CN101653596A - Soluble powder for treating canine colibacillosis and preparation method thereof - Google Patents
Soluble powder for treating canine colibacillosis and preparation method thereof Download PDFInfo
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- CN101653596A CN101653596A CN200810054221A CN200810054221A CN101653596A CN 101653596 A CN101653596 A CN 101653596A CN 200810054221 A CN200810054221 A CN 200810054221A CN 200810054221 A CN200810054221 A CN 200810054221A CN 101653596 A CN101653596 A CN 101653596A
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- soluble powder
- doxycycline hydrochloride
- taurine
- colistin sulfate
- sodium chloride
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Abstract
The invention discloses soluble powder for treating canine colibacillosis and a preparation method thereof and aims to provide the soluble powder which has a quick response to coli infection treatment, treats both symptoms and root causes, and can reduce the drug resistance of escherichia coli and improve the cure rate, and the preparation which has a simple process and is easy to implement. The soluble powder comprises the following components in percentage by weight: 1 to 10 percent of doxycycline hydrochloride, 1 to 10 percent of colistin sulfate, 0.5 to 5 percent of sodium chloride, 0.5 to5 percent of potassium chloride, 5 percent of taurine, and the balance of anhydrous dextrose. The soluble powder is a compound preparation and has multiple effects, wherein the doxycycline hydrochloride and the colistin sulfate have dual antibacterial effects; the sodium chloride and the potassium chloride are electrolyte replenishers; and the taurine has the functions of pyretolysis and liver protection. The soluble powder, through the reasonable blending of the components, can quickly kill the escherichia coli and reduce the drug resistance ratio, supplements electrolytes and improves the immunity and defervesces. Thus, the recovery is accelerated and the cure rate is improved.
Description
Technical field
The present invention relates to a kind of compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis and preparation method thereof.
Background technology
Dog colibacillus infection is a kind of commonly encountered diseases of dog, mainly show as the dog fervescence, the asoscope drying, violent diarrhoea, initial stage feces presents yellow or canescence, occurs watery diarrhea subsequently, and feces is smelt as of rotten fish, had contains white foam, how because of dehydration, electrolyte disturbance, die of exhaustion and die, bring very big loss for vast foster dog fan.
At present, the treatment canine colibacillosis is extensive use of various antibacterials, make drug-resistance of bacteria very general, as the medicine such as doxycycline hydrochloride, colistin sulfate of employing, all can not kill cause of disease fully, simultaneously owing to suffer from the dog dehydration, electrolyte imbalance, can not reach therapeutic effect, that have in addition kill cause of disease after, the after effect that causes owing to disease causes the death of disease dog, simultaneously because diarrhoea causes the change of intestinal microbial population, it is pathogenic to cause other antibacterials to produce, and comes difficulty for complete treatment belt.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat canine colibacillosis, and therapeutic effect is good, instant effect, and can treating both the principal and secondary aspects of a disease, can suit the medicine to the illness and cause of disease treated, alleviate the misery of ill dog, the soluble powder of raising cure rate.
It is simple that another object of the present invention provides a kind of technology, easily the above-mentioned preparation method that is used for the treatment of the soluble powder of canine colibacillosis that realizes.
The present invention is achieved through the following technical solutions:
A kind of soluble powder that is used for the treatment of canine colibacillosis is characterized in that, is made by following component by weight percentage: doxycycline hydrochloride 1～10%; colistin sulfate 1～10%, sodium chloride 0.5～5%, potassium chloride 0.5～5%; taurine 5%, surplus are anhydrous glucose.
Wherein the preferable content of each component is: doxycycline hydrochloride 2～8%, and colistin sulfate 1.5～4%, sodium chloride 1～3%, potassium chloride 1～4%, taurine 5%, surplus is an anhydrous glucose.
Wherein the content of each component the best is doxycycline hydrochloride 5%, colistin sulfate 2%, and sodium chloride 1.5%, potassium chloride 1.5%, taurine 5%, surplus is an anhydrous glucose.
