CN101297794B - Compound kanamycin sulphate injection for dogs and preparation thereof - Google Patents
Compound kanamycin sulphate injection for dogs and preparation thereof Download PDFInfo
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- CN101297794B CN101297794B CN2008100531005A CN200810053100A CN101297794B CN 101297794 B CN101297794 B CN 101297794B CN 2008100531005 A CN2008100531005 A CN 2008100531005A CN 200810053100 A CN200810053100 A CN 200810053100A CN 101297794 B CN101297794 B CN 101297794B
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Abstract
The invention discloses a compound kanamycin sulfate injection for dogs and a preparation method thereof, which aims at providing the compound kanamycin sulfate injection that has rapid onset of action for the treatment for canine parainfluenza and can ease the clinical reactions of the affected dogs, reduce the times and the dosage of the drug administration, alleviate the suffering of the dogs and the difficulty of the treatment operation, and the preparation method that has simple process and easy realization. Each 100l injection contains: 5 to 20 billion units of kanamycin monosulfate, 1 to 10kg of fosfomycin sodium, 0.1 to 2kg of doxofylline, 20kg of analgin, 0.2kg of sodium bisulfite, 0.01kg of EDTA-2Na, 30kg of propylene glycol and the rest of water for injection. The injection of the invention is a compound preparation which combines antibiotics and drugs for the symptomatic treatment for usage, thus having rapid onset of action for the treatment for canine Para influenza and being able to ease the stress reactions of the affected dogs, prevent the secondary infection and accelerate the recovery of the dogs.
Description
Technical field
The present invention relates to a kind of compound kanamycin sulphate injection for dogs and preparation method thereof.
Background technology
The dog parainfluenza is a kind of respiratory tract disease of dog, pathogen is a canine parainfluenza virus, clinical manifestation mainly contains fervescence, flows serosity, mucus even purulence nose liquid from the nostril, violent, the lassitude of sick dog cough, appetite reduces, and generally sb.'s illness took a favorable turn in all backs, but because sick dog resistance descends, cause other secondary infection easily, make state of an illness lengthening, increase the weight of, even cause death.There is not the para-influenzal specific drug of treatment dog at present.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provide a kind of can symptomatic treatment dog parainfluenza, and can control the secondary infection that the dog parainfluenza causes, it is fast to respond well to treatment, can alleviate suffer from the clinical response of dog when ill, reduce the compound kanamycin sulphate injection for dogs of medication number of times and dosage.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned compound kanamycin sulphate injection for dogs of realizing.
The present invention is achieved through the following technical solutions:
A kind of compound kanamycin sulphate injection for dogs, it is characterized in that, consisting of of every 100L injection: 5～20 BOUs of Kanamicina Solfato, fosfomycin sodium 1～10kg, doxofylline 0.1～2kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
The preferable content of each component is in wherein every 100L injection: 7～15 BOUs of Kanamicina Solfato, fosfomycin sodium 3～8kg, doxofylline 0.3～1.5kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
The optimum content of each component is in every 100L injection: 10 BOUs of Kanamicina Solfato, and fosfomycin sodium 5kg, doxofylline 0.8kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
A kind of preparation method of compound kanamycin sulphate injection for dogs is characterized in that, comprises the steps:
(1) gets 5～20 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 1～10kg, dipyrone 20kg again, be stirred to whole dissolvings;
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, be stirred to whole dissolvings.
(3) get propylene glycol 30kg, heating for dissolving doxofylline 0.1～2kg.
(4) the prepared solution of combining step 1, step 2 and step 3 adds water for injection again to 100L, stirs, and keeps 15-20min, treats that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs of the present invention after clear and bright.
The preferable of wherein every 100L injection consists of: 7～15 BOUs of Kanamicina Solfato, fosfomycin sodium 3～8kg, doxofylline 0.3～1.5kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
The best group of every 100L injection becomes: 10 BOUs of Kanamicina Solfato, and fosfomycin sodium 5kg, doxofylline 0.8kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
The present invention has following technique effect:
The present invention is for adopting antibiotic and at the compound preparation of the drug combination of dog parainfluenza clinical symptoms, Kanamicina Solfato and fosfomycin sodium are united use, adopt double effects, dual bacteriostasis and sterilization, reduce antibacterial and produce chemical sproof probability, and the sensitivity of increase antibacterial, the Secondary cases bacterial infection that control dog parainfluenza causes, the fever symptom that dipyrone control dog parainfluenza causes, the cough that doxofylline control dog parainfluenza causes, several drugs is responded well to treatment soon to the para-influenzal of dog by the rational proportion to each amounts of components, can alleviate to suffer from dog health stress, treating both the principal and secondary aspects of a disease, can prevent secondary infection, recover appetite, make dog recover to accelerate.Simultaneously, compound preparation of the present invention is an injection, helps absorbing.Because therapeutic process is accelerated, and has reduced medication number of times and dosage, alleviate the misery of dog and the degree of difficulty of treatment operation.
The preparation method technology of compound kanamycin sulphate injection for dogs of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) gets 5 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 1～10kg, dipyrone 20kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) get propylene glycol 30kg, heating for dissolving doxofylline 0.1kg.
(4) combining step 1 and step 2, the prepared solution of step 3 add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs of the present invention after clear and bright.
Embodiment 2
(1) gets 20 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 10kg, dipyrone 20kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, be stirred to whole dissolvings.
(3) get propylene glycol 30kg, heating for dissolving doxofylline 2kg.
(4) combining step 1 and step 2, the prepared solution of step 3 add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs of the present invention after clear and bright.
Embodiment 3
(1) gets 7 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 8kg, dipyrone 20kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, be stirred to whole dissolvings.
