CN102920771A - Medicine for treating poultry coccidiosis - Google Patents
Medicine for treating poultry coccidiosis Download PDFInfo
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- CN102920771A CN102920771A CN2012104426288A CN201210442628A CN102920771A CN 102920771 A CN102920771 A CN 102920771A CN 2012104426288 A CN2012104426288 A CN 2012104426288A CN 201210442628 A CN201210442628 A CN 201210442628A CN 102920771 A CN102920771 A CN 102920771A
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- NIUFFODHMKLSCH-UHFFFAOYSA-N sodium;(4-aminophenyl)sulfonyl-(6-chloropyrazin-2-yl)azanide Chemical compound [Na+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=CN=CC(Cl)=N1 NIUFFODHMKLSCH-UHFFFAOYSA-N 0.000 claims abstract description 11
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- 229960001031 glucose Drugs 0.000 claims description 10
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- 150000003456 sulfonamides Chemical class 0.000 description 3
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- 241000186016 Bifidobacterium bifidum Species 0.000 description 2
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- 241000223932 Eimeria tenella Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
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- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
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- OZRNSSUDZOLUSN-LBPRGKRZSA-N dihydrofolic acid Chemical compound N=1C=2C(=O)NC(N)=NC=2NCC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OZRNSSUDZOLUSN-LBPRGKRZSA-N 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fodder In General (AREA)
Abstract
The invention belongs to the field of veterinary medicines and particularly relates to a medicine for treating poultry coccidiosis. The medicine comprises, by weight, 2%-8% of sulfaclozine sodium, 0.4%-1.6% of trimethoprim (TMP), 3%-15% of an antifebrile dichroa extractive, 1%-12% of sweet wormwood extractive, 1%-10% of astragalus polysaccharide extractive and the balance an auxiliary material. The medicine is high in safety, and capable of being used for treating the poultry coccidiosis, achieving rapid treatment, preventing recurrence and improving immunity of poultry.
Description
Technical field
The invention belongs to field of veterinary, be specifically related to a kind of medicine that is used for the treatment of coccidiosis of domestic fowls.
Background technology
Coccidiosis is a kind of parasitic disease, can cause poultry meat and egg production heavy losses to occur.Parasite in small intestinal at double propagation cause tissue injury, reduce the absorbance of nutrient in feed intake and the feedstuff, dehydration and blood loss.Coccidiosis is caused that by unicellular parasite its life cycle approximately is 4-7 days.One " egg capsule " is that a capsule has the thick protective layer of one deck protecting parasite, they be " spore " or do not have infective, if but humidity, temperature or oxygen are suitable, they just begin growth.After chicken searched for food egg capsule, coccidiosis is implantation in intestinal, was entrenched in after several are bred at double between the enterocyte, and damaging tissue infects the mortality rate of coccidiosis up to 80%, and is just domestic, larger to the threat of raising poultry scattered.
Current treatment to coccidiosis mainly relies on sulfa drugs, but owing to drug resistance occurs easily, therefore, therapeutic effect is relatively poor at present.
Summary of the invention
The object of the present invention is to provide a kind of medicine that is used for the treatment of coccidiosis of domestic fowls, it is effective to kill coccidiosis.
The technical solution used in the present invention is as follows:
A kind of medicine that is used for the treatment of coccidiosis of domestic fowls, made by the raw material of following percentage by weight:
Sulfaclozine sodium 2%～8%
TMP 0.4%～1.6 %
Radix Dichroae extract 3%～15%
Herba Artemisiae Annuae extract 1%～12%
Astragalus polysaccharide extract 1%-10%,
Surplus is adjuvant.
Described raw material is made soluble powder.
Described Radix Dichroae extract, Herba Artemisiae Annuae extract, astragalus polysaccharide extract are water solubility extract.Preferably adopt powdery product, be convenient to follow-up preparation soluble powder.Corresponding extract adopts the commercially available prod to get final product.
Preferred its lactate of described TMP.
Described adjuvant is anhydrous glucose, oral glucose or auxiliary U.S. powder.
Described medicine is prepared as follows according to conventional preparation method: first sulfaclozine sodium, TMP and adjuvant were pulverized 40 mesh sieves, then with other dusty raw materials mix homogeneously.
Sulfaclozine sodium is sulfa drugs, can compete synthesizing dihydro folic acid synzyme with aminobenzoic acid PABA, has affected the synthetic of dihydrofoilic acid, thereby bacterial growth and breeding are suppressed.
The TMP class is antimicrobial drug, antimicrobial spectrum and sulfonamides basic simlarity, but antibacterial action a little less than, effective to multiple G bacterium, the alone bacterial drug resistance that easily causes.The mechanism of action of TMP is the anti-bacteria dihydrofolate reductase, makes dihydrofoilic acid can not be reduced into tetrahydrofolic acid, stops the synthetic of bacterial nucleic acid.With the effect of sulphonamides, can make the folic acid metabolism of antibacterial suffer that dual the moon is disconnected, the effect that strengthens sulphonamides reaches several times to tens times, even bactericidal action occurs, and can also reduce the generation of Resistant strain.