A kind of preparation method that is used for the treatment of the soluble powder of canine colibacillosis is characterized in that, comprises the steps:
(1) with doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose sieve respectively, and be standby;
(2) take by weighing the good doxycycline hydrochloride of sieve, colistin sulfate, sodium chloride, potassium chloride, taurine fully mix in V word mixer;
(3) will sieve good anhydrous glucose again joins in the said mixture; in common batch mixer, fully mix; discharging, sieving obtains the soluble powder that is used for the treatment of canine colibacillosis of the present invention, wherein; be doxycycline hydrochloride 1～10% by weight percentage; colistin sulfate 1～10%, sodium chloride 0.5～5%, potassium chloride 0.5～5%; taurine 5%, surplus are anhydrous glucose.
Wherein the preferable content of each component is: doxycycline hydrochloride 2～8%, and colistin sulfate 1.5～4%, sodium chloride 1～3%, potassium chloride 1～4%, taurine 5%, surplus is an anhydrous glucose.
The optimum content of each component is: doxycycline hydrochloride 5%, and colistin sulfate 2%, sodium chloride 1.5%, potassium chloride 1.5%, taurine 5%, surplus is an anhydrous glucose.
The present invention has following technique effect:
The present invention is for adopting doxycycline hydrochloride and colistin sulfate; sodium chloride; potassium chloride; the compound preparation that taurine is formed; has multi-efficiency; the oral post-absorption of doxycycline hydrochloride; escherichia coli there is killing action; do not absorb after colistin sulfate is oral; can kill the escherichia coli of intestinal, doxycycline hydrochloride and colistin sulfate have dual antibiotic effect, and sodium chloride and potassium chloride are electrolyte replenisher; taurine has brings down a fever; the effect that protects the liver; by rational proportion, can alleviate the clinical symptoms that dog colibacillus infection causes fast, kill cause of disease; and electrolyte supplement and reinforcement liver function; strengthen or recover its immunologic function, reduce the destruction that disease causes, reduce the misery of disease dog body; alleviate and suffer from dog health stress; make and recover to accelerate, and reduce colibacillary drug resistance probability, cure rate is improved.Soluble powder of the present invention can be realized treatment by drinking-water or spice, and is easy to use.
The preparation method technology of the soluble powder that is used for the treatment of canine colibacillosis of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose are crossed the 80# sieve respectively, standby.
(2) good doxycycline hydrochloride 1kg fully mixed 30 minutes in V word mixer with colistin sulfate 10kg, sodium chloride 5kg, potassium chloride 0.5kg, taurine 5kg to take by weighing sieve.
(3) will sieve again in the mixture that good anhydrous glucose 78.5kg joins above-mentioned doxycycline hydrochloride and colistin sulfate, sodium chloride, potassium chloride, taurine; in common batch mixer, fully mixed 30 minutes; discharging is crossed the 80# sieve and is obtained the compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis of the present invention.
Embodiment 2
(1) with doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose are crossed the 80# sieve respectively, and be standby.
(2) good doxycycline hydrochloride 10kg fully mixed 30 minutes in V word mixer with colistin sulfate 1kg, sodium chloride 0.5kg, potassium chloride 5kg, taurine 5kg to take by weighing sieve.
(3) will sieve good anhydrous glucose 78.5kg again joins in the mixture of above-mentioned doxycycline hydrochloride and colistin sulfate etc., in common batch mixer, fully mixed 30 minutes, discharging is crossed the 80# sieve and is obtained the compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis of the present invention.
Embodiment 3
(1) with doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose are crossed the 80# sieve respectively, and be standby.
(2) good doxycycline hydrochloride 2kg fully mixed 30 minutes in V word mixer with colistin sulfate 4kg, sodium chloride 1kg, potassium chloride 4kg, taurine 5kg to take by weighing sieve.
