CN101983631A - Composition for treating infection of pseudomonas aeruginosa in chicken and preparation method thereof - Google Patents
Composition for treating infection of pseudomonas aeruginosa in chicken and preparation method thereof Download PDFInfo
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- CN101983631A CN101983631A CN2010102599476A CN201010259947A CN101983631A CN 101983631 A CN101983631 A CN 101983631A CN 2010102599476 A CN2010102599476 A CN 2010102599476A CN 201010259947 A CN201010259947 A CN 201010259947A CN 101983631 A CN101983631 A CN 101983631A
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Abstract
The invention discloses a composition for treating infection of pseudomonas aeruginosa in chicken and a preparation method thereof, aiming to provide a composition for treating the infection of pseudomonas aeruginosa in chicken, which is capable of reducing the drug resistance rate of bacteria and addressing both the symptoms and root causes, and a preparation method thereof. The composition consists of the following components in percentage by weight: 4 to 12 percent of gentamycin sulfate, 4 to 8 percent of amoxicillin, 4 to 8 percent of sodium carbonate, 10 to 30 percent of analginum, and the balance of anhydrous dextrose. In the composition, the gentamycin sulfate and the amoxicillin are synergized to kill pseudomonas aeruginosa, can reduce the occurrence probability of pathogeny drug resistance, and increase the sensitivity of pathogeny to the composition; the sodium carbonate has the effect of solubilizing the amoxicillin, and can improve the antibacterial effect of the gentamycin sulfate; and the analginum has the effect of defervescence and anti-inflammatory. The composition has the functions of killing the pathogency, effectively resisting pathogenic bacteria and clinical symptoms caused by the pathogenic bacteria, addressing both the symptoms and root causes, effectively treating the infection of pseudomonas aeruginosa in chicken, and reducing the pathogeny drug resistance by reasonable compatibility of the components. The composition can be dissolved in water, and is convenient to use.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for the treatment of the chicken pseudemonas aeruginosa disease.
Background technology
The chicken pseudemonas aeruginosa disease is the common disease of chicken, cause of disease is a bacillus pyocyaneus, pathogen is prevalent in soil, water, intestinal contents, animal body surfaces etc. are located, chicken essence god is depressed, appetite depression or useless exhausted, fervescence (more than 42 ℃), abdominal distension, two wings are sagging, and feather is contrary upright, row's yellow-white or white watery stools, cut open the visible head of inspection, cervical region is subcutaneous a large amount of yellow glue peptone sample exudates, the spread to chest that has, abdominal part and two inboard legs subcutaneous, cranial periosteum is congested and hemorrhage, incidence muscle and chest muscle irregular bleeding, there is the plain sample exudate of yellow fibers in the later stage.There is faint yellow limpid ascites in the abdominal cavity, and later stage ascites takes on a red color, and liver, fabricius bursa serous coat and glandular stomach serous coat have petechia not of uniform size, and the air bag muddiness thickens.The bacillus pyocyaneus intravenous inoculation causes pericarditis and apostematosa pneumonia.
This sick cause of disease is owing to ubiquity, so the infection rate height, when vaccinate, Changes in weather, environmental stimuli, resistance when descending disease can take place.The generally generation of pathogen in recent years, the extensive application of medicine causes drug resistance serious, and the complicated clinical manifestation of primary disease, use monistic antimicrobial drug,, often do not reach therapeutic effect and bring great loss to the culturist as gentamycin sulfate, amoxicillin etc.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat the chicken pseudemonas aeruginosa disease, treating both the principal and secondary aspects of a disease, the composition and method of making the same of minimizing pathogen drug resistance probability.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of the chicken pseudemonas aeruginosa disease is characterized in that, is made up of following raw material by weight percentage: gentamycin sulfate 4～12%, and amoxicillin 4～8%, sodium carbonate 4～8%, dipyrone 10～30%, surplus is an anhydrous glucose.
