CN104324153A - Traditional Chinese medicine composition for improving immunity of animals and preparation method thereof - Google Patents

Traditional Chinese medicine composition for improving immunity of animals and preparation method thereof Download PDF

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CN104324153A
CN104324153A CN201410565831.3A CN201410565831A CN104324153A CN 104324153 A CN104324153 A CN 104324153A CN 201410565831 A CN201410565831 A CN 201410565831A CN 104324153 A CN104324153 A CN 104324153A
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ethanol
chinese medicine
medicine composition
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董晓盈
赵丽
刘应鹏
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Zhengzhou Houyi Pharmaceutical Co Ltd
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Zhengzhou Houyi Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a traditional Chinese medicine composition for improving immunity of animals. The composition is prepared from the following medicinal raw materials in parts by weight: 5-100 parts of grape seeds, 5-100 parts of astragalus membranaceus, 5-80 parts of codonopsis pilosula, 5-60 parts of coriolus versicolor and 2-50 parts of polyporus umbellatus. The composition is prepared from purely natural traditional Chinese herbs, is easily available in medicinal raw materials, low in price, and safe, does not have residues, and does not have toxic or side effect on bodies of livestock and poultry. According to the technical scheme, the effect of grape seed on improving immunity can be remarkably enhanced by utilizing the remarkable effect of the grape seed and the formula of astragalus membranaceus, codonopsis pilosula, coriolus versicolor, polyporus umbellatus and other traditional Chinese herbal medicinal materials, so that the disease resistance and prevention capabilities of animal bodies can be improved, the palatability of feed can be improved, and the effects of increasing weight and early delivering can be achieved. The traditional Chinese medicine composition for improving immunity of animals is simple in preparation method and easy to operate, and is suitable for large-scale production and popularization, so that economic loss is reduced for farmers, and economic benefits can be greatly increased.

Description

A kind of Chinese medicine composition improving animal immunizing power and preparation method thereof
Technical field
The invention belongs to veterinary drug research and development technology field, be specifically related to a kind of Chinese medicine composition and the preparation method that improve animal immunizing power.
Background technology
In recent years, the various animal epidemics such as reproductive and respiratory syndrome, foot and mouth disease, bird flu, viral diarrhea take place frequently, and old epidemic disease is atypia, new virus and bacteria infectious disease day by day increases, the immuning failure of indivedual infectious disease often occurs, a lot of local epidemic outbreaks, disease becomes more and more refractory and treats, and a lot of plant all suffers heavy losses.To this, many scholars are probing into its basic reason, find effective solution.
Prevention animal generation epidemic disease, first must start with from scientific culture, such as improve the breed, improve feeding environment, management of strengthening comprehension, adopt rational immune programme for children etc.But as previously mentioned, even if these measures have all been carried out, still can not deal with problems completely.Fundamentally control animal epidemic if think, just must make an effort from raising animal body autoimmunity; Must give full play to the physiological function of animal body each side, strengthen animal self body constitution, when an organism self has the ability being enough to resist pathogen invasion, guarantee animal health grows fast.Facts have proved, the immunologic function of animal body completes under the synergism of all many cells such as lymphocyte, killer cell, natural killer cell, mononuclear phagocyte, dendritic cell, erythrocyte, granulocyte, mastocyte, interferon, complement, antibody and molecule, these immunocytes and immune molecule are cruised in vivo everywhere by blood, continue to perform immunologic function, annihilate the pathogen of invasion at any time, its resultant effect determines the power of animal immunizing power and premunition.Therefore, manage effectively to regulate and strengthen cell and the molecule of various control immunologic function in animal body, make it have the ability of annihilating various invasion pathogen at any time, animal can not fall ill naturally; Obviously, this is only the effective way solving epidemic prevention and control.
