CN101606946A - Compound kanamycin sulfate injection liquid for pig and preparation method thereof - Google Patents
Compound kanamycin sulfate injection liquid for pig and preparation method thereof Download PDFInfo
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- CN101606946A CN101606946A CNA2009103047507A CN200910304750A CN101606946A CN 101606946 A CN101606946 A CN 101606946A CN A2009103047507 A CNA2009103047507 A CN A2009103047507A CN 200910304750 A CN200910304750 A CN 200910304750A CN 101606946 A CN101606946 A CN 101606946A
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Abstract
The invention discloses a kind of compound kanamycin sulfate injection liquid for pig and preparation method thereof, aim to provide a kind of instant effect for the treatment of mycoplasma pneumoniae of swine, treating both the principal and secondary aspects of a disease, reduce medication number of times and dosage, medication compound kanamycin sulfate injection liquid and technology thereof easily is simple, easily the preparation method that realizes.Every 100L injection comprises: 5～20 BOUs of Kanamicina Solfato, lincomycin hydrochloride 1～10kg, doxofylline 0.1～2kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.Injection of the present invention is by each amounts of components of several drugs rational proportion, and fast to responding well to treatment of disease of breathing of pig, treating both the principal and secondary aspects of a disease can reduce the pathogenic microorganism drug resistance, makes pig recover quickening.Simultaneously, compound preparation of the present invention is injection, and is easy to use, and a drug just can reach the therapeutic effect of multiple medications.
Description
Technical field
The present invention relates to a kind of compound kanamycin sulfate injection liquid for pig and preparation method thereof.
Background technology
Mycoplasma pneumoniae of swine is a kind of disease that is caused by mycoplasma, with cough, asthma is principal character, and infection rate height, in case morbidity, be difficult in the pig farm and remove, can cause the pig hypoevolutism, reduce feed conversion rate, the major lesions zone is limited to lungs and lymph node, and especially serious inflammatory reaction appears in pulmonary.
Recently generally fall ill owing to primary disease, medication is spread unchecked, pathogen produces stronger drug resistance and causes common single drug therapeutic effect not good, and owing to there is not symptomatic treatment, or symptomatic treatment only, and can not treat disease fast and effectively, prolong the marketing time of pig, feed conversion rate is low, brings very big loss for numerous culturists.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, providing a kind of can reduce the pathogenic microorganism drug resistance to sick, symptomatic treatment mycoplasma pneumoniae of swine, and it is fast to respond well to treatment, clinical symptoms when energy alleviation trouble pig is ill, compound kanamycin sulfate injection liquid for pig easy to use.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned compound kanamycin sulfate injection liquid for pig of realizing.
The present invention is achieved through the following technical solutions:
A kind of compound kanamycin sulfate injection liquid for pig, it is characterized in that, consisting of of every 100L injection: 5～20 BOUs of Kanamicina Solfato, lincomycin hydrochloride 1～10kg, doxofylline 0.1～2kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
A kind of preparation method of compound kanamycin sulfate injection liquid for pig is characterized in that, comprises the steps:
(1) gets 5～20 BOUs of Kanamicina Solfato, put among the water for injection 40L about 80 ℃, add lincomycin hydrochloride 1～10kg again, be stirred to whole dissolvings;
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings;
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.1～2kg;
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulfate injection liquid for pig of the present invention after clear and bright.
The preferable of wherein every 100L injection consists of: 7～15 BOUs of Kanamicina Solfato, lincomycin hydrochloride 3～8kg, doxofylline 0.3～1.5kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
The best group of every 100L injection becomes: 10 BOUs of Kanamicina Solfato, lincomycin hydrochloride 6kg, doxofylline 1kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
The present invention has following technique effect:
The present invention is a compound preparation, adopt Kanamicina Solfato and lincomycin hydrochloride to unite use, adopt double effects, dual pressing down killed pathogenic microorganism, reduce pathogenic microorganism and produce chemical sproof probability, and increase the sensitivity of pathogenic microorganism, the cough and asthma that the doxofylline tool causes at the disease of breathing, serious inflammatory reaction is alleviated in dexamethasone sodium phosphate antiinflammatory, detoxifcation.Several drugs is by to the rational proportion of each amounts of components, to disease of breathing of pig to sick, symptomatic treatment, it is fast to respond well to treatment, treating both the principal and secondary aspects of a disease can reduce the pathogenic microorganism drug resistance, makes pig recover quickening.Simultaneously, compound preparation of the present invention is injection, and is easy to use, and a drug just can reach the therapeutic effect of multiple medications.