A kind of above-mentioned preparation of compositions method that is used for the treatment of the chicken pseudemonas aeruginosa disease, it is characterized in that, comprise the steps: amoxicillin, sodium carbonate, dipyrone pulverize separately were sieved behind the 5# sieve, get gentamycin sulfate 4～12% by weight percentage, amoxicillin 4～8%, sodium carbonate 4～8%, dipyrone 10～30%, surplus are anhydrous glucose, fully mix 1 hour, behind the mixing, promptly get the compositions that is used to treat the chicken pseudemonas aeruginosa disease.
Wherein preferable consisting of: gentamycin sulfate 6～9% by weight percentage, amoxicillin 5～7%, and sodium carbonate 5～7%, dipyrone 15～25%, surplus is an anhydrous glucose.
Best group becomes: gentamycin sulfate 8.5% by weight percentage, amoxicillin 5.5%, sodium carbonate 5.5%, dipyrone 20%, anhydrous glucose 60.5%.
The present invention has following technique effect:
Compositions of the present invention adopts two kinds of disease-resistant ultimate constituents: gentamycin sulfate and amoxicillin, bacillus pyocyaneus is produced bactericidal action, and the two there is synergism, and can reduce the chemical sproof occurrence probability of cause of disease, increase the sensitivity of cause of disease to this product; Sodium carbonate help solubilization to the amoxicillin, and can improve the antibacterial effect of gentamycin sulfate; The dipyrone antiinflammatory of bringing down a fever, hyperpyrexia that the chicken pseudemonas aeruginosa disease is caused and inflammatory symptoms have brings down a fever and antiinflammatory action, the disease chicken is consumed weaken, and inflammatory reaction reduces and reaches therapeutical effect.Compositions of the present invention has the cause of disease of killing, can effectively resist pathogen and causes clinical symptoms that giving consideration to both the incidental and fundamental can be treated the chicken pseudemonas aeruginosa disease effectively by the reasonable compatibility of various components, reduce pathogen drug resistance probability.This product water soluble, easy to use.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
It is standby that amoxicillin, sodium carbonate, dipyrone pulverize separately are crossed 5# sieve back.
Embodiment 1
Take by weighing the amoxicillin 8kg after sieving, sodium carbonate 8kg, dipyrone 30kg and gentamycin sulfate 4kg, anhydrous glucose 50kg fully mixed 1 hour, promptly got the compositions that is used to treat the chicken pseudemonas aeruginosa disease.
Embodiment 2
Take by weighing the amoxicillin 4kg after sieving, sodium carbonate 4kg, dipyrone 10kg and gentamycin sulfate 12kg, anhydrous glucose 70kg fully mixed 1 hour, promptly got the compositions that is used to treat the chicken pseudemonas aeruginosa disease.
Embodiment 3
Take by weighing the amoxicillin 7kg after sieving, sodium carbonate 7kg, dipyrone 25kg and gentamycin sulfate 6kg, anhydrous glucose 55kg fully mixed 1 hour, promptly got the compositions that is used to treat the chicken pseudemonas aeruginosa disease.
Embodiment 4
Take by weighing the amoxicillin 5kg after sieving, sodium carbonate 5kg, dipyrone 15kg and gentamycin sulfate 9kg, anhydrous glucose 66kg fully mixed 1 hour, promptly got the compositions that is used to treat the chicken pseudemonas aeruginosa disease.
Embodiment 5
Take by weighing after sieving, amoxicillin 6kg, sodium carbonate 6kg, dipyrone 16kg and gentamycin sulfate 7kg, anhydrous glucose 65kg fully mixed 1 hour, promptly got the compositions that is used for the treatment of the chicken pseudemonas aeruginosa disease of the present invention.
Embodiment 6
Take by weighing the amoxicillin 5.5kg after sieving, sodium carbonate 5.5kg, dipyrone 20kg and gentamycin sulfate 8.5kg, anhydrous glucose 60.5kg fully mixed 1 hour, promptly got the compositions that is used to treat the chicken pseudemonas aeruginosa disease.
Clinical trial:
1. laboratory animal:
1000 of the ill chickens of picked at random, body weight is about about 1kg.
