CN101590012A - Be used for the treatment of injection of canine paratyphoid and preparation method thereof - Google Patents
Be used for the treatment of injection of canine paratyphoid and preparation method thereof Download PDFInfo
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- CN101590012A CN101590012A CNA2008100533689A CN200810053368A CN101590012A CN 101590012 A CN101590012 A CN 101590012A CN A2008100533689 A CNA2008100533689 A CN A2008100533689A CN 200810053368 A CN200810053368 A CN 200810053368A CN 101590012 A CN101590012 A CN 101590012A
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Abstract
The invention discloses a kind of injection that is used for canine paratyphoid and preparation method thereof, aim to provide a kind of treatment canine paratyphoid instant effect, reduce pathogenic bacterium drug resistance probability, treating both the principal and secondary aspects of a disease, injection and the technology thereof of accelerating rehabilitation are simple, easily the preparation method that realizes.Every 100L injection comprises: sulfamonomethoxine sodium 2～15kg, and lincomycin hydrochloride 1～10kg, atropine sulfate 0.05～0.3kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, surplus is a water for injection.The glucocorticoid of injection employing antimicrobial drug of the present invention and antibiotic, anti inflammatory detoxication and control dog diarrhoea, reduce the atropine sulfate of dehydration, through the compound preparation that the rational proportion of each amounts of components is formed, has dual antibacterial function, and the drug resistance probability of reduction Salmonella typhimurium, and control other gram negative bacterias, positive bacteria infection, make and recover to accelerate the cure rate height.
Description
Technical field
The present invention relates to a kind of composite sulfamonomethoxine sodium injection that is used for the treatment of canine paratyphoid and preparation method thereof.
Background technology
Canine paratyphoid is a kind of disease that is caused by Salmonella typhimurium, this bacterium distributes wide at occurring in nature, generally speaking, healthy dogs all is a carrier, it often hides in digestive tract, lymphoid tissue, when certain inducement descended Abwehrkraft des Koepers, thalline can be bred and endogenous infection taken place and ill, not exclusively boiled simultaneously and the food that goes bad all can cause infection.It mainly shows as diarrhoea, listless, anorexia, vomiting, stomachache, and system is depleted rapidly, mucosa is pale, dewaters at last, suffer a shock and extremely.
Treat the medicine that canine paratyphoid adopts at present, as medicines such as sulfamonomethoxine sodium, lincomycin hydrochloride, because natural antibacterial contacts antibiotic or antimicrobial drug for a long time, sensitivity to medicine reduces greatly, the normal drug resistance situation that produces, and, cause the disease dog to cause death because of dehydration causes acid, alkalosis because kill bacteria is rapidly recovered the disease dog fast.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat canine paratyphoid, reduces bacterial drug resistance, the detoxifcation antiinflammatory, and instant effect can prevent to infect and secondary infection the injection that is used for the treatment of canine paratyphoid for the treatment of both the principal and secondary aspects of a disease.
It is simple that another object of the present invention provides a kind of technology, easily the above-mentioned preparation method that is used for the treatment of the injection of canine paratyphoid that realizes.
The present invention is achieved through the following technical solutions:
A kind of injection that is used for the treatment of canine paratyphoid, it is characterized in that, consisting of of every 100L injection: sulfamonomethoxine sodium 2～15kg, lincomycin hydrochloride 1～10kg, atropine sulfate 0.05～0.3kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, surplus is a water for injection.
A kind of above-mentioned preparation method that is used for the treatment of the injection of canine paratyphoid is characterized in that, comprises the steps:
(1) takes by weighing sulfamonomethoxine sodium 2～15kg and put into 10-30L water for injection, be stirred to whole dissolvings.
(2) take by weighing lincomycin hydrochloride 1～10kg and put into 20-40L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.05～0.3kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
The preferable of wherein every 100L injection consists of: sulfamonomethoxine sodium 5～12kg, lincomycin hydrochloride 3～7kg, atropine sulfate 0.1～0.2kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, surplus is a water for injection.
