CN101966178A - Composition for treating chicken proventriculitis and preparation method thereof - Google Patents
Composition for treating chicken proventriculitis and preparation method thereof Download PDFInfo
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- CN101966178A CN101966178A CN2010102364292A CN201010236429A CN101966178A CN 101966178 A CN101966178 A CN 101966178A CN 2010102364292 A CN2010102364292 A CN 2010102364292A CN 201010236429 A CN201010236429 A CN 201010236429A CN 101966178 A CN101966178 A CN 101966178A
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- florfenicol
- metronidazole
- taurine
- composition
- ranitidine hydrochloride
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Abstract
The invention discloses a composition for treating chicken proventriculitis and a preparation method thereof, which aim to provide a composition for treating the infection of chicken proventriculitis by addressing both symptoms and root causes and a preparation method thereof. The composition comprises the following components in percentage by weight: 1 to 10 percent of florfenicol, 5 to 15 percent of metronidazole, 1 to 6 percent of ranitidine hydrochloride, 2 to 15 percent of taurine and the balance of glucosum anhydricum. In the composition, aiming at pathogeny, the florfenicol and the metronidazole which serve as antimicrobial medicaments are adopted to kill anaerobic bacteria and helicobacter pylori effectively, reduce the occurrence probability of the tolerance of pathogenic bacteria and improve the sensitivity; the ranitidine hydrochloride inhibits the gastric acid effect and reduces the injury of gastric acid to inflamed glandular stomachs; and the taurine has the obvious effect of inflammation resistance, has no irritation on gastrointestinal tracts, and has the effect of diminishing inflammation quickly. Aiming at the pathogeny and diseases, the medicaments are combined, so that the composition can address both symptoms and root causes effectively on antipathogen and clinical symptoms thereof and treat the chicken proventriculitis effectively.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for the treatment of the chicken proventriculitis.
Background technology
The chicken proventriculitis is the common in recent years disease of chicken, and cause of disease is helicobacter pylori, anaerobe etc., and main clinical manifestation is that the chicken feather is fluffy and disorderly, is a cup too low, and wing is sagging, and feed intake and amount of drinking water obviously reduce.The chicken eye symptom of shedding tears and swell, and with respiratory symptom, row's white live green loose stool, dissect enlargement of visible sick chicken glandular stomach such as ball, be creamy white, examine visible canescence trellis outward appearance.Cut the visible glandular stomach wall thickening of glandular stomach, edema, one by flowing out serosity liquid gently.Nipple swelling is hemorrhage, and the nipple boundary merges, and not have boundary can be divided.The muscular stomach atrophy, thymus, the serious atrophy of spleen.Intestinal shows mucosa and breaks away from bleeding.
This disease is treated topmost difficult point for can not the better controlled state of an illness, generally, find the generation of disease, often cluster morbidity, and the existing regular period, this makes corresponding organ pathological changes occur, and simple treatment also can not the better controlled disease, and therapeutic effect is not good because the drug resistance situation often appears in cause of disease.Chang Buneng control cause of disease and pathology and cause bigger economic loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of composition and method of making the same that can treat the chicken proventriculitis to be provided.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of the chicken proventriculitis is characterized in that, is made up of following raw material by weight percentage: florfenicol 1～10%, and metronidazole 5～15%, ranitidine hydrochloride 1～6%, taurine 2～15%, surplus is an anhydrous glucose.
A kind of preparation of compositions method that is used for the treatment of the chicken proventriculitis is characterized in that, comprises the steps: florfenicol; metronidazole; after ranitidine hydrochloride, taurine pulverize separately sieve, get florfenicol 1～10% by weight percentage, metronidazole 5～15%; ranitidine hydrochloride 1～6%; taurine 2～15%, surplus are anhydrous glucose, fully mix 1 hour; behind the mixing, promptly get the compositions that is used to treat the chicken proventriculitis.
Wherein preferable consisting of: florfenicol 2～7% by weight percentage, metronidazole 8～12%, and ranitidine hydrochloride 2～4%, taurine 5～12%, surplus is an anhydrous glucose.
Best group becomes: florfenicol 5% by weight percentage, metronidazole 10%, ranitidine hydrochloride 3%, taurine 10%, anhydrous glucose 72%.