(3) will sieve good anhydrous glucose 84kg again joins in the mixture of above-mentioned doxycycline hydrochloride and colistin sulfate etc., in common batch mixer, fully mixed 30 minutes, discharging is crossed the 80# sieve and is obtained the compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis of the present invention.
Embodiment 4
(1) with doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose are crossed the 80# sieve respectively, and be standby.
(2) good doxycycline hydrochloride 8kg fully mixed 30 minutes in V word mixer with colistin sulfate 1.5kg, sodium chloride 3kg, potassium chloride 1kg, taurine 5kg to take by weighing sieve.
(3) will sieve good anhydrous glucose 81.5kg again joins in the mixture of above-mentioned doxycycline hydrochloride and colistin sulfate etc., in common batch mixer, fully mixed 30 minutes, discharging is crossed the 80# sieve and is obtained the compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis of the present invention.
Embodiment 5
(1) with doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose are crossed the 80# sieve respectively, and be standby.
(2) good doxycycline hydrochloride 6kg fully mixed 30 minutes in V word mixer with colistin sulfate 2.5kg, sodium chloride 2.5kg, potassium chloride 2kg, taurine 5kg to take by weighing sieve.
(3) will sieve good anhydrous glucose 82kg again joins in the mixture of above-mentioned doxycycline hydrochloride and colistin sulfate etc., in common batch mixer, fully mixed 30 minutes, discharging is crossed the 80# sieve and is obtained the compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis of the present invention.
Embodiment 6
(1) with doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose are crossed the 80# sieve respectively, and be standby.
(2) good doxycycline hydrochloride 5kg fully mixed 30 minutes in V word mixer with colistin sulfate 2kg, sodium chloride 1.5kg, potassium chloride 1.5kg, taurine 5kg to take by weighing sieve.
(3) will sieve good anhydrous glucose 85kg again joins in the mixture of above-mentioned doxycycline hydrochloride and colistin sulfate etc., in common batch mixer, fully mixed 30 minutes, discharging is crossed the 80# sieve and is obtained the compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis of the present invention.
Clinical trial:
1. laboratory animal:
100 of the ill one-tenth of picked at random dogs.
2. experiment medicine:
The compound doxycycline hydrochloride soluble powder our unit development that is used for the treatment of canine colibacillosis of the embodiment of the invention 6 preparations;
5% doxycycline hydrochloride soluble powder our unit prepared in laboratory;
2% colistin sulfate soluble powder our unit prepared in laboratory.
3. experimental technique:
Suffer from dog with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 5% doxycycline hydrochloride soluble powder: drinking-water, every 1kg body weight 0.2g, 2 times on the one, logotype 3 days.
The C group is treated usage with 2% colistin sulfate soluble powder: drinking-water, every 1kg body weight 0.2g, 2 times on the one, logotype 3 days.
The D group is treated usage with the compound doxycycline hydrochloride soluble powder that is used for the treatment of canine colibacillosis of the embodiment of the invention 6 preparations: drinking-water, every 1kg body weight 0.2g, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, the distribution of dog health situation of change suffered from record, and treat after the 5th day and add up therapeutic effect, wherein:
Invalid: as after referring to 5 days, to suffer from the dog symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 5 days, suffer from the dog symptom and change, the effect before symptom is better than treating.
Cure: after referring to 5 days, transference cure is suffered from dog and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 5 days, suffer from dog and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from dog and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the compound doxycycline hydrochloride soluble powder treatment group that is used for the treatment of canine colibacillosis, 5% doxycycline hydrochloride treatment group and the 2% colistin sulfate soluble powder group of the embodiment of the invention 6 and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | The symptom number of elements is arranged during end | Dead number of elements |
| ??A | Matched group | ??25 | ??0 | ??0 | ??8 | ??17 |
| ??B | The treatment of 5% doxycycline hydrochloride soluble powder | ??10 | ??15 | ??9 | ??7 | ??9 |
| ??C | The treatment of 2% colistin sulfate soluble powder | ??9 | ??16 | ??10 | ??8 | ??7 |
| ??D | The compound doxycycline hydrochloride soluble powder treatment of embodiment 6 | ??2 | ??23 | ??20 | ??3 | ??2 |
Claims (6)
1, a kind of soluble powder that is used for the treatment of canine colibacillosis is characterized in that, is made by following component by weight percentage: doxycycline hydrochloride 1～10%; colistin sulfate 1～10%, sodium chloride 0.5～5%, potassium chloride 0.5～5%; taurine 5%, surplus are anhydrous glucose.