2. experiment medicine
The compositions our unit development of the embodiment of the invention 6 preparations;
8.5% gentamycin sulfate soluble powder our unit prepared in laboratory;
5.5% amoxicillin soluble powder our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 8.5% gentamycin sulfate soluble powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 4 days.
The C group is treated usage with 5.5% amoxicillin soluble powder: drinking-water, every 1L water 1g, 2 times on the one, logotype 4 days.
The D group is treated usage with the compositions of the embodiment of the invention 6 preparations: drinking-water, every 1L water 1g, 2 times on the one, logotype 3 days.
After the treatment beginning, every day, chicken health situation of change and dead animal distribution suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 preparation be used for the treatment of chicken pseudemonas aeruginosa disease treatment group, 8.5% gentamycin sulfate soluble powder treatment group and 5.5% amoxicillin soluble powder group and matched group difference extremely remarkable (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
Claims (6)
1. a compositions that is used for the treatment of the chicken pseudemonas aeruginosa disease is characterized in that, is made up of following raw material by weight percentage: gentamycin sulfate 4～12%, and amoxicillin 4～8%, sodium carbonate 4～8%, dipyrone 10～30%, surplus is an anhydrous glucose.
2. the compositions that is used for the treatment of the chicken pseudemonas aeruginosa disease according to claim 1 is characterized in that, is made up of following raw material by weight percentage: gentamycin sulfate 6～9%, amoxicillin 5～7%, sodium carbonate 5～7%, dipyrone 15～25%, surplus is an anhydrous glucose.
3. the compositions that is used for the treatment of the chicken pseudemonas aeruginosa disease according to claim 1, it is characterized in that, form by following raw material by weight percentage: gentamycin sulfate 8.5%, amoxicillin 5.5%, sodium carbonate 5.5%, dipyrone 20%, anhydrous glucose 60.5%.
4. described preparation of compositions method that is used for the treatment of the chicken pseudemonas aeruginosa disease of claim 1, it is characterized in that, after comprising the steps: amoxicillin, sodium carbonate, dipyrone pulverize separately sieved, get gentamycin sulfate 4～12% by weight percentage, amoxicillin 4～8%, sodium carbonate 4～8%, dipyrone 10～30%, surplus is an anhydrous glucose, fully mixed 1 hour, behind the mixing, promptly get the compositions that is used to treat the chicken pseudemonas aeruginosa disease.
5. the preparation of compositions method that is used for the treatment of the chicken pseudemonas aeruginosa disease according to claim 4 is characterized in that, by weight percentage: gentamycin sulfate 6～9%, amoxicillin 5～7%, sodium carbonate 5～7%, dipyrone 15～25%, surplus is an anhydrous glucose.
6. the preparation of compositions method that is used for the treatment of the chicken pseudemonas aeruginosa disease according to claim 4 is characterized in that, by weight percentage: gentamycin sulfate 8.5%, amoxicillin 5.5%, sodium carbonate 5.5%, dipyrone 20%, anhydrous glucose 60.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102599476A CN101983631A (en) | 2010-08-23 | 2010-08-23 | Composition for treating infection of pseudomonas aeruginosa in chicken and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102599476A CN101983631A (en) | 2010-08-23 | 2010-08-23 | Composition for treating infection of pseudomonas aeruginosa in chicken and preparation method thereof |
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| CN101983631A true CN101983631A (en) | 2011-03-09 |
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| CN2010102599476A Pending CN101983631A (en) | 2010-08-23 | 2010-08-23 | Composition for treating infection of pseudomonas aeruginosa in chicken and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893424A (en) * | 2014-04-25 | 2014-07-02 | 四川农业大学 | Traditional Chinese medicine oral liquid for preventing and treating cyanomycosis of high-quality chicken and preparation method thereof |
-
2010
- 2010-08-23 CN CN2010102599476A patent/CN101983631A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893424A (en) * | 2014-04-25 | 2014-07-02 | 四川农业大学 | Traditional Chinese medicine oral liquid for preventing and treating cyanomycosis of high-quality chicken and preparation method thereof |
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Application publication date: 20110309 |