The best group of every 100L injection becomes: sulfamonomethoxine sodium 10kg, and lincomycin hydrochloride 5kg, atropine sulfate 0.15kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, surplus is a water for injection.
Wherein, acid or alkali can be added when regulating pH value, sodium hydroxide or hydrochloric acid etc. can be used.
The present invention has following technique effect:
The present invention adopts sulfamonomethoxine sodium as antimicrobial drug and antibiotic hydrochloric acid lincomycin, the glucocorticoid dexamethasone sodium phosphate of anti inflammatory detoxication, and control dog diarrhoea, reduce the atropine sulfate of dehydration and form compound preparation, has dual antibacterial function, and through rational proportion to each amounts of components, can reduce the drug resistance probability of Salmonella typhimurium, control other gram negative bacterias simultaneously, positive bacteria infects, make sick body recover to accelerate, and minimizing bacteriotoxin, inflammation is to the destruction of body, can prevent to infect and secondary infection, treating both the principal and secondary aspects of a disease, the cure rate height.
The preparation method technology of the injection that is used for the treatment of canine paratyphoid of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) takes by weighing sulfamonomethoxine sodium 2kg and put into 10L water for injection, be stirred to whole dissolvings.
(2) take by weighing lincomycin hydrochloride 10kg and put into 40L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.3kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
Embodiment 2
(1) takes by weighing sulfamonomethoxine sodium 15kg and put into 30L water for injection, be stirred to whole dissolvings.
(2) take by weighing lincomycin hydrochloride 1kg and put into 20L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.05kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
Embodiment 3
(1) takes by weighing sulfamonomethoxine sodium 5kg and put into 10L water for injection, be stirred to whole dissolvings.
(2) take by weighing lincomycin hydrochloride 7kg and put into 40L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.2kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
Embodiment 4
(1) takes by weighing sulfamonomethoxine sodium 12kg and put into 30L water for injection, be stirred to whole dissolvings.
(2) take by weighing lincomycin hydrochloride 3kg and put into 30L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.1kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
Embodiment 5
(1) takes by weighing sulfamonomethoxine sodium 8kg and put into 20L water for injection, be stirred to whole dissolvings.
(2) take by weighing lincomycin hydrochloride 4kg and put into 25L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.12kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
Embodiment 6
(1) takes by weighing sulfamonomethoxine sodium 10kg and put into 30L water for injection, be stirred to whole dissolvings.
(2) take by weighing lincomycin hydrochloride 5kg and put into 30L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.15kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
Clinical trial:
1. laboratory animal:
100 of the ill one-tenth of picked at random dogs.
2. experiment medicine
The injection our unit development that is used for the treatment of canine paratyphoid of the embodiment of the invention 6 preparations;
The 10% sulfamonomethoxine sodium injection unit of effecting a permanent cure prepared in laboratory;
5% lincomycin hydrochloride injection our unit prepared in laboratory.
3. experimental technique:
Suffer from dog with 100 and be divided into four groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 10% sulfamonomethoxine sodium injection: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
The C group is used 5% lincomycin hydrochloride injection, treats usage: intramuscular injection, every 1kg body weight 0.2ml, 2 times on the one, logotype 3 days.
The D group is treated usage with the injection that is used for the treatment of canine paratyphoid of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.2ml, 1～2 time on the one, logotype 2 days.
After the treatment beginning, every day, dog health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 5 days, wherein:
Invalid: as after referring to 5 days, to suffer from the dog symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 5 days, suffer from the dog symptom and change, the effect before symptom is better than treating.
Cure: after referring to 5 days, transference cure is suffered from dog and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 5 days, suffer from dog and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from dog and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 preparation be used for the treatment of canine paratyphoid injection for treating group, 10% sulfamonomethoxine sodium injection for treating group and 5% lincomycin hydrochloride injection group and matched group difference extremely remarkable (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | Dead number of elements | The symptom number of elements is arranged during end |
| A | Matched group | 25 | 0 | 0 | 10 | 15 |
| B | 10% sulfamonomethoxine sodium injection is controlled | 7 | 18 | 15 | 5 | 5 |
| C | The treatment of 5% lincomycin hydrochloride injection | 18 | 7 | 5 | 6 | 16 |
| D | The treatment of composite sulfamonomethoxine sodium injection | 2 | 23 | 21 | 1 | 3 |
Claims (6)
1, a kind of injection that is used for the treatment of canine paratyphoid, it is characterized in that, consisting of of every 100L injection: sulfamonomethoxine sodium 2～15kg, lincomycin hydrochloride 1～10kg, atropine sulfate 0.05～0.3kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, surplus is a water for injection.
