CN102988363A - Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof - Google Patents
Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof Download PDFInfo
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- CN102988363A CN102988363A CN2012104673162A CN201210467316A CN102988363A CN 102988363 A CN102988363 A CN 102988363A CN 2012104673162 A CN2012104673162 A CN 2012104673162A CN 201210467316 A CN201210467316 A CN 201210467316A CN 102988363 A CN102988363 A CN 102988363A
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Abstract
The invention belongs to the technical field of veterinary medicines, and particularly relates to a medicine for treating poultry proventriculitis and necrotic enteritis and a preparation method of the medicine. The medicine per 100 parts by weight comprises the following components by weight: 1 to 10 parts of cimetidine, 5 to 30 parts of dimetridazole, 5 to 10 parts of amoxicillin, 1 to 10 parts of colloidal bismuth subcitrate, and the balance of auxiliary material. The medicine for treating poultry proventriculitis and necrotic enteritis, provided by the invention, is convenient for clinical use, and high in effective rate and cure rate.
Description
Technical field
The invention belongs to the veterinary drug technical field, particularly a kind of medicine for the treatment of poultry proventriculitis and necrotic enteritis and preparation method thereof.
Background technology
The poultry proventriculitis is a kind of symptom that is changed by many factors (comprising paathogenic factor and management factors) the glandular stomach function that combined effect causes and structure.In world's fowl diseases conference in 2007, the participant expert has carried out discussing widely in view of this problem, but cause of disease is never definitely assert.Owing in the chicken group of nearly all generation proventriculitis, can both isolate virus, so tentative " viral proventriculitis " by name.Should disease extensively betide northeast, North China, each province, south China at present.Primary disease all can occur throughout the year, but sickness rate is high when substituting with season, when You Yiqiu turns the winter loss more serious, more obvious in the northern area of China performance.The morbidity age in days is indefinite, just can show in the chickling of 3 ages in days, the kind chicken in 16 weeks report is arranged also the time.But the morbidity age in days focuses mostly at the 10-60 age in days.There is this pathogenetic report all parts of the country, but should disease larger limitation (i.e. morbidity focuses mostly on a geographic area) arranged.The chicken group of morbidity derives from the chicken kind of same kind of chicken house or same strain mostly.
Necrotic enteritis is a kind of bacterial infectious disease that is caused by clostridieum welchii (claiming again bacillus perfringens) A type or C type.This bacterium is a kind of conditionality pathogenic bacterium, and healthy chicken also carries this bacterium.Coop ventilation is bad, and ground is moist or feed factors such as fish flour bean cake to moldy metamorphism, all can bring out this disease.Sickness rate, mortality rate are not high, and day mortality rate is about 1%.This disease mainly occurs in the chicken at 2 thoughtful 6 monthly ages, and the multiple broiler of being born in not only affects the chicken fertility performance but also easily lures other sick generation into, causes more serious loss.
These two kinds of diseases have been brought massive losses to aviculture, need to work out corresponding medicine.
Summary of the invention
The object of the present invention is to provide a kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis and preparation method thereof.
The technical solution used in the present invention is as follows:
A kind of medicine for the treatment of poultry proventriculitis and necrotic enteritis, the weight of per 100 parts of medicines consists of: cimetidine 1-10 part, dimetridazole 5-30 part, amoxicillin 5-10 part, bismuth potassium citrate 1-10 part, surplus is adjuvant.
Described medicine is soluble powder.
When being prepared into soluble powder, described adjuvant is polyvinylpyrrolidone, beta-schardinger dextrin-, and a kind of in water soluble starch or the anhydrous glucose.
Polyvinylpyrrolidone is the 5-10 weight portion in the adjuvant, and beta-schardinger dextrin-is the 10-20 weight portion, and all the other are anhydrous glucose or water soluble starch.
The present invention also provides a kind of preparation method for the treatment of the soluble powder of poultry proventriculitis and necrotic enteritis, with cimetidine and amoxicillin and polyvinylpyrrolidone mix homogeneously, grinds 100 mesh sieves; With dimetridazole and beta-schardinger dextrin-mix homogeneously, ground 100 mesh sieves; With said mixture and bismuth potassium citrate mix homogeneously, add at last anhydrous glucose or water soluble starch.
Certainly, above-mentioned raw materials also can be prepared into other regular dosage forms on the materia medica according to conventional method.
