A CN 201510098755A CN 104645311 A CN104645311 A CN 104645311A
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China
Prior art keywords
sodium
tannic acid
colistin sulfate
potassium chloride
chloride
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Pending
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CN201510098755.4A
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Chinese (zh)
Inventor
李�灿
田勇
王真真
张家铭
王书平
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PIZHOU ZHENGKANG BIOTECHNOLOGY Co Ltd
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PIZHOU ZHENGKANG BIOTECHNOLOGY Co Ltd
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Priority to CN201510098755.4A priority Critical patent/CN104645311A/en
Publication of CN104645311A publication Critical patent/CN104645311A/en
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Abstract

The invention discloses a drinking agent for treating intestinal infection of livestock and poultry and a preparation method of the drinking agent. The preparation comprises colistin sulfate, sulfamonomethoxine sodium and anhydrous dextrose; on the basis, tannic acid, sodium chloride and potassium chloride are also added to the raw materials; and the preparation comprises the following components in percentage by weight: 2%-10% of colistin sulfate, 5%-30% of sulfamonomethoxine sodium, 2%-5% of tannic acid, 2.5%-5% of sodium chloride, 1.5%-5% of potassium chloride and the balance of anhydrous dextrose. The drinking agent is capable of relieving intestinal infection symptoms of livestock and poultry and protecting intestinal mucosa; the damages caused by overhasty medication are avoided; electrolyte is supplemented; the immunity of livestock and poultry is enhanced; the effects of treating both symptoms and root causes and significant curative effects are reached; and the drinking agent has wide market prospect and practical value.

Description

A kind of drinking agent and preparation method thereof being used for the treatment of animal and bird intestines and infecting
Technical field
The present invention relates to a kind of drinking agent and preparation method thereof being used for the treatment of animal and bird intestines and infecting, belong to veterinary drug preparing technical field.
Background technology
It is be the disease that sickness rate is higher in poultry that animal and bird intestines infects, this type of common clinically disease has yellow and white dysentery of piglet, diarrhoea is had loose bowels, baby swine paratyphoid, calf diarrhea, calf paratyphoid fever, avian colibacillosis etc., cause primarily of the gram negative bacteria such as escherichia coli, Salmonella, with dysentery of suffering from diarrhoea for main clinic symptoms, many because taking off water and rock-soil coupling, dying of exhaustion and die, very large harm is caused to aquaculture.
At present, the conventional preparation for treating such as aminoglycoside, quinolones animal and bird intestines infects clinically.Colistin sulfate is used for the treatment of the intestinal infection that the gram negative bacteria such as escherichia coli, Salmonella causes, and is the specific drug of Pullorum Disease, yellow and white dysentery of piglet, intractable diarrhea, and colistin sulfate is for oral administration absorbs hardly, and can go directly intestinal, kills pathogenic bacterium; Sulfamonomethoxine sodium is used for the treatment of by the microbial digestive tract infection of sensitivity, the sulfa drugs that inside and outside antibacterial activity is the strongest, and both are collaborative plays antibacterial action.But, owing to being quick-acting medicine, easy in use certain impact is brought on animal and bird intestines, as damaged intestinal mucosa etc., and the electrolyte that body runs off because of disease cannot be supplemented timely, and then reduce the immunity of poultry.
Summary of the invention
For above-mentioned problems of the prior art; the invention provides a kind of drinking agent being used for the treatment of animal and bird intestines and infecting, while guaranteeing treatment animal and bird intestines infectious effect, protection intestinal mucosa; and the electrolyte that supplementary body runs off because of disease, and then strengthen the immunity of poultry.
To achieve these goals, preparation of the present invention comprises colistin sulfate, sulfamonomethoxine sodium and anhydrous glucose; On this basis, also add tannic acid, sodium chloride and potassium chloride in raw material, the percentage by weight of each component is: colistin sulfate 2%-10%, sulfamonomethoxine sodium 5%-30%, tannic acid 2%-5%, sodium chloride 2.5%-5%, potassium chloride 1.5%-5%, surplus is anhydrous glucose.
Preferably, colistin sulfate 2%, sulfamonomethoxine sodium 5%, tannic acid 2%, sodium chloride 2.5%, potassium chloride 1.5%, surplus is anhydrous glucose.
