CN102151269A - Composition for treating pig paratyphus and preparation method thereof - Google Patents
Composition for treating pig paratyphus and preparation method thereof Download PDFInfo
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- CN102151269A CN102151269A CN2011100412296A CN201110041229A CN102151269A CN 102151269 A CN102151269 A CN 102151269A CN 2011100412296 A CN2011100412296 A CN 2011100412296A CN 201110041229 A CN201110041229 A CN 201110041229A CN 102151269 A CN102151269 A CN 102151269A
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- florfenicol
- sulphathiazole
- taurine
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- tmp
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Abstract
The invention discloses a composition for treating pig paratyphus and a preparation method thereof. The invention aims to provide a composition which can treat paratyphus caused by salmonellatyphisuis and reduce pathogen resistance and is convenient for use and a preparation method thereof. The composition comprises the following components in percentage by weight: 3 to 10 percent of florfenicol, 5 to 15 percent of sulphathiazole sodium, 1 to 3 percent of trimethoprim (TMP), 5 percent of potassium chloride, 5 to 15 percent of sodium bicarbonate, 5 to 15 percent of taurine and the balance of anhydrous glucose. In the invention, the florfenicol and the sulphathiazole sodium are used as pathogen-resistance components, so pathogenic microorganisms can be killed effectively, pathogenic sensitivity is improved, possibility of generation of medicine resistance is lowered, and the composition is effective for secondary bacterial infection; the TMP has obvious synergetic effect on the sulphathiazole sodium and the florfenicol; the potassium chloride compensates for electrolyte lost due to diarrhea and hyperpyrexia and increases immunity, and the sodium bicarbonate can relieve the side effect of the sulphathiazole sodium and prevent against production of crystalluria; and the taurine has the effects of abating fever, diminishing inflammation and strengthening liver functions.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for the treatment of swine paratyphoid.
Background technology
Swine paratyphoid is a kind of commonly encountered diseases of pig, and cause of disease is a Salmonella, mainly shows as pig and has a high fever, and body temperature is more than 40 ℃, lassitude, and stomachache, dysentery, feces is yellowish or celadon, and stench, the enteritis that seriously can necrose, mortality rate is higher.
Because primary disease generally takes place recently, has infectiousness, add that medication is general, cause the cause of disease drug resistance serious, and the hyperpyrexia of primary disease clinical manifestation is carried out simultaneously with diarrhoea, cause resistance to descend easily, other bacterial infections of secondary, and be easy to cause the pig of body constitution difference to produce depletion, take the simple treatment of general conventional means, medicine, unsatisfactory curative effect often, the economic loss that causes is bigger.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat the salmonellal paratyphoid fever of pig, reduce the cause of disease drug resistance, prevention secondary infection, compositions easy to use.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned composition of realizing.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of swine paratyphoid is characterized in that, is made up of following raw material by weight percentage: florfenicol 3～10%, soluble sulphathiazole 5～15%; TMP 1～3%; potassium chloride 5%, sodium bicarbonate 5～15%, taurine 5～15%, surplus are anhydrous glucose.
A kind of preparation of compositions method that is used for the treatment of swine paratyphoid; it is characterized in that; after comprising the steps: florfenicol, soluble sulphathiazole, TMP, potassium chloride, sodium bicarbonate, taurine pulverize separately sieved, get florfenicol 3～10%, soluble sulphathiazole 5～15% by weight percentage, TMP 1～3%; potassium chloride 5%; sodium bicarbonate 5～15%, taurine 5～15%, surplus are anhydrous glucose, fully mix 1 hour; behind the mixing, promptly get the compositions of pig with treatment paratyphoid fever.
Wherein the preferable of each compositions in weight percentage consists of: florfenicol 4～7%, soluble sulphathiazole 7～12%, and TMP 1.4～2.4%, potassium chloride 5%, sodium bicarbonate 7～12%, taurine 8～11%, surplus are anhydrous glucose.
Wherein the best group of each compositions in weight percentage becomes: florfenicol 5%, soluble sulphathiazole 10%, TMP 2%, potassium chloride 5%, sodium bicarbonate 10%, taurine 10%, anhydrous glucose 58%.
The present invention has following technique effect:
The present invention is a compound preparation, and adopting florfenicol and soluble sulphathiazole is disease-resistant ultimate constituent, outside the effective pathogenic microbe killing of decapacitation, and the sensitivity of raising cause of disease on the very big limit, reduce chemical sproof occurrence probability, and effective to the secondary bacterial infection; TMP has remarkable potentiation, disease resistance enhancemen to soluble sulphathiazole and florfenicol; Potassium chloride replenishes the electrolyte loss that causes because of diarrhoea and hyperpyrexia; Build up resistance, sodium bicarbonate can alleviate the side effect of soluble sulphathiazole, and prevention produces crystalluria; Taurine have bring down a fever, antiinflammatory, strengthen the effect of liver function, can strengthen the Detoxication of the toxin that liver produces Salmonella.All medicines share and by reasonable proportioning swine paratyphoid are had notable therapeutic effect, can reduce the drug resistance probability of cause of disease, reduce side effects of pharmaceutical drugs, treating both the principal and secondary aspects of a disease.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.To produce 100kg is example;
It is standby that just florfenicol, soluble sulphathiazole, TMP, potassium chloride, sodium bicarbonate, taurine pulverize separately are crossed 5# sieve back.
Embodiment 1
Accurately take by weighing florfenicol 3kg, soluble sulphathiazole 15kg, TMP 3kg, potassium chloride 5kg, sodium bicarbonate 15kg, taurine 5kg, anhydrous glucose 54kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat swine paratyphoid.