Pathogeny, paathogenic factor and the characteristics etc. that the present invention is directed to poultry proventriculitis and necrotic enteritis conduct in-depth research, and carry out reasonably combined according to the characteristics of said medicine.Wherein, cimetidine has the effect of gastric acid secretion inhibiting; can obviously suppress the basis and night gastric acid secretion; also can suppress the gastric acid secretion that caused by histamine, minute stimulations such as peptide gastrin, insulin and food; and its acidity is reduced, the corrosive gastritis that causes because of chemical stimulation there are prevention and protective effect.The effect that has Synergistic after cimetidine and amoxicillin are share.Dimetridazole is the wide spectrum antianaerobic-microbacterial drug, simultaneously coccidiosis is also had inhibitory action.Bismuth potassium citrate can form insoluble bismuth-containing precipitation at gastric, adheres to securely on the rotten to the corn face and forms protective barrier, resists gastric acid and pepsin to the erosion of mucosal surface.Polyvinylpyrrolidone (PVP) and beta-schardinger dextrin-are medicinal macromolecular carriers, not only play the hydrotropy solubilization, have simultaneously the effect of slow release, controlled release.Dosage form is made soluble powder with conventional insoluble drugs, makes clinical use more convenient.
The present invention has following advantage with respect to prior art:
The medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis provided by the invention, clinical easy to use, effective percentage and cure rate are high.
The specific embodiment
Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited to this:
Embodiment 1
A kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis, this medicine of every 100g is comprised of the crude drug of following quality: cimetidine 5g, dimetridazole 20g, amoxicillin 10g, bismuth potassium citrate 5g, polyvinylpyrrolidone (PVP) 10g and beta-schardinger dextrin-20g, all the other are anhydrous glucose.
Preparation method is as follows:
1, with cimetidine and amoxicillin and polyvinylpyrrolidone (PVP) by the said ratio mix homogeneously, grind, cross 100 mesh sieves.
2, dimetridazole and beta-schardinger dextrin-are pressed the said ratio mix homogeneously, grind, cross 100 mesh sieves.
3, with mixture and the bismuth potassium citrate mix homogeneously of first two steps, add anhydrous glucose to 100g, and get final product.
Embodiment 2
A kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis, this medicine of every 100g is comprised of the crude drug of following quality: cimetidine 5g, dimetridazole 10g, amoxicillin 5g, bismuth potassium citrate 5g, polyvinylpyrrolidone (PVP) 5g and beta-schardinger dextrin-10g, all the other are anhydrous glucose.
Preparation method is with embodiment 1.
Embodiment 3
A kind of medicine that is used for the treatment of poultry proventriculitis and necrotic enteritis, this medicine of every 100g is comprised of the crude drug of following quality: cimetidine 5g, dimetridazole 30g, amoxicillin 10g, bismuth potassium citrate 5g, polyvinylpyrrolidone (PVP) 10g and beta-schardinger dextrin-20g, all the other are anhydrous glucose.
Preparation method is with embodiment 1.
Effect example 1
Utilize the medicine of embodiment 1 preparation to carry out the treatment of chicken proventriculitis:
Place: broiler field, Shangqiu City Minquan County, Henan Province:
Incidence: 3000 817 broiler, 16 ages in days.Clinical symptoms is as follows: feed intake descends, and drinking-water descends, and drop-head, flocks together.Sick chicken spirit is depressed, fear of cold, and it is slow-witted vertical to close one's eyes, a part chicken symptom of shedding tears and swell; Row's white, white green, yellow green loose stool.Dissecting the disease chicken finds: the glandular stomach enlargement such as " table tennis " sample, harden, glandular stomach wall thickening, the swelling of glandular stomach nipple, have such as " blister " sample, serious glandular stomach thelorrhagia.The secrete digestive juices amount obviously reduces or does not secrete.
Diagnosis: in conjunction with epidemiology, clinical symptoms with cut open the inspection situation, can be diagnosed as the broiler proventriculitis.
Treatment: because 3000 chickens in this chicken farm are divided into 2 hen houses and feed, therefore, a hen house adopts embodiment 1 medicine to treat, and concrete grammar is to add this medicine 0.3g in the 1L water, freely drinks water, and is used in conjunction 3 days.Another hen house adopts " the ovum liver is relaxed ", and (effective ingredient contains 20% mass content dimetridazole, Henan Xinzhenghao Bio-Engineering Co., Ltd. produces, lot number 20110903) to treat, concrete grammar is to add " the ovum liver is relaxed " 0.3g in the 1L water, freely drink water, be used in conjunction 3 days.
Therapeutic outcome is as follows:
Total effective rate refers to that spirit takes a turn for the better in this test group, and feed intake, the normal chicken of amount of drinking water are organized the ratio of chicken quantity with this.
The test explanation utilizes Drug therapy broiler proventriculitis of the present invention than using the dimetridazole successful, has played extraordinary therapeutic effect for treatment broiler proventriculitis.
