CN102847160A - Compound quinolone injection for livestock, and preparation method thereof - Google Patents
Compound quinolone injection for livestock, and preparation method thereof Download PDFInfo
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Abstract
The present invention specifically discloses a compound quinolone injection for livestock, and a preparation method thereof. The compound quinolone injection for livestock comprises an active component and a solvent, wherein the active component comprises the following components, by mass volume concentration, 1-30% of a quinolone drug, 2-20% of an aminoglycoside drug, 0.2-5% of vitamin C, 1-8% of taurine, 2-10% of a co-solvent, 0.1% of an antioxidant, and 0.01% of EDTA-2Na, and the solvent is water for injection. The preparation method comprises: dissolving the components, adopting a hydrochloric acid solution to adjust the pH value to 3.5-5.5, filtering with a filter membrane, carrying out sub-package, and carrying out flowing steam sterilization. According to the injection of the present invention, gram-positive bacteria infections and gram-negative bacteria infections or mixing infections of bacterial and mycoplasma in the livestock can be treated, the injection is easy to use in clinic, and rapid animal disease rehabilitation is easily achieved.
Description
Technical field
The present invention relates to the poultry drug world, be specifically related to a kind of poultry compound recipe quinolone injection and preparation method thereof.
Background technology
Quinolones is the antibacterials with this structure of 4-quinolinones cyclic group of synthetic.Twentieth century is since the eighties, and this class drug development is rapid, has become the most frequently used class antibacterials of veterinary clinic, has brought into play very important effect in the control of infectious disease.The normal quinolones kind of using of China's veterinary clinic has enrofloxacin, sarafloxacin, difloxacin, danofloxacin, ofloxacin, norfloxacin, ciprofloxacin, pefloxacin, lomefloxacin etc.Such medicine can be widely used in toy, birds, domestic animal, the infectious disease of the system such as the digestion that treatment antibacterial, mycoplasma cause, breathing, urinary system, reproduction and skin soft tissue.There is the wide not and active not strong shortcoming of antimicrobial spectrum to some gram positive bacteria (such as Hemolytic streptococcus) and anaerobe (belonging to and fusobacterium such as bacterioid) in quinolones.
Aminoglycoside is by streptomycin or micromonospora generation or through a semi-synthetic class water soluble antibiotics that makes, the upper kind commonly used of veterinary has kanamycin, gentamycin, streptomycin, neomycin, spectinomycin, GENTAMICIN-micronomicin, amikacin.This class medicine belongs to the bactericidal properties medicine, and is strong to aerobic gram negative bacilli effect, invalid to anaerobe, a little less than gram positive bacteria effect, there is obvious post antibiotic effect in gram negative bacteria and positive bacteria, and drug administration by injection absorbs rapidly and fully.Aminoglycoside medicaments is strong to aerobic gram negative bacilli effect, and to a little less than the gram positive bacteria effect, substantially invalid to anaerobe, and it also exists kidney, ototoxicity; Especially dosage is excessive, the course for the treatment of, the side effect of generation was larger when long.
Vitamin C participates in the redox reaction in the body, promotes the synthetic of intercellular substance, suppresses hyaluronidase, thereby keeps the complete of intercellular substance, increases the density of blood capillary, reduces its permeability and fragility; Has Detoxication; The enhancing body resistance against diseases, but enhancing antibody generates, strengthen phagocytic activity of leukocytes, strengthen the liver detoxification ability, improve cardiac muscle and blood vessel metabolism, also have antiinflammatory, anti-allergic effects, be used for clinically vitamin C deficiency, also be usually used in high heat, heart source property and septic shock, poisoning etc., stress descend such as high temperature, physiological strains, transportation, disease etc. to ascorbic increase in demand, for accelerating also vitamin C commonly used of wound healing or detoxifcation various simultaneously.
At present, often quinolones, aminoglycoside, vitamin C etc. are used separately clinically, the folk prescription medication is for reaching therapeutic effect, must escalated dose or extend working time, so that easily produce drug resistance and drug residue, and the folk prescription administration is wasted time and energy, and larger can the generation of the intensity of drug administration by injection stress unfavorable rehabilitation.