2, the soluble powder that is used for the treatment of canine colibacillosis according to claim 1; it is characterized in that; make by following component by weight percentage: doxycycline hydrochloride 2～8%; colistin sulfate 1.5～4%; sodium chloride 1～3%; potassium chloride 1～4%, taurine 5%, surplus is an anhydrous glucose.
3, the soluble powder that is used for the treatment of canine colibacillosis according to claim 1 is characterized in that, is made by following component by weight percentage: doxycycline hydrochloride 5%; colistin sulfate 2%, sodium chloride 1.5%, potassium chloride 1.5%; taurine 5%, surplus are anhydrous glucose.
4, a kind of preparation method that is used for the treatment of the soluble powder of canine colibacillosis is characterized in that, comprises the steps:
(1) with doxycycline hydrochloride, colistin sulfate, sodium chloride, potassium chloride, taurine, anhydrous glucose sieve respectively, and be standby;
(2) take by weighing the good doxycycline hydrochloride of sieve, colistin sulfate, sodium chloride, potassium chloride, taurine fully mix in V word mixer;
(3) will sieve good anhydrous glucose again joins in the said mixture; in common batch mixer, fully mix; discharging, sieving obtains the soluble powder that is used for the treatment of canine colibacillosis of the present invention, wherein; doxycycline hydrochloride 1～10% by weight percentage; colistin sulfate 1～10%, sodium chloride 0.5～5%, potassium chloride 0.5～5%; taurine 5%, surplus are anhydrous glucose.
5, the preparation method that is used for the treatment of the soluble powder of canine colibacillosis according to claim 4; it is characterized in that; described by weight percentage doxycycline hydrochloride 2～8%; colistin sulfate 1.5～4%; sodium chloride 1～3%; potassium chloride 1～4%, taurine 5%, surplus is an anhydrous glucose.
6, the preparation method that is used for the treatment of the soluble powder of canine colibacillosis according to claim 4 is characterized in that, described by weight percentage doxycycline hydrochloride 5%; colistin sulfate 2%, sodium chloride 1.5%, potassium chloride 1.5%; taurine 5%, surplus are anhydrous glucose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810054221A CN101653596A (en) | 2008-08-22 | 2008-08-22 | Soluble powder for treating canine colibacillosis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810054221A CN101653596A (en) | 2008-08-22 | 2008-08-22 | Soluble powder for treating canine colibacillosis and preparation method thereof |
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| CN101653596A true CN101653596A (en) | 2010-02-24 |
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| CN200810054221A Pending CN101653596A (en) | 2008-08-22 | 2008-08-22 | Soluble powder for treating canine colibacillosis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966200A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating poultry digestive tract bacterial infection and preparation method thereof |
| CN106902083A (en) * | 2017-03-03 | 2017-06-30 | 安徽安丰堂动物药业有限公司 | A kind of colistin sulfate soluble powder and compound method used in outlet fowl |
-
2008
- 2008-08-22 CN CN200810054221A patent/CN101653596A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966200A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating poultry digestive tract bacterial infection and preparation method thereof |
| CN106902083A (en) * | 2017-03-03 | 2017-06-30 | 安徽安丰堂动物药业有限公司 | A kind of colistin sulfate soluble powder and compound method used in outlet fowl |
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Open date: 20100224 |