Be no lack of the product having and improve Immune Function In Animals in the feed additive used in recent years, be also no lack of the product having and accelerate growth of animal.The use of feed additive plays great effect to raising livestock and poultry production performance and culture benefit; it's a great pity that many feed additives that current various countries use are chemical synthetic drug or hormonal substance; with these additive feeding animals; often can produce toxic and side effects to animal; make pathogenic microorganism produce anti-drug resistance, in animal product, produce the problem such as the Harmful Residue and environmental pollution.After people have eaten the animal flesh of these additives of feeding, egg, the phenomenons such as deformity, cancer, senilism, child's precocity occur, and the problem of health risk is very serious.Therefore, national governments have all made laws and have prohibitted the use these additives, and China has also put into effect multiple decree regulation.Along with the development of herbal medicine, Chinese herbal medicine also has obvious effect in Animal nutrition and field of preventing and curing diseases.
Summary of the invention
The technical problem to be solved in the present invention is control animal epidemic, reduces the use of feed additive, improving animal immunizing power, for solving the problem, the invention provides a kind of Chinese medicine composition and the preparation method that improve animal immunizing power.
The object of the invention is to realize in the following manner:
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 5-100 part, Radix Astragali 5-100 part, Radix Codonopsis 5-80 part, the sesame 5-60 part that rues, Polyporus 2-50 part.
Be made up of the crude drug of following parts by weight: Semen Vitis viniferae 15-60 part, Radix Astragali 10-50 part, Radix Codonopsis 10-45 part, the sesame 10-40 part that rues, Polyporus 5-30 part.
Be made up of the crude drug of following parts by weight: Semen Vitis viniferae 35 parts, the Radix Astragali 20 parts, Radix Codonopsis 15 parts, the sesame 20 parts that rues, Polyporus 10 parts.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 8-10 times of Chinese crude drug amount, decoct 2 times, each 1-1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 60-70% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 40-50% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.2-1.5.
Effect of each crude drug is summarized as follows:
Semen Vitis viniferae: 1, contain procyanidin (OPC) in Semen Vitis viniferae, procyanidin has superpower oxidation resistance, it is the antioxidation that current occurring in nature finds, the material that Scavenging ability is the strongest, and its antioxidant activity is 50 times, ascorbic 20 times of vitamin E.The immunne response ability of animal immune system can be significantly improved in Chinese medicine composition, improve immunity of organisms, thus there is antiviral effect.2, Semen Vitis viniferae can divide and tissue regeneration by irritation cell, activation cells of superficial layer, slow down aging.Add Semen Vitis viniferae in fur-bearing animal feedstuff, the pelage quality of fur-bearing animal can be improved, improve fertility performance.3, Semen Vitis viniferae extract has the effect of anticancer, anti-liver neoplasm.Use as Chinese medicine and additive, can immunity of livestock be significantly improved, promote liver cell regeneration, have protect the liver significantly, detoxifying effect, the raising of poultry liver function, can significantly improve fertility performance.
The Radix Astragali: there is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Significantly can increase the total white blood cells in blood, promote phagocytic function and the sterilizing ability of neutrophilic granulocyte and macrophage, promote the lymphocyte transformation that PHA, ConA, PWM (phytolacca american) cause.The Radix Astragali, to 60Co disposable total irradiation mouse spleen antibody-producting cell release hemolysin amount, serum lysozyme amount, has increasing action.To the garland formation rate of delayed hypersensitivity and C 3 b receptor of red blood cells rosette rate, erythrocyte immune complex, all there are promotion in various degree or potentiation.
Radix Codonopsis: the primary efficacy of Radix Codonopsis is QI invigorating, should be used for fatigue and weakness, lassitude usually, more remarkable with Radix Astragali effect.The biosynthesis of the splenocyte DNA that Radix Codonopsis decoct can obviously promote ConA to activate and protein, promote that the optimum concentration that DNA synthesizes is 100 μ g/ml, also there is obvious potentiation to the generation of interleukin-2 (IL-2), also have potentiation to the phagocytic function of mice reticuloendothelial system.
