CN103417570A - Composition for treating bacterial diarrhea of pigs and preparation method thereof - Google Patents
Composition for treating bacterial diarrhea of pigs and preparation method thereof Download PDFInfo
- Publication number
- CN103417570A CN103417570A CN2013103909045A CN201310390904A CN103417570A CN 103417570 A CN103417570 A CN 103417570A CN 2013103909045 A CN2013103909045 A CN 2013103909045A CN 201310390904 A CN201310390904 A CN 201310390904A CN 103417570 A CN103417570 A CN 103417570A
- Authority
- CN
- China
- Prior art keywords
- compositions
- ampicillin
- taurine
- diarrhoea
- sodium bicarbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a composition for treating bacterial diarrhea of pigs and a preparation method of the composition. The composition comprises, by weight, 5-15% of ampicillin sodium, 5-20% of kanamycin sulfate, 5-15% of taurine, 5% of potassium chloride, 8% of sodium bicarbonate, 10% of sodium chloride and the balance sodium chloride. The composition for bacterial diarrhea reduces drug resistance of pathogens, takes effect rapidly, and is high in cure rate. Through reasonable matching, the composition combining the medicines has the obvious therapeutic effect on bacterial diarrhea of the pigs, can lower pathogenic drug resistance probability, reduces side effects of the medicines, treats both symptoms and root causes, and speeds up treatment.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for the treatment of pig antibacterial diarrhoea.
Background technology
Pig bacterial diarrhoea is a kind of commonly encountered diseases of pig, cause of disease is the gram negative bacterias such as escherichia coli, Salmonella, dysentery bacterium, serious enteritis for occurring, arranging a large amount of loose stool in main manifestations, some one-tenth water samples, cause electrolyte to run off in a large number, serious caused intestinal mucosa comes off, the serious dyspepsia of feedstuff, sick pig dehydration, seriously can cause death
Because recent primary disease generally occurs, there is infectiousness, add that medication is general; cause the cause of disease drug resistance serious, and cause that the antibacterial of diarrhoea is most for intestinal resides permanently bacterium, cure the disease under certain condition; cause this disease to purify; therefore primary disease is often sent out, due to current large-scale cultivation, and the cultivation price modification is limit; cause of disease can't accurately be judged or due to bacterial resistance; cause diagnosing unsuccessfully, incur loss through delay golden hour, and cause loss greatly.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provides a kind of and can treat pig bacterial diarrhoea, reduces cause of disease drug resistance probability, complication prevention, compositions easy to use.
It is simple that another object of the present invention is to provide a kind of technique, the preparation method of the above-mentioned composition of easily realizing.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of pig antibacterial diarrhoea, is characterized in that, following raw material, consists of by weight percentage: ampicillin 5～15%; Kanamicina Solfato 5～20%, taurine 5～15%, potassium chloride 5%, sodium bicarbonate 8%; sodium chloride 10%, surplus is anhydrous glucose.
A kind of preparation method that is used for the treatment of the compositions of pig antibacterial diarrhoea; it is characterized in that; comprise the steps: ampicillin; Kanamicina Solfato; taurine, potassium chloride; after sodium bicarbonate was pulverized respectively the 5# sieve; get by weight percentage ampicillin 5～15%, Kanamicina Solfato 5～20%, taurine 5～15%, potassium chloride 5%; sodium bicarbonate 8%; sodium chloride 10% premix 30 minutes, mixture and anhydrous glucose, fully mix 1 hour; after mixing, must treat the pig bacterial cold compositions of suffering from diarrhoea.
The better of above-mentioned each compositions in weight percentage consists of: ampicillin 8～12%, and Kanamicina Solfato 8～16%, taurine 8～12%, potassium chloride 5%, sodium bicarbonate 8%, sodium chloride 10%, surplus is anhydrous glucose.
The best group of above-mentioned each compositions in weight percentage becomes: ampicillin 10%, Kanamicina Solfato 12%, taurine 10%, potassium chloride 5%, sodium bicarbonate 8%, sodium chloride 10%, anhydrous glucose 45%.