Preferably, colistin sulfate 10%, sulfamonomethoxine sodium 30%, tannic acid 5%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
Preferably, colistin sulfate 5%, sulfamonomethoxine sodium 10%, tannic acid 3%, sodium chloride 3.5%, potassium chloride 2.5%, surplus is anhydrous glucose.
In the present invention, the preparation method being used for the treatment of the drinking agent that animal and bird intestines infects is as follows:
(1) each component is according to colistin sulfate 2%-10%, sulfamonomethoxine sodium 5%-30%, tannic acid 2%-5%, sodium chloride 2.5%-5%, potassium chloride 1.5%-5%, surplus be anhydrous glucose percentage by weight take respectively;
(2) colistin sulfate after taking, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, anhydrous glucose are pulverized respectively, sieve 80 orders, continues to employ;
(3) colistin sulfate be sieved, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride are fully mixed 5-15min in mixer;
(4) anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and discharging mix 10-20min in mixer after.
Preferably, in step (3), mixer is V-Mixer.
Preferably, in step (3), colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride fully mix 5min in mixer, in step (4), the anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and mix 20min in mixer.
Preferably, in step (3), colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride fully mix 15min in mixer, in step (4), the anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and mix 10min in mixer.
Preferably, in step (3), colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride fully mix 10min in mixer, in step (4), the anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and mix 15min in mixer.
There is prior art identical: the present invention adopts colistin sulfate, sulfamonomethoxine sodium, colistin sulfate is used for the treatment of the intestinal infection that the gram negative bacteria such as escherichia coli, Salmonella causes, it is the specific drug of Pullorum Disease, yellow and white dysentery of piglet, intractable diarrhea, and colistin sulfate is for oral administration absorbs hardly, can be gone directly intestinal, kills pathogenic bacterium; Sulfamonomethoxine sodium is used for the treatment of by the microbial digestive tract infection of sensitivity, the sulfa drugs that inside and outside antibacterial activity is the strongest, and both are collaborative plays antibacterial action, and then ensure that guarantor has controlled treatment animal and bird intestines infectious effect.
Unlike the prior art: also add tannic acid, sodium chloride and potassium chloride in raw material and carry out used in combination; Wherein, be coated on intestinal mucosa after tannic acid is for oral administration and shield, decompose and discharge tannic acid, produce astringing to arrest diarrhea effect, and then protect intestinal mucosa; Meanwhile, sodium chloride, potassium chloride are electrolyte replenisher, supplement the electrolyte that body runs off because of disease.
The preparation process of contrast prior art, by colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride and potassium chloride, according to specific proportioning, (proportioning is by weight: colistin sulfate 2% in the present invention, sulfamonomethoxine sodium 5%, tannic acid 2%, sodium chloride 2.5%, potassium chloride 1.5%, surplus is anhydrous glucose) take respectively, screening remixes, ensure that the precision of preparation and the property of medicine of each constituent, and join mixer after sieving and mix, and then make drinking agent.
In sum, the present invention can either alleviate animal and bird intestines infection symptoms, can protect intestinal mucosa again; avoid the injury produced because medication is too urgent, electrolyte supplement, enhance the immunity of poultry; reach treating both the principal and secondary aspects of a disease, effect evident in efficacy, there is market prospect and practical value widely.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
(1) colistin sulfate 2kg, sulfamonomethoxine sodium 5kg, tannic acid 2kg, sodium chloride 2.5kg, potassium chloride 1.5kg is taken respectively, anhydrous glucose 87kg;
(2) colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, anhydrous glucose are crossed 80 mesh sieves respectively, for subsequent use.
(3) take the colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, the potassium chloride that are sieved, in v word mixer, fully mix 5 minutes.
(4) anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, fully mixing discharging after 20 minutes in common batch mixer.
Embodiment 2
(1) colistin sulfate 5kg, sulfamonomethoxine sodium 10kg, tannic acid 3kg, sodium chloride 3.5kg, potassium chloride 2.5kg is taken respectively, anhydrous glucose 76kg;
(2) colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, anhydrous glucose are crossed 80 mesh sieves respectively, for subsequent use.