Rue sesame: containing abundant polysaccharide composition in the sesame that rues, and coriolan (PSK), to 60Co200 γ whole body once irradiating, causes immune function of mice low, has certain therapeutical effect.Obviously can increase illuminated mice serum lysozyme content and spleen index, think, to the non-specific immunity of macrophage, there is facilitation.
Polyporus: containing abundant glucosan in Polyporus, polyporusum bellatus can strengthen the phagocytic function of mononuclear phagocyte system, increases bone-marrow-derived lymphocyte to the reaction of antigenic stimulus, antibody forming cell's number is increased.
Beneficial effect of the present invention:
The present invention adopts Semen Vitis viniferae, the Radix Astragali, Radix Codonopsis, the sesame that rues, Polyporus totally 5 kinds of crude drug, wherein Semen Vitis viniferae not only rich in nutritive value, and there is the effect of scavenging free radicals, defying age, enhancing immunity, superpower antioxidation efficiency is 30-50 times of vitamin C and vitamin E, can use as health-caring feedstuff addictive, there is certain disease resistance ability.The effect that Semen Vitis viniferae is applied clinically has: 1, can the antibiotic application of Substitute For Partial, plays a very important role to production antibiotic-free milk, no drug residue Carnis Gallus domesticus and no drug residue animal foodstuff; 2, significant to the preventive care of animal; 3, to raising animal immunizing power, the effect of breeding environment aspect is improved obvious; 4, certain anti-stress effect is had; 5, for raising feed digestion absorbance, improving intestinal function aspect has positive role; 6, protection eyes are had, protection gastric mucosa and the gastral effect of Conservative restoration; 7, the effect of antibacterial anti-feedstuff toxin liver function protecting is had; 8, the Semen Vitis viniferae dregs of rice have no side effect, and use, can ensure Animal Food Security as feed additive; 9, feedstuff outward appearance can be improved, improve commodity; 10, the palatability of feedstuff can be improved, thus embody the positive effect of weightening finish.
The present invention is the compositions configured by the Chinese herbal medicine of pure natural, crude drug is easy to get, cheap and safety, noresidue, without any side effects to poultry body, its technical essential utilizes the significant effect of Semen Vitis viniferae and the Radix Astragali, Radix Codonopsis exactly, rue the herbal prescription such as sesame, Polyporus, obviously can strengthen Semen Vitis viniferae and improve efficacy of immunity, thus improve animal body defending and fighting against diseases ability, improve the palatability of feedstuff, reach the effect that weightening finish is delivered for sale in advance.
The present invention not only utilizes effect of above Chinese medicine composition, also play the effect that superfine powder absorbs in vivo, superfine powder has the following advantages: the dissolution rate and the dissolution rate that 1, improve effective ingredient, 2, the absorbance of medicine is increased, improve bioavailability, 3, improve drug effect, reduce dosage, economize in raw materials medical material, and 4, Chinese medicine ultra-fine powder natural goods has no side effect.
The Chinese medicine composition preparation method of raising animal immunizing power of the present invention is simple, easy to operate, is suitable for large-scale production and applies, decreasing economic loss to raiser, substantially increasing economic benefit.
Detailed description of the invention
Embodiment 1:
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 5-100 part, Radix Astragali 5-100 part, Radix Codonopsis 5-80 part, the sesame 5-60 part that rues, Polyporus 2-50 part.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 8-10 times of Chinese crude drug amount, decoct 2 times, each 1-1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 60-70% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 40-50% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.2-1.5.
Usage and consumption: medication is feeding, the poultry feeding 0.5-1g of the every 1kg body weight of ampoule once-a-day, 5th is a course for the treatment of.
Embodiment 2:
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 5g, Radix Astragali 5g, Radix Codonopsis 5g, the sesame 5g that rues, Polyporus 2g.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 8 times of Chinese crude drug amounts, decoct 2 times, each 1h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 60% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 40% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.2.