The present invention has following technique effect:
The present invention is compound preparation, adopting ampicillin and Kanamicina Solfato is main antimicrobial component, both share for it, there is synergism, escherichia coli, Salmonella etc. are had to powerful killing action, and both synergism, not only strengthen bactericidal effect, and can reduce the probability of bacterial resistance, improve curative effect.The taurine antiinflammatory, protect the liver, and gastrointestinal tract is had no adverse effects, can effectively resist the side effect such as inflammation that bacterial diarrhea brings, and bacteriogenic bacterium is have to suitable cleaning effect, sodium bicarbonate has the intestinal of maintenance meta-alkalescence state, and kanamycin is had to potentiation, sodium chloride, potassium chloride is electrolyte, prevent from suffering from diarrhoea dehydration in a large number and cause the electrolyte deficiency, cause collapse, aggravate disease, all medicines share and by rational proportioning, pig bacterial diarrhoea are had to significant therapeutic effect, can reduce the drug resistance probability of cause of disease, reduce side effects of pharmaceutical drugs, treating both the principal and secondary aspects of a disease, accelerate treatment speed.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
The production 100kg of take is example; At first by ampicillin, Kanamicina Solfato, taurine, potassium chloride, sodium bicarbonate was pulverized respectively after the 5# sieve standby.
Embodiment 1
Accurately take ampicillin 5kg, Kanamicina Solfato 20kg, taurine 5kg, potassium chloride 5kg; sodium bicarbonate 8kg, sodium chloride 10kg premix 30 minutes, mixture and anhydrous glucose 47kg; fully mix 1 hour, after mixing, obtain for treating the compositions of pig antibacterial diarrhoea.
Embodiment 2
Accurately take ampicillin 15kg, Kanamicina Solfato 5kg, taurine 15kg, potassium chloride 5kg; sodium bicarbonate 8kg, sodium chloride 10kg premix 30 minutes, mixture and anhydrous glucose 42kg; fully mix 1 hour, after mixing, obtain for treating the compositions of pig antibacterial diarrhoea.
Embodiment 3
Accurately take ampicillin 8kg, Kanamicina Solfato 16kg, taurine 8kg, potassium chloride 5kg; sodium bicarbonate 8kg, sodium chloride 10kg premix 30 minutes, mixture and anhydrous glucose 45kg; fully mix 1 hour, after mixing, obtain for treating the compositions of pig antibacterial diarrhoea.
Embodiment 4
Accurately take ampicillin 12kg, Kanamicina Solfato 8kg, taurine 12kg, potassium chloride 5kg; sodium bicarbonate 8kg, sodium chloride 10kg premix 30 minutes, mixture and anhydrous glucose 45kg; fully mix 1 hour, after mixing, obtain for treating the compositions of pig antibacterial diarrhoea.
Embodiment 5
Accurately take ampicillin 11kg, Kanamicina Solfato 14kg, taurine 9kg, potassium chloride 5kg; sodium bicarbonate 8kg, sodium chloride 10kg premix 30 minutes, mixture and anhydrous glucose 43kg; fully mix 1 hour, after mixing, obtain for treating the compositions of pig antibacterial diarrhoea.
Embodiment 6
Accurately take ampicillin 10kg, Kanamicina Solfato 12kg, taurine 10kg, potassium chloride 5kg; sodium bicarbonate 8kg, sodium chloride 10kg premix 30 minutes, mixture and anhydrous glucose 45kg; fully mix 1 hour, after mixing, obtain for treating the compositions of pig antibacterial diarrhoea.
Clinical trial:
1. laboratory animal:
Choose at random 100 of ill pigs.
2. Experimental agents
The compositions our unit development of the embodiment of the present invention 6 preparations;
The laboratory preparation of 10% ampicillin powder (remaining 90% be anhydrous glucose) our unit;
The laboratory preparation of 12% Kanamicina Solfato powder (remaining 88% be anhydrous glucose) our unit.
3. experimental technique:
The A group, for the blank group, does not give Drug therapy.
The B group is treated with 10% ampicillin powder, and usage: spice, every 1kg feedstuff 1.5g, 2 times on the one, be used in conjunction 4.
The C group is treated with 12% Kanamicina Solfato powder, and usage: spice, every 1kg feedstuff 1.5g, 2 times on the one, be used in conjunction 4.
