CN104435069A - Veterinary medicine composition capable of improving pig immune function, application and preparation method of veterinary medicine composition - Google Patents
Veterinary medicine composition capable of improving pig immune function, application and preparation method of veterinary medicine composition Download PDFInfo
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- CN104435069A CN104435069A CN201410799433.8A CN201410799433A CN104435069A CN 104435069 A CN104435069 A CN 104435069A CN 201410799433 A CN201410799433 A CN 201410799433A CN 104435069 A CN104435069 A CN 104435069A
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- folium eucommiae
- medicinal composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a veterinary medicine composition capable of improving a pig immune function, an application and a preparation method of the veterinary medicine composition. Each 1,000g of veterinary medicine composition is prepared from the following components by weight: 300-600g of folium cortex eucommiae, 5-12g of bacillus licheniformis, 5-30g of bacillus subtilis, 0.5-5g of vitamin E and the balance of glucose, wherein the folium cortex eucommiae can be replaced with a folium cortex eucommiae extract; and the veterinary medicine composition is prepared by the steps of preprocessing the components, mixing and sub-packaging. The veterinary medicine composition disclosed by the invention can be applied to a feed additive, so that the immune index of the pig can be significantly improved; the immune function of the pig is enhanced; and the growth of the pig is promoted.
Description
Technical field
The present invention relates to field of veterinary, be specifically related to a kind of animal medicinal composition, application and preparation method thereof that improve pig immunologic function.
Background technology
Along with the raising of people's living standard, animal foodstuff health and safety are also more and more paid attention to.The current factor affecting China's animal-derived food safety mainly comprises drug residue and microbial contamination etc.Because some antimicrobial class veterinary drug is except having antibacterial and bactericidal action, also there is good growth promoting function, so be widely used in animal feed additive.But, just because of the excessive use of a large amount of antibacterials, even to abuse, thus result in a current worldwide tackling key problem difficult problem, i.e. the residue problem of medicine in livestock products.China is as a cultivation big country, and the antibacterials consumption every year in cultivation is surprising, and China's breeding enterprise is more in addition, and cultivation level is uneven, and related management and supervisory system are perfect not enough, and drug residue detection technique level is lower.Therefore, drug residue problem drastically influence the animal-derived food safety of China, affects human body healthy simultaneously.
Current many developed countries have advocated not use residual Antibacterial medicines, China has also put into effect series of measures, comprise the interpolation application of stop section chemical classes medicine in veterinary clinic and feedstuff, encourage the research and development carrying out safe and efficient novel fodder additive and veterinary drug.
Summary of the invention
In view of this, the application provides a kind of animal medicinal composition, application and preparation method thereof that improve pig immunologic function, the component of this animal medicinal composition adopts the harmless Chinese medicine of animal and probiotics, utilize its antibacterial bacteriostatic performance, the immunologic function of the animal of improving, and the noresidue in animal body of this animal medicinal composition, be conducive to Animal Food Security.
For solving above technical problem, technical scheme provided by the invention is a kind of animal medicinal composition improving pig immunologic function, and described in every 1000g, animal medicinal composition is composed of the following components: Folium Eucommiae 300-600g, Bacillus licheniformis 5-12g, bacillus subtilis 5-30g, vitamin E 0.5-5g, surplus are glucose.
Preferably, described in every 1000g, animal medicinal composition is composed of the following components: Folium Eucommiae 500g, Bacillus licheniformis 10g, bacillus subtilis 25g, vitamin E 4g, surplus are glucose.
The technical scheme provided of the present invention also comprises the preparation method of above-mentioned animal medicinal composition: get Folium Eucommiae 300-600g, be crushed to 80-200 orders, add bacillus licheniformis 5-12g, bacillus subtilis 5-30g, vitamin E 0.5-5g, add glucose again to 1000g, mix rear subpackage and get final product.