Summary of the invention
For overcoming the defective of prior art, the object of the present invention is to provide a kind of compound recipe quinolone injection, this compound injection can be treated gram positive bacteria and the gram positive bacterial infection of poultry, or the mixed infection of antibacterial and mycoplasma etc., and easy to use clinically, the quick recovery of favourable Animal diseases.
Another object of the present invention is to provide a kind of preparation method of compound recipe quinolone injection, the method preparation technology is simple, easily implements.
The technical solution adopted in the present invention is as follows for achieving the above object:
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Quinolones 1-30%;
Aminoglycoside medicaments 2-20%;
Vitamin C 0.2-5%;
Taurine 1-8%;
Cosolvent 2-10%;
Antioxidant 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
In the preferred scheme, it comprises effective ingredient and solvent to poultry of the present invention with the compound recipe quinolone injection, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Quinolones 5-10%;
Aminoglycoside medicaments 5-10%;
Vitamin C 1-3%;
Taurine 3-5%;
Cosolvent 3-8%;
Antioxidant 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
In the preferred scheme, it comprises effective ingredient and solvent to poultry of the present invention with the compound recipe quinolone injection, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Quinolones 5%;
Aminoglycoside medicaments 5%;
Vitamin C 2%;
Taurine 5%;
Cosolvent 5%;
Antioxidant 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Preferably, described poultry comprise also that with the compound recipe quinolone injection mass body volume concentrations is the hydrochloric acid solution of 4-20%, and hydrochloric acid solution is regulated the pH to 3.5-5.5 of described injection.
Among the present invention, described quinolones is one or more mixing in danofloxacin, ofloxacin, norfloxacin, ciprofloxacin, pefloxacin, lomefloxacin or Danofloxacin mesylate, ofloxacin hydrochloride, norfloxacin nicotinate, ciprofloxacin, ciprofloxacin lactate, pefloxacin mesilate, the lomefloxacin hydrochloride.
Among the present invention, described aminoglycoside medicaments is one or more mixing in kanamycin sulfate, that mycin of sulphuric acid single deck tape-recorder, gentamycin sulfate, polygynax, gentamicin-micronomicin, the amikacin sulfate.
Cosolvent described in the present invention is selected from one or more mixing in propylene glycol, polyvinylpyrrolidone, the Polyethylene Glycol.
Owing to added taurine among the present invention, and taurine being a kind of sulfur-containing amino acid, has multiple pharmacologically active.Have strong liver choleretic effect, liver is had protective effect; Improve immunity of organisms, have analgesic and antiinflammatory action; Have blood pressure lowering, hypoglycemic activity, anticoagulant and thrombosis; Have heart tonifying and antiarrhythmic effect.Taurine also has the cell of enhancing antioxidation, free radical resisting damage and antiviral ability; with the Compound Phases such as vitamin E and vitamin C seemingly; effect with Scavenger of ROS free radical forms the system of defense of life jointly, prevents that toxin is to the injury of cell and tissue.Taurine is one of free amino acid the abundantest in lymphocyte and the granulocyte, can promote lymphocyte proliferation, and sulfacid not only can improve specificity and the non-specific immunity of animal in the present invention, and is a kind of good immunological adjuvant.
Among the present invention, described antioxidant is sodium sulfite.
A kind of poultry preparation method of compound recipe quinolone injection, it may further comprise the steps:
1) adds water for injection in quinolones, and make its dissolving by adding hydrochloric acid solution adjusting pH to 2.5-3.5, obtain the solution I;
2) add water for injection at aminoglycoside medicaments, and make its dissolving by adding hydrochloric acid solution adjusting pH to 4.5-5.5, obtain the solution II;
3) vitamin C, taurine, sodium sulfite and EDTA-2Na are dissolved with injection water, obtain the solution III, for subsequent use;
4) solution I and solution II are mixed, add while stirring again cosolvent and solution III, regulate pH to 3.5-5.5 with hydrochloric acid solution again after stirring, obtain mixed solution;
5) with above-mentioned mixed solution membrane filtration, use flowing steam sterilization after the packing, and get final product.
