CN106138184A - A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin - Google Patents
A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin Download PDFInfo
- Publication number
- CN106138184A CN106138184A CN201610704072.3A CN201610704072A CN106138184A CN 106138184 A CN106138184 A CN 106138184A CN 201610704072 A CN201610704072 A CN 201610704072A CN 106138184 A CN106138184 A CN 106138184A
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- Prior art keywords
- radix glycyrrhizae
- amoxicillin
- poultry
- compound medicine
- weight ratio
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin, be made up of amoxicillin and Radix Glycyrrhizae, the weight ratio of amoxicillin and Radix Glycyrrhizae is 1:3 1:30.Described amoxicillin and the weight ratio of Radix Glycyrrhizae are preferably 1:5.The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.The present invention possesses and provides the benefit that: proving through experimental study, amoxicillin is used in combination with specific part by weight with Radix Glycyrrhizae, has synergism obvious, and curative effect is fast, low cost and other advantages.
Description
Technical field
The invention belongs to poultry compound medicine technical field, particularly relate to a kind of poultry containing Radix Glycyrrhizae and amoxicillin and use
Compound medicine, the disease caused for treating poultry to be infected by colon bacillus.
Background technology
Radix Glycyrrhizae is pulse family Glycyrrhiza perennial herb, and the root and rhizome of Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, eliminates the phlegm
Many effects such as cough-relieving, relieving spasm to stop pain, the mediation property of medicine, raising animal body immunity.At present, the root and rhizome of Radix Glycyrrhizae frequently as in
Medical herbs feed additive, medicine source is enriched, is had no side effect in animal body, almost without residual, does not the most produce drug resistance, collects nutrition
Keep healthy, prevent disease, seasoning flavouring, promote Production of Livestock and Poultry and improve animal meat quality in one.Radix Glycyrrhizae root and rhizome is raised poultry
Feed additives not only has stimulating appetite, strengthening digestion, improve local flavor, function that growth promotion is fattened, and there is prevention and control
Treating the function of multiple livestock and poultry, research shows, adds Radix Glycyrrhizae and can promote growth of animals or poultry, eat for a long time in additive for farm animal feed
With making poultry fur light, domestic animal gets fat soon, and poultry egg laying is many.Radix Glycyrrhizae adds in the Chinese medicine fodder of prevention and treatment common diseases of chickens
When adding in agent application, have that prophylactic treatment is effective, without any side effects, raw material is easy to get, cheap advantage.Additionally,
Radix Glycyrrhizae root and rhizome can be additionally used in the poisoning of piglet furazolidone, domestic animal eats the poisoning of the animal such as toxic plant poisoning, pig mouldy cron poisoning by mistake
Rescue, rescued effect is preferable.Radix Glycyrrhizae root and rhizome can be used for the treatment and prevention of multiple livestock and poultry as veterinary medicine, and obtains
Extraordinary treatment and prevention effect.
After poultry are infected by colon bacillus, the multiple locations such as acute sepsis, peritonitis, hepatitis, pneumonia, enteritis can be caused
Severe infections, causes huge economic loss to livestock and poultry cultivation.Amoxicillin, norfloxacin, florfenicol etc. are to prevent and treat this type of
The conventional Western medicine of disease, along with medication is more and more spread unchecked, its Resistant strain is the most, and drug cost is the most increasing, but
Therapeutic effect and drug resistance situation are not taken a turn for the better, and go from bad to worse on the contrary.
Through retrieval, do not inquire Radix Glycyrrhizae and amoxicillin are combined for treat poultry by colon bacillus infect draw
The relevant report of the disease risen.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin, its association
Same-action is obvious, it is possible to eliminate the colon bacillus drug resistance to amoxicillin, improves therapeutic effect.
For solving above technical problem, the present invention by the following technical solutions: a kind of containing Radix Glycyrrhizae with the poultry of amoxicillin
With compound medicine, being made up of amoxicillin and Radix Glycyrrhizae, the weight ratio of amoxicillin and Radix Glycyrrhizae is 1:3-1:30.
Described amoxicillin and the weight ratio of Radix Glycyrrhizae are preferably 1:5.
The present invention is also claimed by the compound preparation become prepared by above-mentioned poultry compound medicine.
The present invention possesses and provides the benefit that: prove through experimental study, and amoxicillin and Radix Glycyrrhizae are with specific part by weight
Being used in combination, have synergism obvious, curative effect is fast, low cost and other advantages.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme and beneficial effect are described further, except Special Statement
Outward, Radix Glycyrrhizae weight of the present invention is the dry weight of Radix Glycyrrhizae.
One, the Radix Glycyrrhizae mensuration to the drug resistance elimination effect of amoxicillin
1. assay method
It is the mixing medicine that 1:1,1:3,1:5,1:10,1:30,1:50 prepare Radix Glycyrrhizae and various Western medicine respectively according to weight ratio
Liquid；Choose the bacterial strain to Western medicine drug resistance as subjects, utilize plate dilution method to carry out Secondary Culture, measure each process medicinal liquid
MIC situation of change to Resistant strain；Set the Western medicine being not added with Radix Glycyrrhizae to compare as sun, if it is right as the moon to be not added with Radix Glycyrrhizae and Western medicine simultaneously
According to.