Usage and consumption: medication is feeding, the poultry feeding 0.5g of the every 1kg body weight of ampoule once-a-day, 5th is a course for the treatment of.
Embodiment 3
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 35g, Radix Astragali 20g, Radix Codonopsis 15g, the sesame 20g that rues, Polyporus 10g.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 9 times of Chinese crude drug amounts, decoct 2 times, each 1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 62% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 42% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.3.
Usage and consumption: medication is feeding, the poultry feeding 0.6g of the every 1kg body weight of ampoule once-a-day, 5th is a course for the treatment of.
Embodiment 4
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 20g, Radix Astragali 12g, Radix Codonopsis 10g, the sesame 12g that rues, Polyporus 6g.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 10 times of Chinese crude drug amounts, decoct 2 times, each 1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 64% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 44% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.4.
Usage and consumption: medication is feeding, the poultry feeding 0.7g of the every 1kg body weight of ampoule once-a-day, 5th is a course for the treatment of.
Embodiment 5
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 30g, Radix Astragali 30g, Radix Codonopsis 25g, the sesame 25g that rues, Polyporus 15g.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 10 times of Chinese crude drug amounts, decoct 2 times, each 1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 66% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 46% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.5.
Usage and consumption: medication is feeding, the poultry feeding 0.8g of the every 1kg body weight of ampoule once-a-day, 5th is a course for the treatment of.
Embodiment 6
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 40g, Radix Astragali 40g, Radix Codonopsis 32g, the sesame 30g that rues, Polyporus 20g.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 10 times of Chinese crude drug amounts, decoct 2 times, each 1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 68% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 48% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.4.
Usage and consumption: medication is feeding, the poultry feeding 0.9g of the every 1kg body weight of ampoule once-a-day, 5th is a course for the treatment of.
Embodiment 7
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 50g, Radix Astragali 50g, Radix Codonopsis 40g, the sesame 35g that rues, Polyporus 25g.
Concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 10 times of Chinese crude drug amounts, decoct 2 times, each 1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 70% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 50% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
At described filtrate is concentrated into 70 DEG C, relative density is 1.4.
Usage and consumption: medication is feeding, the poultry feeding 1g of the every 1kg body weight of ampoule once-a-day, 5th is a course for the treatment of.
Embodiment 8
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 60g, Radix Astragali 60g, Radix Codonopsis 48g, the sesame 40g that rues, Polyporus 30g.
The other the same as in Example 1.
Embodiment 9
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 70g, Radix Astragali 70g, Radix Codonopsis 55g, the sesame 45g that rues, Polyporus 35g.
The other the same as in Example 1.
Embodiment 10
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 80g, Radix Astragali 80g, Radix Codonopsis 60g, the sesame 50g that rues, Polyporus 40g.
The other the same as in Example 1.
Embodiment 11
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 90g, Radix Astragali 90g, Radix Codonopsis 70g, the sesame 55g that rues, Polyporus 45g.
The other the same as in Example 1.
Embodiment 12
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 100g, Radix Astragali 100g, Radix Codonopsis 80g, the sesame 60g that rues, Polyporus 50g.
The other the same as in Example 1.
Embodiment 13
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 15g, Radix Astragali 10g, Radix Codonopsis 10g, the sesame 10g that rues, Polyporus 5g.
The other the same as in Example 1.
Embodiment 14
Improve a Chinese medicine composition for animal immunizing power, be made up of the crude drug of following parts by weight: Semen Vitis viniferae 60g, Radix Astragali 50g, Radix Codonopsis 45g, the sesame 40g that rues, Polyporus 30g.
The other the same as in Example 1.
The parts by weight of the Chinese medicine composition of other embodiment are as shown in table 1, and the other parts of these embodiments are with embodiment 1.