(3) take the colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, the potassium chloride that are sieved, in v word mixer, fully mix 5 minutes.
(4) anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, fully mixing discharging after 20 minutes in common batch mixer.
Embodiment 3
(1) colistin sulfate 5kg, sulfamonomethoxine sodium 25kg, tannic acid 4kg, sodium chloride 4kg, potassium chloride 3kg is taken respectively, anhydrous glucose 80kg.
(2) colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, anhydrous glucose are crossed 80 mesh sieves respectively, for subsequent use.
(3) take the colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, the potassium chloride that are sieved, in v word mixer, fully mix 5 minutes.
(4) again the anhydrous grape be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, fully mixing discharging after 20 minutes in common batch mixer.
Embodiment 4
(1) colistin sulfate 10kg, sulfamonomethoxine sodium 30kg, tannic acid 5kg, sodium chloride 5kg, potassium chloride 5kg is taken respectively, anhydrous glucose 80kg.
(2) colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, anhydrous glucose are crossed 80 mesh sieves respectively, for subsequent use.
(3) take the colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, the potassium chloride that are sieved, in v word mixer, fully mix 5 minutes.
(4) again the anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, fully mixing discharging after 20 minutes in common batch mixer.
Clinical trial
The present invention is used for the drinking agent that animal and bird intestines infects, and can be used for poultry, is laboratory animal below with chicken, and clinical trial is carried out in effect the present invention being used for the treatment of to the drinking agent that animal and bird intestines infects.
1. laboratory animal:
The chicken 180 of intestinal infection is suffered from random choosing.
2. Experimental agents:
The drinking agent our unit development being used for the treatment of animal and bird intestines infection of the embodiment of the present invention 4 preparation;
The laboratory preparation of 10% colistin sulfate soluble powder our unit;
The laboratory preparation of 30% sulfamonomethoxine sodium soluble powder our unit.
3. experimental technique:
Suffer from chicken by 180 and be divided into four groups at random by body weight, often organize 45.
A group, for infecting matched group, does not give Drug therapy.
B group 10% colistin sulfate soluble powder is treated, usage: drinking-water, and every 1L water 0.6g 2 times on the mono-concentrates and drinks, is used in conjunction 3 days.
C group 30% sulfamonomethoxine sodium soluble powder is treated, usage: drinking-water, and every 1L water 0.6g 2 times on the mono-concentrates and drinks, is used in conjunction 3 days.
The drinking agent being used for the treatment of animal and bird intestines infection of the D group embodiment of the present invention 4 preparation is treated, usage: drinking-water, and every 1L water 0.6g 2 times on the mono-, concentrates and drink, be used in conjunction 3 days.
After treatment starts, every day entry suffers from the distribution of chicken health situation of change, treats and adds up therapeutic effect after the 5th day, wherein:
Dead: occur the classical symptom that chicken intestinal infects and death at duration of test, necropsy has typical characteristics of lesion, and separation and Culture goes out the gram negative bacteria such as chicken colibacillosis, Salmonella from liver, spleen and painstaking effort, is judged to be that intestinal infection is dead.The mortality rate of each group is calculated according to dead chicken number.
Cure: recover normal at duration of test through the administration postoperative infection chicken mental status for oral administration, appetite, no longer occur the clinical symptoms such as row's loose stool, all belong to healing.The ratio accounting for test group chicken according to healing chicken calculates cure rate.
Effective: after administration for oral administration, the chicken of curing completely and do not have death but have clinical symptoms shower, is effectively.During off-test, the chicken number often organizing survival accounts for the percentage rate of test group chicken number, is effective percentage.
Result of the test is as shown in table 1.
4. conclusion:
In conjunction with above-mentioned experiment, the drinking agent group of the embodiment of the present invention 4 preparation, 10% colistin sulfate soluble powder group, 30% sulfamonomethoxine sodium soluble powder group mortality rate are all extremely remarkable in infection matched group (P<0.01), cure rate, effective percentage pole are significantly higher than and infect matched group (P<0.01), show that drinking agent group prepared by the embodiment of the present invention 4,10% colistin sulfate soluble powder group, 30% sulfamonomethoxine sodium soluble powder group have good curative effect to fowl intestinal infection.Drinking agent group cure rate, the effective percentage of the embodiment of the present invention 4 preparation are all significantly higher than 10% colistin sulfate soluble powder group, 30% sulfamonomethoxine sodium soluble powder group (P<0.05), illustrate that the curative effect of drinking agent group prepared by the embodiment of the present invention 4 is higher than 10% colistin sulfate soluble powder group, 30% sulfamonomethoxine sodium soluble powder group.