Preferably, the filter opening diameter of described filter membrane is 0.40 μ m-0.50 μ m, 100 ℃-150 ℃ of the temperature of flowing steam.
Compared to existing technology, beneficial effect of the present invention is: poultry of the present invention are united use with the compound recipe quinolone injection with quinolones and aminoglycoside medicaments, complement each other, promote mutually every component property of medicine performance, has double effects, medication number of times and dosage can be reduced, expected effect can be played; In addition, increase immunity, detoxification ability, antiinflammatory ability, anti-stress ability that vitamin C and taurine can improve rapidly body in the prescription, reached treating both the principal and secondary aspects of a disease; and minimizing is with the administration number of times of kind administration; minimizing stress, make the poultry body obtain quick recovery, also reduce labor intensity.The compound injection liquid and preparation method thereof technique of control poultry multi-infection of the present invention is simple, less energy consumption, and production safety easily realizes.
The specific embodiment
Below introduce in detail the present invention by several embodiment respectively and prevent and treat compound injection of poultry multi-infection and preparation method thereof.
Embodiment 1
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Ofloxacin 5%;
Gentamicin-micronomicin 5%;
Vitamin C 2%;
Taurine 5%;
Polyvinylpyrrolidone 5%;
Sodium sulfite 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Described poultry prepare by the following method with the compound recipe quinolone injection:
1) in ofloxacin, adds water for injection, and be that 12% hydrochloric acid solution is regulated pH to 2.8 and made its dissolving by adding the mass body volume concentrations, obtain the solution I;
2) in gentamicin-micronomicin, add water for injection, and be that 12% hydrochloric acid solution is regulated pH to 4.8 and made its dissolving by adding the mass body volume concentrations, obtain the solution II;
3) vitamin C, taurine, sodium sulfite and EDTA-2Na are dissolved with injection water, obtain the solution III, for subsequent use;
4) solution I and solution II being mixed, add while stirring polyvinylpyrrolidone and solution III again, is 12% hydrochloric acid solution adjusting pH to 4.0 again with the mass body volume concentrations after stirring, and obtains mixed solution;
5) with the membrane filtration of above-mentioned mixed solution with 0.45 μ m, with 100 ℃ of flowing steam sterilizations 20 minutes, and get final product after the packing.
Embodiment 2
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Ofloxacin 1%;
Gentamicin-micronomicin 20%;
Vitamin C 5%;
Taurine 1%;
Polyvinylpyrrolidone 2%;
Sodium sulfite 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Described poultry prepare by the following method with the compound recipe quinolone injection:
1) in ofloxacin, adds water for injection, and be that 20% hydrochloric acid solution is regulated pH to 2.5 and made its dissolving by adding the mass body volume concentrations, obtain the solution I;
2) in gentamicin-micronomicin, add water for injection, and be that 20% hydrochloric acid solution is regulated pH to 5.5 and made its dissolving by adding the mass body volume concentrations, obtain the solution II;
3) vitamin C, taurine, sodium sulfite and EDTA-2Na are dissolved with injection water, obtain the solution III, for subsequent use;
4) solution I and solution II being mixed, add while stirring polyvinylpyrrolidone and solution III again, is 20% hydrochloric acid solution adjusting pH to 3.5 again with the mass body volume concentrations after stirring, and obtains mixed solution;
5) with the membrane filtration of above-mentioned mixed solution with 0.45 μ m, with 100 ℃ of flowing steam sterilizations 20 minutes, and get final product after the packing.