The present invention has following technique effect:
Compositions of the present invention adopts florfenicol and metronidazole at cause of disease, can effectively kill anaerobe, helicobacter pylori, and the combination of two kinds of medicines, can reduce the chemical sproof occurrence probability of pathogenic bacterium, improves sensitivity; Ranitidine hydrochloride has the effect of competitive retardance histamine and H2 receptors bind, and gastric acid inhibitory effect reduces the damage of gastric acid to the inflammation glandular stomach; Taurine has tangible antiinflammatory action, and to the gastrointestinal tract nonirritant, has the effect of quick antiinflammatory.Compositions of the present invention at cause of disease, disease, is effectively resisted cause of disease and clinical symptoms thereof by rational prescription and proportioning, and giving consideration to both the incidental and fundamental can be treated the chicken proventriculitis effectively.
Preparation of compositions method of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Standby with crossing No. 5 sieves behind florfenicol, metronidazole, ranitidine hydrochloride, the taurine pulverize separately.
Embodiment 1
Take by weighing the florfenicol 1kg after sieving, metronidazole 15kg, ranitidine hydrochloride 1kg, taurine 15kg, anhydrous glucose 68kg fully mixed 1 hour, promptly got the compositions that is used to treat the chicken proventriculitis.
Embodiment 2
Take by weighing the florfenicol 10kg after sieving, metronidazole 5kg, ranitidine hydrochloride 6kg, taurine 2kg, anhydrous glucose 77kg fully mixed 1 hour, promptly got the compositions that is used for the treatment of the chicken proventriculitis of the present invention.
Embodiment 3
Take by weighing the florfenicol 2kg after sieving, metronidazole 12kg, ranitidine hydrochloride 2kg, taurine 12kg, anhydrous glucose 72kg fully mixed 1 hour, fully mixed 1 hour, promptly got the compositions that is used for the treatment of the chicken proventriculitis of the present invention.
Embodiment 4
Take by weighing the florfenicol 7kg after sieving, metronidazole 8kg, ranitidine hydrochloride 4kg, taurine 5kg, anhydrous glucose 76kg fully mixed 1 hour, promptly got the compositions that is used for the treatment of the chicken proventriculitis of the present invention.
Embodiment 5
Take by weighing the florfenicol 6kg after sieving, metronidazole 9kg, ranitidine hydrochloride 2.5kg, taurine 8kg, anhydrous glucose 74.5kg fully mixed 1 hour, promptly got the compositions that is used for the treatment of the chicken proventriculitis of the present invention.
Embodiment 6
Take by weighing the florfenicol 5kg after sieving, metronidazole 10kg, ranitidine hydrochloride 3kg, taurine 10kg, anhydrous glucose 72kg fully mixed 1 hour, promptly got the compositions that is used for the treatment of the chicken proventriculitis of the present invention.
Clinical trial:
1. laboratory animal:
1000 of the ill chickens of picked at random, body weight is about about 1kg.
2. experiment medicine
The compositions our unit development of the embodiment of the invention 6 preparations;
5% florfenicol powder powder our unit prepared in laboratory;
3% ranitidine hydrochloride powder our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 5% florfenicol powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 7 days.
The C group is treated usage with 3% ranitidine hydrochloride powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 7 days.
The D group is treated usage with the compositions of the embodiment of the invention 6 preparations: drinking-water, every 1L water 1g, 2 times on the one, logotype 5 days.
After the treatment beginning, every day, chicken health situation of change suffered from record, and treat and add up therapeutic effect after 10 days, wherein:
Invalid: as after referring to 10 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 10 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 10 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 10 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 preparation be used for the treatment of chicken proventriculitis treatment group, 5% florfenicol treated powder group and 3% ranitidine hydrochloride powder group and matched group difference extremely remarkable (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
| Numbering | Group | Invalid number of elements | Effective number of elements | Cure number of elements | Symptom chicken number is arranged during end | Dead number of elements |
| A | Matched group | 250 | 0 | 0 | 153 | 97 |
| B | 6% florfenicol treated powder group | 123 | 127 | 83 | 78 | 89 |
| C | 3% ranitidine hydrochloride treated powder group | 25 | 225 | 43 | 128 | 79 |
| D | The combination treatment of the embodiment of the invention 6 | 14 | 236 | 185 | 29 | 36 |
Remarks: these data representations, the medicine that has has therapeutic effect to disease, can be from seeing therapeutic effect clinically, but can not cure diseases, can not improve mortality rate.
Claims (6)
1. a compositions that is used for the treatment of the chicken proventriculitis is characterized in that, is made up of following raw material by weight percentage: florfenicol 1～10%, and metronidazole 5～15%, ranitidine hydrochloride 1～6%, taurine 2～15%, surplus is an anhydrous glucose.