The preparation method technology of compound kanamycin sulfate injection liquid for pig of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) gets 5 BOUs of Kanamicina Solfato, put among the water for injection 40L about 80 ℃, add lincomycin hydrochloride 10kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings.
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 2kg.
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulfate injection liquid for pig of the present invention after clear and bright.
Embodiment 2
(1) gets 20 BOUs of Kanamicina Solfato, put among the water for injection 40L about 80 ℃, add lincomycin hydrochloride 1kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings.
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.1kg.
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid is clear and bright after, promptly make compound kanamycin sulfate injection liquid for pig of the present invention.
Embodiment 3
(1) gets 7 BOUs of Kanamicina Solfato, put among the water for injection 40L about 80 ℃, add lincomycin hydrochloride 8kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings.
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.3kg.
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid is clear and bright after, promptly make compound kanamycin sulfate injection liquid for pig of the present invention.
Embodiment 4
(1) gets 15 BOUs of Kanamicina Solfato, put among the water for injection 40L about 80 ℃, add lincomycin hydrochloride 3kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings.
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 1.5kg.
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid is clear and bright after, promptly make compound kanamycin sulfate injection liquid for pig of the present invention.
Embodiment 5
(1) gets 12 BOUs of Kanamicina Solfato, put among the water for injection 40L about 80 ℃, add lincomycin hydrochloride 5kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings.
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.8kg.
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid is clear and bright after, promptly make compound kanamycin sulfate injection liquid for pig of the present invention.
Embodiment 6
(1) gets 10 BOUs of Kanamicina Solfato, put among the water for injection 40L about 80 ℃, add lincomycin hydrochloride 6kg again, be stirred to whole dissolvings.
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings.
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 1kg.
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid is clear and bright after, promptly make compound kanamycin sulfate injection liquid for pig of the present invention.
Clinical trial:
1. laboratory animal:
100 of the ill pigs of picked at random.
The experiment medicine
The compound kanamycin sulfate injection liquid for pig our unit development of the embodiment of the invention 6 preparations;
6% lincomycin hydrochloride injection our unit prepared in laboratory;
Kanamycin sulfate injection liquid (10ml:100 ten thousand units) our unit's prepared in laboratory.
3 experimental techniques:
The A group does not give Drug therapy for the blank group.
The B group is treated usage with kanamycin sulfate injection liquid (10ml:100 ten thousand units): intramuscular injection, every 1kg body weight 0.15ml, 2 times on the one, logotype 5 days.
The C group is treated usage with 6% lincomycin hydrochloride injection: every 1kg body weight 0.15ml, 2 times on the one, logotype 5 days.
The D group is treated usage with the compound kanamycin sulfate injection liquid for pig of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.15ml, 1 time on the one, logotype 5 times.
After the treatment beginning, every day, the distribution of pig health situation of change suffered from record, and treat and add up therapeutic effect after 10 days, wherein:
Invalid: as after referring to 10 days, to suffer from the pig symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 10 days, suffer from the pig symptom and change, the effect before symptom is better than treating.
Cure: after referring to 10 days, transference cure is suffered from pig and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 10 days, suffer from pig and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from pig and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, compound kanamycin sulfate injection liquid treatment group, kanamycin sulfate injection liquid (10ml:100 ten thousand units) treatment group and 6% lincomycin hydrochloride injection group and matched group difference is (P＜0.01) extremely significantly.
Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | Symptom pig's head number is arranged during end | The relative weight gain rate % |
| ??A | Matched group | ??25 | ??0 | ??0 | ??25 | |
| ??B | Kanamycin sulfate injection liquid (10ml:100 ten thousand units) treatment | ??6 | ??19 | ??15 | ??10 | ??55.2 |
| ??C | The treatment of 6% lincomycin hydrochloride injection | ??13 | ??12 | ??5 | ??20 | ??50.5 |
| ??D | The compound kanamycin sulfate injection liquid treatment | ??2 | ??23 | ??22 | ??3 | ??80.0 |
Claims (6)
1. compound kanamycin sulfate injection liquid for pig, it is characterized in that, consisting of of every 100L injection: 5～20 BOUs of Kanamicina Solfato, lincomycin hydrochloride 1～10kg, doxofylline 0.1～2kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
2. compound kanamycin sulfate injection liquid for pig according to claim 1, it is characterized in that, consisting of of every 100L injection: 7～15 BOUs of Kanamicina Solfato, lincomycin hydrochloride 3～8kg, doxofylline 0.3～1.5kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
3. compound kanamycin sulfate injection liquid for pig according to claim 1, it is characterized in that, consisting of of every 100L injection: 10 BOUs of Kanamicina Solfato, lincomycin hydrochloride 6kg, doxofylline 1kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
4. the preparation method of the described compound kanamycin sulfate injection liquid for pig of claim 1 is characterized in that, comprises the steps:
(1) gets 5～20 BOUs of Kanamicina Solfato, put among 80 ℃ the water for injection 40L, add lincomycin hydrochloride 1～10kg again, be stirred to whole dissolvings;
(2) get water for injection 10L, add dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, be stirred to whole dissolvings;
(3) get dimethyl acetylamide 10kg, heating for dissolving doxofylline 0.1～2kg;
(4) combining step (1), step (2) and the prepared solution of step (3) add water for injection again to 100L, stir, and keep 15-20min, treat that medicinal liquid promptly makes compound kanamycin sulfate injection liquid for pig of the present invention after clear and bright.
5. the preparation method of compound kanamycin sulfate injection liquid for pig according to claim 4, it is characterized in that, 7～15 BOUs of Kanamicina Solfato in every 100L injection, lincomycin hydrochloride 3～8kg, doxofylline 0.3～1.5kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
6. the preparation method of compound kanamycin sulfate injection liquid for pig according to claim 4, it is characterized in that, 10 BOUs of Kanamicina Solfato in every 100L injection, lincomycin hydrochloride 6kg, doxofylline 1kg, dexamethasone sodium phosphate 0.05kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, dimethyl acetylamide 10kg, surplus is a water for injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009103047507A CN101606946A (en) | 2009-07-23 | 2009-07-23 | Compound kanamycin sulfate injection liquid for pig and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009103047507A CN101606946A (en) | 2009-07-23 | 2009-07-23 | Compound kanamycin sulfate injection liquid for pig and preparation method thereof |
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| CN101606946A true CN101606946A (en) | 2009-12-23 |
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| CNA2009103047507A Pending CN101606946A (en) | 2009-07-23 | 2009-07-23 | Compound kanamycin sulfate injection liquid for pig and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552118A (en) * | 2010-12-16 | 2012-07-11 | 四川科伦药物研究有限公司 | Kanamycin sulfate injection and preparation method thereof |
| CN102920720A (en) * | 2012-11-27 | 2013-02-13 | 衡阳科迪动物药业有限公司 | Animal compound kanamycin sulfate and coramine injection and preparation method thereof |
-
2009
- 2009-07-23 CN CNA2009103047507A patent/CN101606946A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552118A (en) * | 2010-12-16 | 2012-07-11 | 四川科伦药物研究有限公司 | Kanamycin sulfate injection and preparation method thereof |
| CN102552118B (en) * | 2010-12-16 | 2014-10-08 | 四川科伦药物研究有限公司 | Kanamycin sulfate injection and preparation method thereof |
| CN102920720A (en) * | 2012-11-27 | 2013-02-13 | 衡阳科迪动物药业有限公司 | Animal compound kanamycin sulfate and coramine injection and preparation method thereof |
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Application publication date: 20091223 |