Wherein, the Folium Eucommiae described in technical solution of the present invention can be replaced Folium Eucommiae extract.
Preferably, described Folium Eucommiae extract counts 1500-6000g by Folium Eucommiae crude drug in whole.
More preferred, described Folium Eucommiae extract counts 5000g by Folium Eucommiae crude drug in whole.
Wherein, described Folium Eucommiae extract is prepared by following methods: get Folium Eucommiae appropriate, add 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, obtained after pulverizing.
Wherein, above-mentioned to take Folium Eucommiae extract as the preparation method of the animal medicinal composition of component be: get Folium Eucommiae 1500-6000g, add 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, pulverize to obtain Folium Eucommiae extract powder, add Bacillus licheniformis 5-12g, bacillus subtilis 5-30g, vitamin E 0.5-5g, add glucose again to 1000g, mix rear subpackage and get final product.
Technical scheme provided by the invention also comprises the application of above-mentioned animal medicinal composition, and described animal medicinal composition can be applicable to feed additive.
Wherein, the Folium Eucommiae in the application, bacillus licheniformis, bacillus subtilis, vitamin E, glucose all derive from commercially available.
Compared with prior art, it is described in detail as follows the application: the application adopts the harmless Chinese medicine of animal and probiotics, utilizes its antibacterial bacteriostatic performance, the immunologic function of the animal of improving, wherein Folium Eucommiae and Folium Eucommiae extract have invigorating the liver and kidney, bone and muscle strengthening, the effect of enhancing human body immunity function; The dysbacteriosis of Bacillus licheniformis adjustable reaches therapeutic purposes, body can be impelled to produce antibacterial substance, kill pathogenic bacterium, can produce resistant activity material, and the biology with uniqueness takes oxygen mechanism of action by force, can suppress the growth and breeding of pathogenic bacterium; Bacillus subtilis can consume rapidly the free oxygen in environment, cause intestinal hypoxia, promote that useful anaerobe grows, and produce the organic acids such as lactic acid, reduce intestinal pH value, indirectly suppress the growth of other pathogenic bacterium, the growth promoter of stimulating animal immune organ, improve immunoglobulin and antibody horizontal, strengthen cellular immunization and humoral immune function, improve herd immunity; Vitamin E has regulating action to hypophysis-middle brain system, promotes to produce hormone, and stimulate thyroxine and adrenergic secretion, the generation of Promote immunity globulin, improves the resistance to disease, strengthens anti-stress.Prove through test, the composition of each composition and proportioning in the application, the every immune indexes of animal can be significantly improved, strengthen immune effect, compared to the effect of each one-component, show the effect of Synergistic between each component of the application, and proved by animal experiment, the application's compositions can promote growth of animal.
Detailed description of the invention
In order to make those skilled in the art understand technical scheme of the present invention better, below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment one
Get Folium Eucommiae 300g, be crushed to 80-200 orders, add bacillus licheniformis 5g, bacillus subtilis 5g, vitamin E 0.5g, then add glucose to 1000g, subpackage after mixing.
Embodiment two
Get Folium Eucommiae 600g, be crushed to 80-200 orders, add bacillus licheniformis 12g, bacillus subtilis 30g, vitamin E 5g, then add glucose to 1000g, subpackage after mixing.
Embodiment three
Get Folium Eucommiae 500g, be crushed to 80-200 orders, add bacillus licheniformis 10g, bacillus subtilis 25g, vitamin E 4g, then add glucose to 1000g, subpackage after mixing.
Embodiment four
Get Folium Eucommiae 1500g, add 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, pulverizes to obtain Folium Eucommiae extract powder, adds Bacillus licheniformis 5g, bacillus subtilis 5g, vitamin E 0.5g, then add glucose to 1000g, subpackage after mixing.
Embodiment five
Get Folium Eucommiae 6000g, add 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, pulverizes to obtain Folium Eucommiae extract powder, adds Bacillus licheniformis 12g, bacillus subtilis 30g, vitamin E 5g, then add glucose to 1000g, subpackage after mixing.
