CN102114041A - Composition for treating fowl cholera and preparation method thereof - Google Patents
Composition for treating fowl cholera and preparation method thereof Download PDFInfo
- Publication number
- CN102114041A CN102114041A CN201110041260XA CN201110041260A CN102114041A CN 102114041 A CN102114041 A CN 102114041A CN 201110041260X A CN201110041260X A CN 201110041260XA CN 201110041260 A CN201110041260 A CN 201110041260A CN 102114041 A CN102114041 A CN 102114041A
- Authority
- CN
- China
- Prior art keywords
- fowl cholera
- taurine
- sodium chloride
- percent
- gentamycin sulfate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a composition for treating fowl cholera and a preparation method thereof. The invention aims to provide a composition which treats the fowl cholera by treating both manifestation and root cause of disease, reduces the probability of medicine resistance in pathogenic bacteria, and strengthens therapeutic effect and a preparation method thereof. The composition consists of the following raw materials in percentage by weight: 3 to 10 percent of norfloxacin nicotinic, 3 to 10 percent of gentamycin sulfate, 5 to 15 percent of taurine, 5 percent of sodium chloride, 5 percent of potassium chloride, and the balance of anhydrous glucose. In the composition, the combination of the norfloxacin nicotinic and the gentamycin sulfate is adopted to produce a double synergistic bacteria-resistance effect, effectively reduce the probability of medicine resistance of pasteurella, and improve sensitivity and antibacterial effect. The taurine has the effects of reducing fever and resisting inflammation; the sodium chloride and the potassium chloride supplement electrolyte; and the combination of the medicines according to a reasonable proportion treats the fowl cholera by treating both manifestation and root cause of disease, reduces the probability of medicine resistance of the pathogenic bacteria, strengthens therapeutic effect, is convenient for use, and reduces the phenomenon of unsuccessful medication caused by diagnosis reasons.
Description
Technical field
The present invention relates to a kind of composition and method of making the same that is used for the treatment of fowl cholera.
Background technology
Fowl cholera is the normal disease that occurs of fowl, and cause of disease mainly is a pasteurellosis bacillus, and main clinical manifestation is that spirit is depressed, the feather pine disorderly, necking down is closed one's eyes, and head contracts under wing, is reluctant to walk about, it is slow-witted upright to peel off, sick chicken often has diarrhoea, discharges yellow, canescence or green loose stool, fervescence to 43～44 ℃, subtract and eat or do not eat, thirsty desire increases, dyspnea, and mouth, nasal discharge increase, cockscomb and meat whisker paleness purple, the sick Carnis Gallus domesticus whisker swelling that has has the burning pain sense, and egg fowl stops to lay eggs, depletion takes place at last, goes into a coma and death.
At present, because the generally utilization of medicine, cause bacterial drug resistance serious, take single norfloxacin nicotinate or gentamycin sulfate, often because antibacterial is insensitive because of drug resistance, and the primary disease poultry has high temperature and diarrhoea phenomenon, sick fowl often since hyperpyrexia can consume excessively with dysentery excessive damage electrolyte etc. and cause disease fowl body constitution to descend, and cause secondary infection or death easilier, bring great loss to the culturist.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, to provide a kind of and can treat the fowl cholera treating both the principal and secondary aspects of a disease, reduce pathogen drug resistance probability, strengthening the composition and method of making the same of curative effect.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of fowl cholera is characterized in that, is made up of following raw material by mass percentage: norfloxacin nicotinate 3～10%, and gentamycin sulfate 3～10%, taurine 5～15%, sodium chloride 5%, potassium chloride 5%, surplus is an anhydrous glucose.
A kind of preparation of compositions method that is used for the treatment of fowl cholera is characterized in that, comprises the steps:
To promptly get the compositions that is used to treat fowl cholera behind taurine, sodium chloride, the potassium chloride crushing screening with after norfloxacin nicotinate, gentamycin sulfate, anhydrous glucose fully mix; wherein; by weight percentage: norfloxacin nicotinate 3～10%; gentamycin sulfate 3～10%; taurine 5～15%; sodium chloride 5%, potassium chloride 5%, surplus is an anhydrous glucose.
Wherein the preferable of each component consists of by weight percentage: norfloxacin nicotinate 4～8%, and gentamycin sulfate 4～8%, taurine 7～12%, sodium chloride 5%, potassium chloride 5%, surplus is an anhydrous glucose.
The best group of each component becomes by weight percentage: norfloxacin nicotinate 5%, and gentamycin sulfate 6%, taurine 10%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose are 69%.