In sum, the present invention adopts colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride and potassium chloride drug combination, kills pathogenic bacterium fast, alleviates animal and bird intestines infection symptoms, enhances the therapeutic effect of preparation.Meanwhile, in concrete preparation process, to the rational proportion of colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride and potassium chloride, make drinking agent, easy to use, rapid-action, there is specially good effect to the intestinal infection caused by gram negative bacteria, reach object of the present invention.

Claims (9)

1. be used for the treatment of the drinking agent that animal and bird intestines infects, preparation comprises colistin sulfate, sulfamonomethoxine sodium and anhydrous glucose;
It is characterized in that, also add tannic acid, sodium chloride and potassium chloride in raw material, the percentage by weight of each component is: colistin sulfate 2%-10%, sulfamonomethoxine sodium 5%-30%, tannic acid 2%-5%, sodium chloride 2.5%-5%, potassium chloride 1.5%-5%, surplus is anhydrous glucose.
2. a kind of drinking agent being used for the treatment of animal and bird intestines and infecting according to claim 1, it is characterized in that, the percentage by weight of each component is: colistin sulfate 2%, sulfamonomethoxine sodium 5%, tannic acid 2%, sodium chloride 2.5%, potassium chloride 1.5%, surplus is anhydrous glucose.
3. a kind of drinking agent being used for the treatment of animal and bird intestines and infecting according to claim 1, is characterized in that, be made up by weight percentage of following component: colistin sulfate 10%, sulfamonomethoxine sodium 30%, tannic acid 5%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.
4. a kind of drinking agent being used for the treatment of animal and bird intestines and infecting according to claim 1, is characterized in that, be made up by weight percentage of following component: colistin sulfate 5%, sulfamonomethoxine sodium 10%, tannic acid 3%, sodium chloride 3.5%, potassium chloride 2.5%, surplus is anhydrous glucose.
5. a kind of drinking agent being used for the treatment of animal and bird intestines and infecting according to claim 1, it is characterized in that, concrete preparation method is as follows:
(1) each component is according to colistin sulfate 2%-10%, sulfamonomethoxine sodium 5%-30%, tannic acid 2%-5%, sodium chloride 2.5%-5%, potassium chloride 1.5%-5%, surplus be anhydrous glucose percentage by weight take respectively;
(2) colistin sulfate after taking, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, anhydrous glucose are pulverized respectively, sieve 80 orders, continues to employ;
(3) colistin sulfate be sieved, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride are fully mixed 5-15min in mixer;
(4) anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and discharging mix 10-20min in mixer after.
6. a kind of preparation method being used for the treatment of the drinking agent that animal and bird intestines infects according to claim 1, is characterized in that, in step (3), described mixer uses V-Mixer.
7. a kind of preparation method being used for the treatment of the drinking agent that animal and bird intestines infects according to claim 1, it is characterized in that, in step (3), colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride fully mix 5min in mixer, in step (4), the anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and mix 20min in mixer.
8. a kind of preparation method being used for the treatment of the drinking agent that animal and bird intestines infects according to claim 1, it is characterized in that, in step (3), colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride fully mix 15min in mixer, in step (4), the anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and mix 10min in mixer.
9. a kind of preparation method being used for the treatment of the drinking agent that animal and bird intestines infects according to claim 1, it is characterized in that, in step (3), colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride fully mix 10min in mixer, in step (4), the anhydrous glucose be sieved is joined in the mixture of above-mentioned colistin sulfate, sulfamonomethoxine sodium, tannic acid, sodium chloride, potassium chloride, and mix 15min in mixer.
CN201510098755.4A 2015-03-06 2015-03-06 Drinking agent for treating intestinal infection of livestock and poultry and preparation method of drinking agent Pending CN104645311A (en)

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