The D group is treated by the compositions of the embodiment of the present invention 6 preparations, and usage: spice, every 1kg feedstuff 1.5g, 2 times on the one, be used in conjunction 4.
After treatment starts, every day entry affected pig health situation of change distributes, and treat after 7 days and add up therapeutic effect, wherein:
Invalid: after referring to 7 days, the affected pig symptom, without obvious change, still keeps the front symptom for the treatment of.
Effectively: after referring to 7 days, the affected pig symptom changes, and symptom is better than the effect before treatment.
Cure: after referring to 7 days, transference cure, affected pig is got well.Its numeral is included in significant digits.
Symptom is arranged during end: after referring to 7 days, affected pig still has certain symptom, and before its Symptoms is better than treatment or without change, affected pig is not cured.Its numeral has been included in the numeral of invalid number and effective number.
Result of the test is as shown in the table.
Remarks: in a rehabilitation number statistics, the rehabilitation on a back date number has comprised a front number of rehabilitation
4. conclusion:
From the result of the test statistical analysis, learn, combination treatment group, 10% ampicillin treated powder group and the 12% Kanamicina Solfato powder group of the embodiment of the present invention 6 preparations and matched group difference is (P<0.01) extremely significantly.Compositions curative effect of the present invention is better than other two kinds of medicines.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. be used for the treatment of the compositions of pig antibacterial diarrhoea, it is characterized in that, formed by following raw material by weight percentage: ampicillin 5～15%; Kanamicina Solfato 5～20%, taurine 5～15%, potassium chloride 5%, sodium bicarbonate 8%; sodium chloride 10%, surplus is anhydrous glucose.
2. the compositions that is used for the treatment of pig antibacterial diarrhoea according to claim 1; it is characterized in that consisting of of each compositions in weight percentage: ampicillin 8～12%; Kanamicina Solfato 8～16%; taurine 8～12%, potassium chloride 5%; sodium bicarbonate 8%; sodium chloride 10%, surplus is anhydrous glucose.
3. the compositions that is used for the treatment of pig antibacterial diarrhoea according to claim 1, is characterized in that consisting of of each compositions in weight percentage: ampicillin 10%, Kanamicina Solfato 12%; taurine 10%, potassium chloride 5%; sodium bicarbonate 8%, sodium chloride 10%, anhydrous glucose 45%.
4. the preparation method that is used for the treatment of the compositions of pig antibacterial diarrhoea as claimed in claim 1; it is characterized in that; comprise the steps: ampicillin; Kanamicina Solfato; taurine, potassium chloride; after sodium bicarbonate was pulverized respectively the 5# sieve; get by weight percentage ampicillin 5～15%, Kanamicina Solfato 5～20%, taurine 5～15%, potassium chloride 5%; sodium bicarbonate 8%; sodium chloride 10% premix 30 minutes, mixture and anhydrous glucose, fully mix 1 hour; after mixing, must treat the pig bacterial cold compositions of suffering from diarrhoea.
5. the preparation method that is used for the treatment of the compositions of pig antibacterial diarrhoea according to claim 4; it is characterized in that consisting of of each compositions in weight percentage: ampicillin 8～12%; Kanamicina Solfato 8～16%; taurine 8～12%, potassium chloride 5%; sodium bicarbonate 8%; sodium chloride 10%, surplus is anhydrous glucose.