The present invention has following technique effect:
Compositions of the present invention is a compound preparation, and norfloxacin nicotinate and gentamycin sulfate share, and except that synergism is arranged, and can dual antagonism causes the pasteurellosis bacillus of fowl cholera, effectively reduces the drug resistance probability of pasteurellosis bacillus, improves sensitivity and antibacterial effect; Taurine have bring down a fever, antiinflammatory action, can antipyretic effect be arranged to the hyperpyrexia that fowl cholera causes; Sodium chloride, potassium chloride electrolyte supplement, the electrolyte loss that diarrhoea is caused has supplementary function, improves Abwehrkraft des Koepers.All medicines share and by rational proportion, and fowl cholera is had treating both the principal and secondary aspects of a disease, reduces pathogen drug resistance probability, strengthens the effect of curative effect, and are easy to use, can reduce the phenomenon of the medication failure that causes because of the diagnosis reason.
Fowl of the present invention is simple with the preparation method of composition technology of treatment fowl cholera, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.To produce 100kg is example;
It is standby that taurine, sodium chloride, potassium chloride pulverize separately are crossed 5# sieve back.
Embodiment 1
Accurately take by weighing taurine 5kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl cholera after norfloxacin nicotinate 3kg, gentamycin sulfate 10kg, anhydrous glucose 72kg fully mix.
Embodiment 2
Accurately take by weighing taurine 15kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl cholera after norfloxacin nicotinate 10kg, gentamycin sulfate 3kg, anhydrous glucose 62kg fully mix.
Embodiment 3
Accurately take by weighing taurine 7kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl cholera after norfloxacin nicotinate 4kg, gentamycin sulfate 8kg, anhydrous glucose 71kg fully mix.
Embodiment 4
Accurately take by weighing taurine 12kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl cholera after norfloxacin nicotinate 8kg, gentamycin sulfate 4kg, anhydrous glucose 66kg fully mix.
Embodiment 5
Accurately take by weighing taurine 11kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl cholera after norfloxacin nicotinate 6kg, gentamycin sulfate 5g, anhydrous glucose 68kg fully mix.
Embodiment 6
Accurately take by weighing taurine 10kg, sodium chloride 5kg, potassium chloride 5kg and promptly get the compositions that is used to treat fowl cholera after norfloxacin nicotinate 5kg, gentamycin sulfate 6kg, anhydrous glucose 69kg fully mix.
Clinical trial:
Compositions of the present invention both can be used for the chicken class, also can be used for duck, goose etc.Be laboratory animal below with the chicken, the effect that is used for the treatment of the compositions of fowl cholera of the present invention is experimentized.
1. laboratory animal:
1000 of the ill one-tenth of picked at random chickens, body weight is about about 1kg.
2. experiment medicine
The compositions our unit development of the embodiment of the invention 6 preparations;
5% norfloxacin nicotinate soluble powder our unit prepared in laboratory;
6% gentamycin sulfate soluble powder our unit prepared in laboratory.
3. experimental technique:
Suffer from chicken with 1000 and be divided into four groups at random by body weight, 250 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with 5% norfloxacin nicotinate soluble powder: drinking-water, every 1L water 1.5g, 2 times on the one, logotype 4 days.
The C group is treated usage with 6% gentamycin sulfate soluble powder: drinking-water, every 1L water 1.5g, 2 times on the one, logotype 4 days.
The D group is treated usage with the compositions of the embodiment of the invention 6 preparations: drinking-water, every 1L water 1.5g, 2 times on the one, logotype 4 days.
After the treatment beginning, every day, chicken health situation of change suffered from record, and treat and add up therapeutic effect after 7 days, wherein:
Invalid: as after referring to 7 days, to suffer from the chicken symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 7 days, suffer from the chicken symptom and change, the effect before symptom is better than treating.
Cure: after referring to 7 days, transference cure is suffered from chicken and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 7 days, suffer from chicken and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from chicken and does not cure.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Laying rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, the embodiment of the invention 6 is used for the treatment of combination treatment group, 5% norfloxacin nicotinate soluble powder treatment group and the 6% gentamycin sulfate soluble powder group of fowl cholera and matched group difference extremely significantly (P＜0.01).Curative effect of the present invention is better than existing two kinds of medicines.
Table 1
Claims (6)
1. a compositions that is used for the treatment of fowl cholera is characterized in that, is made up of following raw material by weight percentage: norfloxacin nicotinate 3～10%; gentamycin sulfate 3～10%, taurine 5～15%, sodium chloride 5%; potassium chloride 5%, surplus are anhydrous glucose.
2. the compositions that is used for the treatment of fowl cholera according to claim 1 is characterized in that, is made up of following raw material by weight percentage: norfloxacin nicotinate 4～8%; gentamycin sulfate 4～8%; taurine 7～12%, sodium chloride 5%, potassium chloride 5%, surplus is an anhydrous glucose.
3. the compositions that is used for the treatment of fowl cholera according to claim 1 is characterized in that, is made up of following raw material by weight percentage: norfloxacin nicotinate 5%; gentamycin sulfate 6%; taurine 10%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose are 69%.