Embodiment 3
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Ofloxacin 30%;
Gentamicin-micronomicin 2%;
Vitamin C 0.2%;
Taurine 8%;
Polyvinylpyrrolidone 10%;
Sodium sulfite 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Described poultry prepare by the following method with the compound recipe quinolone injection:
1) in ofloxacin, adds water for injection, and be that 6% hydrochloric acid solution is regulated pH to 3.5 and made its dissolving by adding the mass body volume concentrations, obtain the solution I;
2) in gentamicin-micronomicin, add water for injection, and be that 6% hydrochloric acid solution is regulated pH to 4.5 and made its dissolving by adding the mass body volume concentrations, obtain the solution II;
3) vitamin C, taurine, sodium sulfite and EDTA-2Na are dissolved with injection water, obtain the solution III, for subsequent use;
4) solution I and solution II being mixed, add while stirring polyvinylpyrrolidone and solution III again, is 6% hydrochloric acid solution adjusting pH to 4.0 again with the mass body volume concentrations after stirring, and obtains mixed solution;
5) with the membrane filtration of above-mentioned mixed solution with 0.45 μ m, with 150 ℃ of flowing steam sterilizations 20 minutes, and get final product after the packing.
Embodiment 4
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Ciprofloxacin 10%;
Gentamycin sulfate 8%;
Vitamin C 5%;
Taurine 3%;
Propylene glycol 10%;
Sodium sulfite 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Described poultry with the compound recipe quinolone injection according to the preparation of the method for above-described embodiment: the pH value of wherein solution I that different is is 2.5, and the pH value of solution II is 4.5, and the pH value of mixed solution is 3.8.
Embodiment 5
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Danofloxacin mesylate 2.5%;
Polygynax 5%;
Vitamin C 3%;
Taurine 2%;
Propylene glycol 5%;
Sodium sulfite 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Described poultry with the compound recipe quinolone injection according to the preparation of the method for above-described embodiment: the pH value of wherein solution I that different is is 2.8, and the pH value of solution II is 4.8, and the pH value of mixed solution is 4.2.
Embodiment 6
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Pefloxacin mesilate 20%;
Kanamycin sulfate 13.5%;
Vitamin C 5%;
Taurine 8%;
Propylene glycol 5%;
Polyvinylpyrrolidone 5%;
Sodium sulfite 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Described poultry with the compound recipe quinolone injection according to the preparation of the method for above-described embodiment: the pH value of wherein solution I that different is is 2.5, and the pH value of solution II is 4.5, and the pH value of mixed solution is 3.5.
Embodiment 7
A kind of poultry compound recipe quinolone injection, it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Lomefloxacin hydrochloride 6.5%;
Amikacin sulfate 3.5%;
Vitamin C 2%;
Taurine 3%;
Polyethylene Glycol 6%;
Antioxidant (sodium sulfite) 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
Described poultry with the compound recipe quinolone injection according to the preparation of the method for above-described embodiment: the pH value of wherein solution I that different is is 3.0, and the pH value of solution II is 4.8, and the pH value of mixed solution is 4.1.
Prevent and treat the clinical efficacy of the compound injection of poultry multi-infection below by zoopery explanation the present invention.
Application Example 1: with the compound injection treatment diarrhea of pigs clinical effectiveness experiment of the present invention's preparation
Experimental technique: choose certain raiser family and suffer from 120 of cacatory 30 age in days piglets; be divided at random 3 groups; be to remove vitamin C, taurine in experimental group (according to the compound injection of embodiment 1 preparation), the matched group 1(prescription; and other compound injection identical with embodiment 1 preparation), remove vitamin C, taurine, gentamicin-micronomicin in the matched group 2(prescription; and other compound injection identical with embodiment 1 preparation), 40 every group.The medicine of each group carries out the musculi colli injection by ofloxacin with the 10mg/kg body weight, and feeding and management is identical.
Curative effect is judged (cure rate): symptom complete obiteration behind the drug administration by injection 1～3 time, and feces is shaped, and anus is without red and swollen or sticking wet sense, and appetite, the normal person of body temperature is for curing, and calculates cure rate according to these quantity that are defined as curing pig; Effective percentage: behind the drug administration by injection 4～5 times, spirit, appetite take a turn for the better, and sx↓, feces become soft or retrogradation person for effectively, calculate accordingly the treated effect in every treated animal; Inefficiency: after medication death or the medication 6～7 times, symptom does not alleviate or continues and worsens as invalid, calculates accordingly the rate of failing to respond to any medical treatment in every group in the treatment.