2. the compositions that is used for the treatment of the chicken proventriculitis according to claim 1 is characterized in that, is made up of following raw material by weight percentage: florfenicol 2～7%; metronidazole 8～12%; ranitidine hydrochloride 2～4%, taurine 5～12%, surplus is an anhydrous glucose.
3. the compositions that is used for the treatment of the chicken proventriculitis according to claim 1 is characterized in that, is made up of following raw material by weight percentage: florfenicol 5%, and metronidazole 10%, ranitidine hydrochloride 3%, taurine 10%, surplus is an anhydrous glucose.
4. described preparation of compositions method that is used for the treatment of the chicken proventriculitis of claim 1; it is characterized in that; after comprising the steps: florfenicol, metronidazole, ranitidine hydrochloride, taurine pulverize separately sieved, get florfenicol 1～10% by weight percentage, metronidazole 5～15%; ranitidine hydrochloride 1～6%; taurine 2～15%, the anhydrous glucose of surplus fully mixed 1 hour; behind the mixing, promptly get the compositions that is used to treat the chicken proventriculitis.
5. the preparation of compositions method that is used for the treatment of the chicken proventriculitis according to claim 4 is characterized in that, is made up of following raw material by weight percentage: florfenicol 2～7%; metronidazole 8～12%; ranitidine hydrochloride 2～4%, taurine 5～12%, surplus is an anhydrous glucose.
6. the preparation of compositions method that is used for the treatment of the chicken proventriculitis according to claim 4 is characterized in that, is made up of following raw material by weight percentage: florfenicol 5%; metronidazole 10%; ranitidine hydrochloride 3%, taurine 10%, surplus is an anhydrous glucose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102364292A CN101966178A (en) | 2010-07-26 | 2010-07-26 | Composition for treating chicken proventriculitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102364292A CN101966178A (en) | 2010-07-26 | 2010-07-26 | Composition for treating chicken proventriculitis and preparation method thereof |
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| CN101966178A true CN101966178A (en) | 2011-02-09 |
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| CN2010102364292A Pending CN101966178A (en) | 2010-07-26 | 2010-07-26 | Composition for treating chicken proventriculitis and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824630A (en) * | 2012-09-20 | 2012-12-19 | 石家庄维尔利动物药业有限公司 | Pharmaceutical composition for treating chicken proventriculitis and preparation method of pharmaceutical composition |
| CN102908358A (en) * | 2011-09-07 | 2013-02-06 | 菏泽普恩药业有限公司 | Compound preparation for preventing and treating proventriculitis of chicken |
| CN102988363A (en) * | 2012-11-19 | 2013-03-27 | 河南新正好生物工程有限公司 | Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof |
| CN103040848A (en) * | 2011-10-13 | 2013-04-17 | 洛阳惠中兽药有限公司 | Medicinal composition for treating and preventing chicken proventriculitis and preparation method thereof |
| CN104771757A (en) * | 2015-02-04 | 2015-07-15 | 沈阳伟嘉牧业技术有限公司 | Compound preparation for treating broiler proventriculitis |
-
2010
- 2010-07-26 CN CN2010102364292A patent/CN101966178A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908358A (en) * | 2011-09-07 | 2013-02-06 | 菏泽普恩药业有限公司 | Compound preparation for preventing and treating proventriculitis of chicken |
| CN103040848A (en) * | 2011-10-13 | 2013-04-17 | 洛阳惠中兽药有限公司 | Medicinal composition for treating and preventing chicken proventriculitis and preparation method thereof |
| CN103040848B (en) * | 2011-10-13 | 2014-06-18 | 洛阳惠中兽药有限公司 | Medicinal composition for treating and preventing chicken proventriculitis and preparation method thereof |
| CN102824630A (en) * | 2012-09-20 | 2012-12-19 | 石家庄维尔利动物药业有限公司 | Pharmaceutical composition for treating chicken proventriculitis and preparation method of pharmaceutical composition |
| CN102988363A (en) * | 2012-11-19 | 2013-03-27 | 河南新正好生物工程有限公司 | Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof |
| CN102988363B (en) * | 2012-11-19 | 2014-05-21 | 河南新正好生物工程有限公司 | Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof |
| CN104771757A (en) * | 2015-02-04 | 2015-07-15 | 沈阳伟嘉牧业技术有限公司 | Compound preparation for treating broiler proventriculitis |
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Application publication date: 20110209 |