6. the preparation method that is used for the treatment of the compositions of pig antibacterial diarrhoea according to claim 4; it is characterized in that consisting of of each compositions in weight percentage: ampicillin 10%; Kanamicina Solfato 12%; taurine 10%, potassium chloride 5%; sodium bicarbonate 8%; sodium chloride 10%, anhydrous glucose 45%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103909045A CN103417570A (en) | 2013-08-30 | 2013-08-30 | Composition for treating bacterial diarrhea of pigs and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103909045A CN103417570A (en) | 2013-08-30 | 2013-08-30 | Composition for treating bacterial diarrhea of pigs and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103417570A true CN103417570A (en) | 2013-12-04 |
Family
ID=49643312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013103909045A Pending CN103417570A (en) | 2013-08-30 | 2013-08-30 | Composition for treating bacterial diarrhea of pigs and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103417570A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016112552A1 (en) * | 2015-01-17 | 2016-07-21 | 广州自远生物科技有限公司 | Application of taurine in preventing and/or treating disease induced by coronavirus and/or rotavirus virus |
-
2013
- 2013-08-30 CN CN2013103909045A patent/CN103417570A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016112552A1 (en) * | 2015-01-17 | 2016-07-21 | 广州自远生物科技有限公司 | Application of taurine in preventing and/or treating disease induced by coronavirus and/or rotavirus virus |
| KR20170106962A (en) * | 2015-01-17 | 2017-09-22 | 제니팜 레보라토리스 인코포레이티드 | Application of taurine in preventing and/or treating disease induced by coronavirus and/or rotavirus virus |
| JP2018501294A (en) * | 2015-01-17 | 2018-01-18 | 広州自遠生物科技有限公司 | Application of taurine in the prevention and / or treatment of diseases caused by coronavirus and / or rotavirus viruses |
| EP3246024A4 (en) * | 2015-01-17 | 2018-10-24 | Genifarm Laboratories Inc | Application of taurine in preventing and/or treating disease induced by coronavirus and/or rotavirus virus |
| KR101969007B1 (en) | 2015-01-17 | 2019-04-15 | 제니팜 레보라토리스 인코포레이티드 | Application of taurine in preventing and/or treating disease induced by coronavirus and/or rotavirus virus |
| US10314799B2 (en) | 2015-01-17 | 2019-06-11 | Genifarm Laboratories Inc | Use of taurine in prevention and/or treatment of diseases induced by viruses of genus coronavirus and/or genus rotavirus |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101966178A (en) | Composition for treating chicken proventriculitis and preparation method thereof | |
| CN103432162A (en) | Composition for treating poultry intestinal bacteria and anaerobic bacteria mixing infection and preparation method thereof | |
| CN101670094A (en) | Compound gentamycin sulfate soluble powder and preparation method thereof | |
| CN103417570A (en) | Composition for treating bacterial diarrhea of pigs and preparation method thereof | |
| CN102670762B (en) | Chinese medicine composition for treating fowl drug resistance salmonellosis and preparation method thereof | |
| CN102626499A (en) | Traditional Chinese medicinal composition used as both food and medicine for treating porcine respiratory tract infection, and preparation method thereof | |
| CN101966200A (en) | Composition for treating poultry digestive tract bacterial infection and preparation method thereof | |
| CN101612158A (en) | Compound ofloxacin injection of animals for treating postnatal infection and preparation method thereof | |
| CN101966201A (en) | Compound norfloxacin nicotinic soluble powder and preparation method thereof | |
| CN101653417A (en) | Compound colistin sulfate soluble powder for treating lamb dysentery and preparation method thereof | |
| CN103446171A (en) | Composition for treating swine respiratory tract infection and preparation method thereof | |
| CN102579733A (en) | Compound traditional Chinese medicine powder for treating sow constipation | |
| CN101879218A (en) | Compound shuanghuanglian oral solution used for treating cold of dog and preparation method thereof | |
| CN101612118A (en) | Porcine compound astragalus polysaccharide injection and preparation method thereof | |
| CN102114041A (en) | Composition for treating fowl cholera and preparation method thereof | |
| CN101653596A (en) | Soluble powder for treating canine colibacillosis and preparation method thereof | |
| CN102151269A (en) | Composition for treating pig paratyphus and preparation method thereof | |
| CN101653486A (en) | Compound Bailongsan for treating diarrhoea of nursery pig and preparation method thereof | |
| CN101647806A (en) | Composition for treating gallinaceous vibrio hepatitis and preparation method thereof | |
| CN101879179A (en) | Compound Ofloxacin solution and preparation method thereof | |
| CN101653597A (en) | Compound poplar flower oral liquid for treating piglet yellow or white dysentery and preparation thereof | |
| CN101983631A (en) | Composition for treating infection of pseudomonas aeruginosa in chicken and preparation method thereof | |
| CN101590012A (en) | Be used for the treatment of injection of canine paratyphoid and preparation method thereof | |
| CN106605766A (en) | Traditional Chinese medicinal compound feed for dairy cattle | |
| CN101966186A (en) | Composition for treating chicken escherichia coli infection and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131204 |
|
| WD01 | Invention patent application deemed withdrawn after publication |