Experimental result: show through clinical observation on the therapeutic effect statistics: the cure rate of experimental group is 82.5% (33/40), effective percentage is 95.0%(38/40), inefficiency 5.0% (2/40), matched group 1 be respectively 70.0%(28/40), 82.5%(33/40), 17.5%(7/40), matched group 2 be respectively 55.0%(22/40), 65.0%(26/40), 35.0%(14/40).
Experiment conclusion: can find out from experimental result; the cure rate of experimental group is higher by 12.5%, higher by 27.5% than matched group 2 than matched group 1; with both difference extremely significantly (p＜0.01); shown that thus the compound injection liquor ratio according to embodiment 1 preparation does not contain the easier rehabilitation of product of vitamin C, taurine, than the stronger therapeutic effect of quinolones embodiment of folk prescription.Show thus the advantage of the compound injection of this kind control poultry multi-infection aspect control diarrhea of pigs disease.
Application Example 2: the clinical effectiveness experiment of the compound injection of the present invention's preparation being treated porcine respiratory disease
Experimental technique: choose 40 of the 50 age in days pigs that serious respiratory tract disease is suffered from by certain large-scale plant; be divided at random 2 groups; be that experimental group (according to the compound injection of embodiment 1 preparation), matched group (are removed vitamin C, taurine, gentamicin-micronomicin in the prescription; and other compound injection identical with embodiment 1 preparation), 20 every group.The medicine of each group carries out the musculi colli injection by ofloxacin with the 10mg/kg body weight, and feeding and management is identical.
Curative effect is judged (cure rate): symptom complete obiteration behind the drug administration by injection 1～3 time, appetite, body temperature, the normal person of breathing be for curing, and calculates cure rate according to these quantity that are defined as curing pig; Effective percentage: behind the drug administration by injection 4～5 times, spirit, appetite take a turn for the better, and body temperature obviously descends, and other sx↓ be effective, calculates accordingly the treated effect in every group of pig; Inefficiency: in the treatment after medication death or the medication 6～7 times, continue to occur the symptoms such as fervescence, dyspnea, not material feeding, skin rubefaction and do not alleviate or continue and worsen as invalid, calculate accordingly the rate of failing to respond to any medical treatment in every group.
Experimental result: show through clinical observation on the therapeutic effect statistics: the cure rate of experimental group is 80.0% (16/20), effective percentage is 85.0%(17/20), inefficiency 15.0% (3/20), matched group be respectively 65.0%(13/20), 70.0%(14/20), 30.0%(6/20).
Experiment conclusion: can find out from experimental result, the cure rate of experimental group is higher by 15% than matched group, and difference is (p＜0.01) extremely significantly, has shown thus the stronger therapeutic effect of quinolinones product embodiment according to the compound injection liquor ratio folk prescription of embodiment 1 preparation.Show thus the advantage of compound injection aspect the control porcine respiratory disease of this kind control poultry multi-infection.
Application Example 3:The sick clinical effectiveness experiment of compound injection treatment pig arthritis type chain fungus ball with the present invention's preparation
Experimental technique: choose certain large-scale plant and make a definite diagnosis and suffer from 40 of the sick pigs of arthritis type chain fungus ball; be divided at random 2 groups; be that experimental group (according to the compound injection of embodiment 1 preparation), matched group (are removed vitamin C, taurine, gentamicin-micronomicin in the prescription; and other compound injection identical with embodiment 1 preparation), 20 every group.The medicine of each group is injected at the affected part periphery with the 10mg/kg body weight by ofloxacin, and feeding and management is identical.
Curative effect is judged cure rate: the symptom complete obiterations such as 1～3 posterior joint swelling of drug administration by injection, limping, and appetite, body temperature, the normal person of walking are defined as curing the quantity calculating cure rate of pig for curing according to these; Effective percentage: behind the drug administration by injection 4～5 times, spirit, appetite take a turn for the better, and the sx↓s such as arthroncus, limping be effective, calculate accordingly the treated effect in every group of pig; Inefficiency: in the treatment after medication death or the medication 6～7 times, continue to occur the symptoms such as fervescence, not material feeding, arthroncus, limping and do not alleviate or continue and worsen as invalid, calculate accordingly the rate of failing to respond to any medical treatment in every group.