Effect example 2
Utilize embodiment 1 medicine to carry out the chicken necrotizing enterocolitis treatment:
240 of 20 aa broiler chicken are from chicken farm, Xinxiang City, Henan Province Yuanyang.Be divided at random 6 groups, 40 every group, go mouldy feedstuff 5 days of the moderate of feeding continuously.Find that respectively organizing chicken occurs following symptom successively: spirit is depressed, and it is drowsiness to close one's eyes, loss of appetite, the thick disorderly unglazed frangibility of diarrhoea and feather.Row's black, Lycoperdon polymorphum Vitt loose stool are mixed with blood sometimes, and the part chicken can not stood, paralysis, and dipteron is clapped ground, stridulation during touch.Every group is cutd open 2 of inspections, finds that the small intestinal intestinal wall is fragile, the expansion gassy, and intestinal mucosa adheres to loose or fine and close pseudomembrane, and it is yellow or green that the pseudomembrane outward appearance is.The visible ecchymosis of intestinal wall placenta percreta, the capillary rupture that has forms bruise.Mucosal bleeding reaches the flesh layer deeply, diffuse hemorrhage is arranged and occur serious downright bad.
Can be judged as chicken necrotizing enterocolitis according to above symptom.
Each group takes the treatment measure as follows:
| Group | Measure |
| Blank group | Continue to use the feedstuff that goes mouldy, do not use medicine, freely drink water. |
| Matched group | Change fresh feed, do not use medicine, freely drink water. |
| The medicine low dose group | Change fresh feed, add this medicine of 0.1g in the 1L drinking-water, freely drink water. |
| Dosage group in the medicine | Change fresh feed, add this medicine of 0.3g in the 1L drinking-water, freely drink water. |
| The medicine high dose group | Change fresh feed, add this medicine of 0.5g in the 1L drinking-water, freely drink water. |
| The medicine matched group | Change fresh feed, add 0.3g ball bit in the 1L drinking-water, freely drink water. |
" ball bit " is the diclazuril (Henan Xinzhenghao Bio-Engineering Co., Ltd. produces, lot number 20110502) of 1% mass content for effective ingredient in the medicine matched group.
More than continuous 3 days therapeutic effect of post-evaluation for the treatment of, the result is as follows:
| Group | Dead (only) | Cure rate (%) | Effective percentage (%) |
| Blank group | 4 | --- | --- |
| Matched group | 2 | --- | --- |
| The medicine low dose group | 0 | 80 | 85 |
| Dosage group in the medicine | 0 | 87.5 | 92.5 |
| The medicine high dose group | 0 | 92.5 | 95 |
| The medicine matched group | 1 | 60 | 75 |
The dead quantity that refers to respectively organize at duration of test chicken death in the table.
Cure rate refers to clinical symptoms complete obiteration after the medication treatment in the table, and spirit and appetite are recovered the ratio of normal chicken quantity and this group quantity;
Effective percentage refers to that clinical symptoms obviously alleviates after the medication treatment in the table, the ratio of the chicken quantity that spirit and appetite take a turn for the better and this group quantity.
Can find out from upper table data, each medication group of this medicine has in various degree therapeutic effect to the chicken necrotizing enterocolitis of test, this medicine is high, middle dosage group effective percentage is significantly higher than low dose group (0.01＜P＜0.05), and this medicine height, middle dosage group effective percentage, weightening finish are without significant difference, therefore recommend this medicine to the usage and dosage of chicken to be: mixed drink, every 1L water 0.3g is used in conjunction 3 days.
Medicinal application of the present invention effect when other poultry such as duck goose is substantially suitable when being used for chicken.
Above-described embodiment is the preferred embodiment of the present invention, but embodiments of the present invention are not restricted to the described embodiments, and the change that other any the present invention of not deviating from does all should be the substitute mode of equivalence, is included within protection scope of the present invention.
Claims (5)
1. a medicine for the treatment of poultry proventriculitis and necrotic enteritis is characterized in that, the weight of per 100 parts of medicines consists of: cimetidine 1-10 part, and dimetridazole 5-30 part, amoxicillin 5-10 part, bismuth potassium citrate 1-10 part, surplus is adjuvant.
2. the medicine for the treatment of poultry proventriculitis as claimed in claim 1 and necrotic enteritis is characterized in that described medicine is soluble powder.
3. the medicine for the treatment of as claimed in claim 2 poultry proventriculitis and necrotic enteritis is characterized in that described adjuvant is polyvinylpyrrolidone, beta-schardinger dextrin-, and a kind of in water soluble starch or the anhydrous glucose.