2, the injection for the treatment of canine paratyphoid that is used for the treatment of according to claim 1, it is characterized in that, consisting of of every 100L injection: sulfamonomethoxine sodium 5～12kg, lincomycin hydrochloride 3～7kg, atropine sulfate 0.1～0.2kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, surplus is a water for injection.
3, the injection that is used for the treatment of canine paratyphoid according to claim 1, it is characterized in that, consisting of of every 100L injection: sulfamonomethoxine sodium 10kg, lincomycin hydrochloride 5kg, atropine sulfate 0.15kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, surplus is a water for injection.
4, the described preparation method that is used for the treatment of the injection under the canine paratyphoid of a kind of claim 1 is characterized in that, comprises the steps:
(1) takes by weighing sulfamonomethoxine sodium 2～15kg and put into 10-30L water for injection, be stirred to whole dissolvings;
(2) take by weighing lincomycin hydrochloride 1～10kg and put into 20-40L water for injection, be stirred to whole dissolvings after, add atropine sulfate 0.05～0.3kg again, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg is stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds water for injection again to 100L, stirs, and keeps 15-20min, treat that medicinal liquid is clear and bright after, regulate pH value to 10.0～11.0, promptly make the injection that is used for the treatment of canine paratyphoid of the present invention.
5, the preparation method that is used for the treatment of the injection of canine paratyphoid according to claim 4, it is characterized in that, sulfamonomethoxine sodium 5～12kg in every 100L injection, lincomycin hydrochloride 3～7kg, atropine sulfate 0.1～0.2kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, surplus is a water for injection.
6, the preparation method that is used for the treatment of the injection of canine paratyphoid according to claim 4, it is characterized in that, sulfamonomethoxine sodium 10kg in every 100L injection, lincomycin hydrochloride 5kg, atropine sulfate 0.15kg, dexamethasone sodium phosphate 0.06kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, surplus is a water for injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100533689A CN101590012A (en) | 2008-05-30 | 2008-05-30 | Be used for the treatment of injection of canine paratyphoid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100533689A CN101590012A (en) | 2008-05-30 | 2008-05-30 | Be used for the treatment of injection of canine paratyphoid and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101590012A true CN101590012A (en) | 2009-12-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008100533689A Pending CN101590012A (en) | 2008-05-30 | 2008-05-30 | Be used for the treatment of injection of canine paratyphoid and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494834A (en) * | 2013-10-12 | 2014-01-08 | 成都乾坤动物药业有限公司 | Anti-infectious veterinary pharmaceutical composition and preparation method and application thereof |
| CN103622987A (en) * | 2013-12-03 | 2014-03-12 | 湖北武当动物药业有限责任公司 | Veterinary long-acting compound lincomycin hydrochloride injection and preparation method thereof |
-
2008
- 2008-05-30 CN CNA2008100533689A patent/CN101590012A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494834A (en) * | 2013-10-12 | 2014-01-08 | 成都乾坤动物药业有限公司 | Anti-infectious veterinary pharmaceutical composition and preparation method and application thereof |
| CN103622987A (en) * | 2013-12-03 | 2014-03-12 | 湖北武当动物药业有限责任公司 | Veterinary long-acting compound lincomycin hydrochloride injection and preparation method thereof |
| CN103622987B (en) * | 2013-12-03 | 2015-11-25 | 湖北武当动物药业有限责任公司 | A kind of long-acting veterinary compound lincomycin hydrochloride injection and preparation method thereof |
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Open date: 20091202 |