4. the described preparation of compositions method that is used for the treatment of fowl cholera of claim 1 is characterized in that, comprises the steps:
To promptly get the compositions that is used to treat fowl cholera behind taurine, sodium chloride, the potassium chloride crushing screening with after norfloxacin nicotinate, gentamycin sulfate, anhydrous glucose fully mix; wherein; by weight percentage: norfloxacin nicotinate 3～10%; gentamycin sulfate 3～10%; taurine 5～15%; sodium chloride 5%, potassium chloride 5%, surplus is an anhydrous glucose.
5. the preparation of compositions method that is used for the treatment of fowl cholera according to claim 4; it is characterized in that; form by following raw material by weight percentage: norfloxacin nicotinate 4～8%; gentamycin sulfate 4～8%; taurine 7～12%; sodium chloride 5%, potassium chloride 5%, surplus is an anhydrous glucose.
6. the preparation of compositions method that is used for the treatment of fowl cholera according to claim 4 is characterized in that, norfloxacin nicotinate 5%, and gentamycin sulfate 6%, taurine 10%, sodium chloride 5%, potassium chloride 5%, anhydrous glucose are 69%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110041260XA CN102114041A (en) | 2011-02-21 | 2011-02-21 | Composition for treating fowl cholera and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110041260XA CN102114041A (en) | 2011-02-21 | 2011-02-21 | Composition for treating fowl cholera and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102114041A true CN102114041A (en) | 2011-07-06 |
Family
ID=44213041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110041260XA Pending CN102114041A (en) | 2011-02-21 | 2011-02-21 | Composition for treating fowl cholera and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102114041A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102847160A (en) * | 2012-09-07 | 2013-01-02 | 广东大华农动物保健品股份有限公司 | Compound quinolone injection for livestock, and preparation method thereof |
| CN105582197A (en) * | 2014-11-13 | 2016-05-18 | 天津市中敖饲料有限公司 | Traditional Chinese medicinal decoction liquid for treating fowl cholera and preparation method of traditional Chinese medicinal decoction liquid |
-
2011
- 2011-02-21 CN CN201110041260XA patent/CN102114041A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102847160A (en) * | 2012-09-07 | 2013-01-02 | 广东大华农动物保健品股份有限公司 | Compound quinolone injection for livestock, and preparation method thereof |
| CN105582197A (en) * | 2014-11-13 | 2016-05-18 | 天津市中敖饲料有限公司 | Traditional Chinese medicinal decoction liquid for treating fowl cholera and preparation method of traditional Chinese medicinal decoction liquid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102835594B (en) | A kind of chick Chinese medicine bag for preventing infectious disease feed addictive | |
| CN105287790A (en) | Paederia scandens extract and applications thereof | |
| CN102895378B (en) | Pharmaceutical compound preparation for treating livestock respiratory diseases and method for preparing pharmaceutical compound preparation for treating livestock respiratory diseases | |
| CN104304787A (en) | Superfine powdery natural plant feed additive for preventing and controlling pig respiratory disease and preparation method of superfine powder natural plant feed additive | |
| CN102114041A (en) | Composition for treating fowl cholera and preparation method thereof | |
| CN101966178A (en) | Composition for treating chicken proventriculitis and preparation method thereof | |
| CN103432162A (en) | Composition for treating poultry intestinal bacteria and anaerobic bacteria mixing infection and preparation method thereof | |
| CN101642460A (en) | Compound solution of diclazuril for curing avian coccidium infection and preparation method thereof | |
| CN101670094A (en) | Compound gentamycin sulfate soluble powder and preparation method thereof | |
| CN101524479B (en) | Medicine for curing avian infectious bronchitis | |
| CN101167977B (en) | Chinese medicinal herb additive for preventing chicken high febrile disease | |
| CN101966200A (en) | Composition for treating poultry digestive tract bacterial infection and preparation method thereof | |
| CN103432136A (en) | Composition for treating salpingitis of chicken and preparation method of composition | |
| CN101966201A (en) | Compound norfloxacin nicotinic soluble powder and preparation method thereof | |
| CN101653417A (en) | Compound colistin sulfate soluble powder for treating lamb dysentery and preparation method thereof | |
| CN104171498A (en) | Green feed additive capable of treating runt pig and using method thereof | |
| CN104523871A (en) | Traditional Chinese medicine composition treating chicken rhinitis and preparing method of traditional Chinese medicine composition | |
| CN104189219B (en) | A kind of Chinese medicine composition | |
| CN103446171A (en) | Composition for treating swine respiratory tract infection and preparation method thereof | |
| CN104324268A (en) | Feed additive for preventing and treating swine high fever syndrome | |
| CN102357135A (en) | Traditional Chinese medicine oral liquid for preventing and treating chicken caecum coccidiosis and preparation method thereof | |
| CN101953879B (en) | Microbial ecological agent for quickly and efficiently preventing and treating pig high fever | |
| CN101879179A (en) | Compound Ofloxacin solution and preparation method thereof | |
| CN107296864A (en) | A kind of composition for preventing and treating checken pest | |
| CN103417570A (en) | Composition for treating bacterial diarrhea of pigs and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110706 |