Experimental result: show through clinical observation on the therapeutic effect statistics: the cure rate of experimental group is 65.0% (13/20), effective percentage is 85.0%(17/20), inefficiency 15.0% (3/20), matched group be respectively 50.0%(10/20), 65.0%(13/20), 35.0%(7/20).
Experiment conclusion: can find out from experimental result, the cure rate of experimental group is higher by 15% than matched group, and difference is (p＜0.01) extremely significantly, has shown thus the stronger therapeutic effect of quinolinones product embodiment according to the compound injection liquor ratio folk prescription of embodiment 1 preparation.Show thus the advantage of the compound injection of this kind control poultry multi-infection aspect control pig arthritis type chain fungus ball disease.
Application Example 4:Compound injection treatment infectious serositis in duck clinical effectiveness experiment with the present invention's preparation
1.1 for the reagent thing compound injection according to embodiment 1 preparation, remove vitamin C, taurine, gentamicin-micronomicin in the prescription and other prepares identical compound injection with embodiment 1.
1.2 naturally break out this disease and symptom typical case, satisfactory sick duck for examination animal and Muscovy duck field, processing selecting Guangdong; divide 2 groups at random; be that experimental group (according to the compound injection of embodiment 1 preparation), matched group (are removed vitamin C, taurine, gentamicin-micronomicin in the prescription; and other compound injection identical with embodiment 1 preparation), 100 every group.The medicine of each group carries out the leg muscle injection by ofloxacin with the 5mg/kg body weight, once a day, is used in conjunction 3 days, and feeding and management is identical.
1.3 evaluating drug effect index
Invalid: after the medication, clinical symptoms, spiritual appetite situation etc. have the phenomena of mortality without significant change.
Effectively: after the medication, cure and do not have death but clinical symptoms is alleviated to some extent, spiritual appetite takes a turn for the better and does not return to again the premorbid state.
Cure: after the medication, clinical symptoms, spiritual appetite each side recover normal.
Result of the test:
The curative effect of table 1 pair Riemerella anatipestifer infection
| Group | Inefficiency (%) | Effective percentage (%) | Cure rate (%) |
| Experimental group | 4 | 96 | 90 |
| Matched group | 19 | 81 | 76 |
By finding out in the table, two kinds of medicines all have certain curative effect to Riemerella anatipestifer infection, but Analysis of variance, the curative effect of experimental group obviously is better than matched group (P＜0.01).
Above-mentioned embodiment only is preferred implementation of the present invention; can not limit the scope of protection of the invention with this, the variation of any unsubstantiality that those skilled in the art does on basis of the present invention and replacement all belong to the present invention's scope required for protection.
Claims (10)
1. a poultry compound recipe quinolone injection is characterized in that it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Quinolones 1-30%;
Aminoglycoside medicaments 2-20%;
Vitamin C 0.2-5%;
Taurine 1-8%;
Cosolvent 2-10%;
Antioxidant 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
2. poultry according to claim 1 compound recipe quinolone injection is characterized in that it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Quinolones 5-10%;
Aminoglycoside medicaments 5-10%;
Vitamin C 1-3%;
Taurine 3-5%;
Cosolvent 3-8%;
Antioxidant 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
3. poultry according to claim 1 compound recipe quinolone injection is characterized in that it comprises effective ingredient and solvent, and wherein effective ingredient is composed of the following components, and the mass body volume concentrations of each component is:
Quinolones 5%;
Aminoglycoside medicaments 5%;
Vitamin C 2%;
Taurine 5%;
Cosolvent 5%;
Antioxidant 0.1%;
EDTA-2Na 0.01%；
Solvent is water for injection.
4. described poultry compound recipe quinolone injection according to claim 1-3, it is characterized in that: it comprises that also the mass body volume concentrations is the hydrochloric acid solution of 4-20%, and hydrochloric acid solution is regulated the pH to 3.5-5.5 of described injection.