Embodiment six
Get Folium Eucommiae 5000g, add 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, pulverizes to obtain Folium Eucommiae extract powder, adds Bacillus licheniformis 10g, bacillus subtilis 25g, vitamin E 4g, then add glucose to 1000g, subpackage F after mixing.
Embodiment seven
Get Folium Eucommiae 500g, be crushed to 80-200 orders, then add glucose to 1000g, subpackage after mixing.
Embodiment eight
Get Folium Eucommiae 5000g, add 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, pulverize to obtain Folium Eucommiae extract powder, then add glucose to 1000g, subpackage after mixing.
Embodiment nine
Get bacillus licheniformis 10g, then add glucose to 1000g, subpackage after mixing.
Embodiment ten
Get bacillus subtilis 25g, then add glucose to 1000g, subpackage after mixing.
Embodiment 11
Get bacillus licheniformis 10g, bacillus subtilis 25g, add glucose to 1000g again, subpackage after mixing.Experimental example one
Mouse immune effect experimental
Get the kunming mouse (16-18g) 260 that preparation is raised, stochastic averagina is divided into 13 groups, often organizes 20, is respectively 1 group of normal group, 1 group model group, 11 groups of experimental group: A-K.
Except normal group, the each group of intraperitoneal injection of cyclophosphamide 50mg/kg.W modeling in the 3rd, 6,10 day respectively at experiment, experimental group A-K group started to gavage medicine in the experiment first day, gavage medicine and be respectively medicine prepared by embodiment one to embodiment 11, a perfusion amount 200mg/ mice, continuous 14 days, once a day, normal group and model group often only gavage normal saline, keep suitable temperature and light photograph in experimentation, until experiment terminates on the 14th day.
Wherein, mg/kg.W represents: milligram cyclophosphamide/kg animal weight.
At the end of experiment, measure index and spleen index, gather whole blood and serum, measure leukocyte and lymphocytic ratio in whole blood with cellanalyzer respectively.
Table 1 experimental example one immune effect experimental result
Note: * represents with model group comparing difference remarkable
Experimental result shows, the amynologic index of model group, significantly lower than normal group, shows modeling success; Animal medicinal composition in the mouse gavaging of experimental group A-F technical scheme, it respectively organizes the level that every immune indexes all can return to normal group, and most of index is all higher than the immune indexes of normal group, illustrate that the application's animal medicinal composition effectively can improve the immunosuppressive condition of mice, it can also be seen that from Body Mass Index, the animal medicinal composition of the application while recovery immune indexes, can increase the body weight of mice, promotes the growth of mice.By A-F experimental group compared with the experimental group G-K of one-component, can find out, single component experimental group can partly improve every immune indexes, but effectively the immune indexes of mice can not be returned to normal level, its immunoenhancement result is not obvious, the effect selection of each component in technical scheme and proportioning with Synergistic is described, reaches beyond thought remarkable result.A-F experimental group in technical scheme is carried out organizing interior contrast, can find out, wherein B, C, E, F group immunoenhancement result is best, resultant effect and cost, wherein C, F experimental group the optimal technical scheme of corresponding animal medicinal composition the application, and the animal medicinal composition of F group is more excellent.
Experimental example two
To pig growth performance Effect disquisition
Health " DLY " ablactational baby pig 480 that Stochastic choice body weight is close, proceed to normal in nursery house raising 2 days, carry out anthelmintic and epidemic prevention during this period, free choice feeding is drunk water.After 3 days, above 480 piglets are divided into 12 groups at random, are divided into 1 group of matched group, 11 groups of experimental group A-K, each group of 40 pigs.Wherein experimental group A-K group adds in 100kg feedstuff by 1kg medicine interpolation of feeding, the medicine that interpolation is fed is respectively the medicine prepared by embodiment one to embodiment 11, add feeding method and adopt group feeding, free choice feeding, freely drink water, other management is carried out according to a conventional method, and matched group does not add medicine, raises under the same conditions with experimental group.