4. the medicine for the treatment of poultry proventriculitis as claimed in claim 3 and necrotic enteritis is characterized in that polyvinylpyrrolidone is the 5-10 weight portion in the adjuvant, and beta-schardinger dextrin-is the 10-20 weight portion, and all the other are anhydrous glucose or water soluble starch.
5. the preparation method of the soluble powder for the treatment of poultry proventriculitis and necrotic enteritis is characterized in that, with cimetidine and amoxicillin and polyvinylpyrrolidone mix homogeneously, grinds 100 mesh sieves; With dimetridazole and beta-schardinger dextrin-mix homogeneously, ground 100 mesh sieves; With said mixture and bismuth potassium citrate mix homogeneously, add at last anhydrous glucose or water soluble starch; According to 100 parts of meters, more than the weight portion of each raw material consist of: cimetidine 1-10 part, dimetridazole 5-30 part, amoxicillin 5-10 part, bismuth potassium citrate 1-10 part, polyvinylpyrrolidone 5-10 part, beta-schardinger dextrin-10-20 part, all the other are anhydrous glucose or water soluble starch.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690940A (en) * | 2013-12-26 | 2014-04-02 | 南阳新先锋制药有限公司 | Compound dimetridazole premix for preventing and treating poultry enterovirus syndrome |
| CN104323004A (en) * | 2014-10-30 | 2015-02-04 | 马辉 | Feed additive capable of preventing and treating gastric diseases of livestock and poultry |
| CN105919942A (en) * | 2016-07-07 | 2016-09-07 | 杭州爱力迈动物药业有限公司 | Dimetridazole soluble powder and preparation method thereof |
| CN106074514A (en) * | 2016-08-31 | 2016-11-09 | 上海邦森生物科技有限公司 | A kind of water solublity dimetridazole pre-mixing agent and preparation method thereof |
| CN106727350A (en) * | 2016-12-28 | 2017-05-31 | 潍坊宇洋药业有限公司 | A kind of lincomycin solid dispersion preparation and preparation method thereof |
| CN108553423A (en) * | 2018-05-16 | 2018-09-21 | 厦门汇承科技有限公司 | Water-soluble Dimetridazole pre-mixing agent for animals of one kind and preparation method thereof |
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| CN1147380A (en) * | 1995-10-09 | 1997-04-16 | 张晓安 | Medicine compound for gastric and duodenal ulcer |
| CN101297805A (en) * | 2007-09-24 | 2008-11-05 | 天津生机集团有限公司 | Medicament composition for preventing and controlling enteritis necroticans of domestic birds |
| CN101966178A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating chicken proventriculitis and preparation method thereof |
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2012
- 2012-11-19 CN CN201210467316.2A patent/CN102988363B/en active Active
Patent Citations (3)
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| CN1147380A (en) * | 1995-10-09 | 1997-04-16 | 张晓安 | Medicine compound for gastric and duodenal ulcer |
| CN101297805A (en) * | 2007-09-24 | 2008-11-05 | 天津生机集团有限公司 | Medicament composition for preventing and controlling enteritis necroticans of domestic birds |
| CN101966178A (en) * | 2010-07-26 | 2011-02-09 | 天津生机集团股份有限公司 | Composition for treating chicken proventriculitis and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690940A (en) * | 2013-12-26 | 2014-04-02 | 南阳新先锋制药有限公司 | Compound dimetridazole premix for preventing and treating poultry enterovirus syndrome |
| CN104323004A (en) * | 2014-10-30 | 2015-02-04 | 马辉 | Feed additive capable of preventing and treating gastric diseases of livestock and poultry |
| CN105919942A (en) * | 2016-07-07 | 2016-09-07 | 杭州爱力迈动物药业有限公司 | Dimetridazole soluble powder and preparation method thereof |
| CN105919942B (en) * | 2016-07-07 | 2019-05-03 | 杭州爱力迈动物药业有限公司 | A kind of Dimetridazole soluble powder and preparation method thereof |
| CN106074514A (en) * | 2016-08-31 | 2016-11-09 | 上海邦森生物科技有限公司 | A kind of water solublity dimetridazole pre-mixing agent and preparation method thereof |
| CN106727350A (en) * | 2016-12-28 | 2017-05-31 | 潍坊宇洋药业有限公司 | A kind of lincomycin solid dispersion preparation and preparation method thereof |
| CN108553423A (en) * | 2018-05-16 | 2018-09-21 | 厦门汇承科技有限公司 | Water-soluble Dimetridazole pre-mixing agent for animals of one kind and preparation method thereof |
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| CN102988363B (en) | 2014-05-21 |
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