(3) get propylene glycol 30kg, heating for dissolving doxofylline 1.5kg.
(4) combining step 1 and step 2, the prepared solution of step 3 add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs of the present invention after clear and bright.
Embodiment 4
(1) gets 15 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 3kg, dipyrone 20kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, be stirred to whole dissolvings.
(3) get propylene glycol 30kg, heating for dissolving doxofylline 0.3kg.
(4) combining step 1 and step 2, the prepared solution of step 3 add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs of the present invention after clear and bright.
Embodiment 5
(1) gets 8 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 4kg, dipyrone 20kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, be stirred to whole dissolvings.
(3) get propylene glycol 30kg, heating for dissolving doxofylline 0.6kg.
(4) combining step 1 and step 2, the prepared solution of step 3 add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs of the present invention after clear and bright.
Embodiment 6
(1) gets 10 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 5kg, dipyrone 20kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, be stirred to whole dissolvings.
(3) get propylene glycol 30kg, heating for dissolving doxofylline 0.8kg.
(4) combining step 1 and step 2, the prepared solution of step 3 add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs of the present invention after clear and bright.
Clinical trial:
1. laboratory animal:
100 of the ill dogs of picked at random.
2. the compound kanamycin sulfate injection liquid our unit development of the experiment medicine embodiment of the invention 6 preparations;
Kanamycin sulfate injection liquid (10ml:100 ten thousand units) our unit's prepared in laboratory;
Doxofylline injection (10ml:0.8g) our unit prepared in laboratory.
3. experimental technique:
Suffer from dog with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with kanamycin sulfate injection liquid: intramuscular injection, every 1kg body weight 0.1ml, 2 times on the one, logotype 4 days.
The C group is treated usage with the doxofylline injection: intramuscular injection, and, every 1kg body weight 0.1ml, 2 times on the one, logotype 4 days.
The D group is treated usage with the compound kanamycin sulfate injection liquid of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.1ml, 1 time on the one, logotype 3 days.
After the treatment beginning, every day, dog health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 6 days, wherein:
Invalid: as after referring to 6 days, to suffer from the fowl symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 6 days, suffer from the fowl symptom and change, the effect before symptom is better than treating.
Cure: after referring to 6 days, transference cure is suffered from fowl and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 6 days, suffer from fowl and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from fowl and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, compound kanamycin sulfate injection liquid treatment group of the present invention, kanamycin sulfate injection liquid treatment group and doxofylline injection group and matched group difference is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | Symptom dog number of elements is arranged during end | Dead number of elements |
| A | Matched group | 25 | 0 | 0 | 22 | 3 |
| B | The kanamycin sulfate injection liquid treatment | 15 | 10 | 5 | 19 | 1 |
| C | The doxofylline injection for treating | 18 | 7 | 3 | 21 | 1 |
| D | The compound kanamycin sulfate injection liquid treatment of the embodiment of the invention 6 | 2 | 23 | 22 | 3 | 0 |
Claims (6)
1. compound kanamycin sulphate injection for dogs, it is characterized in that, consisting of of every 100L injection: 5～20 BOUs of Kanamicina Solfato, fosfomycin sodium 1～10kg, doxofylline 0.1～2kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
2. compound kanamycin sulphate injection for dogs according to claim 1, it is characterized in that, consisting of of every 100L injection: 7～15 BOUs of Kanamicina Solfato, fosfomycin sodium 3～8kg, doxofylline 0.3～1.5kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
3. compound kanamycin sulphate injection for dogs according to claim 1, it is characterized in that, consisting of of every 100L injection: 10 BOUs of Kanamicina Solfato, fosfomycin sodium 5kg, doxofylline 0.8kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
4. the preparation method of the described compound kanamycin sulphate injection for dogs of claim 1 is characterized in that, comprises the steps:
(1) gets 5～20 BOUs of Kanamicina Solfato, put into water for injection 40L, add fosfomycin sodium 1～10kg, dipyrone 20kg again, be stirred to whole dissolvings;
(2) get water for injection 10L, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg, be stirred to whole dissolvings;
(3) get propylene glycol 30kg, heating for dissolving doxofylline 0.1～2kg;
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulphate injection for dogs after clear and bright.
5. the preparation method of compound kanamycin sulphate injection for dogs according to claim 4, it is characterized in that, 7～15 BOUs of Kanamicina Solfato in every 100L injection, fosfomycin sodium 3～8kg, doxofylline 0.3～1.5kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, propylene glycol 30kg, surplus is a water for injection.
6. the preparation method of compound kanamycin sulphate injection for dogs according to claim 4, it is characterized in that, 10 BOUs of Kanamicina Solfato in every 100L injection, fosfomycin sodium 5kg, doxofylline 0.8kg, dipyrone 20kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, propylene glycol 30kg, surplus is a water for injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100531005A CN101297794B (en) | 2008-05-13 | 2008-05-13 | Compound kanamycin sulphate injection for dogs and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100531005A CN101297794B (en) | 2008-05-13 | 2008-05-13 | Compound kanamycin sulphate injection for dogs and preparation thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101297794A CN101297794A (en) | 2008-11-05 |
| CN101297794B true CN101297794B (en) | 2010-06-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008100531005A Expired - Fee Related CN101297794B (en) | 2008-05-13 | 2008-05-13 | Compound kanamycin sulphate injection for dogs and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102920720A (en) * | 2012-11-27 | 2013-02-13 | 衡阳科迪动物药业有限公司 | Animal compound kanamycin sulfate and coramine injection and preparation method thereof |
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Granted publication date: 20100609 Termination date: 20130513 |