Above-mentioned process was cultivated for 4 generations the most continuously.
2. result of the test
After cultivating for 4 generations continuously, the process flat board of cloudy comparison is long bacterium, and other each medicaments and admixing medical solutions are for large intestine angstrom
The result statistics of the MIC of uncommon Salmonella is as shown in table 1:
As seen from the above table, when the weight ratio of amoxicillin Yu Radix Glycyrrhizae is 1:3 and 1:10, amoxicillin is to drug resistance large intestine angstrom
The minimal inhibitory concentration of uncommon Salmonella all reduces more than 32 times, and when weight ratio is 1:5, amoxicillin is to drug resistance colon bacillus
Minimal inhibitory concentration all reduces more than 64 times, and when weight ratio is 1:30, the minimum of drug resistance colon bacillus is pressed down by amoxicillin
Bacteria concentration all reduces more than 4 times, it is seen then that the drug resistance of amoxicillin is substantially reduced by drug resistance colon bacillus.
And when the weight ratio of amoxicillin Yu Radix Glycyrrhizae is 1:1 and 1:50, amoxicillin is to drug resistance colon bacillus
Minimal inhibitory concentration, compared with the sun comparison being not added with Radix Glycyrrhizae, does not has significant change.
Two, the experiment in vitro that amoxicillin and Radix Glycyrrhizae are used in combination
It is 1:5 mixing by amoxicillin and Radix Glycyrrhizae (powder) according to weight ratio, makes powder, as test group；Separately set Ah not
XiLin single dose and Radix Glycyrrhizae single dose as a control group 1 and matched group 2.
Subjects is the chicken group making a definite diagnosis and having infected E.coli from chickens disease.
Morbidity chicken group is divided into 3 groups of administrations.Test group is administered according to the addition of 1g/kg feedstuff, and matched group 1 uses A Moxi
Woods single dose is administered according to the addition of 0.2g/kg feedstuff, and matched group 2 Radix Glycyrrhizae single dose is administered according to the addition of 1g/kg feedstuff；
The equal SM of each group 5 days.
Result of the test: the sick chicken feed intake of test group increased, without dead, after using 5 days, chicken group can fully recover；Comparison
Chicken group's great majority still wan of group 1, has the sick chicken death of 4%；Chicken group's great majority of matched group 2 are also still wans, have
The sick chicken death of 15%.
Claims (3)
1. one kind contains Radix Glycyrrhizae and the poultry compound medicine of amoxicillin, it is characterised in that be made up of amoxicillin and Radix Glycyrrhizae, Ah
The weight ratio of Amdinocillin and Radix Glycyrrhizae is 1:3-1:30.
Poultry compound medicine containing Radix Glycyrrhizae and amoxicillin the most according to claim 1, it is characterised in that described Ah
The weight ratio of Amdinocillin and Radix Glycyrrhizae is 1:5.
3. by the compound preparation become prepared by the poultry compound medicine described in claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704072.3A CN106138184A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610704072.3A CN106138184A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106138184A true CN106138184A (en) | 2016-11-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610704072.3A Withdrawn CN106138184A (en) | 2016-08-22 | 2016-08-22 | A kind of poultry compound medicine containing Radix Glycyrrhizae and amoxicillin |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511644A (en) * | 2016-12-16 | 2017-03-22 | 范明忠 | Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948930A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN103948657A (en) * | 2014-04-25 | 2014-07-30 | 广西大学 | Creat/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN103948677A (en) * | 2013-03-18 | 2014-07-30 | 广西大学 | Boneset/amoxicillin-containing compound medicine for livestock and fowl |
| CN103989728A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and beta-lactam antibacterial medicine containing compound medicine for livestock and poultry |
-
2016
- 2016-08-22 CN CN201610704072.3A patent/CN106138184A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948677A (en) * | 2013-03-18 | 2014-07-30 | 广西大学 | Boneset/amoxicillin-containing compound medicine for livestock and fowl |
| CN103948657A (en) * | 2014-04-25 | 2014-07-30 | 广西大学 | Creat/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN103948930A (en) * | 2014-05-14 | 2014-07-30 | 广西大学 | Red paeonia/beta-lactam-antibacterial-agent-containing compound medicine for livestock and fowl |
| CN103989728A (en) * | 2014-05-28 | 2014-08-20 | 广西大学 | Acalypha australis L. and beta-lactam antibacterial medicine containing compound medicine for livestock and poultry |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511644A (en) * | 2016-12-16 | 2017-03-22 | 范明忠 | Compound medicine containing Radix Glycyrrhizae, Cissus pteroclada Hayata and amoxicillin and used for livestock and poultry |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161123 |
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