1, clinical indexes
Record the spirit of each group of swinery every day, search for food, the outward appearance body shape such as feces and hair color, observe swinery and record various diseases a situation arises.
2, the growth performance index determining of pig
(1), time from on-test, in units of group, record feeding capacity and the pig number of every day, calculate the average feed intake of each group of pig.
(2) tested rear empty stomach weigh each group of pig Gain weight and make a record, calculate average daily gain.
(3) record feed consumption every day, during off-test, calculate feedstuff-meat ratio.Wherein, the forage volume of feedstuff-meat ratio=certain section of time internal consumption/with the body weight evolution in the time.
3, clinical indexes result:
Whole duration of test, the mental status of the swinery of experimental group and matched group is all better, and search for food, drink water, two just, hair color is all normal, between feeding period, free from infection occurs, and matched group has the raw respiratory tract diseases of 5 hairs, and take a turn for the better after treatment, test group is without incidence.
4, the growth performance index determining result (see table 2) of pig
Table 2 experimental example two experimental result
| Grouping | Average initial weight/kg | Daily gain/g | Equal feed intake/the g of sun | Feedstuff-meat ratio |
| Matched group | 7.66±0.28 | 405.85±24.47 | 671.35±42.33 | 1.66 |
| A | 7.52±0.30 | 416.10±27.11 | 662.14±33.66 | 1.59 |
| B | 7.75±0.23 | 429.27±25.53 | 656.80±27.88 | 1.53 |
| C | 7.71±0.18 | 425.25±31.09 | 649.73±31.02 | 1.52 |
| D | 7.48±0.19 | 420.32±30.27 | 654.30±24.33 | 1.57 |
| E | 7.63±0.20 | 435.71±23.53 | 653.57±31.67 | 1.50 |
| F | 7.81±0.24 | 429.60±21.20 | 648.70±28.90 | 1.51 |
| G | 7.59±0.21 | 408.32±17.41 | 685.97±32.11 | 1.68 |
| H | 7.63±0.17 | 401.02±21.62 | 665.69±29.53 | 1.66 |
| I | 7.64±0.33 | 403.28±27.49 | 665.41±28.14 | 1.65 |
| J | 7.80±0.41 | 411.33±25.52 | 666.35±31.77 | 1.62 |
| K | 7.53±0.25 | 409.26±19.93 | 654.81±29.87 | 1.60 |
As can be seen from experimental result, in average initial weight, 11 experimental grouies and matched group difference are not remarkable, and the daily gain of A-F experimental group is significantly higher than matched group; The daily gain of G-K group is higher than matched group, but increment is not remarkable, illustrates that the animal medicinal composition of technical scheme is compared to one-component, and it promotes that the growth performance of pig significantly improves; In the equal feed intake of sun, A-F experimental group significant difference compared with matched group, feed intake is obviously low than matched group, and G-K group daily ingestion amount and matched group difference not remarkable; In feedstuff-meat ratio index, A-F experimental group significantly lower than matched group, and G-K group and matched group difference not remarkable.Above comparative illustration, the animal medicinal composition of the application is compared to the pharmaceutical composition of one-component, and it promotes that the growth performance of pig has significant effect, and significantly reduces feedstuff-meat ratio, also, in each component of the application and proportioning, has the effect of Synergistic.And carry out A-F experimental group to organize interior contrast, can find out, in daily gain, sun feed intake, feedstuff-meat ratio etc., the index of B group, C group, E group, F group is higher, better effects if, comprehensive product cost and experiment effect, the animal medicinal composition of C group and F group is the optimal technical scheme of the application, and the animal medicinal composition of F group is more excellent.