Embodiment 2
Accurately take by weighing florfenicol 10kg, soluble sulphathiazole 5kg, TMP 1kg, potassium chloride 5kg, sodium bicarbonate 5kg, taurine 15kg, anhydrous glucose 59kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat swine paratyphoid.
Embodiment 3
Accurately take by weighing florfenicol 4kg, soluble sulphathiazole 12kg, TMP 2.4kg, potassium chloride 5kg, sodium bicarbonate 12kg, taurine 8kg, anhydrous glucose 56.6kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat swine paratyphoid.
Embodiment 4
Accurately take by weighing florfenicol 7kg, soluble sulphathiazole 7kg, TMP 1.4kg, potassium chloride 5kg, sodium bicarbonate 7kg, taurine 11kg, anhydrous glucose 61.6kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat swine paratyphoid.
Embodiment 5
Accurately take by weighing florfenicol 6kg, soluble sulphathiazole 9kg, TMP 1.8kg, potassium chloride 5kg, sodium bicarbonate 9kg, taurine 9kg, anhydrous glucose 60.2kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat swine paratyphoid.
Embodiment 6
Accurately take by weighing florfenicol 5kg, soluble sulphathiazole 10kg, TMP 2kg, potassium chloride 5kg, sodium bicarbonate 10kg, taurine 10kg, anhydrous glucose 58kg fully mixed 1 hour, behind the mixing, promptly got the compositions that is used to treat swine paratyphoid.
Clinical trial:
1. laboratory animal:
100 of the ill pigs of picked at random.
2. experiment medicine
The compositions our unit development of the embodiment of the invention 6 preparations;
5% florfenicol powder our unit prepared in laboratory;
10% soluble sulphathiazole powder our unit prepared in laboratory.
3. experimental technique:
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 5% florfenicol powder: spice, every 1kg feedstuff 1.5g, 2 times on the one, logotype 3 days.
The C group is treated usage with 10% soluble sulphathiazole powder: spice, every 1kg feedstuff 1.5g, 2 times on the one, logotype 3 days.
The D group is treated usage with the compositions of the embodiment of the invention 6 preparations: spice, every 1kg feedstuff 1.5g, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, the distribution of pig health situation of change suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the pig symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the pig symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from pig and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from pig and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from pig and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, combination treatment group, 5% florfenicol treated powder group and the 10% soluble sulphathiazole powder group of the embodiment of the invention 6 preparations and matched group difference is (P＜0.01) extremely significantly.Compositions curative effect of the present invention is better than other two kinds of medicines.
Table 1
Claims (6)
1. a compositions that is used for the treatment of swine paratyphoid is characterized in that, is made up of following raw material by weight percentage: florfenicol 3～10%; soluble sulphathiazole 5～15%, TMP 1～3%, potassium chloride 5%; sodium bicarbonate 5～15%, taurine 5～15%, surplus is an anhydrous glucose.
2. the compositions that is used for the treatment of swine paratyphoid according to claim 1; it is characterized in that; form by following raw material by weight percentage: florfenicol 4～7%; soluble sulphathiazole 7～12%; TMP1.4～2.4%, potassium chloride 5%, sodium bicarbonate 7～12%; taurine 8～11%, surplus are anhydrous glucose.
3. the compositions that is used for the treatment of swine paratyphoid according to claim 1 is characterized in that, is made up of following raw material by weight percentage: florfenicol 5%; soluble sulphathiazole 10%, TMP 2%, potassium chloride 5%; sodium bicarbonate 10%, taurine 10%, anhydrous glucose 58%.
4. described preparation of compositions method that is used for the treatment of swine paratyphoid of claim 1; it is characterized in that; after comprising the steps: florfenicol, soluble sulphathiazole, TMP, potassium chloride, sodium bicarbonate, taurine pulverize separately sieved; get florfenicol 3～10%, soluble sulphathiazole 5～15% by weight percentage; TMP 1～3%; potassium chloride 5%; sodium bicarbonate 5～15%; taurine 5～15%, surplus are anhydrous glucose; fully mixed 1 hour; behind the mixing, promptly get the compositions of pig with treatment paratyphoid fever.
5. the preparation of compositions method that is used for the treatment of swine paratyphoid according to claim 4; it is characterized in that; by weight percentage: florfenicol 4～7%; soluble sulphathiazole 7～12%; TMP 1.4～2.4%, potassium chloride 5%, sodium bicarbonate 7～12%; taurine 8～11%, surplus are anhydrous glucose.
6. the preparation of compositions method that is used for the treatment of swine paratyphoid according to claim 4 is characterized in that, by weight percentage: florfenicol 5%; soluble sulphathiazole 10%, TMP 2%, potassium chloride 5%; sodium bicarbonate 10%, taurine 10%, anhydrous glucose 58%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100412296A CN102151269A (en) | 2011-02-21 | 2011-02-21 | Composition for treating pig paratyphus and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100412296A CN102151269A (en) | 2011-02-21 | 2011-02-21 | Composition for treating pig paratyphus and preparation method thereof |
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| CN102151269A true CN102151269A (en) | 2011-08-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115745909A (en) * | 2022-11-12 | 2023-03-07 | 中国农业科学院兰州畜牧与兽药研究所 | Conjugate FST and preparation method and application thereof |
-
2011
- 2011-02-21 CN CN2011100412296A patent/CN102151269A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115745909A (en) * | 2022-11-12 | 2023-03-07 | 中国农业科学院兰州畜牧与兽药研究所 | Conjugate FST and preparation method and application thereof |
| CN115745909B (en) * | 2022-11-12 | 2024-01-26 | 中国农业科学院兰州畜牧与兽药研究所 | Conjugate FST and preparation method and application thereof |
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Application publication date: 20110817 |