5. poultry according to claim 4 compound recipe quinolone injection, it is characterized in that: described quinolones is one or more mixing in danofloxacin, ofloxacin, norfloxacin, ciprofloxacin, pefloxacin, lomefloxacin or Danofloxacin mesylate, ofloxacin hydrochloride, norfloxacin nicotinate, ciprofloxacin, ciprofloxacin lactate, pefloxacin mesilate, the lomefloxacin hydrochloride.
6. poultry according to claim 4 compound recipe quinolone injection, it is characterized in that: described aminoglycoside medicaments is one or more mixing in kanamycin sulfate, that mycin of sulphuric acid single deck tape-recorder, gentamycin sulfate, polygynax, gentamicin-micronomicin, the amikacin sulfate.
7. poultry according to claim 4 compound recipe quinolone injection, it is characterized in that: described cosolvent is selected from one or more mixing in propylene glycol, polyvinylpyrrolidone, the Polyethylene Glycol.
8. poultry according to claim 4 compound recipe quinolone injection, it is characterized in that: described antioxidant is sodium sulfite.
9. poultry is characterized in that it may further comprise the steps with the preparation method of compound recipe quinolone injection:
1) adds water for injection in quinolones, and make its dissolving by adding hydrochloric acid solution adjusting pH to 2.5-3.5, obtain the solution I;
2) add water for injection at aminoglycoside medicaments, and make its dissolving by adding hydrochloric acid solution adjusting pH to 4.5-5.5, obtain the solution II;
3) vitamin C, taurine, sodium sulfite and EDTA-2Na are dissolved with injection water, obtain the solution III, for subsequent use;
4) solution I and solution II are mixed, add while stirring again cosolvent and solution III, regulate pH to 3.5-5.5 with hydrochloric acid solution again after stirring, obtain mixed solution;
5) with above-mentioned mixed solution membrane filtration, use flowing steam sterilization after the packing, and get final product.
10. poultry according to claim 9 are with the preparation method of compound recipe quinolone injection, and it is characterized in that: the filter opening diameter of described filter membrane is 0.40 μ m-0.50 μ m, 100 ℃-150 ℃ of the temperature of flowing steam.
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Cited By (2)
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| CN103405490A (en) * | 2013-08-23 | 2013-11-27 | 卢颖 | Compound medicine for preventing and treating infectious diseases of livestock and poultry and preparation method thereof |
| CN104367553A (en) * | 2014-11-26 | 2015-02-25 | 上海同仁药业有限公司 | Enrofloxacin soluble powder and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101297808A (en) * | 2008-04-08 | 2008-11-05 | 天津生机集团股份有限公司 | Compound ofloxacin injection for fowl and preparation method thereof |
| CN102114041A (en) * | 2011-02-21 | 2011-07-06 | 天津市天合力药物研发有限公司 | Composition for treating fowl cholera and preparation method thereof |
-
2012
- 2012-09-07 CN CN201210329194.0A patent/CN102847160B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101297808A (en) * | 2008-04-08 | 2008-11-05 | 天津生机集团股份有限公司 | Compound ofloxacin injection for fowl and preparation method thereof |
| CN102114041A (en) * | 2011-02-21 | 2011-07-06 | 天津市天合力药物研发有限公司 | Composition for treating fowl cholera and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘迎贵等: "谨慎选兽医科学用兽药", 《当代畜禽养殖业》 * |
| 司红彬等: "常用抗菌药物联合使用的原则", 《兽药与饲料添加剂》 * |
| 闫双银: "喹诺酮类注射液与常用注射液配伍的稳定性", 《医药导报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405490A (en) * | 2013-08-23 | 2013-11-27 | 卢颖 | Compound medicine for preventing and treating infectious diseases of livestock and poultry and preparation method thereof |
| CN104367553A (en) * | 2014-11-26 | 2015-02-25 | 上海同仁药业有限公司 | Enrofloxacin soluble powder and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102847160B (en) | 2014-05-21 |
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