Below be only the preferred embodiment of the present invention, it should be pointed out that above-mentioned preferred implementation should not be considered as limitation of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For those skilled in the art, without departing from the spirit and scope of the present invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. improve an animal medicinal composition for pig immunologic function, it is characterized in that: described in every 1000g, animal medicinal composition is composed of the following components: Folium Eucommiae 300-600g, Bacillus licheniformis 5-12g, bacillus subtilis 5-30g, vitamin E 0.5-5g, surplus are glucose.
2. animal medicinal composition according to claim 1, is characterized in that: described in every 1000g, animal medicinal composition is composed of the following components: Folium Eucommiae 500g, Bacillus licheniformis 10g, bacillus subtilis 25g, vitamin E 4g, surplus are glucose.
3. the preparation method of animal medicinal composition described in a claim 1 or 2, it is characterized in that: get Folium Eucommiae 300-600g, be crushed to 80-200 orders, add bacillus licheniformis 5-12g, bacillus subtilis 5-30g, vitamin E 0.5-5g, add glucose again to 1000g, mix rear subpackage and get final product.
4., according to the arbitrary described animal medicinal composition of claim 1-3, it is characterized in that: described Folium Eucommiae can be replaced Folium Eucommiae extract.
5. animal medicinal composition according to claim 4, is characterized in that: described Folium Eucommiae extract counts 1500-6000g by Folium Eucommiae crude drug in whole.
6. animal medicinal composition according to claim 5, is characterized in that: described Folium Eucommiae extract counts 5000g by Folium Eucommiae crude drug in whole.
7., according to the arbitrary described animal medicinal composition of claim 4-6, it is characterized in that: described Folium Eucommiae extract is prepared by following methods: get Folium Eucommiae appropriate, add 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, obtained after pulverizing.
8. a preparation method for the arbitrary described animal medicinal composition of claim 4-7, is characterized in that: get Folium Eucommiae 1500-6000g, adds 20-30 times of water yields in mass ratio, decoct 3 times, each 2 hours, collecting decoction, vacuum drying, pulverize to obtain Folium Eucommiae extract powder, add Bacillus licheniformis 5-12g, bacillus subtilis 5-30g, vitamin E 0.5-5g, add glucose again to 1000g, mix rear subpackage and get final product.
9. an application for the arbitrary described animal medicinal composition of claim 1-8, is characterized in that: described animal medicinal composition is applied to feed additive.
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Cited By (4)
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| CN106310235A (en) * | 2016-08-23 | 2017-01-11 | 四川恒通动物制药有限公司 | Veterinary drug composition and preparing method and use thereof |
| CN106615787A (en) * | 2016-12-09 | 2017-05-10 | 徐州科星科技发展有限公司 | Reproductive performance improving feed for sows and preparation method thereof |
| CN110384723A (en) * | 2019-08-21 | 2019-10-29 | 江西旭虹药业有限公司 | It is a kind of improve pig hepatic and renal function animal medicinal composition and its application |
| EP3794952A1 (en) * | 2019-09-19 | 2021-03-24 | DSM IP Assets B.V. | Feed additive comprising bacillus strains for increasing vitamine e absorption |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106310235A (en) * | 2016-08-23 | 2017-01-11 | 四川恒通动物制药有限公司 | Veterinary drug composition and preparing method and use thereof |
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| CN106615787A (en) * | 2016-12-09 | 2017-05-10 | 徐州科星科技发展有限公司 | Reproductive performance improving feed for sows and preparation method thereof |
| CN110384723A (en) * | 2019-08-21 | 2019-10-29 | 江西旭虹药业有限公司 | It is a kind of improve pig hepatic and renal function animal medicinal composition and its application |
| EP3794952A1 (en) * | 2019-09-19 | 2021-03-24 | DSM IP Assets B.V. | Feed additive comprising bacillus strains for increasing vitamine e absorption |
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| CN104435069B (en) | 2018-05-08 |
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