The main function of Radix Dichroae and Herba Artemisiae Annuae is the treatment malaria, and research finds that it has the effect of anticoccidial, and can alleviate the drug resistance of coccidiosis.
Astragalus polysaccharides can increase the quantity of chickling intestinal lactobacillus and bacillus bifidus, significantly reduces colibacillary quantity, can effectively promote intestinal beneficial microorganism propagation, and harmful intestinal tract bacteria is had inhibitory action.Metabolite is short-chain fatty acid, can reduce the intestinal pH value.Low pH value can stimulate intestinal peristalsis promoting on the one hand, thereby reduce the quantity of pathogenic bacterium, the opposing party's sour environment is conducive to the propagation of the probioticss such as lactobacillus and bacillus bifidus, simultaneously probiotics produces the metabolite that hydrogen peroxide, organic acid etc. have antibacterial activity in breeding, can suppress the existence of pathogenic class harmful bacteria and exogenous pathogenic bacteria, improve the immunity of chicken.
More than each compatibility of drugs use, can produce synergism, can kill coccidiosis, its anticoccidial effect is compared to single coccidiostat, renders a service to strengthen, and has higher safety, can be widely used in the treatment coccidiosis of domestic fowls, improves the immunity of poultry.
The present invention has following advantage with respect to prior art:
Medicine of the present invention has higher safety, can be widely used in the treatment coccidiosis of domestic fowls, and effectively rapid healing can prevent again recurrence, has improved the immunity of poultry.
The specific embodiment
Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited to this:
Used Powdered Radix Dichroae extract, Powdered Herba Artemisiae Annuae extract, Powdered astragalus polysaccharide extract in following examples all adopt Chengdu Supreme Being sesame bio tech ltd product.
Embodiment 1
Get sulfaclozine sodium 2%, TMP 0.4%, Powdered Radix Dichroae extract 15%, Powdered Herba Artemisiae Annuae extract 12%, Powdered astragalus polysaccharide extract 10%, surplus are oral glucose, amount to 1000g, wherein TMP at first with equivalent incremental method and equivalent oral glucose be mixed to sulfaclozine sodium equivalent after, all medicament mixed 30min are got final product.All adjuvants and medicine all need be pulverized 80 mesh sieves.
Embodiment 2
Get sulfaclozine sodium 6%, TMP 1.0 %, Powdered Radix Dichroae extract 10%, Powdered Herba Artemisiae Annuae extract 8%, Powdered astragalus polysaccharide extract 5%, surplus are oral glucose, amount to 1000g, wherein TMP at first with equivalent incremental method and equivalent oral glucose be mixed to sulfaclozine sodium equivalent after, all medicament mixed 30min are got final product.All adjuvants and medicine all need be pulverized 80 mesh sieves.
Embodiment 3
Get sulfaclozine sodium 8%, TMP 1.6 %, Powdered Radix Dichroae extract 3%, Powdered Herba Artemisiae Annuae extract 1%, Powdered astragalus polysaccharide extract 1%, surplus are oral glucose, amount to 1000g, wherein astragalus polysaccharide extract, Herba Artemisiae Annuae extract, TMP with equivalent incremental method and equivalent oral glucose be mixed to sulfaclozine sodium equivalent after, all medicament mixed 30min are got final product.All adjuvants and medicine all need be pulverized 80 mesh sieves.
The test of pesticide effectiveness:
Be the curative effect of checking medicine of the present invention, get the embodiment of the invention 2 medicines and do clinical trial in Henan cultivation factory.
(1) experiment material: choose close ill (coccidiosis) 400 of the chickens (about body weight 1.5kg) of body condition from certain large-scale chicken farm, be divided at random 2 groups, i.e. test group and matched group, healthy chicken 200 (about body weight 1.5kg) is blank group; Test group is the medication group, and matched group and blank are organized not medication.
(2) test method and dosage:
Initial dose: every premium on currency adds the embodiment of the invention 2 medicine 1.0g, freely drinks water one day;
Maintenance dose: every premium on currency adds the embodiment of the invention 2 medicine 0.5g, and being used in conjunction 3 days is a course for the treatment of.Result of the test sees Table 1.
(3) clinical symptoms and curative effect determinate standard:
Clinical symptoms: sick chicken spirit is depressed, feather is fluffy, head is crispaturaed, and loss of appetite is full of liquid in the crop, cockscomb and visual mucosa anemia, pale, become thin gradually, sick chicken is often arranged red calabash Radix Raphani sample feces, if infect Eimeria tenella, feces is coffee-like during beginning, becomes later on completely bloody stool;
Cure: do not have clinical symptoms; Take a turn for the better: the mental status, appetite recover normal; Invalid: above-mentioned each clinical symptoms does not alleviate or aggravates.