The parts by weight of the Chinese medicine composition of other embodiment of table 1
Embodiment Semen Vitis viniferae/g The Radix Astragali/g Radix Codonopsis/g Rue sesame/g Polyporus/g
15 10 10 8 8 8
16 15 15 12 15 12
17 25 25 18 22 18
18 45 45 30 32 22
19 55 55 35 38 28
20 65 65 45 42 32
21 75 75 50 48 38
22 85 85 58 52 42
23 95 95 65 58 48
Test example
By 600 piglet random assortment in test group and matched group, often organize 150, test group 1 feeding is added with the feedstuff of the made Chinese medicine composition of embodiment 2, test group 2 feeding is added with the feedstuff of the made Chinese medicine composition of embodiment 3, test group 3 feeding is added with the feedstuff of the made Chinese medicine composition of embodiment 4, medication is feeding, the poultry feeding 1g of the every 1kg body weight of ampoule.Free choice feeding, adds duty less and adds, and provides sufficient, clean drinking-water, ensures column home sanitation and hygiene, and regularly to pig house and feed trough sterilization, test period is for wean is to weaning latter 14 days.Record feed intake and pig weight every day, calculate daily gain and feedstuff-meat ratio.Add up piglet diarrhea rate simultaneously, carry out immunological test to piggy injection swine Fever Vaccine, average antibody minuent and the antibody uniformity are analyzed in blood sampling.Result of the test refers to following table 2.
The each group result of the test of table 2
Conclusion: statistical analysis is known, daily gain, the Mean antibody titers of test group are significantly higher than matched group, and feedstuff-meat ratio, piglet diarrhea rate and the antibody uniformity are significantly lower than matched group.

Claims (5)

1. improve a Chinese medicine composition for animal immunizing power, it is characterized in that: be made up of the crude drug of following parts by weight: Semen Vitis viniferae 5-100 part, Radix Astragali 5-100 part, Radix Codonopsis 5-80 part, the sesame 5-60 part that rues, Polyporus 2-50 part.
2. a kind of Chinese medicine composition improving animal immunizing power according to claim 1, is characterized in that: be made up of the crude drug of following parts by weight: Semen Vitis viniferae 15-60 part, Radix Astragali 10-50 part, Radix Codonopsis 10-45 part, the sesame 10-40 part that rues, Polyporus 5-30 part.
3. a kind of Chinese medicine composition improving animal immunizing power according to claim 2, is characterized in that: be made up of the crude drug of following parts by weight: Semen Vitis viniferae 35 parts, the Radix Astragali 20 parts, Radix Codonopsis 15 parts, the sesame 20 parts that rues, Polyporus 10 parts.
4. a kind of preparation method improving the Chinese medicine composition of animal immunizing power according to claim 1,2 or 3, is characterized in that: concrete operation step is:
A, accurately take Semen Vitis viniferae according to parts by weight, first pulverize, then carry out micronizing, Semen Vitis viniferae is crushed to 300 orders, obtains grape seed ultramicro-farina for subsequent use;
B, accurately take all the other four kinds of Chinese herbal medicine according to parts by weight, add the water of 8-10 times of Chinese crude drug amount, decoct 2 times, each 1-1.5h, merging filtrate is also concentrated, and filtrate carries out precipitate with ethanol after being concentrated into thick paste, described precipitate with ethanol is that the ethanol that first to add containing determining alcohol in thick paste be 60-70% carries out first time precipitate with ethanol, carry out second time precipitate with ethanol with the ethanol containing determining alcohol being 40-50% again, reclaim ethanol after precipitate with ethanol, it is for subsequent use that spraying dry obtains dry powder;
C, by two component mix homogeneously of a step and b step gained.
5. a kind of preparation method improving the Chinese medicine composition of animal immunizing power according to claim 4, is characterized in that: at described filtrate is concentrated into 70 DEG C, relative density is 1.2-1.5.
CN201410565831.3A 2014-10-22 2014-10-22 Traditional Chinese medicine composition for improving immunity of animals and preparation method thereof Pending CN104324153A (en)

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