Effective percentage is improvement rate, cure rate sum.
(4) result:
Use the embodiment of the invention 2 medicines to carry out Drug therapy, after the course for the treatment of, most of ill chicken is cured, and effective percentage reaches more than 90%.Each experimental result of organizing after the ill chicken Drug therapy sees Table 1.Adopt the poultry such as duck goose and embodiment 1,3 medicines to test, the result is basic identical.
Table 1
| Group | Mortality rate % | Effective percentage % | Cure rate % |
| Blank group | 0 | —— | —— |
| Matched group | 50 | —— | —— |
| Test group | 8 | 92 | 85 |
Claims (4)
1. a medicine that is used for the treatment of coccidiosis of domestic fowls is characterized in that, is made by the raw material of following percentage by weight:
Sulfaclozine sodium 2%～8%
TMP 0.4%～1.6 %
Radix Dichroae extract 3%～15%
Herba Artemisiae Annuae extract 1%～12%
Astragalus polysaccharide extract 1%-10%,
Surplus is adjuvant.
2. the medicine that is used for the treatment of coccidiosis of domestic fowls as claimed in claim 1 is characterized in that, described raw material is made soluble powder.
3. the medicine that is used for the treatment of coccidiosis of domestic fowls as claimed in claim 2 is characterized in that, described Radix Dichroae extract, Herba Artemisiae Annuae extract, astragalus polysaccharide extract are water solubility extract.
4. the medicine that is used for the treatment of coccidiosis of domestic fowls as claimed in claim 2 is characterized in that, described adjuvant is anhydrous glucose, oral glucose or auxiliary U.S. powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210442628.8A CN102920771B (en) | 2012-11-08 | 2012-11-08 | Medicine for treating poultry coccidiosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210442628.8A CN102920771B (en) | 2012-11-08 | 2012-11-08 | Medicine for treating poultry coccidiosis |
Publications (2)
| Publication Number | Publication Date |
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| CN102920771A true CN102920771A (en) | 2013-02-13 |
| CN102920771B CN102920771B (en) | 2014-12-10 |
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| CN201210442628.8A Active CN102920771B (en) | 2012-11-08 | 2012-11-08 | Medicine for treating poultry coccidiosis |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547898A (en) * | 2014-12-16 | 2015-04-29 | 北京农学院 | Formula of eimeria tenella disease resistant traditional Chinese medicine with fresh bamboo juice as main ingredient |
| CN104706701A (en) * | 2013-12-16 | 2015-06-17 | 洛阳惠中兽药有限公司 | Chinese and western compounded medicinal composition, and preparation method and application thereof |
| CN110484640A (en) * | 2019-08-15 | 2019-11-22 | 华中农业大学 | The ARMS-PCR primer and its molecular detecting method of sulfanilamide (SN) drug resistance Eimeria Tenella |
| CN110495523A (en) * | 2019-09-25 | 2019-11-26 | 南京惠牧生物科技有限公司 | A kind of antibiotic-free, veterinary drug preparation of no drug residue and preparation method thereof |
| CN110898096A (en) * | 2019-11-22 | 2020-03-24 | 佛山市正典生物技术有限公司 | Decoquinate microcapsule and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040924A (en) * | 2007-04-27 | 2007-09-26 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
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2012
- 2012-11-08 CN CN201210442628.8A patent/CN102920771B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040924A (en) * | 2007-04-27 | 2007-09-26 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王国永等: "TMP、DVD与磺胺氯吡嗪钠联用时抗球虫效果的比较研究", 《黑龙江畜牧兽医》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104706701A (en) * | 2013-12-16 | 2015-06-17 | 洛阳惠中兽药有限公司 | Chinese and western compounded medicinal composition, and preparation method and application thereof |
| CN104706701B (en) * | 2013-12-16 | 2018-03-16 | 洛阳惠中兽药有限公司 | A kind of Chinese-western compound pharmaceutical composition and its preparation method and application |
| CN104547898A (en) * | 2014-12-16 | 2015-04-29 | 北京农学院 | Formula of eimeria tenella disease resistant traditional Chinese medicine with fresh bamboo juice as main ingredient |
| CN110484640A (en) * | 2019-08-15 | 2019-11-22 | 华中农业大学 | The ARMS-PCR primer and its molecular detecting method of sulfanilamide (SN) drug resistance Eimeria Tenella |
| CN110495523A (en) * | 2019-09-25 | 2019-11-26 | 南京惠牧生物科技有限公司 | A kind of antibiotic-free, veterinary drug preparation of no drug residue and preparation method thereof |
| CN110898096A (en) * | 2019-11-22 | 2020-03-24 | 佛山市正典生物技术有限公司 | Decoquinate microcapsule and preparation method thereof |
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| CN102920771B (en) | 2014-12-10 |
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